Otay Mesa Vacations from ￥331,426

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The Latest Otay Mesa Vacation Packages

Price found within the past 48 hours. Click for updated prices.
WorldMark San Diego - Balboa Park

WorldMark San Diego - Balboa Park

3.5 out of 5
Downtown San Diego
per person
Aug 23 - Aug 30
found 13 hours ago
Roundtrip non-stop flight included
Tokyo (NRT) to San Diego (SAN)
8.2/10 Very Good! (88 reviews)
The property was lovely and the staff was incredibly friendly and welcoming. The location of the property was also good, close to most attractions. Unfortunately, around the property there were too many homeless people, leaving us slightly uncomfortable when walking in the evenings.

Reviewed on Jul 19, 2025

The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 out of 5
Downtown San Diego
per person
Aug 23 - Aug 30
found 13 hours ago
Roundtrip non-stop flight included
Tokyo (NRT) to San Diego (SAN)
9/10 Wonderful! (2,383 reviews)
Really enjoyed my stay, staff we're helpful and friendly. The hotel is well kept and room was clean and comfy.

Reviewed on Jul 23, 2025

The Bower Coronado

The Bower Coronado

5 out of 5
Historic Downtown Coronado
per person
Aug 23 - Aug 30
found 13 hours ago
Roundtrip non-stop flight included
Tokyo (NRT) to San Diego (SAN)
9.2/10 Wonderful! (33 reviews)
About a five minute walk from the beach, they have beach chairs and towels you can take, which is great! Hotel is clean and cozy. They have yummy complimentary coffee and danishes in the morning. The only down side is, it isn’t as welcoming when checking in. I got thrown off on where to check in. Also, probably not good for families with little kids, probably best for couples or an all adult stay.

Reviewed on Jul 21, 2025

Rancho Bernardo Inn

Rancho Bernardo Inn

4 out of 5
Rancho Bernardo
per person
Aug 23 - Aug 30
found 13 hours ago
Roundtrip non-stop flight included
Tokyo (NRT) to San Diego (SAN)
8.8/10 Excellent! (1,003 reviews)
Staff was not very polite. Gave me wrong information about location of room.

Reviewed on Jul 22, 2025

Glorietta Bay Inn Coronado Island

Glorietta Bay Inn Coronado Island

3.5 out of 5
Historic Downtown Coronado
per person
Aug 23 - Aug 30
found 13 hours ago
Roundtrip non-stop flight included
Tokyo (NRT) to San Diego (SAN)
8.6/10 Excellent! (1,002 reviews)
The location was perfect for our family vacation and staff were so nice. Super friendly. I would absolutely stay there again!

Reviewed on Jul 16, 2025

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa Hotel Deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
Fully refundable
The price is ￥20,489 per night from Aug 10 to Aug 11
￥20,489
￥23,306 total
Aug 10 - Aug 11
includes taxes & fees
7.8/10 Good! (1,405 reviews)
"The property was clean, quiet, and conveniently located. The staff was friendly and helpful throughout our stay. The room was well-equipped and the bed very comfortable."

Reviewed on Jul 18, 2025

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ￥18,750 per night from Aug 17 to Aug 18
￥18,750
￥21,552 total
Aug 17 - Aug 18
includes taxes & fees
8/10 Very Good! (1,891 reviews)
Birthday Celebration
"Check in was easy, Hotel is older but fairly well maintained, The Staff was friendly and helpful, at the front desk during check in one of the staff team (WHO WAS NOT HELPING US AT ALL) went into a back office and came out a few minutes later with a ballon saying "where is that little guy" That simple ..."

Reviewed on Jul 21, 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ￥21,174 per night from Jul 29 to Jul 30
￥21,174
￥28,784 total
Jul 29 - Jul 30
includes taxes & fees
8.2/10 Very Good! (5,758 reviews)
"Nice, but lots of fees and expensive parking"

Reviewed on Jul 22, 2025

Wyndham San Diego Bayside
See all 4,601 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa vacation package cost?
Starting from as low as ￥331,426, a vacation package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa vacation packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighborhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa vacation?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your vacation time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're traveling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organizing an island getaway in a villa or prefer to stay in a cozy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia vacation package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa vacation package?
Don't worry if you're rethinking your Otay Mesa vacation package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Discover the most popular places to visit in Otay Mesa

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and entertainment choices.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

￥13,356
per adult
100% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
Kayak on the San Diego Bay

Kayak on the San Diego Bay

￥2,932
per adult
Kayak on the San Diego Bay
San Diego USS Midway with Waterfront Walking Tour

San Diego USS Midway with Waterfront Walking Tour

￥5,717
per adult
San Diego USS Midway with Waterfront Walking Tour
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.