Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's acclaimed art scene and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Private Winery Tour
From Tijuana: Valle de Guadalupe Shared Winery Tour
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Otay Mesa Hotel Deals
Hilton San Diego Mission Valley
Didn’t use the pool but area very well maintained Only negative comment Saturday morning went to the front desk to have only our beds made . Came back to the hotel at 7:00 pm beds were not made very disappointing I did call when I came back to my room the front desk so the supervisor of my housekeeper ...
Reviewed on Oct 28, 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
A nice, clean Hampton Inn. Everything that you would expect
Reviewed on Oct 27, 2025
Pendry San Diego
The rooms were very nice and the location is perfect for San Diego. It's a very nice hotel.
Reviewed on Oct 22, 2025
Hard Rock Hotel San Diego
Staff was great. My only two complaint is. The main lobby is over powering with some type of air freshener. And also our balcony door did not lock. It is very noisy at night but you are in down town where all the night life is. It’s a nice stay for sure.
Reviewed on Oct 26, 2025
Courtyard by Marriott San Diego Downtown Little Italy
Balcony view and healthy breakfast! Excellent customer service!
Reviewed on Oct 28, 2025
InterContinental San Diego by IHG
So the overall staff and the ambience of the hotel were absolutely outstanding. I love the fact that you have Byredo products in your rooms standard. However, there were a couple things that I would expect from a luxury hotel that were kind of missing. There was no bell cart to take your stuff from ...
Reviewed on Oct 29, 2025
Other neighborhoods around Otay Mesa
Mid-City
If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Del Cerro
Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.
Otay Mesa, CA
- Places of interest
- More Hotel Options in Otay Mesa
- Hotels in top San Diego neighborhoods
- Other vacations you might like
- San Diego Zoo
- San Diego Convention Center
- Mission Bay
- Petco Park
- Mission Beach
- Balboa Park
- Hotel Circle
- Naval Base San Diego
- Port of San Diego
- USS Midway Museum
- Marine Corps Recruit Depot
- Hotel del Coronado
- Coronado Beach
- Naval Base Coronado
- Seaport Village
- Old Town San Diego State Park
- Waterfront Park
- Fashion Valley Mall
- North Island Credit Union Amphitheatre
- Snapdragon Stadium
- Shelter Island
- Belmont Park
More Hotel Options in Otay Mesa
Other Hotels near Otay Mesa, San Diego
Expedia's Latest Trends
- Visit Venice Canals
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- Visit Boyle Heights
- Visit Mission Valley
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- Visit Miramar
- Visit Japantown
- Visit Downtown Los Angeles
- Visit Lake Balboa
- Visit Koreatown
- Visit Chinatown
- Visit Downtown San Jose
- Visit Fashion District
- Visit Ocean Beach
- Visit Fisherman's Wharf
- Visit Downtown San Francisco
- Visit Downtown Oakland
- Visit Chinatown
- Visit Haight-Ashbury
- Visit Little Russia
- Visit Skid Row
