Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's acclaimed art scene and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Hotel Circle
Hotel Circle is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Check out the shops and top-notch restaurants in this family-friendly area.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour
Taco Tuesday Hop to Tijuana from San Diego
From Tijuana: Valle de Guadalupe Private Winery Tour
Otay Mesa Hotel Deals
Sheraton San Diego Resort
Room was clean, hotel is well cared for, staff was friendly and helpful.
Reviewed on Dec 19, 2025
Lafayette Hotel & Club
My favorite hotel in San Diego. Staff is always helpful, kind and professional. The rooms are comfortable, clean, eclectic and possibly the best minibar selection of top shelf products anywhere. The property invites you to discover and play and socialize. The bar and food programs are superb.
Reviewed on Dec 17, 2025
The DEXTRO Little Italy, BW Premier Collection
The room was comfortable & the staff was incredibly friendly. The location is also ideal for exploration and looking around. Really solid pick.
Reviewed on Dec 18, 2025
Legacy Resort Hotel & Spa
Very well and clean
Reviewed on Dec 12, 2025
Hard Rock Hotel San Diego
Yes
Reviewed on Dec 17, 2025
Best Western Plus Marina Gateway Hotel
Don’t recall
Reviewed on Dec 19, 2025
Other neighborhoods around Otay Mesa
East Village
Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Marina District
Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and The Rady Shell at Jacobs Park, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Otay Mesa, CA
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