Otay Mesa Vacations from ¥238,320

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ¥45,448 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Otay Mesa Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel
Beach Village at The Del, LXR Hotels & Resorts
Margaritaville Hotel San Diego Gaslamp Quarter
The Beau Downtown San Diego Gaslamp Quar
InterContinental San Diego by IHG

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa

Otay Mesa Hotel Deals

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is ¥17,451 per night from Jan 6 to Jan 7
¥17,451
¥25,668 total
Jan 6 - Jan 7, 2026
includes taxes & fees
8.2/10 Very Good! (3,174 reviews)
Close to the airport. Very nice hotel. Easy uber to the city.

Reviewed on Dec 13, 2025

Sheraton San Diego Resort
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
The price is ¥35,680 per night from Dec 29 to Dec 30
¥35,680
¥40,943 total
Dec 29 - Dec 30
includes taxes & fees
9.2/10 Wonderful! (1,329 reviews)
The hotel is big on charm and decor. It was in 1937 and the guest rooms haven’t been enlarged or highly modernized. What they did get is a big dash of kitsch. Clashing wall paper, canopied beds, retro appliances, and a huge room bar (you pay per drink). We took a second floor poolside room with a ...

Reviewed on Dec 11, 2025

Lafayette Hotel & Club
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is ¥16,703 per night from Dec 22 to Dec 23
¥16,703
¥19,367 total
Dec 22 - Dec 23
includes taxes & fees
8.8/10 Excellent! (733 reviews)
Room was clean with comfortable bed. View facing the habor is interesting.Outdoor facilities is well coming, nice sitting area. There is an adequate gymn, with treadmill , benche and various free weights, all and all fantastic to get a good workout. Staff are courteous and polite. I would stay again.. ...

Reviewed on Dec 13, 2025

The DEXTRO Little Italy, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa vacation package cost?
Starting from as low as ¥238,320, a vacation package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa vacation packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighborhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa vacation?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your vacation time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're traveling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organizing an island getaway in a villa or prefer to stay in a cozy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia vacation package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa vacation package?
Don't worry if you're rethinking your Otay Mesa vacation package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.