Otay Mesa Vacations from ￥229,819

Book a Hotel + Flight or Car together to unlock savings

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    Save up to ￥45,448 when you book a flight and hotel together*
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    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
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The Latest Otay Mesa Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
per person
Aug 21 - Aug 25
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to San Diego (SAN)
8.4/10 Very Good! (1,474 reviews)
We met some great people

Reviewed on Jul 6, 2025

Barsala City Villas

Barsala City Villas

2.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
Aug 21 - Aug 25
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to San Diego (SAN)
No reviews
Pendry San Diego

Pendry San Diego

5 out of 5
Downtown San Diego
per person
Aug 21 - Aug 25
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to San Diego (SAN)
9.2/10 Wonderful! (1,000 reviews)
Very cool hotel! Everything about the place is great!

Reviewed on Jul 5, 2025

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
per person
Aug 21 - Aug 25
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to San Diego (SAN)
9/10 Wonderful! (920 reviews)
Great location in the Gaslamp district near Petco Park. Very walkable and lots of spots to eat nearby. Bathroom could use a refresh. TV service was spotty at night.

Reviewed on Jun 25, 2025

The Lodge at Torrey Pines

The Lodge at Torrey Pines

5 out of 5
Torrey Pines
per person
Sep 20 - Sep 24
found 1 day ago
Roundtrip non-stop flight included
Tokyo (HND) to San Diego (SAN)
9.2/10 Wonderful! (816 reviews)
One of my favorite properties!

Reviewed on Jun 24, 2025

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa Hotel Deals

Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is ￥21,981 per night from Jul 20 to Jul 21
￥21,981
￥29,676 total
Jul 20 - Jul 21
includes taxes & fees
8.2/10 Very Good! (5,730 reviews)
"Not enough parking on the 4th of July."

Reviewed on Jul 6, 2025

Wyndham San Diego Bayside
Handlery Hotel
Handlery Hotel
3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ￥18,073 per night from Jul 21 to Jul 22
￥18,073
￥20,774 total
Jul 21 - Jul 22
includes taxes & fees
8/10 Very Good! (1,831 reviews)
"Pool area, rooms was clean"

Reviewed on Jul 6, 2025

Handlery Hotel
Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ￥31,805 per night from Jul 20 to Jul 21
￥31,805
￥43,446 total
Jul 20 - Jul 21
includes taxes & fees
9/10 Wonderful! (1,725 reviews)
"One Word ….Amazzzzing"

Reviewed on Jul 4, 2025

Marriott Marquis San Diego Marina
See all 4,581 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa vacation package cost?
Starting from as low as ￥229,819, a vacation package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa vacation packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighborhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa vacation?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your vacation time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're traveling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organizing an island getaway in a villa or prefer to stay in a cozy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia vacation package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa vacation package?
Don't worry if you're rethinking your Otay Mesa vacation package --- it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Discover the most popular places to visit in Otay Mesa

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and entertainment choices.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

4.5/5(2,386 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

￥13,446
per adult
100% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
Sesame Place® San Diego

Sesame Place® San Diego

￥10,700
per traveler
80% of travellers recommend
Sesame Place® San Diego
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.