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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very Good, (1,661 reviews)
"Clean, great breakfast, good service."
United States
Sara
The price is ¥20,403
¥23,209 total
includes taxes & fees
Mar 15 - Mar 16
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,009 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is ¥17,010
¥19,349 total
includes taxes & fees
Apr 5 - Apr 6
Quality Suites San Diego Otay Mesa

Westgate Hotel

Westgate Hotel
4.5 star property
24.9 km from Otay Mesa
9.2 out of 10, Wonderful, (1,002 reviews)
"Great stay"
United States
ESMERALDA
Westgate Hotel

Courtyard by Marriott Old Town

Courtyard by Marriott Old Town
3.0 star property
Old Town San Diego, 29.7 km from Otay Mesa
8.6 out of 10, Excellent, (1,007 reviews)
"Great place!!!"
United States
Hannah
The price is ¥28,326
¥32,559 total
includes taxes & fees
Mar 22 - Mar 23
Courtyard by Marriott Old Town

Super 8 by Wyndham San Diego Hotel Circle

Super 8 by Wyndham San Diego Hotel Circle
2.0 star property
28.8 km from Otay Mesa
7.2 out of 10, Good, (719 reviews)
"Staff was great, the room was very clean."
Canada
Jennifer
The price is ¥12,368
¥14,215 total
includes taxes & fees
Mar 12 - Mar 13
Super 8 by Wyndham San Diego Hotel Circle

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
30.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,019 reviews)
"Super clean rooms and a great location "
United States
Mark
Sea Harbor Hotel

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very Good, (1,194 reviews)
"Beds are super comfy clean and renovated"
United States
Esmeralda
Ocean Villa Inn

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1,004 reviews)
"Great location and stay. "
United States
Simran
The price is ¥17,793
¥25,201 total
includes taxes & fees
Apr 3 - Apr 4
Staypineapple, Hotel Z, Gaslamp San Diego

Fairfield Inn & Suites San Diego Old Town

Fairfield Inn & Suites San Diego Old Town
3.0 star property
Old Town San Diego, 29.4 km from Otay Mesa
8.6 out of 10, Excellent, (1,013 reviews)
"Great location, clean rooms, good breakfast"
United States
Jingyi
The price is ¥23,522
¥27,037 total
includes taxes & fees
Apr 5 - Apr 6
Fairfield Inn & Suites San Diego Old Town

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 25.8 km from Otay Mesa
8.6 out of 10, Excellent, (1,929 reviews)
"Great location and staff "
United States
morgan
The price is ¥21,209
¥24,125 total
includes taxes & fees
Apr 1 - Apr 2
La Pensione Hotel

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very Good, (1,000 reviews)
"Clean, very chill easy check in"
United States
Susana
The price is ¥14,220
¥16,033 total
includes taxes & fees
Mar 15 - Mar 16
Berkshire Motor Hotel

Best Western Plus Bayside Inn

Best Western Plus Bayside Inn
3.0 star property
25.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,015 reviews)
"Clean rooms, friendly staff, hotel close to eateries "
United States
Debbie
The price is ¥22,142
¥25,629 total
includes taxes & fees
Apr 7 - Apr 8
Best Western Plus Bayside Inn

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
31.8 km from Otay Mesa
7.4 out of 10, Good, (1,316 reviews)
"Clean room, staff was great during check in and checking out. "
United States
Amber
The price is ¥9,806
¥11,272 total
includes taxes & fees
Mar 30 - Mar 31
Heritage Inn San Diego

Porto Vista Hotel Downtown

Porto Vista Hotel Downtown
3.5 star property
Little Italy, 25.8 km from Otay Mesa
7.0 out of 10, Good, (1,249 reviews)
"Great location, friendly staff, dog friendly and nice rooms! "
United States
Chelsea
Porto Vista Hotel Downtown

The Beau Hotel Gaslamp Quarter San Diego

The Beau Hotel Gaslamp Quarter San Diego
3.0 star property
Gaslamp Quarter, 24.5 km from Otay Mesa
9.0 out of 10, Wonderful, (639 reviews)
"Clean room, friendly staff, great location."
United States
Bruce
The price is ¥24,023
¥27,327 total
includes taxes & fees
Apr 6 - Apr 7
The Beau Hotel Gaslamp Quarter San Diego

Humphreys Half Moon Inn

Humphreys Half Moon Inn
3.5 star property
29.3 km from Otay Mesa
9.2 out of 10, Wonderful, (2,821 reviews)
"Great stay, highly recommend."
United States
Ryan
The price is ¥27,520
¥34,797 total
includes taxes & fees
Apr 5 - Apr 6
Humphreys Half Moon Inn

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 24.6 km from Otay Mesa
9.0 out of 10, Wonderful, (1,026 reviews)
"Clean quiet friendly helpful staff convenient location will stay there again"
United States
David
The price is ¥19,612
¥22,308 total
includes taxes & fees
Apr 5 - Apr 6
Gaslamp Plaza Suites

Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel
4.0 star property
28.2 km from Otay Mesa
8.6 out of 10, Excellent, (1,719 reviews)
"Great stay!"
United States
Linda
The price is ¥21,352
¥24,544 total
includes taxes & fees
Mar 29 - Mar 30
Sheraton Mission Valley San Diego Hotel

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 30.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,364 reviews)
"Great location, great price, nice hotel "
United States
Estela
The price is ¥22,479
¥25,838 total
includes taxes & fees
Mar 15 - Mar 16
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Ocean Beach Hotel

Ocean Beach Hotel
3.0 star property
Ocean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,268 reviews)
"The hotel was a great environment and felt very safe and comfortable. "
United States
Charity
Ocean Beach Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
Where can I learn more about changing or cancelling my trip to Otay Mesa?
To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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