Find hotels in Otay Mesa, San Diego from ￥16,355

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Discover 4,877 Otay Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
Otay Mesa
8.0 out of 10, Very Good, (1556)
"Good comfortable beds good breakfast "
United States
Andrey
The price is ￥20,845
￥23,711 total
includes taxes & fees
Dec 7 - Dec 8
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2.5 star property
Otay Mesa
7.2 out of 10, Good, (1007)
"Beautiful place "
United States
Joe
The price is ￥15,400
￥17,518 total
includes taxes & fees
Dec 7 - Dec 8
Quality Suites San Diego Otay Mesa
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
24.3 km from Otay Mesa
9.0 out of 10, Wonderful, (2691)
"Clean room, almost everything to walk to, recommended and will booked again. "
United States
Karla
The price is ￥19,180
￥26,465 total
includes taxes & fees
Dec 8 - Dec 9
The Horton Grand, Downtown/Gaslamp Quarter
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1246)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is ￥19,701
￥22,842 total
includes taxes & fees
Dec 14 - Dec 15
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Gaslamp Quarter, 24 km from Otay Mesa
9.0 out of 10, Wonderful, (3144)
"Great stay"
United States
Laurence
The price is ￥37,101
￥50,176 total
includes taxes & fees
Dec 8 - Dec 9
Hard Rock Hotel San Diego
Rooftop terrace
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 24.5 km from Otay Mesa
8.6 out of 10, Excellent, (2072)
"Room was spotless and location great. "
United States
James
The price is ￥16,399
￥19,014 total
includes taxes & fees
Dec 12 - Dec 13
Palihotel San Diego Gaslamp Quarter
Premium bedding, pillowtop beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Gaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1005)
"The room was immaculate, the staff were helpful and friendly and our stay was so wonderful. "
United States
Samantha Erin
The price is ￥16,224
￥23,308 total
includes taxes & fees
Dec 10 - Dec 11
Staypineapple, Hotel Z, Gaslamp San Diego
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3486)
"Clean, staff friendly, great place for a stay"
United States
Derrick
The price is ￥19,462
￥21,446 total
includes taxes & fees
Dec 14 - Dec 15
Best Western Plus Marina Gateway Hotel
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
25.7 km from Otay Mesa
8.4 out of 10, Very Good, (6101)
"Always an amazing stay"
United States
Jana
The price is ￥21,024
￥28,886 total
includes taxes & fees
Dec 7 - Dec 8
Wyndham San Diego Bayside
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

3.5 star property
Gaslamp Quarter, 24.6 km from Otay Mesa
9.0 out of 10, Wonderful, (1016)
"Great room, clean, spacious and quiet. "
United States
Maria
The price is ￥17,267
￥19,641 total
includes taxes & fees
Dec 10 - Dec 11
Gaslamp Plaza Suites
Outdoor pool, sun loungers
Best Western Plus Suites Hotel Coronado Island

Best Western Plus Suites Hotel Coronado Island

2.5 star property
24.1 km from Otay Mesa
8.8 out of 10, Excellent, (1012)
"Good to spend a night or two-- nice staff-- friendly ad awesome breakfast"
United States
MICHELE
The price is ￥25,148
￥27,663 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Plus Suites Hotel Coronado Island
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 star property
24.9 km from Otay Mesa
8.6 out of 10, Excellent, (1448)
"Great stay, clean room. Staff was very friendly as well. Would stay again. "
United States
Alexis
The price is ￥19,491
￥22,599 total
includes taxes & fees
Dec 10 - Dec 11
The Bristol Hotel San Diego
Front of property
The Sofia Hotel

The Sofia Hotel

3.5 star property
24.9 km from Otay Mesa
8.4 out of 10, Very Good, (1661)
"Excellent stay all-around!"
United States
Nalani
The price is ￥15,757
￥21,986 total
includes taxes & fees
Dec 16 - Dec 17
The Sofia Hotel
Property amenity
The Monsaraz San Diego, Tapestry Collection by Hilton

The Monsaraz San Diego, Tapestry Collection by Hilton

3.5 star property
30.1 km from Otay Mesa
8.6 out of 10, Excellent, (612)
"Great hotel "
United States
Judy
The price is ￥21,558
￥24,780 total
includes taxes & fees
Dec 8 - Dec 9
The Monsaraz San Diego, Tapestry Collection by Hilton
2 outdoor pools, open 6 AM to 10:00 PM, cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
24.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1942)
"Great hotel"
United States
Farzana
The price is ￥24,734
￥36,859 total
includes taxes & fees
Dec 13 - Dec 14
Marriott Marquis San Diego Marina
Lobby
Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego

2.5 star property
24.5 km from Otay Mesa
8.2 out of 10, Very Good, (1010)
"Great place "
United States
Fadi
The price is ￥14,868
￥16,355 total
includes taxes & fees
Dec 9 - Dec 10
Best Western Plus La Mesa San Diego
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1148)
"Amenities and location were great. "
United States
Julie
The price is ￥19,959
￥29,479 total
includes taxes & fees
Dec 8 - Dec 9
Margaritaville Hotel San Diego Gaslamp Quarter
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (3174)
"The staff is friendly and the hotel is perfect!"
United States
Mark
The price is ￥18,060
￥20,759 total
includes taxes & fees
Dec 7 - Dec 8
Bay Club Hotel & Marina
Presidential Suite, 2 Bedrooms | Living room | 36-inch LCD TV with digital channels, TV, pay movies
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4.0 star property
24.7 km from Otay Mesa
9.0 out of 10, Wonderful, (866)
"Staff was amazing. Room was really nice and the view was PERFECT."
United States
Porscha
The price is ￥17,383
￥26,493 total
includes taxes & fees
Dec 29 - Dec 30
Alma San Diego Downtown, a Tribute Portfolio Hotel
Suite, 1 King Bed with Sofa bed, City View | View from room
Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego

3.5 star property
24.7 km from Otay Mesa
9.4 out of 10, Exceptional, (1018)
"I like the Hotel!!"
United States
Karla
The price is ￥21,001
￥24,350 total
includes taxes & fees
Dec 15 - Dec 16
Marriott Vacation Club®, San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Gaslamp Quarter showing signage, night scenes and street scenes

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Pacific Beach Park showing a beach

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Belmont Park showing rides and a garden

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Ocean Beach

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Otay Mesa Hotel Reviews

DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

10/10 Excellent
"Confort "
PERLA 1-night trip
Posted 7 hours ago
DoubleTree by Hilton Hotel San Diego - Mission Valley

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Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
Where can I learn more about changing or cancelling my trip to Otay Mesa?
To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.