Find hotels in Otay Mesa, San Diego from ￥12,801

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Discover 4,664 Otay Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for Otay Mesa hotels

Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1079)
"Prefect stay with the family. Would stay again and recommend to friends. "
The price is ￥23,427
￥25,815 total
includes taxes & fees
Sep 8 - Sep 9
Ayres Hotel San Diego South - Chula Vista
Sycuan Casino Resort
3 outdoor pools, cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1521)
"Love this place"
Sycuan Casino Resort
Sea Harbor Hotel
Marina

Sea Harbor Hotel

2.0 star property
8.4 out of 10, Very Good, (954)
"Good property for a few nights before your get on your boat for a fishing trip! "
The price is ￥16,542
￥18,651 total
includes taxes & fees
Sep 3 - Sep 4
Sea Harbor Hotel
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
8.0 out of 10, Very Good, (1458)
"Very good to stayed "
The price is ￥17,352
￥19,738 total
includes taxes & fees
Sep 7 - Sep 8
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Quality Suites San Diego Otay Mesa
Desk, laptop workspace, blackout drapes, iron/ironing board

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1011)
"Nice place. Clean and quiet. "
The price is ￥15,808
￥17,981 total
includes taxes & fees
Sep 21 - Sep 22
Quality Suites San Diego Otay Mesa
SpringHill Suites by Marriott Chula Vista Eastlake
Outdoor pool

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (426)
"Nice pool and decent breakfast"
The price is ￥20,146
￥22,200 total
includes taxes & fees
Sep 7 - Sep 8
SpringHill Suites by Marriott Chula Vista Eastlake
Lamplighter Inn & Suites at SDSU
Outdoor pool, pool umbrellas, sun loungers

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1251)
"We will definitely be staying there again"
The price is ￥18,581
￥20,950 total
includes taxes & fees
Sep 3 - Sep 4
Lamplighter Inn & Suites at SDSU
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1397)
"Great place to stay at , along with a good breakfast variety. Overall I'll stay here again"
The price is ￥15,352
￥16,887 total
includes taxes & fees
Sep 7 - Sep 8
La Quinta Inn by Wyndham San Diego Chula Vista
Best Western Americana Inn
Pillowtop beds, in-room safe, desk, laptop workspace

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1145)
"Breakfast was amazing! "
The price is ￥17,987
￥20,460 total
includes taxes & fees
Sep 7 - Sep 8
Best Western Americana Inn
Hampton Inn & Suites San Diego Seaworld
Reception

Hampton Inn & Suites San Diego Seaworld

2.5 star property
8.6 out of 10, Excellent, (23)
"Staff was very friendly, hotel is modern and rooms spacious and clean. "
The price is ￥17,374
￥19,971 total
includes taxes & fees
Sep 7 - Sep 8
Hampton Inn & Suites San Diego Seaworld
Loews Coronado Bay Resort
Exterior

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1025)
"Nice rooms, great staff close to beach"
The price is ￥32,204
￥42,473 total
includes taxes & fees
Sep 2 - Sep 3
Loews Coronado Bay Resort
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3269)
"Good place to stay"
The price is ￥18,397
￥20,272 total
includes taxes & fees
Sep 7 - Sep 8
Best Western Plus Marina Gateway Hotel
Best Western San Diego Pacific Beach/Mission Bay
Outdoor pool

Best Western San Diego Pacific Beach/Mission Bay

2.5 star property
7.2 out of 10, Good, (1288)
"Excellent hotel !! "
The price is ￥12,801
￥14,714 total
includes taxes & fees
Sep 7 - Sep 8
Best Western San Diego Pacific Beach/Mission Bay
Lafayette Hotel & Club
Outdoor pool, open 7:00 AM to 9:00 PM, cabanas (surcharge)

Lafayette Hotel & Club

4.0 star property
9.2 out of 10, Wonderful, (1113)
"It was nice and cute Hotel, good location!! I really enjoyed it !! 😍"
The price is ￥33,233
￥38,135 total
includes taxes & fees
Sep 22 - Sep 23
Lafayette Hotel & Club
Best Western Yacht Harbor Hotel
Desk, blackout drapes, iron/ironing board, cribs/infant beds

Best Western Yacht Harbor Hotel

2.5 star property
8.6 out of 10, Excellent, (1538)
"Good breakfast, close to where we wanted to be and affordable."
The price is ￥14,692
￥16,859 total
includes taxes & fees
Sep 2 - Sep 3
Best Western Yacht Harbor Hotel
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1495)
"Great hotel"
The price is ￥16,124
￥17,736 total
includes taxes & fees
Sep 7 - Sep 8
Best Western Chula Vista/Otay Valley Hotel
Berkshire Motor Hotel
Suite | Private kitchenette

Berkshire Motor Hotel

2.5 star property
8.4 out of 10, Very Good, (966)
"Great location within walking distance from the places we wanted to visit."
The price is ￥13,883
￥15,653 total
includes taxes & fees
Sep 2 - Sep 3
Berkshire Motor Hotel
Legacy Resort Hotel & Spa
Garden

Legacy Resort Hotel & Spa

4.0 star property
9.2 out of 10, Wonderful, (2881)
"Beautiful Hotel"
The price is ￥21,475
￥24,684 total
includes taxes & fees
Sep 21 - Sep 22
Legacy Resort Hotel & Spa
Sentral Gaslamp Quarter
Premium bedding, pillowtop beds, desk, laptop workspace

Sentral Gaslamp Quarter

3.0 star property
9.2 out of 10, Wonderful, (338)
"Great place to stay!"
The price is ￥19,719
￥27,126 total
includes taxes & fees
Sep 2 - Sep 3
Sentral Gaslamp Quarter
Valli Hi Motel
Desk, blackout drapes, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very Good, (1012)
"Great hotel "
Valli Hi Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Gaslamp Quarter showing signage, night scenes and street scenes

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Belmont Park showing rides and a garden

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Pacific Beach Park showing a beach

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Ocean Beach

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Otay Mesa Hotel Reviews

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Explore a world of travel with Expedia

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.