What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa .

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/ .

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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Dates

February 2026

March 2026

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Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Otay Mesa

Leo

￥17,814 total

includes taxes & fees

Jan 25 - Jan 26

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Otay Mesa

Zulma

￥21,413 total

includes taxes & fees

Jan 25 - Jan 26

Courtyard by Marriott Old Town

Old Town San Diego, 29.7 km from Otay Mesa

Kathleen

￥24,583 total

includes taxes & fees

Jan 30 - Jan 31

Berkshire Motor Hotel

North Park, 26.7 km from Otay Mesa

Susana

￥15,234 total

includes taxes & fees

Jan 25 - Jan 26

Westgate Hotel

24.9 km from Otay Mesa

ESMERALDA

Premium Room, 1 King Bed, Non Smoking, Ocean View (Non-Pet friendly) | Iron/ironing board, free WiFi, bed sheets

Ocean Villa Inn

Ocean Beach, 33.7 km from Otay Mesa

Esmeralda

Sea Harbor Hotel

30.1 km from Otay Mesa

Mark

Springhill Suites San Diego Mission Valley

28.2 km from Otay Mesa

Jodi

￥30,930 total

includes taxes & fees

Jan 30 - Jan 31

Premium bedding, pillowtop beds, desk, laptop workspace

Staypineapple, Hotel Z, Gaslamp San Diego

Gaslamp Quarter, 24.2 km from Otay Mesa

Simran

￥22,729 total

includes taxes & fees

Jan 25 - Jan 26

Fairfield Inn & Suites San Diego Old Town

Old Town San Diego, 29.4 km from Otay Mesa

Jingyi

￥24,627 total

includes taxes & fees

Feb 8 - Feb 9

Deluxe 2 Queen with sofa sleeper | Bathroom | Combined shower/tub, free toiletries, hair dryer, towels

Old Town Western Inn & Suites

Old Town San Diego, 29.6 km from Otay Mesa

Raul

La Pensione Hotel

Little Italy, 25.8 km from Otay Mesa

Monika

Heritage Inn San Diego

31.8 km from Otay Mesa

ASIM

￥10,937 total

includes taxes & fees

Jan 29 - Jan 30

Superior Double Room Single Use, 2 Queen Beds, Non Smoking, City View | Terrace/patio

Ash&9th

24.7 km from Otay Mesa

Darlene

￥12,655 total

includes taxes & fees

Jan 27 - Jan 28

Best Western Plus Bayside Inn

25.4 km from Otay Mesa

D'ette

￥25,420 total

includes taxes & fees

Feb 22 - Feb 23

Porto Vista Hotel Downtown

Little Italy, 25.8 km from Otay Mesa

Sarah

The Inn at Sunset Cliffs

Ocean Beach, 32.9 km from Otay Mesa

Katrina

￥39,239 total

includes taxes & fees

Jan 25 - Jan 26

Ocean Beach Hotel

Ocean Beach, 33.5 km from Otay Mesa

Trinity

The Beau Downtown San Diego Gaslamp Quar

Gaslamp Quarter, 24.5 km from Otay Mesa

Janet

￥22,403 total

includes taxes & fees

Jan 25 - Jan 26

Comfort Inn San Diego Airport At The Harbor

30.1 km from Otay Mesa

Reginald D.

￥16,464 total

includes taxes & fees

Feb 10 - Feb 11

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Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

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Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

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Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

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Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

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Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Dog Beach and Ocean Beach Farmers Market, you won't get bored spending a day wandering around this part of San Diego.

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Top Otay Mesa Hotel Reviews

Paradise Point Resort & Spa

10/10 Excellent

"This was our second visit to Paradise Point. We were so excited to return and were not disappointed! Friendly staff, beautiful grounds, family fun, clean functional rooms, great central location for exploring greater San Diego area. "

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent

"Perfect stay — highly recommend. A near-new hotel with spotless, modern rooms in a very convenient location. The beds were incredibly comfortable, making it easy to relax and unwind. The breakfast buffet was a real highlight — especially the Hampton waffles, which were absolutely delicious. The facilities were well maintained and enjoyable, with a warm pool and hot tub that we loved using. The staff were exceptionally friendly and helpful throughout our stay. A massive shout-out to Malarie, who went above and beyond to make our experience truly superb and accommodating. Thank you so much 🤗🙏"

Sheraton San Diego Resort

10/10 Excellent

"I stayed in one of the newly-remodeled rooms overlooking the pool/bay in the Marina Tower. Really lovely and the room was exceptionally well-appointed. Great view! The staff was also accomodating with arranging a day-rate for use of the room since I wasn't flying out until the evening. Would absolutely stay here again."

Find hotels in Otay Mesa, San Diego

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Courtyard by Marriott Old Town

Berkshire Motor Hotel

Westgate Hotel

Ocean Villa Inn

Sea Harbor Hotel

Springhill Suites San Diego Mission Valley

Staypineapple, Hotel Z, Gaslamp San Diego

Fairfield Inn & Suites San Diego Old Town

Old Town Western Inn & Suites

La Pensione Hotel

Heritage Inn San Diego

Ash&9th

Best Western Plus Bayside Inn

Porto Vista Hotel Downtown

The Inn at Sunset Cliffs

Ocean Beach Hotel

The Beau Downtown San Diego Gaslamp Quar

Comfort Inn San Diego Airport At The Harbor

Where to stay in Otay Mesa

Downtown San Diego

Gaslamp Quarter

Pacific Beach

Mission Beach

Ocean Beach

Top Otay Mesa Hotel Reviews

Paradise Point Resort & Spa

Frequently asked questions

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