Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
￥14,715
per adult
94% of travellers recommend
From Tijuana: Valle de Guadalupe Shared Winery Tour
￥13,626
per adult
100% of travellers recommend
Taco Tuesday Hop to Tijuana from San Diego
￥13,287
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
￥6,404
per adult
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
The price is ￥21,060 per night from Oct 8 to Oct 9
￥21,060
￥23,955 total
Oct 8 - Oct 9
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
The price is ￥35,202 per night from Sep 11 to Sep 12
￥35,202
￥49,192 total
Sep 11 - Sep 12
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
The price is ￥32,055 per night from Oct 4 to Oct 5
￥32,055
￥45,004 total
Oct 4 - Oct 5
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,885 reviews)
"This hotel is very central and a good base. The room was clean and a good size. Moving around the property is a good way to make your step mark. Dining options are limited to 2 restaurants on premises and a market. Will recommend to bring your own snacks and water if you have a large group. Has a ..."
Reviewed on Sep 9, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
The price is ￥23,388 per night from Sep 20 to Sep 21
￥23,388
￥32,467 total
Sep 20 - Sep 21
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,291 reviews)
"Super friendly staff, nice room and nice views of the bay."
Reviewed on Sep 9, 2026
The Sofia Hotel
150 W Broadway San Diego CA
The price is ￥19,501 per night from Sep 30 to Oct 1
￥19,501
￥26,920 total
Sep 30 - Oct 1
includes taxes & fees
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (2,616 reviews)
"We had a wonderful stay at The Sofia Hotel! The hotel has so much charm and character, and the location was incredibly convenient for everything we wanted to do in San Diego. One thing that really stood out to us was the housekeeping. Our room was refreshed and tidied up every single day, which is ..."
Reviewed on Sep 9, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
The price is ￥27,674 per night from Sep 13 to Sep 14
￥27,674
￥39,526 total
Sep 13 - Sep 14
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,332 reviews)
"Unfortunately not somewhere I would stay again. I had too many issues with this property that ruined my experience being a first time visitor."
Reviewed on Sep 9, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Harlem of the West Sites is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Ocean Beach
Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.
Otay Mesa, CA
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