Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
Taco Tuesday Hop to Tijuana from San Diego
From Tijuana: Valle de Guadalupe Private Winery Tour
From Tijuana: Valle de Guadalupe Shared Winery Tour
Otay Mesa Hotel Deals
Wyndham San Diego Bayside
Reviewed on Sep 19, 2025
Manchester Grand Hyatt San Diego
Reviewed on Sep 17, 2025
Hotel del Coronado, Curio Collection by Hilton
Reviewed on Sep 17, 2025
Palihotel San Diego Gaslamp Quarter
Reviewed on Sep 23, 2025
The DEXTRO Little Italy, BW Premier Collection
Reviewed on Sep 23, 2025
Bay Club Hotel & Marina
Reviewed on Sep 19, 2025
Other neighborhoods around Otay Mesa
East Village
Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Otay Mesa, CA
- Places of interest
- More Hotel Options in Otay Mesa
- Hotels in top San Diego neighborhoods
- Other vacations you might like
- San Diego Zoo
- San Diego Convention Center
- Mission Bay
- Petco Park
- Mission Beach
- Balboa Park
- Hotel Circle
- Naval Base San Diego
- Port of San Diego
- USS Midway Museum
- Marine Corps Recruit Depot
- Hotel del Coronado
- Coronado Beach
- Naval Base Coronado
- Seaport Village
- Old Town San Diego State Park
- Waterfront Park
- Fashion Valley Mall
- North Island Credit Union Amphitheatre
- Snapdragon Stadium
- Shelter Island
- Belmont Park
More Hotel Options in Otay Mesa
Other Hotels near Otay Mesa, San Diego
Expedia's Latest Trends
- Visit Venice Canals
- Visit Gaslamp Quarter
- Visit Bel Air
- Visit Union Square
- Visit Hollywood Hills
- Visit Downtown San Diego
- Visit Boyle Heights
- Visit Mission Valley
- Visit Point Loma
- Visit Hollywood
- Visit Miramar
- Visit Japantown
- Visit Downtown Los Angeles
- Visit Lake Balboa
- Visit Koreatown
- Visit Chinatown
- Visit Downtown San Jose
- Visit Fashion District
- Visit Ocean Beach
- Visit Fisherman's Wharf
- Visit Downtown San Francisco
- Visit Downtown Oakland
- Visit Chinatown
- Visit Haight-Ashbury
- Visit Little Russia
- Visit Skid Row
