Otay Mesa, CA

San Diego


Popular places to visit

Things to do


Otay Mesa Hotel Deals

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is ¥22,459 per night from Oct 7 to Oct 8
¥22,459
¥30,321 total
Oct 7 - Oct 8
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,955 reviews)
"I didn’t know or understand why I had to pay a destination fee, when I checked out"

Reviewed on Sep 19, 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
The price is ¥36,041 per night from Sep 25 to Sep 26
¥36,041
¥49,822 total
Sep 25 - Sep 26
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,825 reviews)
"Great experience Nice property"

Reviewed on Sep 17, 2025

Manchester Grand Hyatt San Diego
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4 out of 5
1500 Orange Ave, Coronado, CA
The price is ¥49,969 per night from Oct 16 to Oct 17
¥49,969
¥63,668 total
Oct 16 - Oct 17
includes taxes & fees
Stay at this 4-star beach resort in Coronado. Enjoy free WiFi, 6 restaurants, and a private beach. Our guests praise the helpful staff and the property condition ...
8/10 Very Good! (1,029 reviews)
"Vert nice"

Reviewed on Sep 17, 2025

Hotel del Coronado, Curio Collection by Hilton
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4 out of 5
830 Sixth Avenue, San Diego, CA
The price is ¥14,480 per night from Oct 14 to Oct 15
¥14,480
¥16,789 total
Oct 14 - Oct 15
includes taxes & fees
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in ...
8.6/10 Excellent! (1,821 reviews)
"The 100+ year elevator was quaint. The staff were exceptional!"

Reviewed on Sep 23, 2025

Palihotel San Diego Gaslamp Quarter
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
The price is ¥17,595 per night from Oct 7 to Oct 8
¥17,595
¥20,400 total
Oct 7 - Oct 8
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.6/10 Excellent! (461 reviews)
"I didn't think the prices to pay for breakfast or dinner were worth what we were given. It was just a bit too expensive for us."

Reviewed on Sep 23, 2025

The DEXTRO Little Italy, BW Premier Collection
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ¥22,068 per night from Sep 30 to Oct 1
¥22,068
¥25,366 total
Sep 30 - Oct 1
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant ...
9/10 Wonderful! (2,952 reviews)
"Beautiful"

Reviewed on Sep 19, 2025

Bay Club Hotel & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Otay Mesa

Petco Park featuring a statue or sculpture

East Village

Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.

East Village
Gaslamp Quarter showing signage, night scenes and street scenes

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Gaslamp Quarter
US Grant Hotel

Downtown San Diego

4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Downtown San Diego
Try the tamale eggs Benedict!

North Park

4/5(78 area reviews)

North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.

North Park
Little Italy

Little Italy

Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.

Little Italy
Loads of Loafs

Hillcrest

3.5/5(53 area reviews)

Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.

Hillcrest


Otay Mesa, CA