Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour
Taco Tuesday Hop to Tijuana from San Diego
From Tijuana: Valle de Guadalupe Private Winery Tour
Otay Mesa Hotel Deals
Paradise Point Resort & Spa
The lanai wasn’t the same one from the picture, and neither was the bathroom. Our lanai was dirty and covered in bird crap. I had to clean out the drawers myself before we put our items in, they had crap in it. We didn’t get what was shown to us, nor what we paid for. If I personally pick the room, ...
Reviewed on Mar 9, 2026
Best Western Seven Seas
It is a big property, but quite and always clean.
Reviewed on Mar 9, 2026
Hard Rock Hotel San Diego
Everything was as described
Reviewed on Mar 9, 2026
The DEXTRO Little Italy, BW Premier Collection
Clean room and property managed well. No free continental breakfast though.
Reviewed on Mar 9, 2026
Days Inn by Wyndham San Diego Hotel Circle
Rooms were modern and comfy. Nice pool area. Lounge with coffee in the morning. Helpful staff. Good location.
Reviewed on Mar 9, 2026
Handlery Hotel
The rooms need updating. Carpet is disgusting. Love the little patio but need screens. Pool area is very nice.
Reviewed on Mar 9, 2026
Other neighborhoods around Otay Mesa
East Village
Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Otay Mesa, CA
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