Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's acclaimed art scene and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Things to do
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Crossing Borders: Tijuana Day Trip from San Diego
Stand up Paddle Board Lesson on The San Diego Bay
Otay Mesa Hotel Deals
Handlery Hotel
Clean room awesome staff and quiet space
Reviewed on Oct 19, 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
Everyone was friendly
Reviewed on Oct 22, 2025
Comfort Inn San Diego Airport At The Harbor
Nice clean room. Everything was great.
Reviewed on Oct 19, 2025
Pendry San Diego
The room was perfect, the shower soap, and lotions smelled so good I bought some to take home. Beautiful hotel and easy to walk around gaslamp without need for uber. Walkable to train and trolly also! The hotel bar was very classy and staff went above and beyond!
Reviewed on Oct 15, 2025
Wyndham San Diego Bayside
Older property but great location. Friendly staff and lots nearby.
Reviewed on Oct 20, 2025
Hilton San Diego Mission Valley
Something was going on at the hotel and it smelled like poop all over the place.
Reviewed on Oct 20, 2025
Other neighborhoods around Otay Mesa
Mid-City
If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Del Cerro
Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.
Otay Mesa, CA
- Places of interest
- More Hotel Options in Otay Mesa
- Hotels in top San Diego neighborhoods
- Other vacations you might like
- San Diego Zoo
- San Diego Convention Center
- Mission Bay
- Petco Park
- Mission Beach
- Balboa Park
- Hotel Circle
- Naval Base San Diego
- Port of San Diego
- USS Midway Museum
- Marine Corps Recruit Depot
- Hotel del Coronado
- Coronado Beach
- Naval Base Coronado
- Seaport Village
- Old Town San Diego State Park
- Waterfront Park
- Fashion Valley Mall
- North Island Credit Union Amphitheatre
- Snapdragon Stadium
- Shelter Island
- Belmont Park
More Hotel Options in Otay Mesa
Other Hotels near Otay Mesa, San Diego
Expedia's Latest Trends
- Visit Venice Canals
- Visit Gaslamp Quarter
- Visit Bel Air
- Visit Union Square
- Visit Hollywood Hills
- Visit Downtown San Diego
- Visit Boyle Heights
- Visit Mission Valley
- Visit Point Loma
- Visit Hollywood
- Visit Miramar
- Visit Japantown
- Visit Downtown Los Angeles
- Visit Lake Balboa
- Visit Koreatown
- Visit Chinatown
- Visit Downtown San Jose
- Visit Fashion District
- Visit Ocean Beach
- Visit Fisherman's Wharf
- Visit Downtown San Francisco
- Visit Downtown Oakland
- Visit Chinatown
- Visit Haight-Ashbury
- Visit Little Russia
- Visit Skid Row
