Find hotels in Byron, MN from ¥10,973

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Byron hotels

Kahler Grand Hotel

Kahler Grand Hotel
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (1821)
"Staff was friendly and helpful! Will continue to stay here while at the Mayo, "
United States
Gayle
The price is ¥20,851
¥24,005 total
includes taxes & fees
Dec 13 - Dec 14
Kahler Grand Hotel

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very Good, (1131)
"Great location and value"
United States
Michelle
The price is ¥11,348
¥13,064 total
includes taxes & fees
Dec 26 - Dec 27
AmericInn by Wyndham Rochester Near Mayo Clinic

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (895)
"Good breakfast..shuttle service is excellent..super nice staff.."
United States
DALE K
The price is ¥9,813
¥11,299 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Econo Lodge Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (956)
"Rooms are comfortable and staff was was so professional and helpful."
United States
William
The price is ¥15,728
¥18,418 total
includes taxes & fees
Dec 13 - Dec 14
EVEN Hotel Rochester - Mayo Clinic Area by IHG

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.2 out of 10, Good, (1018)
"Breakfast was good. The staff was great. "
United States
Kjirsta
The price is ¥10,915
¥12,566 total
includes taxes & fees
Dec 14 - Dec 15
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Aspen Suites

Aspen Suites
3.0 star property
Rochester
9.0 out of 10, Wonderful, (688)
"I always stay at this hotel , love it clean comfortable rooms, they gave us vouchers for 4 free meals for Thanksgiving dinner"
United States
Cindy
The price is ¥24,099
¥29,131 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Aspen Suites

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
2.0 star property
Rochester
7.8 out of 10, Good, (1001)
"Front staff are so kind and efficient. "
United States
Brenda
The price is ¥9,531
¥10,973 total
includes taxes & fees
Dec 14 - Dec 15
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (884)
"Great room and stay!"
United States
Trevor
The price is ¥11,817
¥13,605 total
includes taxes & fees
Dec 26 - Dec 27
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area
2.0 star property
Rochester
7.8 out of 10, Good, (1002)
"Great Stay"
United States
Aweng
The price is ¥7,930
¥9,129 total
includes taxes & fees
Dec 20 - Dec 21
Super 8 by Wyndham Rochester Mayo Clinic Area

Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
Rochester
9.6 out of 10, Exceptional, (246)
"Very nice motel "
United States
Jim
The price is ¥16,680
¥19,203 total
includes taxes & fees
Dec 20 - Dec 21
Residence Inn by Marriott Rochester Mayo Clinic Area South

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
3.0 star property
Kutzky Park
8.6 out of 10, Excellent, (934)
"Room was comfortable and convenient.Staff was exceptional.I will stay here when I am next in town."
United States
Rachel
The price is ¥14,616
¥16,827 total
includes taxes & fees
Dec 20 - Dec 21
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

MainStay Suites Rochester South Mayo Clinic

MainStay Suites Rochester South Mayo Clinic
2.5 star property
Rochester
7.0 out of 10, Good, (89)
"Staff is friendly "
United States
Merry
The price is ¥8,536
¥9,826 total
includes taxes & fees
Dec 15 - Dec 16
MainStay Suites Rochester South Mayo Clinic

Country Inn & Suites Rochester South Mayo Clinic

Country Inn & Suites Rochester South Mayo Clinic
3.0 star property
Rochester
8.4 out of 10, Very Good, (1003)
"Clean room, fun staff."
United States
Thomas
The price is ¥15,067
¥17,345 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Country Inn & Suites Rochester South Mayo Clinic

Aspen Select

Aspen Select
3.5 star property
Rochester
8.4 out of 10, Very Good, (1001)
"Beds are very comfortable!"
United States
Laurie
Aspen Select

Baymont by Wyndham Kasson Rochester Area

Baymont by Wyndham Kasson Rochester Area
2.5 star property
Kasson
6.6 out of 10, (370)
"We did not use the pool or the hot tub but loved it! Staff was very nice, rooms were clean and easy to access. "
United States
Breanna
The price is ¥10,045
¥10,786 total
includes taxes & fees
Dec 22 - Dec 23
Baymont by Wyndham Kasson Rochester Area

Baymont by Wyndham Rochester Mayo Clinic Area

Baymont by Wyndham Rochester Mayo Clinic Area
2.5 star property
Rochester
7.2 out of 10, Good, (717)
"Spotless clean"
United States
Brit
The price is ¥9,252
¥10,651 total
includes taxes & fees
Dec 20 - Dec 21
Baymont by Wyndham Rochester Mayo Clinic Area

Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.4 out of 10, Exceptional, (309)
"Great place"
United States
Abidemi
The price is ¥10,698
¥12,316 total
includes taxes & fees
Dec 21 - Dec 22
Spark by Hilton Rochester South

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester
9.6 out of 10, Exceptional, (543)
"Very courteous staff, loved the valet guy!"
United States
Jean
The price is ¥26,648
¥30,679 total
includes taxes & fees
Dec 24 - Dec 25
Hilton Rochester Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
2.5 star property
Kutzky Park
7.8 out of 10, Good, (1002)
"Room was clean, great location, convenient to restaurant. "
United States
Sam
The price is ¥12,455
¥14,339 total
includes taxes & fees
Dec 13 - Dec 14
Med City Inn & Suites - Mayo Clinic Area

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
Rochester
8.2 out of 10, Very Good, (785)
"Great place to stay. Freindly staff"
United States
joel
The price is ¥13,887
¥15,987 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Byron attractions

Top Byron Hotel Reviews

More cheap stays in Byron

Frequently asked questions

Where is the best place to stay in Byron?
Located 9 mi (14.4 km) from the heart of Byron, Kahler Grand Hotel is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Kahler Inn and Suites - Mayo Clinic Area and Spark by Hilton Rochester South. See all available top hotels, or vacation rentals in Byron.
What's the top vacation rental in Byron?
SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO: Visitors like this Byron vacation home rental. It is equipped with a garden, air-conditioning, and laundry facilities to help you feel comfortable during your stay. See all vacation rentals in Byron.
If I need to cancel my hotel reservation in Byron, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Byron.
Where can I learn more about changing or cancelling my trip to Byron?
To find more details about updating your trip to Byron or cancelling it, head over to our customer service page.
Where is the best place to stay near Oxbow Park?
Staybridge Suites Rochester - Commerce Dr NW, an IHG Hotel is one of the top choices for your stay based on our traveler data, and this 3-star hotel offers free breakfast and an indoor pool. You'll find it 7 mi (11.3 km) from Oxbow Park. Other good choices around the area include Baymont by Wyndham Kasson Rochester Area and Hampton Inn & Suites Rochester-North.
How is it to stay in Byron?
Visitors can enjoy all that Byron has to offer including the zoo, golf courses, and bars. Tourists can also enjoy the city's parks and art. In Byron, there are 2 hotels and other accommodations to choose from. Find out more about Byron.
What should I see while I'm in Byron?
Favorite places to visit include High Point Shopping Center, Zollman Zoo, and Links of Byron Mini Golf. A couple of additional sights to add to your agenda are Cheery Meadows Center and Byron Town Square. Check out what more to see and do in Expedia's Byron guide.
What's the weather like in Byron?
The hottest months are usually July and August with an average temp of 67°F, while the coldest months are January and February with an average of 21°F. The snowiest months in Byron are January, March, April, and February, with each month seeing an average of 8 inches of snowfall.