Find hotels in Byron, MN from ￥11,321

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 14 - Dec 15
Tomorrow
Dec 15 - Dec 16
Next weekend
Dec 19 - Dec 21
In two weeks
Dec 26 - Dec 28

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Byron hotels

Lobby
Americas Best Value Inn & Suites Spring Valley

Americas Best Value Inn & Suites Spring Valley

Americas Best Value Inn & Suites Spring Valley
2.0 star property
Spring Valley
8.2 out of 10, Very Good, (432)
"Breakfast was fresh and plentiful. The service was amazing. We always stay here when we come to Spring Valley to meet family. We really enjoy this hotel. We had three rooms this time and they were great"
United States
Carol
The price is ￥12,309
￥13,586 total
includes taxes & fees
Dec 16 - Dec 17
Americas Best Value Inn & Suites Spring Valley
Exterior
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (887)
"Great room and stay!"
United States
Trevor
The price is ￥11,842
￥13,634 total
includes taxes & fees
Dec 27 - Dec 28
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Front of property
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.2 out of 10, Good, (1022)
"Great value for the price. "
United States
Beth Anne
The price is ￥11,218
￥12,914 total
includes taxes & fees
Dec 16 - Dec 17
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Reception
America's Stay Inn Stewartville

America's Stay Inn Stewartville

America's Stay Inn Stewartville
2.5 star property
Stewartville
8.0 out of 10, Very Good, (419)
"Room was nicer and furnished better than most high end places I’ve stayed at. It’s a small hotel on a busy road, but comfortable bed and clean."
Canada
Robert
America's Stay Inn Stewartville
Terrace/patio
Hampton Inn Rochester-South

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1009)
"We had a wonderful stay!"
United States
Sarah
The price is ￥12,783
￥14,717 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hampton Inn Rochester-South
Indoor pool, open 7:00 AM to 11:00 PM, sun loungers
AmericInn by Wyndham Rochester

AmericInn by Wyndham Rochester

AmericInn by Wyndham Rochester
2.0 star property
Rochester
8.8 out of 10, Excellent, (1004)
"Clean rooms, friendly staff, good stay"
United States
Della
The price is ￥11,787
￥13,570 total
includes taxes & fees
Dec 19 - Dec 20
AmericInn by Wyndham Rochester
Exterior
Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1001)
"Clean rooms, very friendly staff and just all around homey "
United States
Kathy
The price is ￥11,374
￥13,093 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Express Rochester South - Mayo Area by IHG
Free daily full breakfast
Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (896)
"Good breakfast..shuttle service is excellent..super nice staff.."
United States
DALE K
The price is ￥9,833
￥11,321 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Econo Lodge Mayo Clinic Area
Exterior
Spark by Hilton Rochester South

Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.4 out of 10, Exceptional, (314)
"Great place"
United States
Abidemi
The price is ￥10,720
￥12,342 total
includes taxes & fees
Dec 21 - Dec 22
Spark by Hilton Rochester South
Serves lunch, dinner, and happy hour
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very Good, (1137)
"Good price, room clean, descent breakfast. I have stayed here several time"
United States
Amy M
The price is ￥11,371
￥13,092 total
includes taxes & fees
Dec 26 - Dec 27
AmericInn by Wyndham Rochester Near Mayo Clinic
Free daily full breakfast
Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (824)
"Room was clean, comfortable and quiet. Staff were very helpful throughout our stay."
United States
John
The price is ￥9,933
￥11,603 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Quality Inn & Suites Mayo Clinic Area
Efficiency King Suite with Sofa Bed - Non-Smoking | Premium bedding, desk, blackout drapes, iron/ironing board
Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center
2.5 star property
Rochester
9.0 out of 10, Wonderful, (580)
"Nice place to stay "
United States
Melissa
The price is ￥10,463
￥12,045 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Sleep Inn & Suites West-Near Medical Center
Front of property - evening/night
Kahler Grand Hotel

Kahler Grand Hotel

Kahler Grand Hotel
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (1828)
"Staff was friendly and helpful! Will continue to stay here while at the Mayo, "
United States
Gayle
The price is ￥20,894
￥24,054 total
includes taxes & fees
Dec 17 - Dec 18
Kahler Grand Hotel
Courtyard
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (958)
"Rooms are comfortable and staff was was so professional and helpful."
United States
William
The price is ￥16,983
￥19,864 total
includes taxes & fees
Dec 26 - Dec 27
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Exterior
Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
2.5 star property
Rochester
9.2 out of 10, Wonderful, (1000)
"Everything in this Hampton was fabulous!! From the great room to the great breakfast to the coloring pages and crayons for our grandchildren to the desk person to the man who brought more towels, coffee to the room!!! We loved our stay!!!"
United States
Pamela
The price is ￥13,586
￥15,641 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn & Suites Rochester-North
Terrace/patio
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.2 out of 10, Wonderful, (1004)
"Clean rooms, very friendly staff and was perfect for our stay, was a 5 to 10 minute walk to Mayo clinic. Great location."
United States
Kim
The price is ￥20,099
￥23,140 total
includes taxes & fees
Dec 20 - Dec 21
Hyatt House Rochester/Mayo Clinic Area
Executive Room, 2 Queen Beds, Refrigerator & Microwave, Pool View (Living Room) | Blackout drapes, soundproofing, iron/ironing board, rollaway beds
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
Rochester
8.2 out of 10, Very Good, (785)
"Great place to stay. Freindly staff"
United States
joel
The price is ￥13,915
￥16,020 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Room, 2 Queen Beds | Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area
3.5 star property
Downtown Rochester
8.0 out of 10, Very Good, (1518)
"Clean Great breakfast, friendly staff "
United States
ilona
The price is ￥19,009
￥21,884 total
includes taxes & fees
Dec 21 - Dec 22
Kahler Inn and Suites - Mayo Clinic Area
BBQ/picnic area
Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
Rochester
9.6 out of 10, Exceptional, (246)
"Very nice motel "
United States
Jim
The price is ￥18,510
￥21,309 total
includes taxes & fees
Dec 20 - Dec 21
Residence Inn by Marriott Rochester Mayo Clinic Area South
Breakfast served
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester
8.8 out of 10, Excellent, (853)
"Everything was wonderful! Helpful, friendly staff, great location, nice amenities."
United States
kristi
The price is ￥16,676
￥19,199 total
includes taxes & fees
Dec 21 - Dec 22
Hilton Garden Inn Rochester Downtown, MN
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Byron attractions

Somerby Golf Club

Enjoy a round of golf in Byron at Somerby Golf Club. Amble around the area's parks or experience its art scene.
See properties

High Point Shopping Center

You can search for that perfect souvenir at High Point Shopping Center during your trip to Byron. Amble around the area's parks or experience its art scene.
See properties

Top Byron Hotel Reviews

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent
"Scrambled eggs, sausage, hard boiled eggs, fresh fruit, muffins, bagels nd more"
Elizabeth 1-night trip
Posted 2 days ago
Med City Inn & Suites - Mayo Clinic Area

More cheap stays in Byron

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area

1850 S Broadway Rochester MN
The price is ￥9,833 per night from Jan 2 to Jan 3
￥9,833
￥11,321 total
Jan 2 - Jan 3, 2026
includes taxes & fees
9/10 Wonderful! (894 reviews)

Frequently asked questions

Where is the best place to stay in Byron?
Located 9 mi (14.4 km) from the heart of Byron, Kahler Grand Hotel is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Kahler Inn and Suites - Mayo Clinic Area and Hampton Inn Rochester-South. See all available top hotels, or vacation rentals in Byron.
What's the top vacation rental in Byron?
SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO: Visitors like this Byron vacation home rental. It offers a patio, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. See all vacation rentals in Byron.
If I need to cancel my hotel reservation in Byron, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Byron.
Where can I learn more about changing or cancelling my trip to Byron?
To find more details about updating your trip to Byron or cancelling it, head over to our customer service page.
Where is the best place to stay near Oxbow Park?
Staybridge Suites Rochester - Commerce Dr NW, an IHG Hotel is one of the top choices for your stay based on our traveler data, and this 3-star hotel offers free breakfast and an indoor pool. You'll find it 7 mi (11.3 km) from Oxbow Park. Other good choices around the area include Baymont by Wyndham Kasson Rochester Area and Hampton Inn & Suites Rochester-North.
How is it to stay in Byron?
Visitors can enjoy all that Byron has to offer including the zoo, golf courses, and bars. Tourists can also enjoy the city's parks and art. In Byron, there are 2 hotels and other accommodations to choose from. Find out more about Byron.
What should I see while I'm in Byron?
Favorite places to visit include High Point Shopping Center, Links of Byron Mini Golf, and Cheery Meadows Center. A couple of additional sights to add to your agenda are Byron Town Square and Somerby Golf Club. Check out what more to see and do in Expedia's Byron guide.
What's the weather like in Byron?
The hottest months are usually July and August with an average temp of 67°F, while the coldest months are January and February with an average of 21°F. The snowiest months in Byron are January, March, April, and February, with each month seeing an average of 8 inches of snowfall.

Explore a world of travel with Expedia