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Our top choices for Byron hotels

Front of property

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.2 out of 10, Good, (1,039 reviews)
  • cleanliness
    Convenient hotel near Mayo Clinic with free Wi-Fi, parking, and daily breakfast.
"Everything was excellent"
United States
Barbara
The price is ￥10,983
￥12,644 total
includes taxes & fees
Jan 30 - Jan 31
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Exterior

Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Enjoy a stay near Mayo Clinic with a refreshing hot tub and free breakfast.
"Clean room, clean hotel, friendly staff Would stay here again."
United States
Chee
The price is ￥11,639
￥13,398 total
includes taxes & fees
Feb 8 - Feb 9
Holiday Inn Express Rochester South - Mayo Area by IHG
Reception

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,001 reviews)
  • cleanliness
    Peaceful haven 5 minutes from Mayo Clinic, with complimentary breakfast daily.
"Great place"
United States
Randall
The price is ￥12,548
￥14,446 total
includes taxes & fees
Feb 22 - Feb 23
Hampton Inn Rochester-South
Reception

Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.4 out of 10, Exceptional, (365 reviews)
  • cleanliness
    Unwind in this modern Rochester hotel close to Mayo Clinic for medical visits.
"Clean, quiet and a really nice place to stay."
United States
Tony
The price is ￥10,799
￥12,432 total
includes taxes & fees
Feb 8 - Feb 9
Spark by Hilton Rochester South
Exterior

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (922 reviews)
  • cleanliness
    Peaceful stay near Mayo Clinic, featuring rooftop terrace and fitness center.
"Great stay as always! "
United States
Misty
The price is ￥15,161
￥17,455 total
includes taxes & fees
Feb 21 - Feb 22
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Lobby

Americas Best Value Inn & Suites Spring Valley

Americas Best Value Inn & Suites Spring Valley
2.0 star property
Spring Valley
8.2 out of 10, Very Good, (436 reviews)
  • cleanliness
    Modern motel with fitness center and daily continental breakfast in Spring Valley.
"The place was very clean, very quiet and the staff was extremely helpful. We will be back"
United States
Melissa
The price is ￥14,133
￥15,599 total
includes taxes & fees
Feb 1 - Feb 2
Americas Best Value Inn & Suites Spring Valley
Lobby

Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Experience comfort near Rochester International Airport with a complimentary shuttle.
"Enjoyed our stay, rated breakfast as a erage as we did not try it."
United States
jeanne
The price is ￥11,585
￥13,337 total
includes taxes & fees
Feb 27 - Feb 28
Comfort Inn & Suites Rochester South Mayo Clinic
Serves lunch, dinner, and happy hour

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.0 out of 10, Very Good, (1,195 reviews)
  • cleanliness
    Quiet retreat near Mayo Clinic with convenient dining and wellness amenities.
"Room was clean and very comfortable beds. "
United States
susan
The price is ￥11,302
￥13,012 total
includes taxes & fees
Feb 15 - Feb 16
AmericInn by Wyndham Rochester Near Mayo Clinic
Breakfast served

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester
8.8 out of 10, Excellent, (869 reviews)
  • cleanliness
    Convenient downtown Rochester lodging, minutes from Mayo Clinic.
"Very convenient and clean hotel "
United States
Kirsten
The price is ￥16,326
￥18,795 total
includes taxes & fees
Feb 13 - Feb 14
Hilton Garden Inn Rochester Downtown, MN
Courtyard

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (988 reviews)
  • cleanliness
    Stroll to Mayo Clinic or unwind in the indoor pool at this convenient hotel.
"Great hotel!"
United States
Narcedalia
The price is ￥14,781
￥17,322 total
includes taxes & fees
Jan 31 - Feb 1
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Terrace/patio

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.0 out of 10, Wonderful, (1,011 reviews)
  • cleanliness
    Experience premium comfort just 5 minutes from Mayo Clinic facilities.
"Great place to stay"
United States
Cristopher
The price is ￥20,135
￥23,180 total
includes taxes & fees
Jan 31 - Feb 1
Hyatt House Rochester/Mayo Clinic Area
Exterior

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park
9.2 out of 10, Wonderful, (780 reviews)
"Staff was very helpful and positive. "
United States
Bradley
The price is ￥15,864
￥18,264 total
includes taxes & fees
Jan 31 - Feb 1
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Restaurant

Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
2.5 star property
Rochester
9.2 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Explore Mayo Clinic then unwind in this modern Rochester hotel's heated pool.
"Good staff great place "
United States
Juan
The price is ￥13,634
￥15,695 total
includes taxes & fees
Mar 1 - Mar 2
Hampton Inn & Suites Rochester-North
View from property

Kahler Grand Hotel

Kahler Grand Hotel
3.0 star property
Downtown Rochester
8.4 out of 10, Very Good, (1,862 reviews)
  • cleanliness
    Historic hotel with indoor pool near Mayo Clinic and praised for its quiet rooms.
"Always an enjoyable place in a good location."
United States
Thomas
Kahler Grand Hotel
Reception

America's Stay Inn Stewartville

America's Stay Inn Stewartville
2.5 star property
Stewartville
8.0 out of 10, Very Good, (422 reviews)
  • cleanliness
    Central hotel near Mayo Clinic offers free breakfast and Wi-Fi in a clean setting.
"Room was nicer and furnished better than most high end places I’ve stayed at. It’s a small hotel on a busy road, but comfortable bed and clean."
Canada
Robert
America's Stay Inn Stewartville
2 indoor pools

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
2.5 star property
Kutzky Park
7.8 out of 10, Good, (1,000 reviews)
  • cleanliness
    Relax close to Mayo Clinic with indoor pools and convenient dining options.
"Friendly Staff comfortable bed"
United States
Shereen
The price is ￥11,440
￥13,171 total
includes taxes & fees
Jan 31 - Feb 1
Med City Inn & Suites - Mayo Clinic Area
Exterior

Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
9.0 out of 10, Wonderful, (541 reviews)
  • cleanliness
    Just a short drive from Mayo Clinic, with an indoor pool for year-round comfort.
"Staff friendly "
United States
Gina
The price is ￥11,155
￥12,843 total
includes taxes & fees
Feb 26 - Feb 27
Comfort Inn & Suites West - Medical Center
Property entrance

Country Inn & Suites Rochester South Mayo Clinic

Country Inn & Suites Rochester South Mayo Clinic
3.0 star property
Rochester
8.4 out of 10, Very Good, (1,001 reviews)
  • cleanliness
    Contemporary hotel near Mayo Clinic offers comfort with indoor pool and hot tub.
"Rooms are always clean wonderful service from the staff. It’s a great place to stay."
United States
Jamie
The price is ￥12,887
￥14,836 total
includes taxes & fees
Feb 22 - Feb 23
Country Inn & Suites Rochester South Mayo Clinic
Presidential Suite, Multiple Beds | Living area | 55-inch LCD TV with satellite channels, TV

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester
9.6 out of 10, Exceptional, (556 reviews)
  • cleanliness
    Stay minutes from Mayo Clinic with rooftop dining and luxury spa services.
"Very courteous staff, loved the valet guy!"
United States
Jean
The price is ￥26,142
￥30,097 total
includes taxes & fees
Feb 13 - Feb 14
Hilton Rochester Mayo Clinic Area
Lobby sitting area

Brentwood Inn & Suites

Brentwood Inn & Suites
2.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,002 reviews)
  • cleanliness
    Stay close to Mayo Clinic at this comfortable Rochester hotel with free breakfast.
"Clean and comfortable Close to the hospital for convenience "
United States
Dianne
Brentwood Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Byron attractions

Oxbow Park

Explore the great outdoors at Oxbow Park, a lovely green space in Byron. Check out the charming coffeehouses or top-notch restaurants in this walkable area.
See properties

Salem Glen Winery

You can enjoy a tasting or tour at Salem Glen Winery during your travels to Byron. Amble around the area's parks or experience its art scene.
See properties

Top Byron Hotel Reviews

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent
"Happy with the stay, great breakfast included. Happy with our room. No concerns, so continently located to Mayo. "
Erin 1-night trip
Posted 12 hours ago
Kahler Inn and Suites - Mayo Clinic Area

More cheap stays in Byron

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area

1850 S Broadway Rochester MN
The price is ￥9,595 per night from Feb 13 to Feb 14
￥9,595
￥11,045 total
Feb 13 - Feb 14
includes taxes & fees
9/10 Wonderful! (926 reviews)

Frequently asked questions

Where is the best place to stay in Byron?
Located 9 mi (14.4 km) from the heart of Byron, Kahler Grand Hotel is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Kahler Inn and Suites - Mayo Clinic Area and Hotel Indigo Rochester – Mayo Clinic Area by IHG. See all available top hotels, or vacation rentals in Byron.
What's the top vacation rental in Byron?
Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: Visitors like this Byron vacation home rental. It offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind. See all vacation rentals in Byron.
If I need to cancel my hotel reservation in Byron, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Byron.
Where can I learn more about changing or cancelling my trip to Byron?
To find more details about updating your trip to Byron or cancelling it, head over to our customer service page.
Where is the best place to stay near Oxbow Park?
Staybridge Suites Rochester - Commerce Dr NW, an IHG Hotel is one of the top choices for your stay based on our traveler data, and this 3-star hotel offers free breakfast and an indoor pool. You'll find it 7 mi (11.3 km) from Oxbow Park. Other good choices around the area include Baymont by Wyndham Kasson Rochester Area and Hampton Inn & Suites Rochester-North.
How is it to stay in Byron?
Visitors can enjoy all that Byron has to offer including the zoo, golf courses, and bars. Tourists can also enjoy the city's parks and art. In Byron, there are 2 hotels and other accommodations to choose from. Find out more about Byron.
What should I see while I'm in Byron?
Favorite places to visit include Putting Green, Links of Byron Mini Golf, and Cheery Meadows Center. A couple of additional sights to add to your agenda are High Point Shopping Center and Byron Town Square. Check out what more to see and do in Expedia's Byron guide.
What's the weather like in Byron?
The hottest months are usually July and August with an average temp of 67°F, while the coldest months are January and February with an average of 21°F. The snowiest months in Byron are January, March, April, and February, with each month seeing an average of 8 inches of snowfall.

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