Byron Vacation Rentals

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Check prices for these dates

In two weeks
Jan 9 - Jan 11
In two months
Feb 20 - Feb 22
In three months
Mar 20 - Mar 22
In four months
Apr 17 - Apr 19

Our top choices for Byron vacation rentals

Terrace/patio
The Berkman

Aparthotel in Folwell

The Berkman
3.0 star property
9.6 out of 10, Exceptional, (372)
"Staff was great, as was the room."
United States
Scott
The price is ￥21,888
￥25,452 total
includes taxes & fees
Dec 24 - Dec 25
The Berkman
Interior
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

Vacation Home in East Side Pioneers

Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
9.0 out of 10, Wonderful, (19)
"Nicely updated, very clean. Great location. They do allow pets, however it does not have a fenced yard. It is a duplex."
United States
Chris P.
The price is ￥8,630
￥33,238 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
Exterior
Valley Cabin

Cabin in Spring Valley

Valley Cabin
9.2 out of 10, Wonderful, (7)
"Great property with plenty of outdoor activities. Had fun fishing the stream and exploring the area. Dan is a great host and I will be visiting again."
United States
JAKE I.
The price is ￥8,473
￥19,881 total
includes taxes & fees
Dec 26 - Dec 27
Valley Cabin
Fridge, microwave, oven, stovetop
Broadway Plaza, Trademark Collection by Wyndham

Apartment in Downtown Rochester

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
9.2 out of 10, Wonderful, (167)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
The price is ￥24,853
￥28,611 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Broadway Plaza, Trademark Collection by Wyndham
Fridge, microwave, oven, stovetop
Across St. to St Mary hospital Covered By Faith 2

Apartment in Kutzky Park

Across St. to St Mary hospital Covered By Faith 2
2.0 star property
8.0 out of 10, Very Good, (1)
"Easy check in/ Secure entry system "
United States
Ann R.
The price is ￥9,307
￥24,123 total
includes taxes & fees
Dec 24 - Dec 25
Across St. to St Mary hospital Covered By Faith 2
Microwave, oven, stovetop, dishwasher
Discounted Charming 2-bedroom house in Rochester

Vacation Home in East Side Pioneers

Discounted Charming 2-bedroom house in Rochester
8.6 out of 10, Excellent, (11)
"Great stay for a quick stop in Rochester. Clean, quiet neighborhood."
United States
Jill S.
The price is ￥10,591
￥30,258 total
includes taxes & fees
Dec 30 - Dec 31
Discounted Charming 2-bedroom house in Rochester
Interior
Charming 2-bedroom apartment in delightful Rochester with WiFi, AC

Apartment in Meadow Park

Charming 2-bedroom apartment in delightful Rochester with WiFi, AC
10.0 out of 10, Exceptional, (1)
"Quiet, clean and in a friendly neighborhood. Staying there took some of the stress out of my Mayo Clinic visits. I always worry about my follow-up visits, but a good quiet place to stay helps me let that go."
United States
Maria L E.
The price is ￥14,906
￥31,566 total
includes taxes & fees
Dec 30 - Dec 31
Charming 2-bedroom apartment in delightful Rochester with WiFi, AC
Dining
Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!

Apartment in Rochester

Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!
9.6 out of 10, Exceptional, (25)
"Very clean had everything I needed "
United States
Victoria
The price is ￥7,767
￥28,269 total
includes taxes & fees
Dec 30 - Dec 31
Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!
Smart TV, DVD player, books, video library
1 mile to Mayo 2 step entry Brave Covered By Faith

Vacation Home in Parkway

1 mile to Mayo 2 step entry Brave Covered By Faith
2.0 star property
10.0 out of 10, Exceptional, (9)
"This was a PERFECT place to stay if you're going to the Mayo!Jessica is very easy to work with and incredibly responsive!"
United States
Kristin T.
The price is ￥10,042
￥34,635 total
includes taxes & fees
Dec 28 - Dec 29
1 mile to Mayo 2 step entry Brave Covered By Faith
Smart TV, fireplace
The June // A one bedroom basement apartment, 3 mi to Mayo Clinic

Apartment in Rochester

The June // A one bedroom basement apartment, 3 mi to Mayo Clinic
10.0 out of 10, Exceptional, (5)
"This place was quiet, comfortable, well-stocked, and incredibly close to everything we were looking for. The hosts were great communicators, and accessing the place was a snap."
United States
Josh P.
The price is ￥11,109
￥30,853 total
includes taxes & fees
Dec 28 - Dec 29
The June // A one bedroom basement apartment, 3 mi to Mayo Clinic
Terrace/patio
The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic

Vacation Home in Slatterly Park

The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic
10.0 out of 10, Exceptional, (17)
"We had a wonderful time visiting Minnesota for our first time! We would most definitely stay here again. Had everything we needed and was so great for our dogs to tag along too! Would 100% recommend staying here. "
United States
Hannah C.
The price is ￥15,816
￥35,912 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Little House // Stylish & Cozy ~ 2 mi from Mayo Clinic
Fridge, microwave, oven, stovetop
The Cozy Hideaway - 5-Minute Drive to Mayo Clinic

Vacation Home in Northrup

The Cozy Hideaway - 5-Minute Drive to Mayo Clinic
9.0 out of 10, Wonderful, (4)
"Perfect place to stay if needing to be close to Mayo. "
United States
Andrea S.
The price is ￥14,906
￥37,754 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Cozy Hideaway - 5-Minute Drive to Mayo Clinic
Fridge, microwave, oven, stovetop
Lux 3 BR mins to Mayo & Dwtwn I Charming Haven

Vacation Home in Rochester

Lux 3 BR mins to Mayo & Dwtwn I Charming Haven
2.0 star property
10.0 out of 10, Exceptional, (6)
"This property had everything we needed. Super cute and simple decor, comfortable beds and clean. We would stay here again!! "
United States
Anonymous traveler
The price is ￥23,533
￥70,416 total
includes taxes & fees
Dec 27 - Dec 28
Lux 3 BR mins to Mayo & Dwtwn I Charming Haven
Smart TV, DVD player, foosball, books
3 blks to St. Marys Pet Friendly CoveredByFaith

Vacation Home in Folwell

3 blks to St. Marys Pet Friendly CoveredByFaith
9.4 out of 10, Exceptional, (11)
"It was everything we needed for our short stay in Rochester. Place was as described. "
United States
Joseph N.
The price is ￥17,510
￥44,749 total
includes taxes & fees
Dec 30 - Dec 31
3 blks to St. Marys Pet Friendly CoveredByFaith
Dining
Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester

Vacation Home in Washington

Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester
10.0 out of 10, Exceptional, (15)
"We stayed here for a quick night before heading into WI to visit family! We loved how cozy and pet friendly it was! We will stay again! "
United States
Jazlyn J.
The price is ￥23,551
￥30,728 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester
Fridge, microwave, oven, stovetop
4 blks St Marys Main fl beds/bath CoveredByFaith

Vacation Home in Kutzky Park

4 blks St Marys Main fl beds/bath CoveredByFaith
9.8 out of 10, Exceptional, (59)
"We enjoyed our stay."
United States
Joseph V.
The price is ￥19,403
￥47,367 total
includes taxes & fees
Jan 1 - Jan 2, 2026
4 blks St Marys Main fl beds/bath CoveredByFaith
Smart TV
The Color House // 2 Bed, 2 Ba, 1 mi to Mayo Clinic, No Stairs to Entry

Vacation Home in East Side Pioneers

The Color House // 2 Bed, 2 Ba, 1 mi to Mayo Clinic, No Stairs to Entry
9.4 out of 10, Exceptional, (13)
"Great place!"
United States
Jeremiah E.
The price is ￥19,205
￥43,244 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Color House // 2 Bed, 2 Ba, 1 mi to Mayo Clinic, No Stairs to Entry
Fridge, microwave, oven, stovetop
1 mile Mayo 2 step entry Encourage Covered ByFaith

Vacation Home in Parkway

1 mile Mayo 2 step entry Encourage Covered ByFaith
2.0 star property
The price is ￥10,199
￥35,184 total
includes taxes & fees
Dec 29 - Dec 30
1 mile Mayo 2 step entry Encourage Covered ByFaith
Interior
Quiet 3 BDR Home- private sauna & skyline view- close to downtown & Mayo Clinic

Vacation Home in Rochester

Quiet 3 BDR Home- private sauna & skyline view- close to downtown & Mayo Clinic
10.0 out of 10, Exceptional, (1)
"This was a fantastic experience, far better than anticipated! Only a couple of comments: this high tech house was a little over the head of my crew and a guidebook to show us how to use all those remotes would have been most welcome. And one of my folks was looking for a can opener… We had a lovely time and the next convention we have in Rochester I will book here again without hesitation! "
United States
Patricia B.
The price is ￥59,465
￥78,034 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Quiet 3 BDR Home- private sauna & skyline view- close to downtown & Mayo Clinic
Exterior detail
Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio

Vacation Home in Folwell

Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio
10.0 out of 10, Exceptional, (11)
"A lovely home that was so comfortable for us to stay in "
United States
Najla A.
Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Byron Hotel Reviews

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent
"Clean room, good room service and good breakfast."
Donald 2-night trip
Posted 2 days ago
Kahler Inn and Suites - Mayo Clinic Area

Find out more about Byron

Search for holiday rentals in Byron on Expedia! You can easily find your home rentals, villas, holiday apartments in Byron using one of the methods below:

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Look no further and take a look at our great range of rental properties in Byron!

Frequently asked questions

Can I find vacation rentals in Byron?

Yes, we offer vacation rentals in Byron close to Zollman Zoo, or you can go with a more remote option if you want a relaxing stay. Byron is known for its zoo and golf courses. Make sure you have time to check out the bars and parks during your trip.

What's the top vacation rental that Byron has to offer?

Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester: Visitors like this Byron vacation home rental. It has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a stovetop, and a microwave.

What’s there to see and do in Byron?

Family-friendly attractions include Zollman Zoo, whereas Oxbow Park is a spot to enjoy the outdoors. While here, High Point Shopping Center and Putting Green are other places worth a visit.

What’s a vacation rental in Byron like?

A vacation rental is a private property you can stay in for a few weeks or just a few days in Byron. Vacation rentals offer amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about a sanitized environment, a vacation rental can offer a sense of safety away from public hotel elevators and busy reception areas while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a great option for a family getaway.