The Best Hotels Closest to Mayo Clinic in Rochester for 2026

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Our top choices for Mayo Clinic hotels

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

1. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic and includes a fitness center and a separate living room. Guests appreciate the complimentary breakfast and shuttle service. Nearby, you'll find various dining options.

￥19,808

￥22,803 total

includes taxes & fees

Oct 23 - Oct 24

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern restaurant with a counter, seating area, and a TV screen.

A modern lounge area with a sofa, chairs, and tables.

A modern hotel room with a bed, desk, and kitchenette.

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic, ideal for business travelers. Enjoy spacious suites with separate living rooms and complimentary breakfast. Nearby dining options add convenience.

￥18,714

￥21,545 total

includes taxes & fees

Nov 12 - Nov 13

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

3. The Berkman

Folwell, 1.4 km from Mayo Clinic

This aparthotel is a brief ride from Mayo Clinic, ideal for business travelers. Enjoy a separate living room, sofa bed, and nearby restaurants for dining options.

￥30,097

￥34,998 total

includes taxes & fees

Nov 1 - Nov 2

4. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic and features a fitness center and spacious living rooms. Guests appreciate the proximity to local dining and the civic center.

￥28,182

￥32,445 total

includes taxes & fees

Nov 7 - Nov 8

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern lounge area with seating, a fireplace, and a bar area.

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

This hotel is a quick ride from Mayo Clinic and provides a separate living room and a fitness center. Many guests highlight the free breakfast and nearby dining options.

￥21,851

￥25,156 total

includes taxes & fees

Nov 8 - Nov 9

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

6. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic, making it ideal for business travelers. Enjoy complimentary breakfast and convenient office space for productivity. Nearby dining options are plentiful.

￥21,693

￥24,973 total

includes taxes & fees

Oct 23 - Oct 24

A modern indoor patio with a fire feature, seating, and large windows.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic, boasting spacious suites with separate living rooms and a fitness center. Guests often highlight the nearby dining options.

￥18,051

￥22,922 total

includes taxes & fees

Oct 23 - Oct 24

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic, providing spacious suites with separate living areas. Guests enjoy a complimentary breakfast and a fitness center nearby restaurants and bars.

￥19,195

￥22,416 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

A hotel room with a large round table, two sofas, a TV, and a bed.

Two armchairs with striped pillows, a small round table, a clock, and a phone on a counter.

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

9. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

￥18,402

￥21,185 total

includes taxes & fees

Oct 17 - Oct 18

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

A modern living room with a sofa, a round coffee table, and a side table. There are large windows with a view of the outside.

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

This hotel is a quick ride from Mayo Clinic, offering comfortable, clean rooms and a fitness center. Guests often mention the spacious living areas and connecting rooms. Dining options are nearby.

￥17,934

￥20,645 total

includes taxes & fees

Nov 6 - Nov 7

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

A modern kitchen with wooden cabinets, a granite countertop, and a stainless steel stove.

11. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

￥26,834

￥30,893 total

includes taxes & fees

Oct 24 - Oct 25

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A gym with exercise equipment, a clock, and a window with blinds.

12. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

This hotel is a quick drive from Mayo Clinic. Spacious, clean rooms ensure comfort, while a fitness center and complimentary breakfast enhance your stay. Enjoy nearby dining options.

￥18,708

￥21,538 total

includes taxes & fees

Nov 14 - Nov 15

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern bar area with seating and a counter.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern indoor pool area with lounge chairs and a pool.

13. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

This hotel is a brief walk from Mayo Clinic and offers a separate living room and kitchenette for added comfort. Numerous dining options and bars are nearby.

￥18,684

￥21,510 total

includes taxes & fees

Oct 23 - Oct 24

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

14. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic, offering spacious suites with separate living areas and complimentary breakfast. Enjoy nearby dining and shopping options.

￥10,558

￥12,155 total

includes taxes & fees

Nov 8 - Nov 9

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

15. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

This hotel is a brief drive from Mayo Clinic and provides a fitness center and complimentary breakfast. Nearby, diners can explore numerous restaurants and bars.

￥17,362

￥19,989 total

includes taxes & fees

Nov 5 - Nov 6

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

16. Aspen Suites

1.2 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic and provides spacious rooms with comfortable living areas. Nearby, you'll find a variety of dining options.

￥22,462

￥27,152 total

includes taxes & fees

Oct 31 - Nov 1

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A reception area with a curved counter, ceiling lights, and a potted plant.

17. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic, offering spacious living rooms. Many travelers cite its prime location and convenience for a comfortable stay.

￥19,793

￥22,787 total

includes taxes & fees

Nov 13 - Nov 14

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

18. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

￥11,670

￥13,605 total

includes taxes & fees

Nov 6 - Nov 7

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.

19. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

This hotel is a brief walk from Mayo Clinic, offering spacious suites with separate living areas and a fitness center. Dining options are conveniently accessible via a skywalk.

￥18,708

￥21,538 total

includes taxes & fees

Oct 23 - Oct 24

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A garden with a water feature, rocks, and yellow umbrellas.

20. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest, 0.6 km from Mayo Clinic

This hotel is a brief walk from Mayo Clinic, offering a separate living room and a fitness center. Guests highlight the nearby dining options, enhancing their stay.

￥18,082

￥20,817 total

includes taxes & fees

Oct 23 - Oct 24

View all properties

Compare popular hotels close to Mayo Clinic

Property	Star rating	Guest rating
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 743 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,002 reviews	View
The Berkman	9.6 Exceptional 448 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 650 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 315 reviews	View

Top Mayo Clinic Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

10/10 Excellent

"Nice place"

Kahler Grand Hotel

8/10 Good

"Got locked in the pool area and had to walk down 11 flights of steps."

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

8/10 Good

"Hallways had overwhelming floral odor. What are they trying to cover up? Went to leave key and check out. Woman at desk was on a long phone call. Couldn’t give me eye contact and multi task. Disappointed for the price."

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Muy buena atención"

Hilton Rochester Mayo Clinic Area

10/10 Excellent

"Very nice hotel that’s in an excellent location. It has a good restaurant. Nice toiletries. Towels were thin and need replacement."

Hilton Garden Inn Rochester Downtown, MN

8/10 Good

"Staff were very nice and helpful. The traffic noise was very loud in the room as the hotel is in a busy area."

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

8/10 Good

"Killed a spider in our room"

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Close to the Mayo Clinic (easy walking distance), and easy to park"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"Good! Didn’t use the pool but it looked great, especially for families with kids! Just peeked in quick at the breakfast to get a few things and it was good!"

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 153 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 153 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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Find hotels near Mayo Clinic, Rochester from ￥12,155

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Our top choices for Mayo Clinic hotels

1. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

3. The Berkman

4. Hilton Rochester Mayo Clinic Area

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

6. TownePlace Suites by Marriott Rochester Mayo Clinic Area

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. Candlewood Suites Rochester Mayo Clinic Area by IHG

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

11. Broadway Plaza, Trademark Collection by Wyndham

12. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

13. Hyatt House Rochester/Mayo Clinic Area

14. Econo Lodge Mayo Clinic Area

15. Hampton Inn Rochester-South

16. Aspen Suites

17. Brentwood Inn & Suites

18. Quality Inn & Suites Mayo Clinic Area

19. Hilton Garden Inn Rochester Downtown, MN

20. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

Kahler Grand Hotel

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Hilton Rochester Mayo Clinic Area

Hilton Garden Inn Rochester Downtown, MN

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Frequently asked questions

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