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Our top choices for Mayo Clinic hotels

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

1. The Berkman

The Berkman
3.0 star property
Folwell, 1.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (454 reviews)
"Excellent service and wonderful room!"
United States
Suzette
The price is ￥28,411
￥33,033 total
includes taxes & fees
Dec 1 - Dec 2
The Berkman
A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

2. Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
2.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (321 reviews)
"Clean hotel, friendly staff, great location."
United States
Chee
The price is ￥20,789
￥23,934 total
includes taxes & fees
Nov 14 - Nov 15
Residence Inn by Marriott Rochester Mayo Clinic Area South
A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.

3. Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
9.6 out of 10, Exceptional, (655 reviews)
"Clean rooms, great staff, convenient location."
United States
Jennifer
The price is ￥26,639
￥30,667 total
includes taxes & fees
Nov 27 - Nov 28
Hilton Rochester Mayo Clinic Area
A coffee shop interior with a wooden counter, menu boards, and seating area.

4. TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Kutzky Park, 0.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (575 reviews)
"Excellent service, room was great and the lobby area is great for hanging out in the evenings!"
Canada
Cory
The price is ￥21,576
￥24,838 total
includes taxes & fees
Nov 14 - Nov 15
TownePlace Suites by Marriott Rochester Mayo Clinic Area
A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

5. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park, 1.4 km from Mayo Clinic
9.2 out of 10, Wonderful, (808 reviews)
"shower was excellent"
United States
francis
The price is ￥17,901
￥20,609 total
includes taxes & fees
Nov 27 - Nov 28
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

6. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
3.0 star property
Kutzky Park, 1.4 km from Mayo Clinic
9.2 out of 10, Wonderful, (541 reviews)
"Perfect location for our hockey tournament weekend"
United States
KELLY
The price is ￥17,269
￥19,882 total
includes taxes & fees
Nov 27 - Nov 28
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

7. Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
Downtown Rochester, 0.3 km from Mayo Clinic
9.2 out of 10, Wonderful, (188 reviews)
"Clean room and great location"
United States
Jennifer
The price is ￥26,639
￥30,667 total
includes taxes & fees
Nov 27 - Nov 28
Broadway Plaza, Trademark Collection by Wyndham
An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

8. Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester, 0.5 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,000 reviews)
"Nice stay"
United States
Arlan
The price is ￥17,513
￥20,163 total
includes taxes & fees
Nov 27 - Nov 28
Hyatt House Rochester/Mayo Clinic Area
A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

9. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
3.1 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,005 reviews)
"This was a very nice place to stay. It felt cozy, warm.... walking distance to a Perkins. Loved it."
United States
Lorraine
The price is ￥10,810
￥12,446 total
includes taxes & fees
Dec 6 - Dec 7
Econo Lodge Mayo Clinic Area
A hotel entrance with a stone facade, a glass door, and a metal roof structure.

10. Aspen Suites

Aspen Suites
3.0 star property
1.2 km from Mayo Clinic
9.0 out of 10, Wonderful, (917 reviews)
"Room was clean, common areas were well kept, staff was friendly and accommodating."
United States
Lee
The price is ￥18,826
￥22,756 total
includes taxes & fees
Nov 22 - Nov 23
Aspen Suites
A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

11. Brentwood Inn & Suites

Brentwood Inn & Suites
2.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (1,002 reviews)
"Our stay was very nice"
United States
Anne
The price is ￥18,899
￥21,757 total
includes taxes & fees
Nov 7 - Nov 8
Brentwood Inn & Suites
A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

12. Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (967 reviews)
"Great place"
United States
Richard
The price is ￥18,607
￥21,420 total
includes taxes & fees
Nov 13 - Nov 14
Hilton Garden Inn Rochester Downtown, MN
A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

13. Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
2.6 km from Mayo Clinic
8.8 out of 10, Excellent, (971 reviews)
"Nice location, staff very helpful and friendly, and nice big room"
United States
Mark
The price is ￥10,448
￥12,199 total
includes taxes & fees
Nov 28 - Nov 29
Quality Inn & Suites Mayo Clinic Area
A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

14. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
3.0 star property
Kutzky Park, 1.1 km from Mayo Clinic
8.6 out of 10, Excellent, (1,000 reviews)
"Clean rooms & nice breakfast"
United States
Jackie
The price is ￥16,158
￥18,601 total
includes taxes & fees
Dec 6 - Dec 7
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

15. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park, 1.6 km from Mayo Clinic
8.6 out of 10, Excellent, (848 reviews)
"The staff was super helpful and friendly. My room felt quite clean. The continental breakfast was above average. Really no complaints and I would stay again."
United States
Laura
The price is ￥15,906
￥18,312 total
includes taxes & fees
Nov 14 - Nov 15
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
An outdoor terrace with tables and chairs, a large umbrella, and a view of a modern building with string lights.

16. Residence Inn by Marriott Rochester Mayo Clinic Area

Residence Inn by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester, 0.2 km from Mayo Clinic
8.6 out of 10, Excellent, (213 reviews)
"Room was clean but the bed sheets should be replaced."
United States
Keith
The price is ￥23,466
￥27,016 total
includes taxes & fees
Nov 23 - Nov 24
Residence Inn by Marriott Rochester Mayo Clinic Area
A lobby with leather chairs, a reception desk, a TV, and a coffee station.

17. Aspen Select

Aspen Select
3.5 star property
Kutzky Park, 1.2 km from Mayo Clinic
8.4 out of 10, Very good, (1,001 reviews)
"The continental breakfast is great- lots of good, healthy choices to satisfy everyone"
United States
Trudy
The price is ￥14,831
￥17,929 total
includes taxes & fees
Nov 7 - Nov 8
Aspen Select
A swimming pool with a glass ceiling, a neon sign for the KAFFLER HOTEL, and a view of the city skyline at dusk.

18. Kahler Grand Hotel

Kahler Grand Hotel
3.0 star property
Downtown Rochester, 0.1 km from Mayo Clinic
8.4 out of 10, Very good, (2,398 reviews)
"We love the pool and hot tub!"
United States
Kathryn
The price is ￥21,726
￥25,013 total
includes taxes & fees
Nov 26 - Nov 27
Kahler Grand Hotel
A modern building with large glass windows and indoor plants.

19. Marriott Rochester Mayo Clinic

Marriott Rochester Mayo Clinic
3.5 star property
Downtown Rochester, 0.2 km from Mayo Clinic
8.4 out of 10, Very good, (579 reviews)
"Always clean, in a great location with many amenities. Staff are extremely helpful"
United States
Christine
The price is ￥32,915
￥37,894 total
includes taxes & fees
Nov 7 - Nov 8
Marriott Rochester Mayo Clinic
A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.

20. Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area
3.5 star property
Downtown Rochester, 0.2 km from Mayo Clinic
8.2 out of 10, Very good, (1,713 reviews)
"very good place!"
United States
Li
The price is ￥22,263
￥25,630 total
includes taxes & fees
Dec 4 - Dec 5
Kahler Inn and Suites - Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Mayo Clinic

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A spacious living area with a modern staircase, leather sofas, and contemporary lighting.
The Berkman
3.0 star property
9.6
Exceptional
454 reviews
View
A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.
Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
9.6
Exceptional
321 reviews
View
A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.
Hilton Rochester Mayo Clinic Area
3.5 star property
9.6
Exceptional
655 reviews
View
A coffee shop interior with a wooden counter, menu boards, and seating area.
TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
9.6
Exceptional
575 reviews
View
A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
9.2
Wonderful
808 reviews
View

Top Mayo Clinic Hotel Reviews

A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.
Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
Downtown Rochester

10/10 Excellent

I got a notice from the state disease control about a sickness passses through the pool, and my child did get very sick after swimming in the pool. Everything else was excellent!
United States
Ryan
Reviewed March 21, 2025
Hilton Rochester Mayo Clinic Area

Frequently Asked Questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 153 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 153 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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