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Check prices for these dates

Next weekend
Jul 17 - Jul 19
In two weeks
Jul 24 - Jul 26

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Our top choices for Byron hotels

Breakfast included
Lobby

Americas Best Value Inn & Suites Spring Valley

Americas Best Value Inn & Suites Spring Valley
2.0 star property
Spring Valley
8.2 out of 10, Very Good, (456 reviews)
"It was a very clean and well maintained hotel"
United States
Tade
The price is ￥12,773
￥14,098 total
includes taxes & fees
Jul 19 - Jul 20
Americas Best Value Inn & Suites Spring Valley
Interior detail

Birch Hill Suite Rochester – Med City

Birch Hill Suite Rochester – Med City
2.5 star property
Rochester
7.2 out of 10, Good, (48 reviews)
"The staff and room was great! "
United States
Cheryl
The price is ￥9,384
￥10,804 total
includes taxes & fees
Aug 2 - Aug 3
Birch Hill Suite Rochester – Med City
Desk, laptop workspace, soundproofing, iron/ironing board

MainStay Suites Rochester South Mayo Clinic

MainStay Suites Rochester South Mayo Clinic
2.5 star property
Rochester
7.4 out of 10, Good, (123 reviews)
"This was a nice place to stay especially for the price!! I would recommend."
United States
Brian
The price is ￥9,830
￥11,316 total
includes taxes & fees
Aug 8 - Aug 9
MainStay Suites Rochester South Mayo Clinic
Reception

America's Stay Inn Stewartville

America's Stay Inn Stewartville
2.5 star property
Stewartville
8.0 out of 10, Very Good, (459 reviews)
"Very nice clean rooms with plenty of parking. Will stay here again when traveling in the future."
United States
Debbie
The price is ￥10,621
￥11,405 total
includes taxes & fees
Aug 8 - Aug 9
America's Stay Inn Stewartville
Lobby

Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,004 reviews)
"Really like this hotel!"
United States
Stephanie
The price is ￥13,526
￥15,573 total
includes taxes & fees
Jul 31 - Aug 1
Comfort Inn & Suites Rochester South Mayo Clinic
In-room safe, desk, iron/ironing board, free cribs/infant beds

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
2.0 star property
Rochester
7.8 out of 10, Good, (1,005 reviews)
"The rooms were not clean at all Very basic breakfast"
United States
Mahmoud
The price is ￥11,544
￥13,290 total
includes taxes & fees
Jul 15 - Jul 16
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Front of property

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.4 out of 10, Good, (1,077 reviews)
"we enjoyed our stay"
United States
Richard
The price is ￥12,951
￥14,909 total
includes taxes & fees
Jul 19 - Jul 20
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Lobby

Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area
2.0 star property
Rochester
7.8 out of 10, Good, (1,005 reviews)
"Enjoyed my stay"
United States
Guled
The price is ￥8,522
￥9,811 total
includes taxes & fees
Aug 9 - Aug 10
Super 8 by Wyndham Rochester Mayo Clinic Area
Free daily full breakfast

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (1,009 reviews)
"Prefect place to stay at the worker there are awesome would be staying there again"
United States
Jesus
The price is ￥11,174
￥12,864 total
includes taxes & fees
Aug 9 - Aug 10
Econo Lodge Mayo Clinic Area
Serves lunch, dinner, and happy hour

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.0 out of 10, Very Good, (1,385 reviews)
"Our room was very nice and we liked that there was a restaurant attached that was very good. Would stay again!"
United States
Julie
The price is ￥12,643
￥14,556 total
includes taxes & fees
Aug 9 - Aug 10
AmericInn by Wyndham Rochester Near Mayo Clinic
Iron/ironing board, free cribs/infant beds, free WiFi, bed sheets

Baymont by Wyndham Rochester Mayo Clinic Area

Baymont by Wyndham Rochester Mayo Clinic Area
2.5 star property
Rochester
7.0 out of 10, Good, (810 reviews)
"Very nice stay."
United States
Tramisha
The price is ￥9,895
￥11,391 total
includes taxes & fees
Aug 9 - Aug 10
Baymont by Wyndham Rochester Mayo Clinic Area
Free WiFi, bed sheets

Motel 6 Rochester, MN

Motel 6 Rochester, MN
2.0 star property
Rochester
5.8 out of 10, (440 reviews)
"Easy to enter and exit the parking lot"
United States
Joyce
The price is ￥8,891
￥10,235 total
includes taxes & fees
Jul 17 - Jul 18
Motel 6 Rochester, MN
Reception

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,010 reviews)
"Great experience, would definitely stay again!!"
United States
Mike
The price is ￥15,052
￥17,330 total
includes taxes & fees
Aug 2 - Aug 3
Hampton Inn Rochester-South
2 indoor pools

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
2.5 star property
Kutzky Park
8.0 out of 10, Very Good, (1,020 reviews)
"Affordable stay close to Mayo Clinic."
United States
Ionn Carlo
The price is ￥12,223
￥14,072 total
includes taxes & fees
Jul 14 - Jul 15
Med City Inn & Suites - Mayo Clinic Area
Indoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
Rochester
8.2 out of 10, Very Good, (983 reviews)
"They helped with all of our handicapped needs. Breakfast was excellent. Pool area looked amazing. Very assessable to Mayo Clinic, provided shuttle picks you up at the door."
United States
Debora
The price is ￥12,805
￥14,741 total
includes taxes & fees
Jul 19 - Jul 20
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, free wired internet

Quality Inn near Medical Center

Quality Inn near Medical Center
2.5 star property
Rochester
7.8 out of 10, Good, (920 reviews)
"Good location."
United States
Jerry
The price is ￥10,857
￥12,498 total
includes taxes & fees
Aug 2 - Aug 3
Quality Inn near Medical Center
Studio, 2 Double Beds, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets

Extended Stay America Suites Rochester North

Extended Stay America Suites Rochester North
2.5 star property
Rochester
7.6 out of 10, Good, (713 reviews)
"Clean, comfortable and easy checkin "
United States
Jean
The price is ￥11,057
￥12,729 total
includes taxes & fees
Jul 14 - Jul 15
Extended Stay America Suites Rochester North
Lobby

Red Carpet Inn Rochester

Red Carpet Inn Rochester
2.0 star property
Rochester
7.6 out of 10, Good, (545 reviews)
"You get what you pay for. Basic room close to shops"
United States
Cindy
The price is ￥8,731
￥10,052 total
includes taxes & fees
Jul 14 - Jul 15
Red Carpet Inn Rochester
Reception

Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (527 reviews)
"Lots of good dog walking around the hotel."
United States
Phoebe
The price is ￥13,125
￥15,110 total
includes taxes & fees
Jul 31 - Aug 1
Spark by Hilton Rochester South
Exterior

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,006 reviews)
"As always it was a wonderful stay!"
United States
Misty
The price is ￥14,335
￥16,503 total
includes taxes & fees
Jul 31 - Aug 1
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Byron attractions

Somerby Park

Somerby Park is just one of the places to see in Byron, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its art scene.
See properties

Top Byron Hotel Reviews

Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent
"I love everything about it. I stay here atleast 2 to 3 times a month and always have a very good experience. Staff is always pleasant except for my last stay from 06/25 - 06/31. There was a lady working the breakfast area was rude and closed the breakfast are early. I have never seen that behavior from Any staff members since I started staying since 2025 as I regularly go to Mayo/St Mary's. I hope she will not be there or change her attitude when I return. Room 109"
Shereen 5-night trip
Posted 1 hour ago
Med City Inn & Suites - Mayo Clinic Area

More cheap stays in Byron

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

4210 Highway 52 North Rochester MN
The price is ￥11,544 per night from Jul 15 to Jul 16
￥11,544
￥13,290 total
Jul 15 - Jul 16
includes taxes & fees
7.8/10 Good! (1,005 reviews)

Frequently asked questions

Where is the best place to stay in Byron?
Located 9 mi (14.4 km) from the heart of Byron, Kahler Grand Hotel is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area. See all available top hotels, or vacation rentals in Byron.
What's the top vacation rental in Byron?
Magical Nest Hideaway: Visitors like this Byron vacation home rental. It is located on a river and offers a patio, air-conditioning, and a Smart TV to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. See all vacation rentals in Byron.
If I need to cancel my hotel reservation in Byron, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Byron.
Where can I learn more about changing or cancelling my trip to Byron?
To find more details about updating your trip to Byron or cancelling it, head over to our customer service page.
Where is the best place to stay near Oxbow Park?
Staybridge Suites Rochester - Commerce Dr NW, an IHG Hotel is one of the top choices for your stay based on our traveler data, and this 3-star hotel offers free breakfast and an indoor pool. You'll find it 7 mi (11.3 km) from Oxbow Park. Other good choices around the area include Baymont by Wyndham Kasson Rochester Area and Hampton Inn & Suites Rochester-North.
How is it to stay in Byron?
Visitors can enjoy all that Byron has to offer including the zoo, golf courses, and bars. Tourists can also enjoy the city's parks and art. In Byron, there are 3 hotels and other accommodations to choose from. Find out more about Byron.
What should I see while I'm in Byron?
Favorite places to visit include Links of Byron Mini Golf, Cheery Meadows Center, and High Point Shopping Center. A couple of additional sights to add to your agenda are Byron Town Square and Somerby Golf Club. Check out what more to see and do in Expedia's Byron guide.
What's the weather like in Byron?
The hottest months are usually July and August with an average temp of 67°F, while the coldest months are January and February with an average of 21°F. The snowiest months in Byron are January, March, April, and February, with each month seeing an average of 8 inches of snowfall.

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