Southeast Minnesota Luxury Vacations 2026

Photo by Sara Crotts

Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,264 reviews)

"Clean room, location is perfect for visits to Mayo Clinic."

Reviewed on Aug 16, 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN

2 hours drive from Mayo Clinic

AmericInn by Wyndham Northfield offers a luxury stay. Popular amenities include an indoor pool and a hot tub.

8.2/10 Very Good! (683 reviews)

"Friendly staff, easy check and breakfast was simple but fine. Hallway carpet should be changed, maybe figure out a way to reduce dampness in the air in the room. Room itself was clean."

Reviewed on Aug 13, 2026

See all 924 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.