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Top Luxury Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,091 reviews)

Staff was very friendly. Room was meticulously cleaned. Very easy to get to and from my appointments at the Mayo Clinic from the hotel.

Reviewed on May 18, 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

8/10 Very Good! (1,006 reviews)

Beds were comfy. Staff was polite. We didn’t use the pool but it looked good

Reviewed on May 17, 2026

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN

2 hours drive from Mayo Clinic

AmericInn by Wyndham Northfield offers a luxury stay. Popular amenities include an indoor pool and a hot tub.

8.4/10 Very Good! (655 reviews)

Clean room

Reviewed on May 17, 2026

See all 941 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.