Photo by Kristen Howell

Plan, book, travel with confidence
Better together
Save up to ￥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Adventure Northeast Florida Hotels

Omni Amelia Island Resort & Spa

39 Beach Lagoon Road Fernandina Beach FL

49 min drive from Mayo Clinic Florida

Book a stay at this beach resort in Fernandina Beach. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in our reviews. ...

8.6/10 Excellent! (1,008 reviews)

Staff is friendly and helpful. Rooms could use a microwave but overall an excellent experience.

Reviewed on Jan 18, 2026

Ponte Vedra Inn & Club

200 Ponte Vedra Blvd Ponte Vedra Beach FL

6 min drive from Mayo Clinic Florida

Book a stay at this luxury hotel in Ponte Vedra Beach. Enjoy a full-service spa, 2 restaurants, and a beach locale. Our guests praise the helpful staff in our ...

9.4/10 Exceptional! (815 reviews)

Amazing. Loved it

Reviewed on Jan 12, 2026

The Flagler Inn

2700 N Ponce de Leon Blvd St. Augustine FL

58 min drive from Mayo Clinic Florida

Book a stay at this family-friendly hotel in St. Augustine. Enjoy free parking, a 24-hour front desk, and a 24-hour business center. Our guests praise the breakfast ...

7.6/10 Good! (1,003 reviews)

This is an older facility and I loved it A taste of old St Augustine. Staff was seen constantly checking the property, scooping up even leaves that blew in, talking with guests and delivering extra supplies. The room was spacious and very comfortable. Staying at the Flagger Inn was the best part ...

Reviewed on Jan 11, 2026

See all 11,985 properties in Northeast Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.