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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Our top choices for Southeast Missouri hotels with a spa

A spacious lobby with a reception desk, seating area, and large windows.

1. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, great food, excellent staff."
United States
Dean
The price is ￥14,173
￥16,013 total
includes taxes & fees
Nov 13 - Nov 14
Drury Inn & Suites Poplar Bluff
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

2. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,009 reviews)
"Everything was great about the stay!"
United States
Denise
The price is ￥14,058
￥15,741 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

3. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is ￥15,587
￥17,584 total
includes taxes & fees
Nov 15 - Nov 16
Drury Plaza Hotel Cape Girardeau Conference Center
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

4. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (977 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is ￥15,261
￥17,241 total
includes taxes & fees
Nov 15 - Nov 16
Fairfield Inn & Suites by Marriott Poplar Bluff
A modern lounge area with seating arrangements, a kitchen area, and a bar.

5. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (82 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is ￥15,368
￥17,411 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn By Hilton Dexter
A living room with a blue wall, a fireplace, a sofa, and a chair.

6. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is ￥14,737
￥16,041 total
includes taxes & fees
Nov 15 - Nov 16
EC Reed's Mercantile and Hotel
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

7. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is ￥15,906
￥18,089 total
includes taxes & fees
Nov 15 - Nov 16
Fairfield Inn & Suites by Marriott Sikeston
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

8. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (702 reviews)
"Every time I stay here I truly enjoy my stay Clean rooms and staff is very attentive Will stay here again"
United States
Irvin
The price is ￥17,013
￥19,193 total
includes taxes & fees
Nov 18 - Nov 19
The Riverview
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

9. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (199 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is ￥13,431
￥15,287 total
includes taxes & fees
Nov 16 - Nov 17
Tru By Hilton Cape Girardeau
A spacious living room with a sofa set, a coffee table, and a dining area.

10. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (557 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is ￥18,285
￥20,719 total
includes taxes & fees
Nov 19 - Nov 20
Courtyard by Marriott Cape Girardeau Downtown
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

11. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Awesome place will be staying in more of them"
United States
Tim
The price is ￥14,802
￥17,019 total
includes taxes & fees
Nov 15 - Nov 16
Drury Inn & Suites Sikeston, MO
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

12. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is ￥15,043
￥17,121 total
includes taxes & fees
Dec 6 - Dec 7
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A Holiday Inn hotel with a covered entrance, multiple floors, and a parking lot.

13. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (805 reviews)
"Always an enjoyable stay"
United States
Nathan
The price is ￥12,442
￥14,055 total
includes taxes & fees
Dec 5 - Dec 6
Holiday Inn Poplar Bluff by IHG
Two armchairs with a patterned upholstery, a small round table with a vase of flowers, and a large abstract painting on the wall.

14. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (858 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is ￥15,368
￥17,337 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Cape Girardeau I 55 East
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

15. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,000 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is ￥11,338
￥12,792 total
includes taxes & fees
Nov 15 - Nov 16
Pear Tree Inn Cape Girardeau West
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

16. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,001 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is ￥11,198
￥12,538 total
includes taxes & fees
Nov 20 - Nov 21
Motel 6 Poplar Bluff, MO
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

17. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (240 reviews)
"Great hotel…!!"
United States
Carlos
The price is ￥15,930
￥17,972 total
includes taxes & fees
Nov 12 - Nov 13
Fairfield Inn & Suites by Marriott Cape Girardeau
Property amenity

18. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (29 reviews)
"I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great."
United States
Mark
The price is ￥16,600
￥18,877 total
includes taxes & fees
Nov 15 - Nov 16
TownePlace Suites by Marriott Sikeston
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

19. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
9.4 out of 10, Exceptional, (22 reviews)
"This was a wonderful hotel and had a wonderful stay. Room was clean and staff was wonderful."
United States
Misty
The price is ￥17,563
￥20,084 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn & Suites By Hilton Festus
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

20. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (338 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is ￥19,419
￥21,211 total
includes taxes & fees
Nov 9 - Nov 10
Shepherd Mountain Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"Clean and well maintained."
Randall 1-night trip
Posted 8 hours ago
Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Always stay at a Drury"
Noelle 1-night trip
Posted 3 days ago
Drury Inn & Suites Cape Girardeau