The Best Resorts & Hotels with Spas in Southeast Missouri, MO from ￥17,275 in 2026 | Expedia

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Tonight

Nov 12 - Nov 13

Tomorrow

Nov 13 - Nov 14

This weekend

Nov 13 - Nov 15

Next weekend

Nov 20 - Nov 22

Our top choices for Southeast Missouri hotels with a spa

A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

1. Hampton Inn Poplar Bluff

Poplar Bluff

United States

Denise

￥15,966 total

includes taxes & fees

Dec 13 - Dec 14

A Drury Inn & Suites building with a covered entrance, multiple windows, and a parking lot.

2. Drury Inn & Suites Sikeston, MO

Sikeston

United States

Tiffany

￥17,266 total

includes taxes & fees

Nov 22 - Nov 23

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

3. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

United States

Dane

￥15,473 total

includes taxes & fees

Dec 6 - Dec 7

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

4. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

United States

ELAINE

￥16,724 total

includes taxes & fees

Nov 22 - Nov 23

A Hampton Inn hotel with a modern design, featuring a flat roof and a prominent signage.

5. Hampton Inn By Hilton Dexter

Dexter

United States

Bryan

￥17,661 total

includes taxes & fees

Nov 22 - Nov 23

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

6. Pear Tree Inn Cape Girardeau West

Cape Girardeau

United States

Livia

￥12,976 total

includes taxes & fees

Nov 22 - Nov 23

A living room with a blue wall, a fireplace, a sofa, and a chair.

7. EC Reed's Mercantile and Hotel

Marble Hill

United States

Jan

￥18,284 total

includes taxes & fees

Nov 15 - Nov 16

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

8. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

United States

Melody

￥18,022 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel lobby with a reception desk, seating area, and a view of the outdoors.

9. Motel 6 Poplar Bluff, MO

Poplar Bluff

United States

Jim

￥11,593 total

includes taxes & fees

Nov 26 - Nov 27

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

10. Tru By Hilton Cape Girardeau

Cape Girardeau

United States

Shannon

￥15,507 total

includes taxes & fees

Nov 19 - Nov 20

Two armchairs with a patterned upholstery, a small round table with a vase of flowers, and a large abstract painting on the wall.

11. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

United States

Britney

￥17,587 total

includes taxes & fees

Nov 22 - Nov 23

An indoor swimming pool with a clear view of the outside through large windows.

12. Drury Inn & Suites Poplar Bluff

Poplar Bluff

United States

Alan

￥16,966 total

includes taxes & fees

Nov 19 - Nov 20

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

13. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

United States

Rebecca

￥17,275 total

includes taxes & fees

Dec 11 - Dec 12

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

14. The Riverview

Cape Girardeau

United States

Irvin

￥19,779 total

includes taxes & fees

Nov 15 - Nov 16

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

15. Shepherd Mountain Inn

Ironton

United States

Jonathan

￥21,518 total

includes taxes & fees

Nov 16 - Nov 17

A Holiday Inn hotel with a covered entrance, multiple floors, and a parking lot.

16. Holiday Inn Poplar Bluff by IHG

Poplar Bluff

United States

Nathan

￥13,536 total

includes taxes & fees

Dec 13 - Dec 14

A spacious living room with a sofa set, a coffee table, and a dining area.

17. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

United States

Kelly

￥21,019 total

includes taxes & fees

Nov 22 - Nov 23

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a landscaped entrance area.

18. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

United States

richard

￥13,816 total

includes taxes & fees

Nov 15 - Nov 16

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

19. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

United States

Roslyn

￥19,987 total

includes taxes & fees

Nov 19 - Nov 20

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

20. Hampton Inn & Suites By Hilton Festus

Festus

United States

Shanna

￥20,824 total

includes taxes & fees

Nov 22 - Nov 23

View all properties

Choose what matters most at spa hotels in Southeast Missouri

Pool

Breakfast included

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Drury is always an elevated experience for the price point! Comfy beds, clean room and shower and always good food."

Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent

"Clean and well maintained."

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