A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Find Resorts & Hotels with Spas in Southeast Missouri, MO

Check availability on Southeast Missouri Resorts & Hotels with Spas

Tonight
Oct 17 - Oct 18
Tomorrow
Oct 18 - Oct 19
Next weekend
Oct 23 - Oct 25
In two weeks
Oct 30 - Nov 1

Our top choices for Southeast Missouri hotels with a spa

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
View all properties

Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great as usual"
Frank 1-night trip
Posted 13 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"The evening food was especially good! The two women working were outstanding and made the evening more fun. One's name was San."
Denise 1-night trip
Posted 14 hours ago
Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"The room was clean, the pillows were great and the bed was comfy. the dinner service and breakfast were very nice and the staff was helpful and friendly! 10/10"
Cynthia 1-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau

Explore a world of travel with Expedia