Photo by George Zimzores
Find hotels in South Central Houston, Houston
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for South Central Houston hotels
Downtowner Inns - Houston Downtown
Downtowner Inns - Houston DowntownSouth Central Houston
8.4 out of 10, Very Good, (99 reviews)
"Good hotel. great location. "
Porfirio
The price is ￥13,349
￥15,619 total
includes taxes & fees
Apr 27 - Apr 28
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterSouth Central Houston
8.4 out of 10, Very Good, (1,877 reviews)
"Very clean property, staff was helpful"
Elton
The price is ￥20,501
￥24,170 total
includes taxes & fees
Apr 26 - Apr 27
Americas Best Value Inn Medical Center Downtown
Americas Best Value Inn Medical Center DowntownSouth Central Houston
8.0 out of 10, Very Good, (1,008 reviews)
"Clean, convenient, quiet and very friendly staff. Would stay here again."
Ruben
The price is ￥13,190
￥15,432 total
includes taxes & fees
Apr 9 - Apr 10
DoubleTree by Hilton Houston Medical Center Hotel & Suites
DoubleTree by Hilton Houston Medical Center Hotel & SuitesSouth Central Houston
8.4 out of 10, Very Good, (551 reviews)
"Room was excellent and staff was amazing."
Ronald
The price is ￥19,243
￥22,515 total
includes taxes & fees
Apr 26 - Apr 27
The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictSouth Central Houston
9.2 out of 10, Wonderful, (1,137 reviews)
"Great central location within the walking distance to many places. "
Kasey
The price is ￥27,032
￥33,647 total
includes taxes & fees
Apr 19 - Apr 20
Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum DistrictSouth Central Houston
9.0 out of 10, Wonderful, (1,005 reviews)
"An amzing stay, great staff and overal luxery feeling"
Wendy
The price is ￥33,958
￥47,020 total
includes taxes & fees
Apr 9 - Apr 10
Sentral Forme Houston
Sentral Forme HoustonSouth Central Houston
10.0 out of 10, Exceptional, (2 reviews)
"Jerrick (front desk) was super friendly and helpful, and the room and amenities were great."
Cade
The price is ￥21,478
￥29,778 total
includes taxes & fees
Apr 12 - Apr 13
InterContinental Houston by IHG
InterContinental Houston by IHGSouth Central Houston
9.2 out of 10, Wonderful, (1,000 reviews)
"Wonderful location to events at NRG. Very clean, friendly staff and great bar area. "
Staci
The price is ￥25,932
￥33,519 total
includes taxes & fees
Apr 12 - Apr 13
Houston Marriott Medical Center/Museum District
Houston Marriott Medical Center/Museum DistrictSouth Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"This is our second visit to this particular Marriott. The staff are more than accommodating! The wait staff at breakfast are amazing! "
Anna
The price is ￥31,625
￥42,226 total
includes taxes & fees
Apr 25 - Apr 26
La Maison in Midtown an urban B&B
La Maison in Midtown an urban B&BSouth Central Houston
9.8 out of 10, Exceptional, (567 reviews)
"Loved the area, the staff was super friendly and accomodating. "
Silvia Alejandra
The price is ￥28,447
￥33,284 total
includes taxes & fees
Apr 13 - Apr 14
Luxurious 3 Bed3 Bath Near Downtown Houston
Luxurious 3 Bed3 Bath Near Downtown HoustonSouth Central Houston
10.0 out of 10, Exceptional, (2 reviews)
"This was made for a perfect family vacation… super clean kid friendly with an awesome view of Houston for the adults on rooftop "
Ebony
The price is ￥12,229
￥49,451 total
includes taxes & fees
May 6 - May 7
Hilton University of Houston
Hilton University of HoustonSouth Central Houston
9.0 out of 10, Wonderful, (926 reviews)
"Booking was easy, staff was super friendly, and the location was perfect for what I needed! "
Brandon
The price is ￥27,598
￥32,291 total
includes taxes & fees
May 3 - May 4
Wanderstay Boutique Hotel
Wanderstay Boutique HotelSouth Central Houston
9.8 out of 10, Exceptional, (69 reviews)
"Great location will stay again "
Jason
The price is ￥20,253
￥23,697 total
includes taxes & fees
Apr 12 - Apr 13
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults OnlySouth Central Houston
9.6 out of 10, Exceptional, (208 reviews)
"Thoroughly enjoyed our stay. Nick, the property manager is very nice and thoughtful. The bed was so comfortable and the best part for me was the incredibly private and quiet spaces. "
Misty
The price is ￥32,896
￥40,872 total
includes taxes & fees
Apr 9 - Apr 10
Southmore Boulevard Motel
Southmore Boulevard MotelSouth Central Houston
5.6 out of 10, (234 reviews)
"Quiet and comfortable rooms; good access to the area around. "
Timothy
The price is ￥9,297
￥10,878 total
includes taxes & fees
Apr 10 - Apr 11
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Extended Stay America Suites Houston Med Ctr Braeswood BlSouth Central Houston
5.8 out of 10, (1,012 reviews)
"Room was clean and had a very comfortable bed We had a very pleasant stay. We were very comfortable and felt quite safe st this property. "
Nilda
The price is ￥11,584
￥13,599 total
includes taxes & fees
Apr 13 - Apr 14
Rodeway Inn & Suites Houston near Medical Center
Rodeway Inn & Suites Houston near Medical CenterSouth Central Houston
6.0 out of 10, (511 reviews)
"Very economical. Great price for one night stay."
AUGUSTIN
The price is ￥9,295
￥10,875 total
includes taxes & fees
Apr 11 - Apr 12
Golden Motel Near Houston Medical Center
Golden Motel Near Houston Medical CenterSouth Central Houston
2.0 out of 10, (1 review)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
Jacari
The price is ￥9,058
￥10,597 total
includes taxes & fees
Apr 9 - Apr 10
Wanderstay Houston Hostel
Wanderstay Houston HostelSouth Central Houston
8.2 out of 10, Very Good, (198 reviews)
"Great place to stay. Very clean."
Hoang
The price is ￥9,283
￥10,861 total
includes taxes & fees
Apr 12 - Apr 13
Posh Dtwn Midtown Home w Stunning Roof-topterrace
Posh Dtwn Midtown Home w Stunning Roof-topterraceSouth Central Houston
The price is ￥34,897
￥98,424 total
includes taxes & fees
Apr 13 - Apr 14
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Central Houston
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Wanderstay Boutique Hotel | 9.8 Exceptional 69 reviews | View | ||||||
 La Maison in Midtown an urban B&B | 9.8 Exceptional 567 reviews | View | ||||||
 Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only | 9.6 Exceptional 208 reviews | View | ||||||
 Hilton University of Houston | 9.0 Wonderful 926 reviews | View | ||||||
 Hotel Zaza Houston Museum District | 9.0 Wonderful 1,005 reviews | View |
Where to stay in South Central Houston
Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top South Central Houston Hotel Reviews
Hilton Houston Plaza/Medical Center
8/10 Good
Frequently asked questions
Explore a world of travel with Expedia
- Houston Hotels
- Hotels with Early Check-in in Houston
- Historic Hotels in Texas Medical Center
- Boutique Hotels in East Downtown Houston
- Hotels near Greater Houston Convention and Visitors Bureau
- Apartments in Bellaire
- Harris County Hotels
- Hotels with smoking rooms in Houston Central Business District
- Hotels with Early Check-in in South Main
- Family Hotels in South Central Houston
- All-Inclusive Hotel Hotels in East Downtown Houston
- Ryokans in Houston
- Hotels near Houston Museum of Fine Arts
- Adults Only Resorts & in Houston
- Hotel with a Concierge Hotels in Braeswood Place
- Apartments in Houston
- Hotels near University of St. Thomas
- Cheap Hotels in Downtown Houston
- Beach Hotels in Houston Central Business District
- Shopping Hotels in Texas Medical Center
- Inns in Houston
- Hotels near Houston Station
- Hotels near Rice University
- Hotels with Bars in Houston
- Town Houses in Houston
- Adults Only Resorts & in Texas Medical Center
- Luxury Hotels in Downtown Houston
- Hotels near Shops at Houston Center
- Hotels near Greenway Plaza
- Treehouses in Houston
- Cheap Hotels in Magnolia Park
- Boutique Hotels in Greenway Plaza-Upper Kirby
- Hotels with Early Check-in in The Galleria
- Guest Houses in Houston
- University Place Hotels
- Hotels near Houston Natural Science Museum
- Pet-Friendly Hotels in Houston
- Business Hotels in Downtown Houston
- Business Hotels in East Downtown Houston
- All-Inclusive Hotel Hotels in Downtown Houston
- Hotels with Hot Tubs in Houston
- Motels in Memorial Hermann Hospital/Houston Zoo Station
- Business Hotels in Park Place
- Hotels with Early Check-in in Houston Convention District
- Hotels with an Indoor Pool in Houston
- Houston Convention District Hotels
- Shopping Hotels in Braeswood Place
- Hotels near Discovery Green
- Cheap Hotels in Theater District
- Hotels with Free Parking in Houston
- Capsule Hotels in Houston
- Family Hotels in Houston
- Cheap Hotels in Texas Medical Center
- Hotels with Early Check-in in Houston Central Business District
- Greater Third Ward Hotels
- Hotels near Toyota Center
- Hotels near Central Business District Heliport
- Waterpark Hotels in Houston
- All-Inclusive Hotel Hotels in Houston
- East Downtown Houston Hotels
- Hotels with an Indoor Pool in Houston Heights
- Hotels near Houston Contemporary Arts Museum
- Waterpark Hotels in Houston Central Business District
- Family Hotels in Midtown
- Business Hotels in Houston Heights
- Hotels near Houston City Hall
- Beach Hotels in Houston
- Cheap Hotels in Houston
- Historic Hotels in Houston
- Hotels near George R. Brown Convention Center
- Pet-Friendly Hotels in The Galleria
- Hotels near Main Street Theater - Rice Village
- Luxury Hotels in Greater Uptown
- Gay friendly Hotels in Houston
- Hotels near Rothko Chapel
- Hotels with Free Parking in The Galleria
- Cheap Hotels in Greater Third Ward
- Ranches in Houston
- Hotels near Alley Theater
- B&B in Houston
- Hotels near House of Blues Houston
- Luxury Hotels in Braeswood Place
- Texas Medical Center Hotels
- Montrose Hotels
- Cheap Hotels in East Downtown Houston
- Downtown Houston Hotels
- Beach Hotels in Downtown Houston
- Hotels near Texas Southern University
- Hotels near University of Houston
- Boutique Hotels in Montrose
- 5 Star Hotels in Houston
- Hotels near Market Square Park
- Luxury Hotels in Houston
- Shopping Hotels in Houston
- Hotels with smoking rooms in Houston