Photo by George Zimzores

Find Family Hotels in South Central Houston, TX

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on South Central Houston Family Hotels

This weekend
Next weekend

Our top choices for South Central Houston family-friendly hotels

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center
8.4 out of 10, Very Good, (1796)
"The hotel was great and convenient. Easy check in an check out. Will definitely stay again. "
United States
Allison
The price is ¥13,684
¥16,192 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hilton Houston Plaza/Medical Center

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (1032)
"Excellent breakfast and bar"
United States
Misty
The price is ¥20,242
¥25,196 total
includes taxes & fees
Dec 30 - Dec 31
The Westin Houston Medical Center/Museum District

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
Texas Medical Center
8.4 out of 10, Very Good, (482)
"Solid hotel and amenities"
United States
Kenneth
The price is ¥17,411
¥20,372 total
includes taxes & fees
Jan 23 - Jan 24, 2026
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (1002)
"Comfortable bed, very clean, very good food, quite, friendly stuff and hotel shuttle works easy."
United States
Elena
The price is ¥22,405
¥31,201 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Houston Marriott Medical Center/Museum District

The Right House @ East Downtown

The Right House @ East Downtown
South Central Houston
10.0 out of 10, Exceptional, (3)
"Amazing stay, 10/10 recommend! "
United States
Natalie D.
The price is ¥12,134
¥66,570 total
includes taxes & fees
Dec 30 - Dec 31
The Right House @ East Downtown

Universal Apartment at East Downtown

Universal Apartment at East Downtown
South Central Houston
9.6 out of 10, Exceptional, (21)
"Love it the house was amazing thank you for trusting me with your home "
United States
lynice s.
The price is ¥12,134
¥17,329 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Universal Apartment at East Downtown

Charming Lux Gem in Med Center w/ 2 King Beds-Patio-Backyard

Charming Lux Gem in Med Center w/ 2 King Beds-Patio-Backyard
2.0 star property
Southeast Houston
10.0 out of 10, Exceptional, (1)
"The host was extremely welcoming. She had my name on a small blackboard. The home is absolutely beautiful and well decorated. The amenities were top notch. It is close to the medical center and stores. I am going to go take that screened in porch in my suitcase because it was relaxing and welcoming. Macy thanks you for the comfy bed and her unannounced neighborhood tour. She says the backyard lights were great"
United States
Susy C.
The price is ¥15,657
¥48,819 total
includes taxes & fees
Dec 30 - Dec 31
Charming Lux Gem in Med Center w/ 2 King Beds-Patio-Backyard

Quantum Tiny Loft at East End Revitalized

Quantum Tiny Loft at East End Revitalized
South Central Houston
9.8 out of 10, Exceptional, (6)
"It was a very cozy stay and the atmosphere was very nice."
United States
Charlie Q.
The price is ¥18,602
¥24,898 total
includes taxes & fees
Dec 30 - Dec 31
Quantum Tiny Loft at East End Revitalized

Intergalactic Abode at East Downtown

Intergalactic Abode at East Downtown
South Central Houston
10.0 out of 10, Exceptional, (3)
"clean, nice and amazing host"
United States
Lauryn G.
The price is ¥9,062
¥62,662 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Intergalactic Abode at East Downtown

Cozy 2BR Queen Bed Central Houston

Cozy 2BR Queen Bed Central Houston
2.0 star property
Southeast Houston
The price is ¥11,508
¥30,336 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Cozy 2BR Queen Bed Central Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top South Central Houston Hotel Reviews

Frequently asked questions

What's South Central Houston like for family-friendly vacations?
The destination of South Central Houston is a good option if you've been considering a getaway with the kids. There are some interesting activities the entire family might enjoy. Arrange a flight into Houston William Hobby Airport (HOU), which is the closest airport, or Houston, TX (EFD-Ellington Field), which is located 14.4 mi (23.1 km) from the center of South Central Houston.
What's the best hotel for a family vacation in South Central Houston?
The Westin Houston Medical Center/Museum District is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other good options for your stay with the kids include DoubleTree by Hilton Houston Medical Center Hotel & Suites and Houston Marriott Medical Center/Museum District.
What's there to see and do with your family in South Central Houston?
While you and your family are visiting South Central Houston, you might want to check out some kid-friendly attractions such as Continental Club and Midtown Arts and Theater Center Houston. Make sure you have plenty of time to take in activities in the area like Toyota Center, Daikin Park, and NRG Stadium.

Explore a world of travel with Expedia