Find Business Hotels in South Carolina Midlands, SC

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Check availability on South Carolina Midlands Business Hotels

Tonight
Dec 31 - Jan 1
Tomorrow
Jan 1 - Jan 2
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for South Carolina Midlands business-friendly hotels

Lobby
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area
2.5 star property
Florence
9.2 out of 10, Wonderful, (1185)
"Great location, friendly staff. "
United States
Defelicio
The price is ￥15,407
￥17,255 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Comfort Inn & Suites Florence Center Area
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1416)
"Room was very nice and staff was very nice"
United States
Rupert
The price is ￥11,696
￥12,983 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Baymont by Wyndham Santee
Free continental breakfast
Holiday Inn Express & Suites Newberry by IHG

Holiday Inn Express & Suites Newberry by IHG

Holiday Inn Express & Suites Newberry by IHG
2.5 star property
Newberry
9.0 out of 10, Wonderful, (633)
"Room was clean staff was great !"
United States
R Scott
The price is ￥13,257
￥14,319 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Holiday Inn Express & Suites Newberry by IHG
Free daily buffet breakfast
Hampton Inn & Suites Lexington Columbia

Hampton Inn & Suites Lexington Columbia

Hampton Inn & Suites Lexington Columbia
2.5 star property
Lexington
9.8 out of 10, Exceptional, (597)
"Clean and comfortable room, friendly staff, great location."
United States
Allison
The price is ￥16,542
￥18,362 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Hampton Inn & Suites Lexington Columbia
Exterior
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC
2.5 star property
Florence
9.0 out of 10, Wonderful, (2217)
"Clean room and friendly staff!"
United States
Daria
The price is ￥13,195
￥14,777 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Park Inn by Radisson Florence, SC
Front of property - evening/night
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown
3.0 star property
Florence
9.0 out of 10, Wonderful, (1000)
"Great experience in a nice hotel in downtown."
United States
HATIM
The price is ￥15,597
￥17,469 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Hyatt Place Florence Downtown
Lobby
Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison
3.0 star property
Columbia
9.0 out of 10, Wonderful, (1900)
"Great stay, would do it again."
United States
Fred
The price is ￥12,695
￥14,219 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton Garden Inn Columbia/Harbison
Lobby
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence
2.0 star property
Florence
8.6 out of 10, Excellent, (2516)
"Great room and staff."
United States
LEE
The price is ￥10,399
￥11,647 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Howard Johnson by Wyndham Florence
Terrace/patio
Tru by Hilton Florence I-95

Tru by Hilton Florence I-95

Tru by Hilton Florence I-95
2.5 star property
Florence
8.4 out of 10, Very Good, (1000)
"We enjoyed our stay. Everything stood out Staff, Clean room and Amenities. "
United States
Marita
The price is ￥14,580
￥16,875 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Tru by Hilton Florence I-95
Exterior
La Quinta Inn & Suites by Wyndham Rock Hill

La Quinta Inn & Suites by Wyndham Rock Hill

La Quinta Inn & Suites by Wyndham Rock Hill
3.0 star property
Rock Hill
8.8 out of 10, Excellent, (1082)
"Yes the room was great and the breakfast was great, we will be back."
United States
Tom
The price is ￥12,495
￥13,870 total
includes taxes & fees
Jan 5 - Jan 6, 2026
La Quinta Inn & Suites by Wyndham Rock Hill
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top South Carolina Midlands Hotel Reviews

Graduate by Hilton Columbia SC

Graduate by Hilton Columbia SC

10/10 Excellent
"Just slept and showered Shower was spacious but hand held need help in room 111"
Charles 1-night trip
Posted 19 hours ago
Graduate by Hilton Columbia SC

Frequently asked questions

How much do business-friendly hotels in South Carolina Midlands cost?
You can expect to pay between ￥11,647 and ￥18,362 per night for business-friendly hotels in South Carolina Midlands. Epic deals on stays that cater to work-related guests are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in South Carolina Midlands?
There are multiple business-friendly hotels in South Carolina Midlands with a total average guest review rating of 8.7, so you're sure to discover a place that suits your needs. Basing yourself in Columbia? Staybridge Suites Columbia, an IHG Hotel is popular with corporate travelers. This 3-stars option offers conveniences like a barbecue grill and a swimming pool. Hampton Inn Columbia I-26/Harbison Blvd. also scores top marks from business guests. Take advantage of complimentary use of a nearby fitness center and a swimming pool at this 2.5-stars property in Columbia.
How many business-friendly hotels are there in South Carolina Midlands?
When your next meeting or networking event takes you someplace in South Carolina Midlands, you'll have 268 business-friendly hotels to choose from.
What are the best cheap business-friendly hotels in South Carolina Midlands?
That depends on where in South Carolina Midlands your journey is taking you. If your destination is Columbia, Hampton Inn Columbia I-26/Harbison Blvd. meets the needs of business travelers at an affordable price. A terrace and pool sun loungers are among its many conveniences. On your way to Florence? Consider staying at Hampton Inn & Suites Florence Center. A swimming pool and WiFi help make this cheaper property a top choice for corporate guests. Business-friendly hotels start from ￥11,647 a night, so your next work trip doesn't have to cost a lot. Want to see the sights of South Carolina Midlands without the high admission prices? Take time out from your business commitments to visit free attractions like Trinity Episcopal Cathedral in Columbia. Florence also has plenty of things to do that don't cost anything, including Florence Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the top business-friendly motels in South Carolina Midlands?
If your South Carolina Midlands business visit includes Columbia, check in to Days Inn by Wyndham Columbia. Around 6 kilometers northwest of the downtown area and offering a swimming pool and a terrace, it's popular with corporate guests. Alternatively, work comfortably from America's Best Inn Columbia. A balcony and front desk services are among the conveniences at this property, located around 6 kilometers northwest of the center of Columbia.There's no shortage of things to keep you entertained during your downtime in Columbia. Riverbanks Zoo and Garden and Township Auditorium should be on your travel itinerary.
Are there any family-friendly hotels in South Carolina Midlands that are also business friendly?
If you're traveling for business in South Carolina Midlands and bringing family along with you, Expedia will help you find a cozy and convenient stay. Hampton Inn Columbia I-26/Harbison Blvd. in Columbia is the perfect option for those juggling work and pleasure. This 2.5-stars hotel offers all the amenities you need, like a playground and complimentary breakfast. Holiday Inn Columbia - Downtown, an IHG Hotel is another good choice in Columbia. You'll be able to combine corporate travel and quality time with your family at this 3-stars property. Laundry facilities and housekeeping services are among the numerous conveniences here. There are plenty of exciting things to do with your little travelers in Columbia. Riverbanks Zoo and Garden and South Carolina State Museum offer a memorable day out.
Why book your business-friendly hotel in South Carolina Midlands with Expedia?
Expedia is here to help you find a fabulous business-friendly hotel when work takes you out of town. From free WiFi and parking to on-site cafés and restaurants, our stays have the things you need to get the job done.
How can I find cheap business-friendly hotels in South Carolina Midlands?
Expedia can help you narrow down your search for cheap business-friendly hotels in South Carolina Midlands. Simply go to the "traveler experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work effectively and comfortably, like free WiFi and included breakfast. You can also choose your preferred star rating and budget to keep costs to a minimum.
What is there to do in South Carolina Midlands near my business-friendly hotel?
You'll discover plenty of things to keep you entertained in South Carolina Midlands. If you're making your way to Columbia, drop by Riverbanks Zoo and Garden, Township Auditorium and South Carolina State Museum. Packing your suitcases for Florence? Florence Museum, Mcleod Regional Medical Center and Florence National Cemetery are top attractions here.

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