Find Gay friendly Hotels in Otay Mesa, CA

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Check availability on Otay Mesa Gay friendly Hotels

Our top choices for Otay Mesa LGBT-friendly hotels

Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very Good, (1560)
"Great place to stay. Really clean and helpful staff "
United States
Zulma
The price is ￥18,541
￥21,090 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Suite, 1 King Bed with Sofa Bed (Marina Tower Newly Renovated Marina view) | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.2 out of 10, Very Good, (3181)
"Great stay! "
United States
Melissa
The price is ￥17,451
￥25,668 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Sheraton San Diego Resort
Outdoor pool
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
7.8 out of 10, Good, (1005)
"Good value Nice place to stay "
United States
John
The price is ￥14,490
￥16,720 total
includes taxes & fees
Dec 21 - Dec 22
Crowne Plaza San Diego - Mission Valley by IHG
Outdoor pool, sun loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1864)
"Enjoyed my stay"
United States
Brandon
The price is ￥15,425
￥25,529 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton San Diego Bayfront
3 outdoor pools, cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1633)
"Nice rooms. Great food at all restaurants "
United States
Steve
Sycuan Casino Resort
Premium bedding, pillowtop beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is ￥12,911
￥19,473 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1572)
"Loved our stay "
United States
Jeremy
The price is ￥20,099
￥31,347 total
includes taxes & fees
Dec 18 - Dec 19
Hyatt Regency Mission Bay Spa and Marina
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillowtop beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (733)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is ￥16,080
￥18,644 total
includes taxes & fees
Dec 28 - Dec 29
The DEXTRO Little Italy, BW Premier Collection
Reception
Kings Inn San Diego

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (3571)
"Room was very clean, and the breakfast was good"
United States
Roxana
The price is ￥11,665
￥13,386 total
includes taxes & fees
Dec 17 - Dec 18
Kings Inn San Diego
Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (1282)
"Room was clean,buffet bkfast was good,staff were friendly & helpful!"
United States
Barry
The price is ￥14,833
￥17,050 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hampton Inn San Diego/Mission Valley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa Hotel Reviews

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Frequently asked questions

Searching for an LGBTQ-friendly accommodation in Otay Mesa?
Consider this your open invitation to pack your bags and find Otay Mesa hotels that are members of the International Gay & Lesbian Travel Association on Expedia. People like Otay Mesa for its shopping and restaurants.
What's the best LGBTQ-friendly place to stay in Otay Mesa?
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is a top LGBTQ-friendly hotel that features free breakfast and free WiFi.
What should I see while I'm in Otay Mesa?
During your trip, get out and explore everything Otay Mesa offers. You and your traveling companions may want to visit San Diego Zoo, San Ysidro Border Crossing, and Petco Park. While you're here, capture some great memories of your trip with a stop at Port of San Diego.
What is a gay-friendly hotel in Otay Mesa?
LGBTQ-friendly hotels, also known as gay-friendly hotels, welcome all travelers who identify as LGBTQIA+. Expedia has worked with the International Gay and Lesbian Travel Association (IGLTA) to compile a selection of LGBTQ-friendly hotels worldwide. In Otay Mesa, hotels affiliated with IGLTA will provide lesbian, gay, bisexual, and transgender adventurers with the information needed to design the trip of a lifetime.
What can I expect from a gay-friendly hotel in Otay Mesa?
Take a vacation from the ordinary; stay at an LGBTQ-friendly hotel in Otay Mesa, and you'll be around like-minded people, so you can relax and enjoy your trip. Some of Expedia's LGBTQ-friendly hotels go the extra mile and offer concierge services that provide information about nearby LGBTQ restaurants and local events.