Top 10 Hotels in St. Charles, MN from ￥10,293 - Competitive Prices

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Our top choices for St. Charles hotels

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

An indoor swimming pool with a slide, seating area, and a large frog statue.

A hotel room with two beds, a desk, a chair, and a mirror.

1. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Jeanne

￥12,123

￥13,956 total

includes taxes & fees

Oct 29 - Oct 30

An indoor swimming pool with clear water, wooden flooring, and a ceiling with wooden beams and lights.

A room with a TV mounted on the wall, a wooden table, and two patterned armchairs.

A hotel room with two beds, a desk, a chair, a television, and a window with curtains.

A café with multiple tables and chairs, a kitchen area with appliances, and a clock on the wall.

2. Med City Inn & Suites - Mayo Clinic Area

Kutzky Park

Rick

￥11,230

￥12,928 total

includes taxes & fees

Sep 29 - Sep 30

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

3. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Kathryn

￥11,898

￥13,697 total

includes taxes & fees

Oct 4 - Oct 5

A hotel lobby with a reception desk, seating area, and a bar.

A front-loading white washer and dryer in a laundry room with a window and a door.

A hotel room with two beds, a desk, a TV, and a large window with curtains.

A gym with treadmills, an elliptical, and a stationary bike.

4. Super 8 by Wyndham Rochester Mayo Clinic Area

Rochester

Amber

￥8,422

￥9,695 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A gym with treadmills, elliptical machines, and a stationary bike.

A kitchen with a waffle maker, a waffle iron, and a waffle maker instruction manual.

A hotel room with a desk, a chair, a flat-screen TV mounted on the wall, and a lamp on the desk.

5. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

Darlene

￥13,457

￥15,492 total

includes taxes & fees

Oct 29 - Oct 30

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A small, well-organized pantry with shelves stocked with snacks and beverages.

A hotel with a covered entrance, multiple floors, and a parking lot.

6. Spark by Hilton Rochester South

Rochester

Kimberly

￥12,768

￥14,700 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a television, a desk, and a window with curtains.

A hotel lobby with a reception desk, a 'WELCOME' sign, a seating area, and a buffet counter.

A modern kitchen with a coffee machine, a refrigerator, and a window with a view. There are tables and chairs arranged for dining.

A lobby with two leather armchairs, a welcome sign, and a lamp on a small table.

7. MainStay Suites Rochester South Mayo Clinic

Rochester

Linda

￥9,563

￥11,009 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

A breakfast area with a coffee station, a refrigerator, and a dining table with chairs.

A reception area with a counter, a clock, a desk with a computer, and a framed picture on the wall.

8. Days Inn by Wyndham Winona

Winona

William

￥11,096

￥12,385 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

A hotel lobby with seating, a fireplace, a clock, and a reception area.

An indoor swimming pool with clear water, a lifeguard on duty sign, and a seating area with chairs and tables.

A hotel room with a sofa, a small table, a TV, a microwave, and a door.

9. AmericInn by Wyndham Winona

Winona

SANDRA

￥18,583

￥20,743 total

includes taxes & fees

Oct 11 - Oct 12

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

10. Econo Lodge Mayo Clinic Area

Rochester

Ashley

￥11,096

￥12,774 total

includes taxes & fees

Oct 25 - Oct 26

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

11. Hampton Inn Rochester-South

Rochester

dennis

￥16,637

￥19,153 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

A Microtel Inn & Suites building with a signboard, a parking lot, and a clear sky.

A reception area with a reception desk, two armchairs, a clock, and a framed artwork on the wall.

A compact hotel room with a kitchenette, a dining area, a sofa, and a bed.

12. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Rochester

Richard

￥10,964

￥12,623 total

includes taxes & fees

Sep 30 - Oct 1

13. Birch Hill Suite Rochester – Med City

Rochester

Latosha

￥9,129

￥10,510 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a desk with a chair, a television, and a view of the outdoors through a door.

A compact hotel room with a kitchenette, a leather chair, and a view of the balcony.

An indoor swimming pool with clear blue water, a ladder, and blue chairs around the pool.

A breakfast corner with a counter, seating area, and a red partition.

14. Baymont by Wyndham Rochester Mayo Clinic Area

Rochester

Bobbi

￥10,027

￥11,544 total

includes taxes & fees

Oct 4 - Oct 5

A modern hotel lobby with a reception desk, seating area, and a dining space.

A Holiday Inn Express building with a stone facade and illuminated signage.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

15. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Melissa

￥15,099

￥17,382 total

includes taxes & fees

Oct 18 - Oct 19

A spacious living area with a wooden dining table, bar stools, and a patterned armchair. A staircase leads to an upper level with a balcony.

A spacious lobby with a high ceiling, a central seating area with patterned sofas and ottomans, a reception desk, and a staircase leading to an upper level.

A restaurant with a staircase, dining tables, chairs, a coffee machine, and a refrigerator.

16. Quality Inn near Medical Center

Rochester

Lerry

￥9,893

￥11,389 total

includes taxes & fees

Oct 19 - Oct 20

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A restaurant interior with wooden tables, chairs, and a stone wall.

17. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Carrie

￥16,963

￥19,529 total

includes taxes & fees

Oct 2 - Oct 3

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A hotel room with a kitchen area, a bed, a TV, and a seating area.

A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.

18. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

Vicky

￥15,539

￥17,889 total

includes taxes & fees

Oct 3 - Oct 4

A hotel room with two beds, a desk with a chair, a TV, and a large waterfall painting on the wall.

A hotel room with large windows, a clock, and framed pictures on the walls.

A reception area with a modern design, featuring a check-in counter, a door, and a small seating area with red stools.

An outdoor patio with a table and chairs, a red umbrella, and a view of trees and a sunset.

19. Super 8 by Wyndham Winona MN

Winona

William

￥9,059

￥10,293 total

includes taxes & fees

Oct 25 - Oct 26

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

A spacious living room with a stone fireplace, blue sofas, and a flat-screen TV.

A spacious lobby with a central seating area, a reception desk, and a fireplace.

A hotel room with a blue sofa, a wooden coffee table, a bed with white linens, a TV, and a large mirror.

20. Comfort Inn & Suites West - Medical Center

Rochester

yuan

￥14,011

￥16,131 total

includes taxes & fees

Oct 10 - Oct 11

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St. Charles awaits: its natural setting and more!

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Top St. Charles Hotel Reviews

Express Suites Riverport Inn & Suites

10/10 Excellent

"Friendly staff, quiet environment. My son particularly liked the pool."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Short stay but property was better than most. Plus it's walking distance to the Canadian Honker restaurant!"

The Plaza Hotel & Suites Winona

8/10 Good

"The breakfast could be better for the price of a hotel room. I loved my spacious room."

Brentwood Inn & Suites

8/10 Good

"Walking distance to Mayo—very handy amidst construction."

Kahler Grand Hotel

10/10 Excellent

"Love the 40’s vibes that this modern hotel has."

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"Great price, my child enjoyed the pool area, room was comfortable, staff was great!"

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Na"

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

10/10 Excellent

"Very nice place! I would definitely stay there again."

Holiday Inn Express Rochester South - Mayo Area by IHG

10/10 Excellent

"Room was very clean, staff was amazing. Hot tub not working."

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

￥9,059

￥10,293 total

Oct 25 - Oct 26

includes taxes & fees

7.6/10 Good! (1,006 reviews)

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN

￥9,129

￥10,510 total

Oct 4 - Oct 5

includes taxes & fees

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

￥11,230

￥12,928 total

Sep 29 - Sep 30

includes taxes & fees

Comfort Inn & Suites Rochester South Mayo Clinic

7320 Airport View Dr Sw Rochester MN

￥13,457

￥15,492 total

Oct 29 - Oct 30

includes taxes & fees

8.8/10 Excellent! (1,009 reviews)

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

￥14,745

￥16,975 total

Oct 2 - Oct 3

includes taxes & fees

8.8/10 Excellent! (1,007 reviews)

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

￥15,099

￥17,382 total

Oct 18 - Oct 19

includes taxes & fees

8.8/10 Excellent! (1,002 reviews)

Frequently asked questions

Where is the best place to stay in St. Charles?

AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

What's the top vacation rental in St. Charles?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This vacation home rental outside of St. Charles offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind. See all vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

Where can I learn more about changing or cancelling my trip to St. Charles?

To access more information about updating your trip to St. Charles or cancelling it, go to https://www.expedia.com/service/.

Where is the best hotel to stay near Whitewater State Park?

White Valley Motel is one of the top choices for your stay based on our traveler data, and this property offers free parking and free WiFi. You'll find it 6.4 mi (10.3 km) from Whitewater State Park. Other good choices around the area include Kahler Inn and Suites - Mayo Clinic Area and La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S.

What's the best hotel for staying near Rochester International Airport (RST)?

AmericInn by Wyndham Rochester Airport is a popular hotel, featuring free breakfast and an indoor pool. It's located a short 0.6 mi (1 km) from Rochester Intl. Airport. Other choices near the airport include La Quinta Inn & Suites by Wyndham Rochester and Comfort Suites.

What's it like staying in St. Charles?

Visitors can enjoy all that St. Charles has to offer including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodations to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favorite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Check out what more to see and do in Expedia's St. Charles guide.

What's the seasonal weather like in St. Charles?

The hottest months are usually July and August with an average temp of 67°F, while the coldest months are January and February with an average of 22°F. The snowiest months in St. Charles are January, March, February, and April, with each month seeing an average of 8 inches of snowfall.

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Find hotels in St. Charles, MN from ￥10,293

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in St. Charles

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for St. Charles hotels

1. AmericInn by Wyndham Rochester Near Mayo Clinic

2. Med City Inn & Suites - Mayo Clinic Area

3. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

4. Super 8 by Wyndham Rochester Mayo Clinic Area

5. Comfort Inn & Suites Rochester South Mayo Clinic

6. Spark by Hilton Rochester South

7. MainStay Suites Rochester South Mayo Clinic

8. Days Inn by Wyndham Winona

9. AmericInn by Wyndham Winona

10. Econo Lodge Mayo Clinic Area

11. Hampton Inn Rochester-South

12. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

13. Birch Hill Suite Rochester – Med City

14. Baymont by Wyndham Rochester Mayo Clinic Area

15. Holiday Inn Express Rochester South - Mayo Area by IHG

16. Quality Inn near Medical Center

17. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

18. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

19. Super 8 by Wyndham Winona MN

20. Comfort Inn & Suites West - Medical Center

Learn more about St. Charles

Top St. Charles Hotel Reviews

Express Suites Riverport Inn & Suites

EVEN Hotel Rochester - Mayo Clinic Area by IHG

The Plaza Hotel & Suites Winona

Brentwood Inn & Suites

Kahler Grand Hotel

AmericInn by Wyndham Rochester Near Mayo Clinic

Hyatt House Rochester/Mayo Clinic Area

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Holiday Inn Express Rochester South - Mayo Area by IHG

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

Birch Hill Suite Rochester – Med City

Med City Inn & Suites - Mayo Clinic Area

Comfort Inn & Suites Rochester South Mayo Clinic

Brentwood Inn & Suites

Holiday Inn Express Rochester South - Mayo Area by IHG

Frequently asked questions

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