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Our top choices for St. Charles hotels

Breakfast included
Pet friendly
Hotel
Reserve now, pay later
Whitewater River
Lobby
Desk, blackout drapes, iron/ironing board, cribs (free)
Fitness facility
Indoor pool, open 7:00 AM to 11:00 PM, sun loungers

1. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
Rochester
United States
Anne
￥12,617
￥14,525 total
includes taxes & fees
Aug 30 - Aug 31
Comfort Inn & Suites Rochester South Mayo Clinic
Reception
In-room safe, laptop workspace, blackout drapes, iron/ironing board
Restaurant
Lobby

2. Hampton Inn Rochester-South

Hampton Inn Rochester-South
Rochester
United States
Lynne
￥15,030
￥17,304 total
includes taxes & fees
Aug 23 - Aug 24
Hampton Inn Rochester-South
Serves lunch, dinner, and happy hour
Indoor pool
Apartment, 1 Bedroom, 2 Queen Beds, Non Smoking | Premium bedding, down comforters, pillowtop beds, desk
Lunch and dinner served

3. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
Rochester
United States
Luis
￥12,024
￥13,843 total
includes taxes & fees
Aug 23 - Aug 24
AmericInn by Wyndham Rochester Near Mayo Clinic
Lobby
Laundry room
Exterior
Room, 2 Queen Beds, Non Smoking (Ground Floor) | Laptop workspace, iron/ironing board, WiFi (free)

4. Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area
Rochester
United States
Amber
￥8,264
￥9,515 total
includes taxes & fees
Aug 30 - Aug 31
Super 8 by Wyndham Rochester Mayo Clinic Area
Reception
Lobby
Studio, 1 Queen Bed | Living area | 40-inch flat-screen TV with digital channels, TV
Snack bar

5. Spark by Hilton Rochester South

Spark by Hilton Rochester South
Rochester
United States
Lijing
￥12,939
￥14,897 total
includes taxes & fees
Aug 23 - Aug 24
Spark by Hilton Rochester South
Front of property
Lobby sitting area
Restaurant
Lobby

6. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Rochester
United States
Darrel
￥12,058
￥13,881 total
includes taxes & fees
Aug 23 - Aug 24
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Iron/ironing board (on request), cribs (free), WiFi (free), bed sheets
Free daily continental breakfast
Indoor pool
Iron/ironing board (on request), cribs (free), WiFi (free), bed sheets

7. Baymont by Wyndham Rochester Mayo Clinic Area

Baymont by Wyndham Rochester Mayo Clinic Area
Rochester
United States
Denise
￥9,485
￥10,919 total
includes taxes & fees
Aug 30 - Aug 31
Baymont by Wyndham Rochester Mayo Clinic Area
Studio Suite, 1 King Bed, Non Smoking | Desk, blackout drapes, iron/ironing board, cribs (free)
Lobby
Suite, 1 King Bed, Non Smoking | Desk, blackout drapes, iron/ironing board, cribs (free)
Exterior

8. AmericInn by Wyndham Winona

AmericInn by Wyndham Winona
Winona
United States
Jacob
￥18,832
￥21,021 total
includes taxes & fees
Sep 13 - Sep 14
AmericInn by Wyndham Winona
Free daily full breakfast
Laundry room
Lobby sitting area
Reception

9. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
Rochester
United States
Markus
￥11,211
￥12,906 total
includes taxes & fees
Sep 13 - Sep 14
Econo Lodge Mayo Clinic Area
Indoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers
Executive Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave (Living Room) | Blackout drapes, soundproofing, iron/ironing board
Standard Room, 2 Queen Beds, Accessible, Refrigerator & Microwave | Blackout drapes, soundproofing, iron/ironing board
Executive Room, 2 Queen Beds, Refrigerator & Microwave, Pool View (Living Room) | Blackout drapes, soundproofing, iron/ironing board

10. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Rochester
United States
Margita
￥14,991
￥17,259 total
includes taxes & fees
Aug 23 - Aug 24
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
In-room safe, desk, iron/ironing board, cribs (free)
Exterior
Lobby
Lobby

11. Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic

Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Rochester
United States
Siddhartha
￥11,111
￥12,791 total
includes taxes & fees
Sep 3 - Sep 4
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
In-room safe, desk, blackout drapes, iron/ironing board
Fitness facility
Lobby
Lobby

12. Days Inn by Wyndham Winona

Days Inn by Wyndham Winona
Winona
United States
Twila
￥10,839
￥12,099 total
includes taxes & fees
Sep 13 - Sep 14
Days Inn by Wyndham Winona
2 indoor pools
Desk, laptop workspace, iron/ironing board, WiFi (free)
Free daily continental breakfast
Lobby sitting area

13. Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
Kutzky Park
United States
Olivia
￥12,050
￥13,872 total
includes taxes & fees
Aug 16 - Aug 17
Med City Inn & Suites - Mayo Clinic Area
Exterior
Exterior
Suite, 1 King Bed, Jetted Tub | In-room safe, desk, laptop workspace, iron/ironing board
Restaurant

14. Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
Rochester
United States
Stephanie
￥15,301
￥17,616 total
includes taxes & fees
Aug 29 - Aug 30
Holiday Inn Express Rochester South - Mayo Area by IHG
Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, bed sheets
Lobby sitting area
Indoor pool
Free daily buffet breakfast

15. Quality Inn near Medical Center

Quality Inn near Medical Center
Rochester
United States
Rodney
￥10,026
￥11,542 total
includes taxes & fees
Sep 3 - Sep 4
Quality Inn near Medical Center
Room, 2 Queen Beds, Non Smoking (Pet-Friendly) | Desk, laptop workspace, blackout drapes, iron/ironing board (on request)
Lobby
Free daily on-the-go breakfast
Lobby

16. Super 8 by Wyndham Winona MN

Super 8 by Wyndham Winona MN
Winona
United States
Nicole
￥9,882
￥11,230 total
includes taxes & fees
Sep 13 - Sep 14
Super 8 by Wyndham Winona MN
Lunch and dinner served
Reception
Bar (on property)
Terrace/patio

17. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Historic Southwest
United States
Brandolyn
￥18,189
￥20,940 total
includes taxes & fees
Sep 6 - Sep 7
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Interior detail
Fitness facility
Lobby sitting area
Coffee/tea maker, fridge, microwave, stovetop

18. Birch Hill Suite Rochester – Med City

Birch Hill Suite Rochester – Med City
Rochester
United States
Jhoneyda
￥8,223
￥9,468 total
includes taxes & fees
Sep 13 - Sep 14
Birch Hill Suite Rochester – Med City
Terrace/patio
Free daily buffet breakfast
Egyptian cotton sheets, premium bedding, pillowtop beds, minibar
Lobby

19. Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
Rochester
United States
Timothy
￥19,474
￥22,419 total
includes taxes & fees
Aug 22 - Aug 23
Home2 Suites by Hilton Rochester Mayo Clinic Area
Desk, laptop workspace, soundproofing, iron/ironing board
Lobby
Free daily continental breakfast
Lobby sitting area

20. MainStay Suites Rochester South Mayo Clinic

MainStay Suites Rochester South Mayo Clinic
Rochester
United States
Brian
￥9,691
￥11,157 total
includes taxes & fees
Sep 1 - Sep 2
MainStay Suites Rochester South Mayo Clinic
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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

See all hotels in St. Charles
An aerial view of a town with industrial buildings, roads, and green areas.

Top St. Charles Hotel Reviews

Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites

8/10 Good
"We had black mold in our bathroom on the ceiling, and it showed a previous leak in the bedroom area."
Ami 2-night trip
Posted 5 hours ago
Express Suites Riverport Inn & Suites
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

8/10 Good
"Only problem I had was it smelled like pot."
Randall 3-night trip
Posted 6 hours ago
Med City Inn & Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good
"Clean facility"
Mohamed 2-night trip
Posted 19 hours ago
Kahler Inn and Suites - Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

10/10 Excellent
"Late check in and early departure"
Merlyn 1-night trip
Posted 23 hours ago
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hampton Inn Rochester-South

Hampton Inn Rochester-South

10/10 Excellent
"Nice staff, clean room with good breakfast."
Lynne 2-night trip
Posted 1 day ago
Hampton Inn Rochester-South
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good
"Very clean. Comfortable bed. Excellent restaurant"
Tony 1-night trip
Posted 2 days ago
AmericInn by Wyndham Rochester Near Mayo Clinic
Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area

10/10 Excellent
"The room is very nice and clean"
Okong 1-night trip
Posted 3 days ago
Super 8 by Wyndham Rochester Mayo Clinic Area
Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG

8/10 Good
"Office staff, particularly Affinity, wss extremely helpful! Major drawback was parking was oversold which seriously inconvenience guests who went out for dinner."
Kalvin 6-night trip
Posted 4 days ago
Staybridge Suites Rochester - Mayo Clinic Area by IHG
The Berkman

The Berkman

8/10 Good
"Good stuff"
Greg 1-night trip
Posted 11 days ago
The Berkman

More cheap stays in St. Charles

Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area

106 SE 21st Street Rochester MN
￥8,264
￥9,515 total
Aug 30 - Aug 31
includes taxes & fees
7.8/10 Good! (1,001 reviews)
Super 8 by Wyndham Rochester Mayo Clinic Area
Super 8 by Wyndham Winona MN

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN
￥9,882
￥11,230 total
Sep 13 - Sep 14
includes taxes & fees
Super 8 by Wyndham Winona MN
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN
￥12,050
￥13,872 total
Aug 16 - Aug 17
includes taxes & fees
8/10 Very Good! (1,001 reviews)
Med City Inn & Suites - Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN
￥14,991
￥17,259 total
Aug 23 - Aug 24
includes taxes & fees
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Hampton Inn Rochester-South

Hampton Inn Rochester-South

1755 S Broadway Rochester MN
￥15,030
￥17,304 total
Aug 23 - Aug 24
includes taxes & fees
9/10 Wonderful! (1,002 reviews)
Hampton Inn Rochester-South
Brentwood Inn & Suites

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN
￥19,924
￥22,938 total
Aug 14 - Aug 15
includes taxes & fees
Brentwood Inn & Suites

Frequently asked questions

Where is the best place to stay in St. Charles?
Kahler Grand Hotel, located 20.6 mi (33.1 km) from the heart of St. Charles, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Med City Inn & Suites - Mayo Clinic Area and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.
What's the top vacation rental in St. Charles?
The Hen House Retreat - A Comfortable Place to Roost: This vacation home rental outside of St. Charles is located in a rural location and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. See all vacation rentals in St. Charles.
If I need to cancel my hotel reservation in St. Charles, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.
Where can I learn more about changing or cancelling my trip to St. Charles?
To access more information about updating your trip to St. Charles or cancelling it, go to https://www.expedia.com/service/.
Where is the best hotel to stay near Whitewater State Park?
White Valley Motel is one of the top choices for your stay based on our traveler data, and this property offers free parking and free WiFi. You'll find it 6.4 mi (10.3 km) from Whitewater State Park. Other good choices around the area include Kahler Inn and Suites - Mayo Clinic Area and La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S.
What's the best hotel for staying near Rochester International Airport (RST)?
AmericInn by Wyndham Rochester Airport is a popular hotel, featuring free breakfast and an indoor pool. It's located a short 0.6 mi (1 km) from Rochester Intl. Airport. Other choices near the airport include La Quinta Inn & Suites by Wyndham Rochester and Comfort Suites.
What's it like staying in St. Charles?
Visitors can enjoy all that St. Charles has to offer including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodations to choose from. Find out more about St. Charles.
What is there to see in St. Charles?
A couple of favorite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Check out what more to see and do in Expedia's St. Charles guide.
What's the seasonal weather like in St. Charles?
The hottest months are usually July and August with an average temp of 67°F, while the coldest months are January and February with an average of 22°F. The snowiest months in St. Charles are January, March, February, and April, with each month seeing an average of 8 inches of snowfall.

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