The Best Hotels Closest to Mayo Clinic in Rochester for 2026

A historic building with a prominent tower, two American flags, and a modern glass structure in the foreground.

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Our top choices for Mayo Clinic hotels

A swimming pool with a glass ceiling, a neon sign for the KAFFLER HOTEL, and a view of the city skyline at dusk.

A bar area with a long counter, multiple bar stools, and a television mounted above the bar.

A banquet hall with round tables, chairs, chandeliers, and a fireplace.

A hotel room with a large bed, a desk, a chair, a microwave, and a framed picture on the wall.

1. Kahler Grand Hotel

Downtown Rochester, 0.1 km from Mayo Clinic

Gary

￥21,224

￥24,434 total

includes taxes & fees

Oct 1 - Oct 2

A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.

A reception area with a wooden reception desk, a clock, and a wall-mounted display.

A modern building with large windows and a parking lot.

A hotel room with a sofa, two beds, a large window, and a framed artwork on the wall.

2. Kahler Inn and Suites - Mayo Clinic Area

Downtown Rochester, 0.2 km from Mayo Clinic

Dana

￥22,648

￥26,075 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor dining area with wooden beams, tables, and chairs.

A hotel room with a bed, a desk, a chair, a television, and artwork on the walls.

A hotel room with a bed, a desk, a chair, a TV, and artwork on the walls.

A modern kitchen with a built-in microwave, refrigerator, and dark cabinetry.

3. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

thomas

￥16,351

￥18,825 total

includes taxes & fees

Oct 24 - Oct 25

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A modern indoor swimming pool with seating areas and a city view.

A spacious lobby with modern furniture, a spiral staircase, and large windows offering views of the outdoors.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

4. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Raymond

￥28,508

￥32,820 total

includes taxes & fees

Oct 17 - Oct 18

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

5. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Daniel

￥14,838

￥17,082 total

includes taxes & fees

Sep 26 - Sep 27

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel room with a bed, bedside table, and a window with curtains.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

6. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Hafsa

￥21,683

￥24,964 total

includes taxes & fees

Oct 3 - Oct 4

A modern building with large glass windows and indoor plants.

A spacious indoor area with multiple seating arrangements and a pool.

A clean, well-lit food service area with a 'Market To Go!' sign, refrigerated display cases, and a variety of packaged goods.

A modern hotel lobby with a large dining table, wicker chairs, a sofa, and a hanging green plant.

7. Marriott Rochester Mayo Clinic

Downtown Rochester, 0.2 km from Mayo Clinic

￥34,766

￥40,024 total

includes taxes & fees

Oct 24 - Oct 25

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A reception area with two counters, a patterned wall, and a wooden floor.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

8. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

John

￥18,094

￥20,830 total

includes taxes & fees

Oct 23 - Oct 24

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A restaurant interior with wooden tables, chairs, and a stone wall.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

9. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest, 0.6 km from Mayo Clinic

Carrie

￥17,071

￥19,654 total

includes taxes & fees

Oct 3 - Oct 4

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern indoor pool area with lounge chairs and a pool.

A modern bar area with seating and a counter.

10. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Kathy

￥18,733

￥21,567 total

includes taxes & fees

Oct 2 - Oct 3

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern interior with a large dining table, sofas, and a kitchen area.

11. The Berkman

Folwell, 1.4 km from Mayo Clinic

Kathleen

￥27,086

￥31,495 total

includes taxes & fees

Sep 28 - Sep 29

A modern indoor patio with a fire feature, seating, and large windows.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

12. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Brooke

￥18,733

￥23,713 total

includes taxes & fees

Oct 23 - Oct 24

An outdoor terrace with tables and chairs, a large umbrella, and a view of a modern building with string lights.

A modern kitchen with stainless steel appliances, a built-in oven, and a variety of food items on the counter.

A modern hotel room with a fireplace, a sofa, a TV, and a large window with curtains.

A hotel reception area with a curved reception desk, a refrigerator stocked with snacks, a vending machine, and a large abstract painting on the wall.

13. Residence Inn by Marriott Rochester Mayo Clinic Area

Downtown Rochester, 0.2 km from Mayo Clinic

Greg

￥25,165

￥28,971 total

includes taxes & fees

Sep 26 - Sep 27

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

A modern interior with a dining area, a kitchen, and a pantry stocked with snacks.

14. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

matthew

￥16,986

￥19,873 total

includes taxes & fees

Oct 25 - Oct 26

An indoor swimming pool with clear water, wooden flooring, and a ceiling with wooden beams and lights.

A hotel room with two beds, a desk, a chair, a television, and a window with curtains.

A room with a TV mounted on the wall, a wooden table, and two patterned armchairs.

A gym with treadmills, an elliptical, and a water station.

15. Med City Inn & Suites - Mayo Clinic Area

Kutzky Park, 1.6 km from Mayo Clinic

Jose

￥11,300

￥13,011 total

includes taxes & fees

Sep 27 - Sep 28

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

A hotel entrance with a prominent Aspen sign, a large brick building in the background, and a clear sky.

16. Aspen Suites

1.2 km from Mayo Clinic

Dana

￥22,511

￥27,213 total

includes taxes & fees

Sep 27 - Sep 28

A lobby with leather chairs, a reception desk, a TV, and a coffee station.

An outdoor patio with tables and chairs, a sign for Aspen Suites, and a building in the background.

A restaurant with tables and chairs, a trash bin, a coffee machine, and a television displaying a sports game.

17. Aspen Select

Kutzky Park, 1.2 km from Mayo Clinic

Sue

￥20,479

￥24,755 total

includes taxes & fees

Sep 26 - Sep 27

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

A modern conference room with a long table, multiple chairs, and a wooden partition.

A modern hotel room with a large bed, two bedside tables, and built-in lighting.

A hotel reception desk with a modern design, a clock, and a digital screen.

18. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park, 1.1 km from Mayo Clinic

Jackie

￥16,239

￥18,695 total

includes taxes & fees

Oct 17 - Oct 18

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

A bar with wooden stools and a neon sign.

A hotel room with two beds, a desk, a chair, and a mirror.

19. AmericInn by Wyndham Rochester Near Mayo Clinic

2.6 km from Mayo Clinic

Jeanne

￥12,848

￥14,792 total

includes taxes & fees

Sep 28 - Sep 29

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A gym with exercise equipment, a clock, and a window with blinds.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

20. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

￥18,094

￥20,830 total

includes taxes & fees

Oct 3 - Oct 4

View all properties

Compare popular hotels close to Mayo Clinic

Property	Star rating	Guest rating
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 562 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,002 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 739 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 310 reviews	View
The Berkman	9.6 Exceptional 440 reviews	View

Top Mayo Clinic Hotel Reviews

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"This place will be my cozy retreat whenever I’m in Rochester. I had such a wonderful time during my 9-day visit! Jenni and Johnny (aka Johnny Cash) were incredibly kind and always ready to lend a hand. When navigating health issues a friendly face and helpful staff and feeling as though you matter changes everything. Breakfast items changed everyday and were tasty, but my favorite part had to be the evening soup Mon - Thu at 5:30p while supplies last. LOL"

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Love this place!"

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"Room was clean"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

8/10 Good

"I will always stay here when I am visiting my childhood home. It is just very comfortable!! Like coming home... thanks to all the staff! Sincerely, Jim Reardon"

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Great breakfast"

Aspen Select

10/10 Excellent

"Very convenient to Saint Mary's hospital"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"We enjoyed our stay. The breakfast was wonderful. We were disappointed the hot tub only ran for the first evening though and was down for maintenance after. And the exercise room was a bit grimy"

Hilton Garden Inn Rochester Downtown, MN

8/10 Good

"The staff are very friendly and helpful! They have valet parking and shuttle buses to both Mayo Clinic and St Mary’s, so I only needed to pay for valet while I went to both locations. This service was even available at 4 am, when I needed a ride back from the ER at St Mary’s! Otherwise, they put my room facing the parking lot so it was quieter. Also, I overslept the check out time, so the cleaning staff gave me extra time to get ready and the front desk didn’t charge me extra for the late checkout. I’d recommend this place for the staff alone, but the hotel and room were great, too! Clean, access to the skyway system, close to Mayo Clinic, and a hot breakfast with pancakes to order! The room had what I needed to work remotely, pillows that didn’t trigger an allergic reaction, and panel-controlled heat/AC."

TownePlace Suites by Marriott Rochester Mayo Clinic Area

8/10 Good

"Lovely spot and spaces. Rooms large and more than adequate, Only negative was that the rooms smelled a little "moldy.""

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 152 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 152 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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Find hotels near Mayo Clinic, Rochester from ￥13,330

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Treat yourself

Be picky

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Property class

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Our top choices for Mayo Clinic hotels

1. Kahler Grand Hotel

2. Kahler Inn and Suites - Mayo Clinic Area

3. Hotel Indigo Rochester – Mayo Clinic Area by IHG

4. Hilton Rochester Mayo Clinic Area

5. Brentwood Inn & Suites

6. TownePlace Suites by Marriott Rochester Mayo Clinic Area

7. Marriott Rochester Mayo Clinic

8. Hilton Garden Inn Rochester Downtown, MN

9. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10. Hyatt House Rochester/Mayo Clinic Area

11. The Berkman

12. EVEN Hotel Rochester - Mayo Clinic Area by IHG

13. Residence Inn by Marriott Rochester Mayo Clinic Area

14. Staybridge Suites Rochester - Mayo Clinic Area by IHG

15. Med City Inn & Suites - Mayo Clinic Area

16. Aspen Suites

17. Aspen Select

18. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

19. AmericInn by Wyndham Rochester Near Mayo Clinic

20. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

Hyatt House Rochester/Mayo Clinic Area

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kahler Inn and Suites - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Aspen Select

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Hilton Garden Inn Rochester Downtown, MN

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Frequently asked questions

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