The Best Hotels Closest to Mayo Clinic in Rochester for 2026

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Our top choices for Mayo Clinic hotels

A coffee shop interior with a wooden counter, menu boards, and seating area.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

A hotel room with a bed, bedside table, and a window with curtains.

1. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Jorge

￥20,227

￥23,286 total

includes taxes & fees

Sep 4 - Sep 5

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A modern indoor swimming pool with seating areas and a city view.

A modern hotel entrance with a glass facade, illuminated signage, and a covered walkway.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

2. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Jennifer

￥27,296

￥31,426 total

includes taxes & fees

Sep 4 - Sep 5

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern hotel room with a bed, desk, and kitchenette.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

3. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

Vickie

￥19,460

￥22,403 total

includes taxes & fees

Sep 4 - Sep 5

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

4. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Jon

￥17,775

￥20,463 total

includes taxes & fees

Sep 3 - Sep 4

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern lounge area with seating, a fireplace, and a bar area.

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Richard

￥21,832

￥25,135 total

includes taxes & fees

Sep 4 - Sep 5

A modern indoor patio with a fire feature, seating, and large windows.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

paul

￥16,723

￥21,406 total

includes taxes & fees

Sep 4 - Sep 5

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern interior with a large dining table, sofas, and a kitchen area.

7. The Berkman

Folwell, 1.4 km from Mayo Clinic

William

￥32,611

￥37,920 total

includes taxes & fees

Sep 1 - Sep 2

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

matthew

￥16,405

￥19,205 total

includes taxes & fees

Sep 4 - Sep 5

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

A modern living room with a sofa, a round coffee table, and a side table. There are large windows with a view of the outside.

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

￥16,502

￥18,999 total

includes taxes & fees

Sep 19 - Sep 20

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A gym with exercise equipment, a clock, and a window with blinds.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

￥18,154

￥20,900 total

includes taxes & fees

Sep 19 - Sep 20

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

A modern kitchen with wooden cabinets, a granite countertop, and a stainless steel stove.

An indoor swimming pool with a clock on the wall, lounge chairs, and a lifeguard warning sign.

11. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Camille

￥26,956

￥31,033 total

includes taxes & fees

Sep 4 - Sep 5

A hotel room with a large round table, two sofas, a TV, and a bed.

A reception area with a clock, a counter, and a nameplate.

A hotel lobby with a reception desk, seating area, and a large window.

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

12. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Sean

￥18,475

￥21,271 total

includes taxes & fees

Sep 6 - Sep 7

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

13. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Markus

￥10,938

￥12,593 total

includes taxes & fees

Sep 20 - Sep 21

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

14. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

Lynne

￥16,195

￥18,644 total

includes taxes & fees

Sep 7 - Sep 8

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern indoor pool area with lounge chairs and a pool.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern bar area with seating and a counter.

15. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Bridgett

￥22,151

￥25,500 total

includes taxes & fees

Aug 29 - Aug 30

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

A hotel room with a large bed, a TV, a bathroom with a sink and mirror, and a window with curtains.

16. Aspen Suites

1.2 km from Mayo Clinic

Dr. suzette

￥20,171

￥24,384 total

includes taxes & fees

Sep 3 - Sep 4

A modern lobby with a reception desk, a green sofa, and a black spherical table.

An indoor dining area with wooden ceiling beams, large windows, and modern furniture.

An outdoor dining area with wooden beams, tables, and chairs.

A modern bar area with a central island, bar stools, and hanging spherical light fixtures.

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

Kyle

￥15,768

￥18,152 total

includes taxes & fees

Sep 25 - Sep 26

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A reception area with two counters, a patterned wall, and a wooden floor.

18. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

Eileen

￥18,164

￥20,912 total

includes taxes & fees

Sep 4 - Sep 5

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

19. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Bryan

￥19,909

￥22,921 total

includes taxes & fees

Aug 30 - Aug 31

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

20. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Cassandra

￥12,191

￥14,206 total

includes taxes & fees

Sep 4 - Sep 5

View all properties

Compare popular hotels close to Mayo Clinic

Property	Star rating	Guest rating
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 553 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 642 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,001 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 737 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 302 reviews	View

Top Mayo Clinic Hotel Reviews

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Excellent hotel within walking distance of the Mayo Clinic. I will definitely stay again if I return to the clinic..."

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"Stayed 5 days and didn't have 1 single problem."

Med City Inn & Suites - Mayo Clinic Area

10/10 Excellent

"This place is great! They have nice beds. Better than the Springhill Marriott. It was clean and the right price for people coming to Mayo. They don't gouge you like the other hotels do. There are plenty of food options around and a grocery store. My new favorite place to stay in Rochester."

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"The staff was very helpful, friendly, and knew places to visit and eat"

Brentwood Inn & Suites

10/10 Excellent

"A comfortable stay close by Mayo Clinic"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"We loved our stay! Staff was excellent, we will be back"

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached restaurant!"

TownePlace Suites by Marriott Rochester Mayo Clinic Area

10/10 Excellent

"Great staff"

Broadway Plaza, Trademark Collection by Wyndham

10/10 Excellent

"The space was perfect. Close to everywhere I needed. I love the pool and the workout room."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 150 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Med City Inn & Suites - Mayo Clinic Area.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 150 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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Find hotels near Mayo Clinic, Rochester from ￥12,593

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Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Mayo Clinic hotels

1. TownePlace Suites by Marriott Rochester Mayo Clinic Area

2. Hilton Rochester Mayo Clinic Area

3. Home2 Suites by Hilton Rochester Mayo Clinic Area

4. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

7. The Berkman

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Broadway Plaza, Trademark Collection by Wyndham

12. Candlewood Suites Rochester Mayo Clinic Area by IHG

13. Econo Lodge Mayo Clinic Area

14. Hampton Inn Rochester-South

15. Hyatt House Rochester/Mayo Clinic Area

16. Aspen Suites

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

18. Hilton Garden Inn Rochester Downtown, MN

19. Brentwood Inn & Suites

20. Quality Inn & Suites Mayo Clinic Area

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

Hyatt House Rochester/Mayo Clinic Area

AmericInn by Wyndham Rochester Near Mayo Clinic

Med City Inn & Suites - Mayo Clinic Area

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Brentwood Inn & Suites

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Hotel Indigo Rochester – Mayo Clinic Area by IHG

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Broadway Plaza, Trademark Collection by Wyndham

Frequently asked questions

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