The Best Hotels Closest to Mayo Clinic in Rochester for 2026

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Our top choices for Mayo Clinic hotels

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern hotel room with a bed, desk, and kitchenette.

A modern restaurant with a counter, seating area, and a TV screen.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic, ideal for business travelers. Enjoy spacious suites with separate living rooms and complimentary breakfast. Nearby dining options add convenience.

￥17,185

￥19,785 total

includes taxes & fees

Nov 7 - Nov 8

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

2. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic and includes a fitness center and a separate living room. Guests appreciate the complimentary breakfast and shuttle service. Nearby, you'll find various dining options.

￥18,196

￥20,949 total

includes taxes & fees

Nov 6 - Nov 7

A modern kitchen with a central island, wooden cabinets, and pendant lighting.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

A hotel room with a bed, bedside table, and a window with curtains.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

3. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic, making it ideal for business travelers. Enjoy complimentary breakfast and convenient office space for productivity. Nearby dining options are plentiful.

￥21,472

￥24,719 total

includes taxes & fees

Nov 6 - Nov 7

A modern hotel room with a dining area, a sofa, and a view of the landscape.

A rooftop terrace with outdoor seating and a city skyline in the background.

A hotel room with a large bed, a sofa, a desk with a TV, and a view of the city.

4. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic and features a fitness center and spacious living rooms. Guests appreciate the proximity to local dining and the civic center.

￥27,843

￥32,055 total

includes taxes & fees

Nov 7 - Nov 8

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern interior with a large dining table, sofas, and a kitchen area.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

5. The Berkman

Folwell, 1.4 km from Mayo Clinic

This aparthotel is a brief ride from Mayo Clinic, ideal for business travelers. Enjoy a separate living room, sofa bed, and nearby restaurants for dining options.

￥29,818

￥34,672 total

includes taxes & fees

Nov 21 - Nov 22

A modern indoor patio with a fire feature, seating, and large windows.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic, boasting spacious suites with separate living rooms and a fitness center. Guests often highlight the nearby dining options.

￥17,240

￥21,964 total

includes taxes & fees

Nov 6 - Nov 7

A person standing in a room with white walls and a window, observing paintings with red and yellow colors.

A modern urban street with tall buildings, a pedestrian walkway, and a parking area.

A modern bar area with a long counter, bar stools, and a television screen mounted on the wall.

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic, providing spacious suites with separate living areas. Guests enjoy a complimentary breakfast and a fitness center nearby restaurants and bars.

￥17,883

￥20,901 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

A gym with exercise equipment, a clock, and a window with blinds.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

8. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

This hotel is a quick drive from Mayo Clinic. Spacious, clean rooms ensure comfort, while a fitness center and complimentary breakfast enhance your stay. Enjoy nearby dining options.

￥18,401

￥21,184 total

includes taxes & fees

Nov 24 - Nov 25

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

A conference room with a long table, multiple chairs, and decorative wall art.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

This hotel is a quick ride from Mayo Clinic, offering comfortable, clean rooms and a fitness center. Guests often mention the spacious living areas and connecting rooms. Dining options are nearby.

￥16,229

￥18,682 total

includes taxes & fees

Nov 6 - Nov 7

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

10. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic, offering spacious suites with separate living areas and complimentary breakfast. Enjoy nearby dining and shopping options.

￥10,368

￥11,937 total

includes taxes & fees

Nov 15 - Nov 16

A multi-story hotel with a stone facade, a central entrance, and a parking lot.

Two armchairs with striped pillows, a small round table, a clock, and a phone on a counter.

A hotel room with a dining area, a sofa, a TV, and a bed.

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

￥17,554

￥20,209 total

includes taxes & fees

Nov 9 - Nov 10

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern bar area with seating and a counter.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern indoor pool area with lounge chairs and a pool.

12. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

This hotel is a brief walk from Mayo Clinic and offers a separate living room and kitchenette for added comfort. Numerous dining options and bars are nearby.

￥19,905

￥22,917 total

includes taxes & fees

Oct 30 - Oct 31

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

13. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

This hotel is a brief drive from Mayo Clinic and provides a fitness center and complimentary breakfast. Nearby, diners can explore numerous restaurants and bars.

￥15,334

￥17,654 total

includes taxes & fees

Nov 1 - Nov 2

A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

A spacious outdoor dining area with multiple tables and chairs, large windows, and a wooden ceiling structure.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

14. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic and the Civic Center, making it ideal for event attendees. Enjoy spacious living areas and downtown dining options nearby.

￥16,158

￥18,602 total

includes taxes & fees

Nov 14 - Nov 15

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A hotel room with a kitchenette, a dining area with striped chairs, a sofa, a TV, and a window with curtains.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

15. Aspen Suites

1.2 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic and provides spacious rooms with comfortable living areas. Nearby, you'll find a variety of dining options.

￥21,587

￥26,093 total

includes taxes & fees

Nov 24 - Nov 25

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

16. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

￥10,735

￥12,527 total

includes taxes & fees

Nov 13 - Nov 14

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A reception area with a curved counter, ceiling lights, and a potted plant.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

17. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

This hotel is an easy walk from Mayo Clinic, offering spacious living rooms. Many travelers cite its prime location and convenience for a comfortable stay.

￥18,808

￥21,653 total

includes taxes & fees

Oct 25 - Oct 26

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A reception area with two counters, a patterned wall, and a wooden floor.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

18. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

This hotel is a brief walk from Mayo Clinic, offering spacious suites with separate living areas and a fitness center. Dining options are conveniently accessible via a skywalk.

￥18,518

￥21,319 total

includes taxes & fees

Nov 7 - Nov 8

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A restaurant interior with wooden tables, chairs, and a stone wall.

A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest, 0.6 km from Mayo Clinic

This hotel is a brief walk from Mayo Clinic, offering a separate living room and a fitness center. Guests highlight the nearby dining options, enhancing their stay.

￥17,898

￥20,604 total

includes taxes & fees

Nov 1 - Nov 2

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A hotel lobby with leather armchairs, a fireplace, patterned carpet, and a dining area in the background.

A hotel room with a bed, a sofa, a desk, and a television.

20. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park, 1.6 km from Mayo Clinic

This hotel is a brief ride from Mayo Clinic, offering spacious suites with separate living areas. A fitness center and nearby dining options enhance your stay.

￥15,830

￥18,225 total

includes taxes & fees

Nov 7 - Nov 8

View all properties

Compare popular hotels close to Mayo Clinic

Property	Star rating	Guest rating
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,001 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 748 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 574 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 654 reviews	View
The Berkman	9.6 Exceptional 450 reviews	View

Top Mayo Clinic Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

10/10 Excellent

"Convenient"

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"The hotel was very nice and convenient for travel to the Mayo Clinic with direct access to the underground walk way. The room was clean and nice to have the continental breakfast option. Construction was taking place outside of the hotel to improve the Mayo Clinic buildings in the area. The windows seemed to be rather low on their sound proofing ability. Almost seemed like the windows were open at times."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Close to Mayo with hourly shuttle service. Also parking underground was secure. Good breakfast included and the bar/restaurant very nice too. We will stay here again when my husband gets his other shoulder done."

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Nice stay"

Kahler Grand Hotel

10/10 Excellent

"My fourth hotel in the area, and one of the best. Great old hotel vibe. Hot tub and pool on the roof. Perfect location if fast Mayo appointments are on your itinerary. Two very different eating options inside the hotel. I will be Back"

Hotel Indigo Rochester – Mayo Clinic Area by IHG

8/10 Good

"Parking was an additional fee but the walk wasn't bad and there was a skyway. The beds had some hair on the outer most layers, I suspect housekeeping didn't use their lint rollers on that part. Housekeeping knocked on our door and tried to enter despite us hanging the do not disturb sign and getting a late checkout with front desk, which was a bit alarming early in the morning."

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Room was spotless. Staff was very helpful."

Aspen Select

8/10 Good

"Small area to park in and not easy to get to"

Broadway Plaza, Trademark Collection by Wyndham

10/10 Excellent

"The property had two bathrooms which was a nice surprise. The kitchen had a full size refrigerator, dishwasher, and laundry machine. The room also had a very pleasant air freshener smell and the bathroom had night lights so you didn'thave to turn on the bathroom's big light in during the night. Thank you for making our stay so pleasant."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 153 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 153 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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Find hotels near Mayo Clinic, Rochester from ￥11,937

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Treat yourself

Be picky

Check prices for these dates

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Property class

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Our top choices for Mayo Clinic hotels

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

3. TownePlace Suites by Marriott Rochester Mayo Clinic Area

4. Hilton Rochester Mayo Clinic Area

5. The Berkman

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

8. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

10. Econo Lodge Mayo Clinic Area

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

12. Hyatt House Rochester/Mayo Clinic Area

13. Hampton Inn Rochester-South

14. Hotel Indigo Rochester – Mayo Clinic Area by IHG

15. Aspen Suites

16. Quality Inn & Suites Mayo Clinic Area

17. Brentwood Inn & Suites

18. Hilton Garden Inn Rochester Downtown, MN

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

20. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

Kahler Inn and Suites - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Hyatt House Rochester/Mayo Clinic Area

Kahler Grand Hotel

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Aspen Select

Broadway Plaza, Trademark Collection by Wyndham

Frequently asked questions

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