The Best Hotels Closest to Mayo Clinic in Rochester for 2026

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Our top choices for Mayo Clinic hotels

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel room with a bed, bedside table, and a window with curtains.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

1. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Amanda

￥21,005

￥24,182 total

includes taxes & fees

Sep 19 - Sep 20

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A spacious lobby with modern furniture, a spiral staircase, and large windows offering views of the outdoors.

A modern indoor swimming pool with seating areas and a city view.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

2. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Jennifer

￥27,533

￥31,697 total

includes taxes & fees

Sep 19 - Sep 20

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Jon

￥17,111

￥19,699 total

includes taxes & fees

Sep 19 - Sep 20

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern hotel room with a bed, desk, and kitchenette.

A modern lounge area with a sofa, chairs, and tables.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

4. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

Vickie

￥18,757

￥21,593 total

includes taxes & fees

Sep 26 - Sep 27

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern lounge area with seating, a fireplace, and a bar area.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Heather

￥20,238

￥23,297 total

includes taxes & fees

Sep 26 - Sep 27

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern interior with a large dining table, sofas, and a kitchen area.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

6. The Berkman

Folwell, 1.4 km from Mayo Clinic

Jana

￥22,641

￥26,327 total

includes taxes & fees

Sep 18 - Sep 19

A modern indoor patio with a fire feature, seating, and large windows.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Amuor

￥18,218

￥23,060 total

includes taxes & fees

Oct 3 - Oct 4

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A modern interior with a dining area, a kitchen, and a pantry stocked with snacks.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

matthew

￥17,632

￥20,605 total

includes taxes & fees

Sep 19 - Sep 20

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

A conference room with a long table, multiple chairs, and decorative wall art.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

￥15,987

￥18,405 total

includes taxes & fees

Sep 18 - Sep 19

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A gym with exercise equipment, a clock, and a window with blinds.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

￥17,475

￥20,117 total

includes taxes & fees

Sep 19 - Sep 20

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A hotel room with a large round table, two sofas, a TV, and a bed.

An outdoor patio with a stone wall, a grill, and seating.

A person at a checkout counter in a store, with various snack items and a sign indicating a price of $1.50.

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Sean

￥17,909

￥20,618 total

includes taxes & fees

Sep 13 - Sep 14

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

An indoor swimming pool with a clock on the wall, lounge chairs, and a lifeguard warning sign.

12. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Camille

￥27,237

￥31,358 total

includes taxes & fees

Sep 19 - Sep 20

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern indoor pool area with lounge chairs and a pool.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern bar area with seating and a counter.

13. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Mary Jo

￥18,218

￥20,973 total

includes taxes & fees

Oct 2 - Oct 3

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A compact laundry area with a washing machine, dryer, and a water fountain.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

14. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

James

￥10,834

￥12,472 total

includes taxes & fees

Oct 4 - Oct 5

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

15. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

dennis

￥14,559

￥16,762 total

includes taxes & fees

Oct 11 - Oct 12

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

16. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Richard

￥14,374

￥16,548 total

includes taxes & fees

Sep 16 - Sep 17

A modern lobby with a reception desk, a green sofa, and a black spherical table.

A modern bar area with a central island, bar stools, and hanging spherical light fixtures.

An indoor dining area with wooden ceiling beams, large windows, and modern furniture.

An outdoor dining area with wooden beams, tables, and chairs.

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

Kyle

￥16,520

￥19,020 total

includes taxes & fees

Sep 25 - Sep 26

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

18. Aspen Suites

1.2 km from Mayo Clinic

Dr. suzette

￥21,885

￥26,456 total

includes taxes & fees

Sep 12 - Sep 13

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A reception area with two counters, a patterned wall, and a wooden floor.

19. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

BRIAN

￥18,733

￥21,566 total

includes taxes & fees

Sep 19 - Sep 20

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

20. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Edward

￥11,811

￥13,765 total

includes taxes & fees

Oct 4 - Oct 5

View all properties

Compare popular hotels close to Mayo Clinic

Property	Star rating	Guest rating
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 560 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 645 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 738 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,002 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 306 reviews	View

Top Mayo Clinic Hotel Reviews

TownePlace Suites by Marriott Rochester Mayo Clinic Area

10/10 Excellent

"Great stay! Staff are welcoming, breakfast is great. Location very convenient"

Brentwood Inn & Suites

8/10 Good

"Clean older facility good price"

Kahler Grand Hotel

8/10 Good

"Unfortunately our original reservation was lost due to a computer shutdown. A new reservation was made but not at the original discounted price. The hotel staff was very pleasant, especially the valet staff!"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"Staff were courteous and pleasant. Breakfast had a good selection of hot and cold.food. The room was clean and large but showing it's age. Our carpet seemed damp the whole time we.were.there Not sure if it was.the old noisy a/c.leaking or hwat.it was. Might stay there again. Our. A O"

Aspen Select

10/10 Excellent

"I had surgery at Mayo Clinic right across the street this is the most convenient hotel to stay at. Parking is included and breakfast."

Hotel Indigo Rochester – Mayo Clinic Area by IHG

8/10 Good

"We enjoyed our stay, but there was a strange and pungent, smoky odor in the room that never completely dissipated even though we turned the air conditioning down, thinking it would help. The location was great, the beds were very comfortable and I would recommend."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"It’s a beautiful place to stay while you’re in town. Just be mindful about the parking, and road constructions which aren’t their faults"

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Great place"

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Very good stay. I found the wifi to be excellent and the motel was served by a free shuttle to the Mayo Clinic. I have stayed here several times in the past and like the property. It is also directly connected to Famous Dave's Bar-B-Que where guests receive a discount."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 152 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Hotel Indigo Rochester – Mayo Clinic Area by IHG.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 152 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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Find hotels near Mayo Clinic, Rochester from ￥12,472

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Treat yourself

Be picky

Check prices for these dates

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Property class

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Our top choices for Mayo Clinic hotels

1. TownePlace Suites by Marriott Rochester Mayo Clinic Area

2. Hilton Rochester Mayo Clinic Area

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

4. Home2 Suites by Hilton Rochester Mayo Clinic Area

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

6. The Berkman

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

12. Broadway Plaza, Trademark Collection by Wyndham

13. Hyatt House Rochester/Mayo Clinic Area

14. Econo Lodge Mayo Clinic Area

15. Hampton Inn Rochester-South

16. Brentwood Inn & Suites

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

18. Aspen Suites

19. Hilton Garden Inn Rochester Downtown, MN

20. Quality Inn & Suites Mayo Clinic Area

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Brentwood Inn & Suites

Kahler Grand Hotel

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Aspen Select

Hotel Indigo Rochester – Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Med City Inn & Suites - Mayo Clinic Area

Frequently asked questions

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