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Our top choices for Southeast Minnesota hotels

A modern dining area with high tables, chairs, and pendant lighting.

1. Hampton Inn & Suites Rochester-North

Rochester

Mark

￥19,187 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

2. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Arlan

￥25,213 total

includes taxes & fees

Nov 27 - Nov 28

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

3. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

howard

￥19,889 total

includes taxes & fees

Nov 29 - Nov 30

A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.

4. Hilton Rochester Mayo Clinic Area

Downtown Rochester

Jennifer

￥30,682 total

includes taxes & fees

Nov 27 - Nov 28

A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

5. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

LeeAnn

￥14,381 total

includes taxes & fees

Dec 3 - Dec 4

A modern indoor patio with a fire feature, seating, and large windows.

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

James

￥22,807 total

includes taxes & fees

Nov 6 - Nov 7

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

7. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park

Jackie

￥20,244 total

includes taxes & fees

Nov 22 - Nov 23

A modern kitchen with a central island, wooden cabinets, and pendant lighting.

8. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

Cory

￥24,850 total

includes taxes & fees

Nov 13 - Nov 14

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

9. Comfort Inn & Suites West - Medical Center

Rochester

Tammy

￥15,731 total

includes taxes & fees

Nov 28 - Nov 29

10. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Tammy

￥13,684 total

includes taxes & fees

Nov 8 - Nov 9

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

11. Hampton Inn Rochester-South

Rochester

Susan

￥17,731 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor patio area with a concrete floor, wooden fence, and string lights.

12. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Brien

￥21,059 total

includes taxes & fees

Nov 14 - Nov 15

A spacious lobby with a reception desk, sofas, and a coffee table.

13. Sleep Inn & Suites West-Near Medical Center

Rochester

Jacqueline

￥14,162 total

includes taxes & fees

Nov 22 - Nov 23

A Staybridge Suites hotel with a stone facade, a covered entrance, and multiple windows.

14. Staybridge Suites Rochester - Commerce Dr NW by IHG

Rochester

MATTHEW

￥18,864 total

includes taxes & fees

Nov 22 - Nov 23

A modern interior with a bar area, seating, and a large window.

15. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

Naomi

￥16,870 total

includes taxes & fees

Nov 26 - Nov 27

A modern hotel lobby with a reception desk, seating area, and a dining space.

16. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Rick

￥15,599 total

includes taxes & fees

Nov 7 - Nov 8

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

17. Econo Lodge Mayo Clinic Area

Rochester

Ashley

￥12,590 total

includes taxes & fees

Nov 29 - Nov 30

An indoor swimming pool with a curved design, surrounded by palm trees and a white pool ladder.

18. Treasure Island Resort & Casino

Welch

Jacob

￥16,154 total

includes taxes & fees

Nov 12 - Nov 13

A hotel reception desk with a wooden counter, a computer, and a vase with flowers.

19. Baymont by Wyndham Kasson Rochester Area

Kasson

Dana

￥11,072 total

includes taxes & fees

Nov 9 - Nov 10

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

20. Brentwood Inn & Suites

Downtown Rochester

Anne

￥21,767 total

includes taxes & fees

Nov 5 - Nov 6

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Vacation Rentals in Southeast Minnesota

Aparthotel

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

The Berkman

Folwell

"Excellent service and wonderful room!"

Apartment

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester

"Clean room and great location"

Apartment

A wooden interior with a kitchen, bar area, and a staircase.

Lake Pepin Escape: Loft Cottage & Fireplace

Pepin

"Great location and very well furnished with new appliances."

Apartment

A two-story building with a green exterior, a covered porch, and a driveway leading to a garage.

Downtown Northfield Apt: Winter Walk & Shops

Northfield

"It was amazing!"

Cottage

A kitchen with wooden cabinets, a granite countertop, a refrigerator, and bar stools.

Lake City Retreat Near Wineries & State Park

Lake City

Apartment

A modern kitchen with a central island, bar stools, and a large window.

1 Block to Lake City Marina: Condo w/ Rooftop Deck

Lake City

"Wonderful property, spacious, well-appointed and comfortable. Would definitely rent again."

Apartment

A bedroom with a bed, a chair, a table, a fireplace, and a ceiling fan.

Pet-friendly Wabasha Studio: Boat, Ski & Explore!

Wabasha

"Great property! Very convenient location as well."

Cottage

A modern interior with a stone fireplace, wooden walls, a leather sofa, and a dining area.

Pet-friendly Cabin Retreat: Walk to Lake Pepin!

Pepin

"What a fun place! Plenty of room. We played foosball had a fire outside. We enjoyed the fireplace too. We hadn’t anticipated no TV though. You might want to add that to your description. The water is definitely smelly, so we truly appreciated the 40 bottles of water you provided. Definitely a great place for a girl’s weekend or family reunion!"

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Hotels recommended for families in Southeast Minnesota

Hampton Inn & Suites Rochester-North

Rochester

￥19,187 total

includes taxes & fees

Nov 8 - Nov 9

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Stay near popular Southeast Minnesota attractions

Villa Bellezza

8.4/10 (31 reviews)

You can enjoy a tasting or tour at Villa Bellezza during your travels to Pepin. While you're in the area, stroll along the lakeside.

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Learn more about Southeast Minnesota

Explore the family-friendly area of Southeast Minnesota—restaurants, sports teams, and sights from Mayowood Mansion to Apache Mall.

See all hotels in Southeast Minnesota

A lake surrounded by dense forest and a distant hill with a fort.

Top Southeast Minnesota Hotel Reviews

Treasure Island Resort & Casino

10/10 Excellent

"Beds were great. The location was exactly halfway to home for us. Resort was very nice. Tv could have been a bit larger and Iwas a little put off by being charged a $10 resort fee. We arrived in time to go to bed, got up and were on the road by 7 - not much time to use the resort. It’s a long walk from the parking lot to the hotel entrance. We could park in handicap parking, but that was a long way away too. Hard for handicapped to go up steps of a shuttle."

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"We had a fantastic stay at Centerstone Plaza Hotel! The rooms were clean, spacious and comfortable, the staff was friendly and welcoming, and the overall experience was excellent. We would definitely stay here again. Highly recommended!!"