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Our top choices for South Central Houston hotels

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
8.4 out of 10, Very Good, (75 reviews)
"great stay "
United States
Jordan
The price is ¥13,222
¥15,468 total
includes taxes & fees
Apr 8 - Apr 9
Downtowner Inns - Houston Downtown

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,133 reviews)
"Excellent stay!"
United States
Travis
The price is ¥29,441
¥36,645 total
includes taxes & fees
Mar 29 - Mar 30
The Westin Houston Medical Center/Museum District

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very Good, (1,854 reviews)
"Always a great stay at this hotel with good staff nice rooms and good food "
United States
Diane
The price is ¥15,712
¥18,566 total
includes taxes & fees
Mar 29 - Mar 30
Hilton Houston Plaza/Medical Center

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (562 reviews)
"Good rooms and location, great staff!"
United States
Eugene
The price is ¥22,593
¥26,539 total
includes taxes & fees
Mar 19 - Mar 20
La Maison in Midtown an urban B&B

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very Good, (1,014 reviews)
"It was a quick stop for us and the room had everything we needed"
United States
Deiedra
The price is ¥15,658
¥18,320 total
includes taxes & fees
Mar 23 - Mar 24
Americas Best Value Inn Medical Center Downtown

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"Rooms were tidy, clean and comfortable bedding. Staff extremely courteous and accommodating. "
United States
Linda
The price is ¥28,326
¥38,285 total
includes taxes & fees
Apr 3 - Apr 4
Houston Marriott Medical Center/Museum District

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,000 reviews)
"Very clean room & responsive staff!"
United States
ERIC
The price is ¥29,101
¥37,211 total
includes taxes & fees
Apr 10 - Apr 11
InterContinental Houston by IHG

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very Good, (538 reviews)
"Room accommodations for disability, clean, comfortable beds and bedding, and having a resturant on site. Thank you for a great stay!"
United States
Judy
The price is ¥18,755
¥21,943 total
includes taxes & fees
Mar 30 - Mar 31
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1,919 reviews)
"Great location "
United States
Tolbert
The price is ¥75,443
¥96,713 total
includes taxes & fees
Mar 23 - Mar 24
Hotel Zaza Houston Museum District

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (65 reviews)
"Great location will stay again "
United States
Jason
The price is ¥20,156
¥23,583 total
includes taxes & fees
Apr 1 - Apr 2
Wanderstay Boutique Hotel

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (204 reviews)
"I absolutely loved my stay here!!"
United States
Daniella
The price is ¥32,739
¥40,677 total
includes taxes & fees
Mar 23 - Mar 24
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Newly Built Modern 3 Bedroom Houston Home

Newly Built Modern 3 Bedroom Houston Home
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (2 reviews)
"The pictures do not do this property justice. The three story home has 3 beautiful bedrooms, each with luxurious bathrooms. The main bedroom and the living room has a small patio and then there's a rooftop seating area that is an excellent spot for gazing at the Houston night skyline. The quiet area is gated off a not too busy street in a beautiful neighborhood. We did have a couple of issues upon our arrival but the hosts were on top of it and had it resolved the next day. They have great...
United States
robin
The price is ¥21,065
¥62,952 total
includes taxes & fees
Mar 24 - Mar 25
Newly Built Modern 3 Bedroom Houston Home

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (914 reviews)
"Nice place to stay"
United States
Alexandra
The price is ¥23,726
¥27,758 total
includes taxes & fees
Apr 8 - Apr 9
Hilton University of Houston

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (233 reviews)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is ¥9,252
¥10,826 total
includes taxes & fees
Apr 2 - Apr 3
Southmore Boulevard Motel

Rodeway Inn & Suites Houston near Medical Center

Rodeway Inn & Suites Houston near Medical Center
2.0 star property
South Central Houston
6.0 out of 10, (504 reviews)
"Very economical. Great price for one night stay."
United States
AUGUSTIN
The price is ¥10,081
¥11,794 total
includes taxes & fees
Apr 9 - Apr 10
Rodeway Inn & Suites Houston near Medical Center

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,018 reviews)
"It was all okay."
United States
Tekle
The price is ¥12,217
¥14,339 total
includes taxes & fees
Mar 30 - Mar 31
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very Good, (196 reviews)
"This is an amazing place to stay."
United States
Darius
The price is ¥8,708
¥10,187 total
includes taxes & fees
Mar 22 - Mar 23
Wanderstay Houston Hostel

Luxurious 3 Bed3 Bath Near Downtown Houston

Luxurious 3 Bed3 Bath Near Downtown Houston
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (2 reviews)
"This was made for a perfect family vacation… super clean kid friendly with an awesome view of Houston for the adults on rooftop "
United States
Ebony
The price is ¥28,688
¥71,870 total
includes taxes & fees
Mar 25 - Mar 26
Luxurious 3 Bed3 Bath Near Downtown Houston

Downtown Houston 3BR Bachelorette Escape

Downtown Houston 3BR Bachelorette Escape
2.0 star property
South Central Houston
9.6 out of 10, Exceptional, (5 reviews)
"Everything was great. Look no further and book this property. "
United States
Iesheal
The price is ¥26,688
¥69,530 total
includes taxes & fees
Mar 17 - Mar 18
Downtown Houston 3BR Bachelorette Escape

Paradise Palace Best Rooftop in HTX w Hot Tub

Paradise Palace Best Rooftop in HTX w Hot Tub
3.0 star property
South Central Houston
The price is ¥39,081
¥98,925 total
includes taxes & fees
Apr 2 - Apr 3
Paradise Palace Best Rooftop in HTX w Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Central Houston Hotel Reviews

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out Children's Museum of Houston and Houston Natural Science Museum as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, La Maison in Midtown an urban B&B is the highest ranked property in South Central Houston. This B&B is a short 5-minute walk from Westheimer Road, and it offers free breakfast and free parking. Other favorite options in the area include Wanderstay Boutique Hotel and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1038 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and Bagby Dog Park. Children's Museum of Houston and Houston Natural Science Museum are some other stops to visit in the neighborhood. Toyota Center and Daikin Park are some favorite places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.

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