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Find hotels in South Central Houston, Houston from ¥9,798

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Discover 1,167 South Central Houston hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Hilton Houston Plaza/Medical Center

4.5 star property
South Central Houston
8.4 out of 10, Very Good, (1719)
"Clean rooms, comfortable bed, & friendly staff"
United States
Thomas
The price is ¥14,458
¥17,097 total
includes taxes & fees
Dec 21 - Dec 22
Hilton Houston Plaza/Medical Center

Downtowner Inns - Houston Downtown

2.0 star property
South Central Houston
7.8 out of 10, Good, (31)
"Minimal breakfast/continental, small area to grab food. Rooms and facility very clean, looks newly renovated & well done. Front office/desk guy was very nice. Easy check in/out process. Convenient location for Midtown outting. I would stay here again & recommend this place. "
United States
Jalyn
The price is ¥13,259
¥15,514 total
includes taxes & fees
Dec 5 - Dec 6
Downtowner Inns - Houston Downtown

InterContinental Houston by IHG

4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1000)
"Clean room, excellent staff, kind and respectful."
United States
DIANA
The price is ¥18,210
¥24,408 total
includes taxes & fees
Dec 7 - Dec 8
InterContinental Houston by IHG

Hotel Zaza Houston Museum District

4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1839)
"Very nice room, great staff, excellent food & drink."
United States
Mary
Hotel Zaza Houston Museum District

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4.0 star property
South Central Houston
8.4 out of 10, Very Good, (467)
"Staff was helpful in getting me back & forth to MD Anderson Cancer Hospital. "
United States
Patricia
The price is ¥13,027
¥15,241 total
includes taxes & fees
Dec 22 - Dec 23
DoubleTree by Hilton Houston Medical Center Hotel & Suites

The Westin Houston Medical Center/Museum District

4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1000)
"Perfect location & amazing staff at the hotel"
United States
Orlando
The price is ¥21,235
¥26,431 total
includes taxes & fees
Dec 19 - Dec 20
The Westin Houston Medical Center/Museum District

Americas Best Value Inn Medical Center Downtown

2.0 star property
South Central Houston
8.0 out of 10, Very Good, (999)
"Nice hotel"
United States
Robert Jeanmard
The price is ¥13,050
¥15,269 total
includes taxes & fees
Dec 5 - Dec 6
Americas Best Value Inn Medical Center Downtown

Houston Marriott Medical Center/Museum District

4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1000)
"Comfortable bed, very clean, very good food, quite, friendly stuff and hotel shuttle works easy."
United States
Elena
The price is ¥23,588
¥32,563 total
includes taxes & fees
Dec 13 - Dec 14
Houston Marriott Medical Center/Museum District

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 star property
South Central Houston
5.8 out of 10, (1000)
"Great receptionist. Clean room. Perfect location to access Md Anderson. "
United States
Rebecca
The price is ¥11,164
¥13,106 total
includes taxes & fees
Dec 7 - Dec 8
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Wanderstay Houston Hostel

2.0 star property
South Central Houston
8.4 out of 10, Very Good, (188)
"This is an amazing place to stay."
United States
Darius
The price is ¥8,905
¥10,420 total
includes taxes & fees
Dec 5 - Dec 6
Wanderstay Houston Hostel

La Maison in Midtown an urban B&B

3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (541)
"great neighborhood, friendly staff, and delicious breakfast"
United States
Anna
The price is ¥25,261
¥29,555 total
includes taxes & fees
Dec 8 - Dec 9
La Maison in Midtown an urban B&B

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (201)
" Beautiful relaxing love this place best I seen thank you"
United States
James
The price is ¥32,102
¥39,885 total
includes taxes & fees
Dec 22 - Dec 23
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Wanderstay Boutique Hotel

2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (57)
"Great location will stay again "
United States
Jason
The price is ¥16,749
¥19,596 total
includes taxes & fees
Dec 5 - Dec 6
Wanderstay Boutique Hotel

Hilton University of Houston

3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (884)
"Nice place to stay"
United States
Alexandra
The price is ¥22,763
¥26,633 total
includes taxes & fees
Dec 21 - Dec 22
Hilton University of Houston

Southmore Boulevard Motel

2.0 star property
South Central Houston
5.6 out of 10, (225)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is ¥8,374
¥9,798 total
includes taxes & fees
Dec 7 - Dec 8
Southmore Boulevard Motel

Newly Built Modern 3 Bedroom Houston Home

2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (2)
"The pictures do not do this property justice. The three story home has 3 beautiful bedrooms, each with luxurious bathrooms. The main bedroom and the living room has a small patio and then there's a rooftop seating area that is an excellent spot for gazing at the Houston night skyline. The quiet area is gated off a not too busy street in a beautiful neighborhood. We did have a couple of issues upon our arrival but the hosts were on top of it and had it resolved the next day. They have great...
United States
robin
The price is ¥16,413
¥54,634 total
includes taxes & fees
Dec 7 - Dec 8
Newly Built Modern 3 Bedroom Houston Home

Paradise Palace Best Rooftop in HTX w Hot Tub

3.0 star property
South Central Houston
Paradise Palace Best Rooftop in HTX w Hot Tub

Modern Cozy Home with King Bed

3.5 star property
South Central Houston
9.4 out of 10, Exceptional, (22)
"Very spacious and close to just about everything. The view is amazing too"
United States
Brenden
The price is ¥20,936
¥53,960 total
includes taxes & fees
Dec 8 - Dec 9
Modern Cozy Home with King Bed

Downtown Houston 3BR Bachelorette Escape

2.0 star property
South Central Houston
9.6 out of 10, Exceptional, (5)
"Everything was great. Look no further and book this property. "
United States
Iesheal
The price is ¥11,941
¥49,243 total
includes taxes & fees
Dec 8 - Dec 9
Downtown Houston 3BR Bachelorette Escape

Posh Dtwn Midtown Home w Stunning Roof-topterrace

3.0 star property
South Central Houston
The price is ¥32,509
¥95,845 total
includes taxes & fees
Dec 8 - Dec 9
Posh Dtwn Midtown Home w Stunning Roof-topterrace
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Central Houston Hotel Reviews

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Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out Midtown Arts and Theater Center Houston and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, La Maison in Midtown an urban B&B is the highest ranked property in South Central Houston. This B&B is a short 4-minute walk from Westheimer Road, and it offers free breakfast and free parking. Other favorite options in the area include Wanderstay Boutique Hotel and MyCrib Houston Hostel.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1150 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and James Turrell's Twilight Epiphany Skyscape. Midtown Arts and Theater Center Houston and Children's Museum of Houston are some other stops to visit in the neighborhood. Toyota Center, Shape Community Center, and Project Row Houses are just a few of the places to visit in and around South Central Houston. H&PE Arena and Eldorado Ballroom are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station.