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Our top choices for South Central Houston hotels

A rooftop terrace with outdoor seating and a city skyline view at sunset.

1. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,288 reviews)
"Great location and wonderful staff!"
United States
Cynthia
The price is ￥18,010
￥22,417 total
includes taxes & fees
Nov 21 - Nov 22
The Westin Houston Medical Center/Museum District
A modern hotel building with a prominent entrance, large windows, and a visible name sign.

2. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,009 reviews)
"Great stay!"
United States
Luke
The price is ￥24,276
￥31,595 total
includes taxes & fees
Nov 22 - Nov 23
InterContinental Houston by IHG
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

3. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.6 out of 10, Excellent, (2,257 reviews)
"Very nice, would stay again!"
United States
Amanda
The price is ￥15,332
￥18,124 total
includes taxes & fees
Nov 23 - Nov 24
Hilton Houston Plaza/Medical Center
A spacious living area with a dining table, chairs, and a chandelier.

4. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,021 reviews)
"Courteous staff, conveniently located. Very good amenities."
United States
David
The price is ￥30,811
￥43,620 total
includes taxes & fees
Nov 22 - Nov 23
Hotel Zaza Houston Museum District
A building with a stone facade, a prominent entrance, and a parking lot.

5. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (282 reviews)
"Great place and close to downtown."
United States
Israel
The price is ￥14,719
￥17,220 total
includes taxes & fees
Nov 17 - Nov 18
Downtowner Inns - Houston Downtown
A modern lounge area with a sofa, chairs, and a round table. A decorative wall with vertical elements is visible.

6. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"Location was best"
United States
Nafisa
The price is ￥24,300
￥33,546 total
includes taxes & fees
Nov 22 - Nov 23
Houston Marriott Medical Center/Museum District
A spacious lobby with a sofa, armchairs, a coffee table, and a bar area in the background.

7. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (724 reviews)
"Great stay in the medical center. I would stay here again - love the fitness center."
United States
Alexia
The price is ￥18,204
￥21,298 total
includes taxes & fees
Nov 22 - Nov 23
DoubleTree by Hilton Houston Medical Center Hotel & Suites
A high-rise building with multiple floors, a glass facade, and a parking garage.

8. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (102 reviews)
"Enjoyable stay with all the comforts of home."
United States
ebony noelle
The price is ￥30,185
￥39,989 total
includes taxes & fees
Dec 13 - Dec 14
Sentral Forme Houston
A multi-story hotel with a brick facade, balconies, and a well-lit entrance.

9. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (612 reviews)
"Lovely hotel, run by staff who go out of their way to make your stay easy and enjoyable."
United States
Paul
The price is ￥27,444
￥32,110 total
includes taxes & fees
Nov 17 - Nov 18
La Maison in Midtown an urban B&B
A restaurant with large windows, wooden tables, and chairs. A sign indicates it's the Americas First Value Inn.

10. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,003 reviews)
"Great Stay"
United States
Randy
The price is ￥13,895
￥16,257 total
includes taxes & fees
Nov 16 - Nov 17
Americas Best Value Inn Medical Center Downtown
A modern kitchen with a marble island, stainless steel appliances, pendant lighting, and a view of the outdoors.

11. Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
3.0 star property
South Central Houston
9.6 out of 10, Exceptional, (85 reviews)
"Everything about our stay here was wonderful."
United States
jennifer k
The price is ￥21,481
￥25,134 total
includes taxes & fees
Nov 17 - Nov 18
Wanderstay Boutique Hotel
A two-story building with a balcony and a staircase.

12. 2824 Aeon Living

2824 Aeon Living
3.5 star property
South Central Houston
The price is ￥18,622
￥21,787 total
includes taxes & fees
Nov 22 - Nov 23
2824 Aeon Living
The exterior of the Hilton University of Houston hotel with a prominent sign, a set of stairs leading to the entrance, and a modern architectural design.

13. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1,001 reviews)
"Great stay!"
United States
Elizabeth
The price is ￥23,442
￥27,427 total
includes taxes & fees
Nov 23 - Nov 24
Hilton University of Houston
A pool area with a built-in jacuzzi, outdoor furniture, and a balcony with a railing.

14. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (222 reviews)
"The room was very clean, the staff was just great and the breakfast was very good! The Parking was a little difficult, but it was very safe!"
United States
Walter
The price is ￥33,060
￥41,076 total
includes taxes & fees
Nov 16 - Nov 17
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
A hotel with a sign for Extended Stay America, a lobby entrance, and a modern building in the background.

15. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
6.2 out of 10, (1,006 reviews)
"The perfect place to stay!"
Mexico
Maria Fernanda
The price is ￥10,779
￥12,656 total
includes taxes & fees
Dec 13 - Dec 14
Extended Stay America Suites Houston Med Ctr Braeswood Bl
A hotel room with a bed, a desk with a chair, a small table, a trash bin, and a window with curtains.

16. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very good, (50 reviews)
"It was close to downtown, easily accessible from the convention center and the host was pretty helpful"
United States
Daniel
The price is ￥10,301
￥12,051 total
includes taxes & fees
Nov 17 - Nov 18
Scott Inn Suites - Downtown Houston
A hotel room with a bed, bedside table, desk, and a mirror.

17. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.8 out of 10, (245 reviews)
"Very sweet lady I will be back"
United States
LaKeara
The price is ￥9,343
￥10,931 total
includes taxes & fees
Nov 16 - Nov 17
Southmore Boulevard Motel
A modern hotel lobby with a wooden floor, a blackboard with handwritten notes, a teal sofa, and a colorful rug.

18. Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (222 reviews)
"Horrible do not stay here."
United States
Nathalia
The price is ￥7,714
￥9,027 total
includes taxes & fees
Nov 16 - Nov 17
Wanderstay Houston Hostel
A large outdoor swimming pool with a slide and multiple lanes, surrounded by a modern building with large windows.

19. Fifa 2 Apt Bundle Near NRG DT Med Center - 12

Fifa 2 Apt Bundle Near NRG DT Med Center - 12
2.0 star property
South Central Houston
The price is ￥69,917
￥132,032 total
includes taxes & fees
Nov 18 - Nov 19
Fifa 2 Apt Bundle Near NRG DT Med Center - 12
A modern kitchen with a central island, a dining area with chairs, and a staircase leading to an upper level.

20. Houston Lux Townhome

Houston Lux Townhome
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (10 reviews)
"The proximity to places we wanted to go was very close."
United States
Bobbi
The price is ￥37,278
￥43,616 total
includes taxes & fees
Dec 16 - Dec 17
Houston Lux Townhome
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in South Central Houston

A rooftop terrace with outdoor seating and a city skyline view at sunset.

The Westin Houston Medical Center/Museum District

4.0 star property
South Central Houston
View
A modern hotel building with a prominent entrance, large windows, and a visible name sign.

InterContinental Houston by IHG

4.0 star property
South Central Houston
View
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

Hilton Houston Plaza/Medical Center

4.5 star property
South Central Houston
View
A spacious living area with a dining table, chairs, and a chandelier.

Hotel Zaza Houston Museum District

4.5 star property
South Central Houston
View
A building with a stone facade, a prominent entrance, and a parking lot.

Downtowner Inns - Houston Downtown

2.0 star property
South Central Houston
View
9.2
Wonderful
1,288 reviews
9.4
Exceptional
1,009 reviews
8.6
Excellent
2,257 reviews
9.2
Wonderful
1,021 reviews
9.2
Wonderful
282 reviews
The price is ￥18,010
￥22,417 total
includes taxes & fees
Nov 21 - Nov 22
The price is ￥24,276
￥31,595 total
includes taxes & fees
Nov 22 - Nov 23
The price is ￥15,332
￥18,124 total
includes taxes & fees
Nov 23 - Nov 24
The price is ￥30,811
￥43,620 total
includes taxes & fees
Nov 22 - Nov 23
The price is ￥14,719
￥17,220 total
includes taxes & fees
Nov 17 - Nov 18
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • No WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • Yes, Spa
  • Yes, Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • No Pool
  • No Spa
  • No Pet friendly
  • Yes, WiFi included
  • Yes, Parking

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

10/10 Excellent
"All wonderful! The staff are so friendly!"
Brittany 2-night trip
Posted less than an hour ago
The Westin Houston Medical Center/Museum District

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out TDECU Stadium and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveler data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel is a short 6-minute walk from Rice University, and it offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1272 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and Twilight Epiphany Skyspace. TDECU Stadium and Children's Museum of Houston are some other stops to visit in the neighborhood. Daikin Park and Toyota Center are some favorite places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.

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