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Oct 23 - Oct 25
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Oct 30 - Nov 1

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Our top choices for South Central Houston hotels

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

1. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.6 out of 10, Excellent, (2,210 reviews)
"The bar/restaurant and staff was excellent."
United States
Stephen
The price is ￥13,824
￥16,357 total
includes taxes & fees
Nov 1 - Nov 2
Hilton Houston Plaza/Medical Center
A spacious lobby with modern furniture, large windows, and indoor plants.

2. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,004 reviews)
"Great stay!"
United States
Luke
The price is ￥24,293
￥31,558 total
includes taxes & fees
Nov 22 - Nov 23
InterContinental Houston by IHG
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.

3. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (265 reviews)
"Great place and close to downtown."
United States
Israel
The price is ￥13,842
￥16,196 total
includes taxes & fees
Oct 25 - Oct 26
Downtowner Inns - Houston Downtown
A spacious living area with a dining table, chairs, and a chandelier.

4. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,005 reviews)
"Love this hotel. Been here 4 times. Great pool area, great restaurant, upbeat ambiance. Location is superb for museums and gardens."
United States
Cathy
The price is ￥40,214
￥54,389 total
includes taxes & fees
Oct 30 - Oct 31
Hotel Zaza Houston Museum District
A rooftop pool area with lounge chairs and a view of a tall building at night.

5. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,260 reviews)
"great location and the hotel is quite comfortable"
United States
Juan
The price is ￥26,660
￥33,184 total
includes taxes & fees
Nov 8 - Nov 9
The Westin Houston Medical Center/Museum District
A modern restaurant with a bar area, featuring a patterned floor, multiple dining tables, and contemporary lighting fixtures.

6. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,001 reviews)
"Was best location to Houston Methodist"
United States
John
The price is ￥23,846
￥32,920 total
includes taxes & fees
Nov 22 - Nov 23
Houston Marriott Medical Center/Museum District
A multi-story hotel with a brick facade, balconies, and a well-lit entrance.

7. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (604 reviews)
"Lovely welcoming staff, beautiful building with wonderful communal areas. We enjoyed the outside verandah. It's in a fairly noisy location but this didn't bother us. Walking distance to local bars/restaurants, 10 minutes drive to Downtown. Oh and let's not forget the lovely breakfast!"
United Kingdom
Joanna
The price is ￥26,091
￥30,526 total
includes taxes & fees
Nov 9 - Nov 10
La Maison in Midtown an urban B&B
A high-rise hotel with a rooftop pool, multiple floors, and a cityscape view.

8. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (93 reviews)
"Great place to stay!"
United States
Keeshaun
The price is ￥28,055
￥37,407 total
includes taxes & fees
Nov 8 - Nov 9
Sentral Forme Houston
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

9. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (710 reviews)
"Great place to stay. Convenient to Medical center, clean, quiet, comfortable"
United States
Danny
The price is ￥17,864
￥20,900 total
includes taxes & fees
Nov 22 - Nov 23
DoubleTree by Hilton Houston Medical Center Hotel & Suites
A modern kitchen with dark wood cabinets, a granite countertop, and a built-in island with a glass enclosure.

10. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,000 reviews)
"Great Stay"
United States
Randy
The price is ￥15,516
￥18,153 total
includes taxes & fees
Oct 24 - Oct 25
Americas Best Value Inn Medical Center Downtown
A spacious lobby with a large sectional sofa, a coffee table, and a reception desk.

11. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (990 reviews)
"Wonderful hotel located on UH campus. Friendly staff and good food on the restaurant"
United States
Diane
The price is ￥23,005
￥26,917 total
includes taxes & fees
Nov 23 - Nov 24
Hilton University of Houston
A large, multi-story house with a swimming pool, outdoor seating, and a red umbrella.

12. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (221 reviews)
"The room was very clean, the staff was just great and the breakfast was very good! The Parking was a little difficult, but it was very safe!"
United States
Walter
The price is ￥32,443
￥40,309 total
includes taxes & fees
Oct 27 - Oct 28
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
A modern kitchen with a large island, bar stools, and a stainless steel refrigerator.

13. Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
3.0 star property
South Central Houston
9.8 out of 10, Exceptional, (80 reviews)
"Solo trip and it was a perfect location staff was nice and it was nice and clean!! Would stay there again. "
United States
Sharon
The price is ￥19,859
￥23,233 total
includes taxes & fees
Nov 16 - Nov 17
Wanderstay Boutique Hotel
A large outdoor swimming pool with a slide and multiple lanes, surrounded by a modern building with large windows.

14. Fifa Stay 2BR Near NRG DT Med Center -1

Fifa Stay 2BR Near NRG DT Med Center -1
2.0 star property
South Central Houston
The price is ￥19,760
￥23,119 total
includes taxes & fees
Oct 28 - Oct 29
Fifa Stay 2BR Near NRG DT Med Center -1
A spacious lobby with a high ceiling, a central seating area with sofas and armchairs, a staircase leading to an upper level, and a flat-screen TV mounted on the wall.

15. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
6.2 out of 10, (1,002 reviews)
"The perfect place to stay!"
Mexico
Maria Fernanda
The price is ￥12,129
￥14,235 total
includes taxes & fees
Oct 25 - Oct 26
Extended Stay America Suites Houston Med Ctr Braeswood Bl
A hotel room with a bed, a desk, a chair, a mirror, a television, and a heater.

16. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very good, (48 reviews)
"Nice staff, good clean room and close to public transportation"
United States
Sergio
The price is ￥10,085
￥11,799 total
includes taxes & fees
Nov 23 - Nov 24
Scott Inn Suites - Downtown Houston
Private kitchen

17. 2824 Aeon Living

2824 Aeon Living
3.0 star property
South Central Houston
The price is ￥17,491
￥20,464 total
includes taxes & fees
Oct 28 - Oct 29
2824 Aeon Living
A hotel room with a bed, bedside table, desk, and a mirror.

18. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (245 reviews)
"Very sweet lady I will be back"
United States
LaKeara
The price is ￥9,169
￥10,727 total
includes taxes & fees
Nov 8 - Nov 9
Southmore Boulevard Motel
A modern reception area with a blackboard, a blue sofa, a yellow armchair, and a colorful rug.

19. Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (218 reviews)
"Excellent stay experience"
United States
Binkeung
The price is ￥9,733
￥11,388 total
includes taxes & fees
Oct 24 - Oct 25
Wanderstay Houston Hostel
A reception desk with a computer, a keyboard, a mouse, and a telephone. There are certificates and keys on the wall.

20. Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (5 reviews)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is ￥8,933
￥10,453 total
includes taxes & fees
Nov 15 - Nov 16
Golden Motel Near Houston Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in South Central Houston

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

Hilton Houston Plaza/Medical Center

4.5 star property
South Central Houston
View
A spacious lobby with modern furniture, large windows, and indoor plants.

InterContinental Houston by IHG

4.0 star property
South Central Houston
View
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.

Downtowner Inns - Houston Downtown

2.0 star property
South Central Houston
View
A spacious living area with a dining table, chairs, and a chandelier.

Hotel Zaza Houston Museum District

4.5 star property
South Central Houston
View
A rooftop pool area with lounge chairs and a view of a tall building at night.

The Westin Houston Medical Center/Museum District

4.0 star property
South Central Houston
View
8.6
Excellent
2,210 reviews
9.4
Exceptional
1,004 reviews
9.2
Wonderful
265 reviews
9.2
Wonderful
1,005 reviews
9.2
Wonderful
1,260 reviews
The price is ￥13,824
￥16,357 total
includes taxes & fees
Nov 1 - Nov 2
The price is ￥24,293
￥31,558 total
includes taxes & fees
Nov 22 - Nov 23
The price is ￥13,842
￥16,196 total
includes taxes & fees
Oct 25 - Oct 26
The price is ￥40,214
￥54,389 total
includes taxes & fees
Oct 30 - Oct 31
The price is ￥26,660
￥33,184 total
includes taxes & fees
Nov 8 - Nov 9
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • No Pool
  • No Spa
  • No Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • Yes, Spa
  • Yes, Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • No WiFi included
  • Yes, Parking

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Learn more about South Central Houston
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

8/10 Good
"I expected the room to be cleaner and the refrigerator was very noisy and kept us up at night"
Elsie 1-night trip
Posted 3 hours ago
Hilton Houston Plaza/Medical Center

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out TDECU Stadium and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveler data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel is a short 6-minute walk from Rice University, and it offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1272 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and Twilight Epiphany Skyspace. TDECU Stadium and Children's Museum of Houston are some other stops to visit in the neighborhood. Daikin Park and Toyota Center are some favorite places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.

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