Find Casinos in Northeast Missouri, MO

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Our top choices for Northeast Missouri hotels with a casino

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (832)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is ¥12,931
¥15,251 total
includes taxes & fees
Dec 25 - Dec 26
Holiday Inn Express St. Louis West - O'Fallon by IHG

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
Maryland Heights
8.4 out of 10, Very Good, (2215)
"Front staff was very friendly and very helpful. Check-in and check out was smooth and very easy. "
United States
James
The price is ¥16,356
¥21,345 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Hollywood Casino & Hotel St. Louis

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1241)
"Great hospitality"
United States
Alejandro
The price is ¥16,701
¥19,862 total
includes taxes & fees
Dec 19 - Dec 20
Embassy Suites by Hilton St. Louis Downtown

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1000)
"Love this hotel. "
United States
Lisa
The price is ¥18,415
¥21,164 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Country Inn & Suites by Radisson, St. Charles Historic District

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very Good, (1003)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is ¥23,703
¥30,286 total
includes taxes & fees
Dec 15 - Dec 16
Ameristar Casino Resort and Spa

Best Western Plus St. Louis Airport Hotel

Best Western Plus St. Louis Airport Hotel
2.5 star property
Woodson Terrace
9.2 out of 10, Wonderful, (1007)
"Room was nice and comfortable, pool was awesome, and breakfast left us all happy"
United States
Letez
The price is ¥17,082
¥21,129 total
includes taxes & fees
Dec 19 - Dec 20
Best Western Plus St. Louis Airport Hotel

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1006)
"Nice staff at reception. "
United States
Denise
The price is ¥13,662
¥15,702 total
includes taxes & fees
Dec 17 - Dec 18
Comfort Suites St Charles - St Louis

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very Good, (1002)
"I'd stay at this place again. "
United States
Suzanne
The price is ¥11,786
¥13,545 total
includes taxes & fees
Dec 18 - Dec 19
Super 8 by Wyndham St Charles

Best Western St. Louis Airport North Hotel & Suites

Best Western St. Louis Airport North Hotel & Suites
2.5 star property
Hazelwood
7.4 out of 10, Good, (860)
"Friendly front desk"
United States
Phillip
The price is ¥12,329
¥15,071 total
includes taxes & fees
Dec 17 - Dec 18
Best Western St. Louis Airport North Hotel & Suites

Holiday Inn St. Louis Arpt West-Earth City by IHG

Holiday Inn St. Louis Arpt West-Earth City by IHG
3.5 star property
Earth City
7.6 out of 10, Good, (1001)
"Staff was welcoming and pleasant "
United States
Michelle
The price is ¥11,605
¥13,345 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Holiday Inn St. Louis Arpt West-Earth City by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Northeast Missouri

Discover top Northeast Missouri attractions

Northeast Missouri offers a unique blend of outdoor beauty and gaming excitement, making it a great choice for travelers who enjoy casinos. Start your adventure at the Mark Twain Riverboat, where you can take a scenic cruise down the Mississippi River, soaking in the historic landscapes that inspired the famed author. After some relaxation on the water, head to the nearby Casino Queen in East St. Louis for thrilling gaming options, including slots and table games, right next to the river. For those who appreciate the arts, the historic town of Hannibal boasts the Mark Twain Boyhood Home and Museum, providing a cultural touch to your trip. You can also explore the picturesque trails at Thousand Hills State Park, perfect for hiking or picnicking with family. Lastly, indulge in local cuisine at cozy restaurants in Kirksville, known for its welcoming atmosphere and farm-to-table offerings. For your stay, consider booking a hotel near the riverfront area in East St. Louis, where you can relax in luxurious accommodations with easy access to the casino and enjoy attentive service that will meet your high expectations. Whether you're enjoying a night at the tables or relaxing by the water, Northeast Missouri combines adventure and comfort seamlessly.

Top Northeast Missouri Hotel Reviews

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