Find Casinos in Northeast Missouri, MO

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Check availability on Northeast Missouri Casinos

Our top choices for Northeast Missouri hotels with a casino

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (833)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is ¥12,906
¥15,223 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Express St. Louis West - O'Fallon by IHG

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1002)
"Great service - quaint location"
United States
Kim
The price is ¥17,836
¥20,498 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Country Inn & Suites by Radisson, St. Charles Historic District

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1446)
"Awesome place to stay!!"
United States
Kaitlyn
The price is ¥12,861
¥17,225 total
includes taxes & fees
Dec 21 - Dec 22
River City Casino & Hotel

Best Western Plus St. Louis Airport Hotel

Best Western Plus St. Louis Airport Hotel
2.5 star property
Woodson Terrace
9.2 out of 10, Wonderful, (1001)
"Room was nice and comfortable, pool was awesome, and breakfast left us all happy"
United States
Letez
The price is ¥17,049
¥21,089 total
includes taxes & fees
Dec 20 - Dec 21
Best Western Plus St. Louis Airport Hotel

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very Good, (1004)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is ¥23,658
¥30,228 total
includes taxes & fees
Dec 14 - Dec 15
Ameristar Casino Resort and Spa

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very Good, (1000)
"I'd stay at this place again. "
United States
Suzanne
The price is ¥11,763
¥13,519 total
includes taxes & fees
Dec 18 - Dec 19
Super 8 by Wyndham St Charles

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1002)
"Nice staff at reception. "
United States
Denise
The price is ¥12,273
¥14,106 total
includes taxes & fees
Dec 14 - Dec 15
Comfort Suites St Charles - St Louis

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1242)
"Great hospitality"
United States
Alejandro
The price is ¥16,669
¥19,825 total
includes taxes & fees
Dec 18 - Dec 19
Embassy Suites by Hilton St. Louis Downtown

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.2 out of 10, Wonderful, (627)
"Clean room, great staff, liked the gym"
United States
Emily
The price is ¥16,046
¥19,379 total
includes taxes & fees
Dec 18 - Dec 19
Hampton Inn & Suites St. Charles Old Town Area

Best Western St. Louis Airport North Hotel & Suites

Best Western St. Louis Airport North Hotel & Suites
2.5 star property
Hazelwood
7.4 out of 10, Good, (860)
"Friendly front desk"
United States
Phillip
The price is ¥12,225
¥14,945 total
includes taxes & fees
Dec 18 - Dec 19
Best Western St. Louis Airport North Hotel & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Northeast Missouri

Discover top Northeast Missouri attractions

Northeast Missouri offers a unique blend of outdoor beauty and gaming excitement, making it a great choice for travelers who enjoy casinos. Start your adventure at the Mark Twain Riverboat, where you can take a scenic cruise down the Mississippi River, soaking in the historic landscapes that inspired the famed author. After some relaxation on the water, head to the nearby Casino Queen in East St. Louis for thrilling gaming options, including slots and table games, right next to the river. For those who appreciate the arts, the historic town of Hannibal boasts the Mark Twain Boyhood Home and Museum, providing a cultural touch to your trip. You can also explore the picturesque trails at Thousand Hills State Park, perfect for hiking or picnicking with family. Lastly, indulge in local cuisine at cozy restaurants in Kirksville, known for its welcoming atmosphere and farm-to-table offerings. For your stay, consider booking a hotel near the riverfront area in East St. Louis, where you can relax in luxurious accommodations with easy access to the casino and enjoy attentive service that will meet your high expectations. Whether you're enjoying a night at the tables or relaxing by the water, Northeast Missouri combines adventure and comfort seamlessly.

Top Northeast Missouri Hotel Reviews

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