Find Business Hotels in Northeast Missouri, MO

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Check availability on Northeast Missouri Business Hotels

Tonight
Dec 27 - Dec 28
Tomorrow
Dec 28 - Dec 29
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Northeast Missouri business-friendly hotels

Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
Hannibal
8.0 out of 10, Very Good, (1000)
"Very friendly staff. "
United States
Lawrence
The price is ￥10,985
￥12,726 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Quality Inn & Suites Hannibal West
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
Hannibal
9.6 out of 10, Exceptional, (1006)
"Very personable staff, easy check in"
United States
Cherie
The price is ￥15,162
￥17,564 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Sleep Inn & Suites Hannibal West
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (851)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is ￥17,175
￥20,610 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Indoor pool
Depot Inn and Suites

Depot Inn and Suites

Depot Inn and Suites
3.5 star property
La Plata
9.8 out of 10, Exceptional, (618)
"This place is a hidden gem. Super clean with great staff and well outfitted rooms. "
United States
Johnathan
Depot Inn and Suites
Lobby
Hampton Inn Kirksville

Hampton Inn Kirksville

Hampton Inn Kirksville
2.5 star property
Kirksville
9.2 out of 10, Wonderful, (577)
"Better than a typical hotel, premium bedding, great lobby space for families to gather."
United States
Lynn
The price is ￥19,001
￥21,533 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn Kirksville
Ballroom
The Wildwood Hotel

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1613)
"Great place!"
United States
Biju
The Wildwood Hotel
Property amenity
Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1003)
"Nice place and nice people "
United States
Columbus
The price is ￥10,647
￥12,215 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Baymont by Wyndham Warrenton
Room, 2 Double Beds, Non Smoking | Pillowtop beds, desk, blackout drapes, free cribs/infant beds
Super 8 by Wyndham Kirksville-University Area

Super 8 by Wyndham Kirksville-University Area

Super 8 by Wyndham Kirksville-University Area
2.5 star property
Kirksville
9.0 out of 10, Wonderful, (154)
"The rooms were clean and the breakfast bar is outstanding staff was very friendly and helpful "
United States
Bill
The price is ￥11,554
￥12,980 total
includes taxes & fees
Dec 30 - Dec 31
Super 8 by Wyndham Kirksville-University Area
Exterior
Best Western Teal Lake Inn

Best Western Teal Lake Inn

Best Western Teal Lake Inn
2.5 star property
Mexico
8.4 out of 10, Very Good, (489)
"Very clean, well ran hotel"
United States
Leslie
The price is ￥12,951
￥14,485 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Best Western Teal Lake Inn
Family Suite, Multiple Beds | Premium bedding, desk, laptop workspace, iron/ironing board
Heritage Hotel Quincy

Heritage Hotel Quincy

Heritage Hotel Quincy
2.0 star property
Quincy
8.8 out of 10, Excellent, (274)
"Room was very clean Breakfast was satisfying "
United States
Mark
The price is ￥13,279
￥15,135 total
includes taxes & fees
Jan 27 - Jan 28, 2026
Heritage Hotel Quincy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Northeast Missouri Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Perfect"
Mary 1-night trip
Posted 21 hours ago
Pear Tree Inn St. Louis Airport

Frequently asked questions

How much do business-friendly hotels in Northeast Missouri cost?
Business-friendly hotels in Northeast Missouri range between ￥12,215 and ￥21,533 per night. This means you can lock in a property with handy amenities like conference rooms and workspaces at a price that fits your work budget. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Northeast Missouri?
That depends on where in Northeast Missouri you're headed. Lots of business travelers to St. Louis recommend Drury Inn & Suites St. Louis Brentwood. This 3-stars property offers a swimming pool and express check-out services. Drury Plaza Hotel St. Louis at the Arch is another great option if you're scheduling a meeting or working remotely in St. Louis. A terrace and a swimming pool are among the useful amenities at this 3-stars getaway. You can choose from multiple business-friendly hotels in Northeast Missouri that have a total average guest review rating of 8.8.
How many business-friendly hotels are there in Northeast Missouri?
There are 230 business-friendly hotels in Northeast Missouri. When work takes you on the road, Expedia makes it easy to find the ideal space with the amenities you need.
What are the best cheap business-friendly hotels in Northeast Missouri?
When work is taking you on the road in Northeast Missouri, Expedia will help you find the ideal business-friendly hotel. Hampton Inn & Suites St. Louis at Forest Park is a budget favorite in St. Louis. Pillow top mattresses and a swimming pool are among its many amenities. On the lookout for low-cost accommodations in Maryland Heights? Best Western Plus St. Louis Airport Hotel is the first choice for many corporate guests. It offers conveniences that make it easy to both work and feel at home, such as pillow top mattresses and a swimming pool. Business-friendly hotels in Northeast Missouri start at only ￥12,215 per night. Like to see the sights of Northeast Missouri without hurting your hip pocket? Take a break from your work events to visit free attractions like Forest Park in St. Louis. Maryland Heights also has plenty of things to do that don't cost a penny, including St. Louis Art Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Northeast Missouri that are also business friendly?
Certainly. You'll find some fantastic family-friendly hotels that are also business friendly in Northeast Missouri. If you're on your way to St. Louis, make a reservation at Drury Plaza Hotel St. Louis at the Arch. It includes useful amenities such as complimentary breakfast and WiFi and has a 3-stars rating. Another property worth considering is Drury Inn & Suites St. Louis Forest Park. This 3-stars stay in St. Louis welcomes both leisure and business travelers and offers complimentary breakfast, laundry facilities and much more. St. Louis has lots of family-friendly attractions when it's time to get out and explore. St. Louis Zoo and Forest Park will keep everyone entertained.
Are there any 5-star business-friendly hotels in Northeast Missouri?
Experience luxury as you work at one of our 5-star business-friendly hotels in Northeast Missouri. Four Seasons Hotel St Louis in St. Louis is one of our top picks. This 5-star escape features plenty of amenities, including a swimming pool and a sauna. You can also experience the finer things at The Ritz-Carlton, St. Louis. Business-friendly conveniences, designer toiletries and massage services help make this a fantastic base for the corporate traveler in St. Louis.
Why book your business-friendly hotel in Northeast Missouri with Expedia?
At Expedia, our business is to help you find an amazing stay at the right price. From deluxe, corporate-friendly escapes to affordable hotels filled with all the amenities you need, you'll have your next work trip organized in a few simple clicks.
How can I find cheap business-friendly hotels in Northeast Missouri?
Expedia can help you easily find cheap business-friendly hotels in Northeast Missouri. Simply head to our "traveler experience" filter and click on "business friendly." This will show you accommodations with amenities designed to help you work and relax, like free WiFi and included breakfast. You can also choose your hotel star rating and budget to keep costs to a minimum.
What is there to do in Northeast Missouri near my business-friendly hotel?
One of the most important travel accessories for your Northeast Missouri business trip is an epic itinerary for when you have a few hours to spare! Fox Theater, Anheuser-Busch Brewery and St. Louis Aquarium at Union Station are some of the top things to do if you're heading to St. Louis. Maryland Heights also has lots of wonderful attractions, such as New Jewish Theatre, Hollywood Casino Amphitheatre and Payne-Gentry Historical House.

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