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Our top choices for Esquilino luxury hotels

NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento
5.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (1000)
"The hotel was the best location to be at. Amazing stay and so convenient."
United States
Jalin
The price is ¥42,649
¥50,594 total
includes taxes & fees
Jan 12 - Jan 13, 2026
NH Collection Roma Palazzo Cinquecento

Radisson Blu es. Hotel, Roma

Radisson Blu es. Hotel, Roma
Rome City Centre
6.6 out of 10, (995)
"It’s not the sparkling gem it should be. I stayed one night in a junior suite overlooking....well, Termini station. The room was large and clearly at one point relatively flash (if it was the 90’s), but tired. Random switches that did nothing, worst stocked mini bar in history (one miniature Jonny Walker red label and a bottle of tonic amongst a couple of cokes and a bottle of Evian!!??). The whole place needs updating,,,, but on the flip side, pretty good rates for such a large room, great bed...
United Kingdom
MinktonPMinkton
Radisson Blu es. Hotel, Roma

Mirko Luxury Inn

Mirko Luxury Inn
Rome Historic Centre
6.6 out of 10, (14)
"No one was on site when we arrived. Had to call and waited for almost an hour for some to come and let use in. No breakfast was provided. No staff on site. Must of the stuff in the room was broken. Such as the wardrobe. It was falling apart. Almost fell apart on me. But I must say it had a wicked shower. Best I have seen in a long time. "
United Kingdom
Anonymous traveler
Mirko Luxury Inn

Mecenate Palace

Mecenate Palace
4.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (1003)
"We have been here twice. The staff is very friendly it’s close to everything and very clean "
Canada
Joseph
The price is ¥21,157
¥26,033 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Mecenate Palace

Napoleon Hotel

Napoleon Hotel
4.0 star property
Rome City Centre
8.4 out of 10, Very Good, (1001)
"Perfect location and great breakfast."
United States
Marcia
Napoleon Hotel

Lucky Home

Lucky Home
Rome City Centre
8.0 out of 10, Very Good, (161)
"Many thanks for the stay "
United Kingdom
Paulo
The price is ¥9,473
¥12,996 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Lucky Home

Merulana Inn Guest House

Merulana Inn Guest House
Rome City Centre
9.0 out of 10, Wonderful, (976)
"Everything was great. Karen and the whole staff were so sweet, friendly, and helpful with giving us directions and navigating the area. Would definitely stay again and recommend to others! "
United States
Khadine
Merulana Inn Guest House

Hotel Contilia

Hotel Contilia
3.0 star property
Rome City Centre
7.2 out of 10, Good, (1001)
"Would definitely stay again! "
Canada
Isabella
The price is ¥16,076
¥19,892 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Hotel Contilia

Hotel Moscatello

Hotel Moscatello
2.0 star property
Rome Historic Centre
8.0 out of 10, Very Good, (443)
"Decent little hotel, especially for the price and the location. The only reason I rate a bit lower is due to the shower not draining properly, nor was it fixed when we asked, but for the price we can’t complain too much."
Canada
Kiana
The price is ¥9,232
¥11,995 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Hotel Moscatello

Holiday Sunny Roma B&B

Holiday Sunny Roma B&B
Rome City Centre
6.8 out of 10, (5)
"Habitación básica, para pasar una noche. Está muy bien situado, cerca de términi, y regentado por una familia china. Desayuno incluido. Baño compartido, pero limpio."
Spain
Anonymous traveler
Holiday Sunny Roma B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Esquilino Hotel Reviews

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Esquilino?
During your visit, you might want to enjoy the sightseeing and museums which Esquilino is known for.
What's the best high-end place to stay in Esquilino?
NH Collection Roma Palazzo Cinquecento is a luxury hotel with a rooftop terrace and a deli, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your stay is Mirko Luxury Inn.
What's there to see and do in Esquilino?
Enjoy all that Esquilino has to offer when you visit Piazza Vittorio Emanuele II, Piazza Santa Maria Maggiore, and Basilica di Santa Croce in Gerusalemme. If you have a bit of extra time while you're in the area, you might want to check out Via Marsala and Historic Museum of the Liberation.
How can I get around Esquilino?
It's easier to get around town comfortably when you know your options. You can access metro transit at S Bibiana Station, Vittorio Emanuele Station, and Manzoni - Museo della Liberazione Station.

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