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Check prices for these dates

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Dec 20 - Dec 21
Tomorrow
Dec 21 - Dec 22
Next weekend
Dec 26 - Dec 28
In two weeks
Jan 2 - Jan 4

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Our top choices for Advance hotels

Front of property
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ￥10,890
￥12,286 total
includes taxes & fees
Dec 24 - Dec 25
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1003)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ￥12,913
￥13,652 total
includes taxes & fees
Dec 23 - Dec 24
Drury Inn & Suites Jackson MO
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1005)
"Great place and staff, very accommodating!"
United States
Megan
The price is ￥14,002
￥15,795 total
includes taxes & fees
Dec 24 - Dec 25
Drury Plaza Hotel Cape Girardeau Conference Center
Free daily buffet breakfast
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is ￥14,002
￥15,795 total
includes taxes & fees
Dec 24 - Dec 25
Drury Inn & Suites Cape Girardeau
Exterior
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (672)
"Great place "
United States
GUY
The price is ￥13,275
￥14,367 total
includes taxes & fees
Jan 7 - Jan 8, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ￥14,782
￥16,676 total
includes taxes & fees
Dec 26 - Dec 27
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is ￥18,050
￥20,452 total
includes taxes & fees
Dec 29 - Dec 30
Courtyard by Marriott Cape Girardeau Downtown
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (446)
"Friendly staff clean rooms "
United States
Christopher
The price is ￥15,393
￥17,430 total
includes taxes & fees
Dec 28 - Dec 29
Hampton Inn Sikeston
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (474)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is ￥14,085
￥15,889 total
includes taxes & fees
Dec 29 - Dec 30
The Riverview
Property amenity
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is ￥15,933
￥18,040 total
includes taxes & fees
Dec 26 - Dec 27
Fairfield Inn & Suites by Marriott Sikeston
Free daily buffet breakfast
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
Heather
The price is ￥10,890
￥12,286 total
includes taxes & fees
Dec 24 - Dec 25
Pear Tree Inn Cape Girardeau West
Snack bar
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (102)
"It was a nice stay"
United States
Douglas
The price is ￥14,100
￥16,048 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Tru By Hilton Cape Girardeau
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (685)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is ￥8,963
￥10,111 total
includes taxes & fees
Dec 29 - Dec 30
Quality Inn Cape Girardeau North
Lobby sitting area
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (83)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
EC Reed's Mercantile and Hotel
Breakfast area
Dexter Inn

Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (332)
"Room was nice and spacious."
United States
Rebecca
The price is ￥10,648
￥11,957 total
includes taxes & fees
Dec 23 - Dec 24
Dexter Inn
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is ￥14,671
￥16,611 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (882)
"Room was clean and spacious."
United States
George
The price is ￥12,147
￥14,571 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Candlewood Suites Cape Girardeau by IHG
Lobby
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is ￥15,821
￥17,848 total
includes taxes & fees
Dec 26 - Dec 27
Hampton Inn Cape Girardeau I 55 East
Property amenity
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is ￥18,615
￥21,076 total
includes taxes & fees
Dec 28 - Dec 29
TownePlace Suites by Marriott Sikeston
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn

Town House Inn

Town House Inn
2.5 star property
Jackson
7.6 out of 10, Good, (425)
"Room was clean and had a refrigerator and microwave for use if needed."
United States
Sherry
The price is ￥10,190
￥11,028 total
includes taxes & fees
Jan 20 - Jan 21, 2026
Town House Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Advance Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Didn’t eat the breakfast but I’m sure it is wonderful. Everything from the Check in process to the condition of the rooms to the comfort of the stay was worth the money "
Corrie 1-night trip
Posted 2 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

More cheap stays in Advance

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
The price is ￥10,890 per night from Dec 24 to Dec 25
￥10,890
￥12,286 total
Dec 24 - Dec 25
includes taxes & fees
9/10 Wonderful! (1,002 reviews)

Frequently asked questions

Where is the best place to stay in Advance?
Based on Expedia's traveler preferences, Private Getaway on 270 Acres w/ Lake: Swim & Canoe is a top place to stay in Advance. Two other options for your trip to the area are Drury Plaza Hotel Cape Girardeau Conference Center and The Riverview. See all available top hotels, or vacation rentals in Advance.
What are some of the best vacation rentals that Advance has to offer?
Little Blue Cottage on Spanish: This vacation home rental outside of Advance comes with WiFi so you can feel at home during your trip. See all vacation rentals in Advance.
If I need to cancel my hotel reservation in Advance, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Advance.
Where can I learn more about changing or cancelling my trip to Advance?
To access more information about changing or cancelling your trip to Advance, go to https://www.expedia.com/service/.
How is it to stay in Advance?
Travelers to Advance will find plenty to explore and enjoy. In Advance, there are 4 hotels and other accommodations to choose from. Find out more about Advance.
What is there to see in Advance?
Places to visit in the wider area include Mingo Wilderness, Bollinger Mill State Historic Site, and Stoddard County Civil War Memorial Cemetery. Check out what more to see and do in Expedia's Advance guide.
What's the weather like in Advance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Advance is 59 inches.