Top Santa Lucia Hotels from ￥6,064

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Our top choices for Santa Lucia hotels

A historic building with ornate balconies, a grand entrance, and flags of the European Union and Italy.

1. Grande Albergo Alfeo

Santa Lucia

Anna

￥15,353 total

includes taxes & fees

Nov 21 - Nov 22

A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.

2. Caportigia Boutique Hotel

Santa Lucia

Rene

￥24,118 total

includes taxes & fees

Nov 19 - Nov 20

A building facade with a classical architectural style, featuring a large arched window with blue curtains, a decorative balcony railing, and intricate stone carvings.

3. Nostos rooms & Apartments

Santa Lucia

Evelyne

￥8,460 total

includes taxes & fees

Nov 18 - Nov 19

A hotel room with a large bed, a chair, a small table, and a chandelier.

4. Hotel Palazzo Cavalieri

Santa Lucia

Jose

￥13,986 total

includes taxes & fees

Nov 20 - Nov 21

A hotel room with a bed, a desk, a chair, a TV, and a balcony with a view of buildings.

5. Syraka Design Rooms & Suites

Santa Lucia

Vera Gomes

￥19,668 total

includes taxes & fees

Nov 17 - Nov 18

A balcony with wicker chairs and a glass table overlooking a marina with boats.

6. Fortaleza Charme House

Santa Lucia

Martine

￥33,035 total

includes taxes & fees

Nov 16 - Nov 17

A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.

7. Lakkios

Santa Lucia

Marsel

￥16,419 total

includes taxes & fees

Nov 16 - Nov 17

A balcony with a table set for two, a chair, and a view of a building with multiple windows and balconies.

8. B&B Nike

Santa Lucia

Chris

￥13,684 total

includes taxes & fees

Nov 16 - Nov 17

A neatly made bed with a dark quilt, white pillows, and a beige headboard. There are two bedside lamps on either side of the bed.

9. Melody rooms

Santa Lucia

Phillipe

￥6,913 total

includes taxes & fees

Nov 25 - Nov 26

A terrace with white tables and chairs, white umbrellas, and a view of the sea.

10. Giuggiulena Villa

Santa Lucia

Duane

￥37,488 total

includes taxes & fees

Nov 30 - Dec 1

An open balcony with a table and chairs, potted plants, and a view of a building with balconies and windows.

11. Calafatari B&B

Santa Lucia

Petri

￥22,759 total

includes taxes & fees

Nov 16 - Nov 17

A bedroom with a stone wall, a bed with a wooden headboard, a tray with a plant, and a window with curtains.

12. B&B Siracusa

Santa Lucia

Malcolm

￥13,589 total

includes taxes & fees

Nov 16 - Nov 17

A modern dining area with a white table, green chairs, and a potted plant.

13. San Nicola Rooms Siracusa

Santa Lucia

Lin

￥18,916 total

includes taxes & fees

Nov 16 - Nov 17

14. Casa Miranda Boutique

Santa Lucia

Hossein

￥38,044 total

includes taxes & fees

Dec 14 - Dec 15

A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.

15. Gymnasium

Santa Lucia

Richard

￥9,103 total

includes taxes & fees

Nov 16 - Nov 17

A marina with numerous boats docked, a clear sky, and a building with outdoor seating.

16. Regina Margherita

Santa Lucia

Laura

￥8,997 total

includes taxes & fees

Nov 23 - Nov 24

A woman in a black swimsuit sitting in a hot tub overlooking a beach with a clear sky and the sun shining.

17. Re Dionisio Luxury Suites

Santa Lucia

Anthony

￥41,953 total

includes taxes & fees

Nov 16 - Nov 17

An outdoor café with tables and chairs, a bar sign, and a restaurant sign.

18. Residence Agatocle

Santa Lucia

Joanne

￥14,991 total

includes taxes & fees

Dec 7 - Dec 8

A modern bedroom with a bed, bedside table, and a unique feature of a table with a fire effect.

19. B&B IL MORO

Santa Lucia

"Personne sur place pour nous aider. La carte de la chambre était défectueuse dès l'arrivée. Par la suite l'électricité a manqué à 21h, nous avons du contacter les propriétaires via What's App dans le noir. Nous apprécions faire affaire avec des humains et non des applications impersonnelles et des vidéos. Le lit était petit et inconfortable. Pas d'oreiller d'extra ni de boîte de mouchoirs. Le quartier est lugubre."

Celine B. La

￥14,743 total

includes taxes & fees

Nov 20 - Nov 21

A wooden hotel entrance with a sign reading "HOTEL POPULUS."

20. Populus

Santa Lucia

Thomas

￥11,305 total

includes taxes & fees

Nov 16 - Nov 17

View all properties

Hotels recommended for families in Santa Lucia

Grande Albergo Alfeo

Santa Lucia

￥15,353 total

includes taxes & fees

Nov 21 - Nov 22

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.

A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

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Ancient ruins with a large amphitheater surrounded by trees.

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

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An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Grottasanta

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

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An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

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Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

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Top Santa Lucia Hotel Reviews

A hot tub with a view of the sea, wicker chairs, and a table with drinks and flowers.

Maniace Boutique Hotel Ortigia UNA Esperienze

Ortigia

10/10 Excellent

Michele

Fortaleza Charme House

Santa Lucia

10/10 Excellent

The hotel is quite cool - looks unimpressive from the outside but inside the rooms are very modern and clean. We had 2 rooms on the top floor with skylights which had remote-controlled shades. We were given code access to get in - which was perfect as we arrived early and dropped our bags off. We were lucky to fin street parking just across the street from the hotel. The location was awesome. Right next to the bridge to Ortigia. Plenty of coffee shops and restaurants near by. The staff...

Steven

Giuggiulena Villa

Santa Lucia

10/10 Excellent

The hosts were very considerate and helpful during our stay. They provided a detailed map of Syracuse and Ortigia and provided personalized recommendations for food and attractions that were amazing. The sea view was so mesmerizing from our room that we almost wanted to stay in our rooms to watch the sea. The room was also very comfortable, spacious and clean. We were able to enjoy breakfast provided by the hosts while watching the sea. Highly recommend if you are planning to stay in Syracuse!

Sandra

Ornate architectural details, a balcony with wrought iron railing, and a large arched window.

Algila' Ortigia Charme Hotel

Ortigia

10/10 Excellent

The Agilia Ortigia Charme Hotel is absolutely superb. Firstly, we were lost in Syracuse, but when we called the hotel to get some guidance, very nice man name Marchello gave us excellent directions and then met us outside the hotel which was a huge help after a long day of driving in Sicily. After check in, we were given a tour of the the hotel by another hotel employee who was also very friendly. Everybody we met at this hotel was so accommodating and friendly. On our way to the hotel, we...

Jeff Harrison

A large metal sculpture in an outdoor setting.

Antares Bed And Breakfast

Syracuse

10/10 Excellent

Dario G

Calafatari B&B

Santa Lucia

10/10 Excellent

So the truth is we don’t end up staying. Not because the accommodations weren’t lovely and cleanly it was because I didn’t understand that. It wasn’t the whole apartment. It is just a room in the apartment. You do have people staying in the apartment with you as well in one room over just not enough privacy for us, unfortunately. If you’re looking for something like this, though, it would be perfect for you.

amanda

An open door leading to an outdoor patio with a table and chairs.

Lanterne Magiche Ortigia Suites

Ortigia

10/10 Excellent

This hotel is stunning, in all aspects. The interior is like a castle, with winding stone stairs. I cannot say enough about the luxurious experience. Front desk staff super helpful, friendly and accommodating. We only stayed one night but would love to come again. The room we stayed in was very spacious and unique, with a huge heavenly bathroom having a large open shower, lots of hot water. The bed was so so comfortable and luxurious. The included buffet breakfast was great and offered...

Vincent

A terrace with outdoor furniture, including sofas and chairs, arranged around a central table.

Lanterne Magiche Ortigia

Ortigia

10/10 Excellent

Jong Cheol

A narrow street with a building featuring a pink awning and a sign for 'Aretusa Vacanze'.

Aretusa Vacanze B&B

Ortigia

10/10 Excellent

Maria

A sunset view from a balcony with a stone wall, cacti, and wine glasses.

Palazzo Giunta - Porta Marina Ortigia

Ortigia

10/10 Excellent

Lauren Lucia

A woman relaxing in a hot tub with a view of a historic monument and a green wall.

Noto Boutique Hotel

Noto

10/10 Excellent

christine

A balcony with a hot tub, a lounge chair, and a view of the sea.

Archinuè Suite & Apartments

Syracuse

10/10 Excellent

Stayed for 3 nights and the place is very close to Ortigia (old town) and though still in a quiet location with a lot of amenities close by. The actual apartment was very well set up, very comfortable and big rooms and we were very satisfied with all that was on offer. Only downside is that parking at certain hours is a bit hard to come by but always managed with little hassle in the end. Never met the owners of the place due to unfortunate timings but was in contact very often with them and...

David

Frequently Asked Questions

What is Santa Lucia like?

Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood.

Where is the best place to stay in Santa Lucia?

Based on our traveler data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.

How many hotels can I expect to find in Santa Lucia?

Expedia has 313 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.

If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia.

Where can I learn more about changing or cancelling my trip to Santa Lucia?

For more details about changing or cancelling your trip to Santa Lucia, click here.

What are the top things to see and do in Santa Lucia?

Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

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Find hotels in Santa Lucia, Syracuse from ￥6,064

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Property class

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Our top choices for Santa Lucia hotels

1. Grande Albergo Alfeo

2. Caportigia Boutique Hotel

3. Nostos rooms & Apartments

4. Hotel Palazzo Cavalieri

5. Syraka Design Rooms & Suites

6. Fortaleza Charme House

7. Lakkios

8. B&B Nike

9. Melody rooms

10. Giuggiulena Villa

11. Calafatari B&B

12. B&B Siracusa

13. San Nicola Rooms Siracusa

14. Casa Miranda Boutique

15. Gymnasium

16. Regina Margherita

17. Re Dionisio Luxury Suites

18. Residence Agatocle

19. B&B IL MORO

20. Populus

Hotels recommended for families in Santa Lucia

Grande Albergo Alfeo

Where to stay in Santa Lucia

Ortigia

Neapolis

Grottasanta

Tiche

Acradina

Top Santa Lucia Hotel Reviews

Maniace Boutique Hotel Ortigia UNA Esperienze

10/10 Excellent

Frequently Asked Questions

What is Santa Lucia like?

Where is the best place to stay in Santa Lucia?

How many hotels can I expect to find in Santa Lucia?

If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Santa Lucia?

What are the top things to see and do in Santa Lucia?

Explore a world of travel with Expedia