A coastal fortress with a stone wall and a tiled-roof building.

Find Luxury Hotels in Syracuse

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Syracuse Luxury Hotels

Tonight
Oct 21 - Oct 22
Tomorrow
Oct 22 - Oct 23
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for Syracuse luxury hotels

A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A spacious dining area with round tables and blue chairs, large windows offering a city view, and a wooden ceiling structure.
A grand hallway with ornate columns, a tiled floor, and large potted plants.
A grand hallway with a marble floor, ornate columns, and a staircase leading to an upper level.

1. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
  • Discover the epitome of Mediterranean luxury steps from Ortigia's coastline at this spa-focused retreat with poolside indulgence.
￥100,102
￥111,889 total
includes taxes & fees
Nov 2 - Nov 3
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A balcony with a view of the sea and a cityscape, furnished with two chairs and a small table with a vase of flowers.
A grand atrium with a central column, ornate railings, and a large mural on the wall.
A dining table with multiple plates and wine glasses, set against a backdrop of a scenic ocean view.

2. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
  • Mediterranean luxury awaits at this 5-star Syracuse hotel with spa, sauna, and two restaurants near Ortigia's beaches.
￥46,400
￥52,817 total
includes taxes & fees
Nov 8 - Nov 9
Ortea Palace Hotel, Sicily, Autograph Collection
A large swimming pool with a modern building in the background.
An outdoor dining area with tables and chairs, a pool, and palm trees in the background.
A beach with clear turquoise water, sandy shore, and sparse vegetation.
A sauna with wooden benches and a central stone pillar.

3. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
  • Sicilian spa escape boasts 2 outdoor pools and a serene full-service wellness center.
￥52,188
￥59,183 total
includes taxes & fees
Nov 4 - Nov 5
Wellness & Spa Hotel Principe di Fitalia
A spa room with a large window, a hot tub, and two candles.
A spacious lobby with arched ceilings, a central round table with decorative items, and a modern chandelier.
A courtyard with a stone pathway, palm trees, and potted plants.
A spacious living room with a high ceiling, white sofas, a coffee table, and a large mirror.

4. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Syracuse
  • Coastal luxury awaits at this five-star retreat offering a full-service spa, two outdoor pools, and Mediterranean dining near Fanusa Beach.
￥50,916
￥57,784 total
includes taxes & fees
Oct 22 - Oct 23
Dimora Caiammari Luxury Hotel & Spa
A balcony with a view of the sea, a cactus, and potted plants.
A poolside area with lounge chairs and umbrellas, a clear pool, and a building with multiple windows in the background.
A large, multi-story building with a symmetrical facade, arched windows, and a central entrance with a colorful awning.
A dining area with a table set for two, overlooking a coastal view.

5. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
  • Experience luxury at grand hotel with spa services, private beach, and seaside dining in Ortigia.
￥37,952
￥43,525 total
includes taxes & fees
Nov 18 - Nov 19
Grand Hotel Ortigia Siracusa
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A pathway lined with palm trees leading to a building with a red-tiled roof.
A modern bathroom with a freestanding bathtub, a small table with toiletries, and a view of the ocean.
A modern bathroom with a freestanding bathtub, a round table with a magazine, and a view of a pool and greenery.

6. Minareto

Minareto
Syracuse
  • Syracuse seaside splendor offers indulgent relaxation with private beach access, beachfront dining, and Art Deco elegance.
￥44,166
￥50,360 total
includes taxes & fees
Nov 16 - Nov 17
Minareto
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A multi-story building with a rooftop terrace, balconies, and a street view.
A multi-story building with a rooftop terrace featuring outdoor seating and a hot tub.
A modern hotel room with a stone wall, a staircase, a seating area with two chairs, a small table, and a desk with a phone and a lamp.

7. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
  • Elegant Mediterranean luxury, impeccable service, and fine dining near Ortigia await at this boutique Syracuse hotel.
￥22,054
￥26,036 total
includes taxes & fees
Nov 21 - Nov 22
Caportigia Boutique Hotel
A modern kitchen with grey cabinets, a marble backsplash, and a dining area with a long table and chairs.
A bedroom with a bed, a wardrobe, a window, and a wall-mounted picture.
A covered outdoor dining area with a table and chairs, a wooden ceiling, and a view of the surrounding landscape.
A modern dining area with a table set for four, a decorative bowl centerpiece, and a view into a living area with a sofa and a window.

8. Villa Segesta holiday flat with terrace, WiFi and air conditioning

Villa Segesta holiday flat with terrace, WiFi and air conditioning
Tiche
￥90,680
￥99,566 total
includes taxes & fees
Oct 22 - Oct 23
Villa Segesta holiday flat with terrace, WiFi and air conditioning
An outdoor seating area with sofas, a table with candles, and lanterns.
A villa with a spacious patio, a well-maintained garden, and a view of the surrounding landscape.
A dining area with stone walls, wooden beams, and tables set for dining.
A garden with a pool, lounge chairs, and a gazebo.

9. Donna Coraly Country Boutique Hotel

Donna Coraly Country Boutique Hotel
Syracuse
￥43,587
￥49,723 total
includes taxes & fees
Oct 26 - Oct 27
Donna Coraly Country Boutique Hotel
A beachside restaurant with outdoor seating overlooking the sea, a clear sky, and a distant mountain range.
A balcony with a view of the ocean, a glass shower enclosure, and a table with fruits and drinks.
A beach with clear shallow waters, a sandy shore, and a distant pier with buildings.
A room with a large window overlooking the sea, a bathtub, a table with a magazine, and a towel hanging on the wall.

10. White Bay Resort

White Bay Resort
Syracuse
￥24,978
￥29,253 total
includes taxes & fees
Oct 23 - Oct 24
White Bay Resort
View all properties

Top Syracuse Hotel Reviews

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World

10/10 Excellent
"Clean room but not all rooms have a coffee maker which seems odd otherwise great property and breakfast was amazing"
Lisa 2-night trip
Posted 13 hours ago
Grand Hotel Des Ètrangers - The Leading Hotels of the World
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

10/10 Excellent
"Lovely location by the sea. And easy to park."
Henry 1-night trip
Posted 1 day ago
Algila' Ortigia Charme Hotel
Grand Hotel Villa Politi

Grand Hotel Villa Politi

8/10 Good
"Overall, we had a good stay at Grand Hotel Villa Politi. The hotel has a beautiful historic character and was very clean. The breakfast was excellent, with a wide variety of both continental and traditional Italian options. The swimming pool was another great highlight. Its location was very convenient for travelling by car, just outside the ZTL, with on-site parking available. However, the hotel has quite a lot of stairs, which can make getting around less convenient, and we found the staff could have been more helpful and attentive. Overall, a good option for exploring Syracuse, especially for travellers arriving by car."
Cristian 2-night trip
Posted 1 day ago
Grand Hotel Villa Politi
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"A splendid, classic property with first rate service, comfortable beds and a glorious breakfast on a breathtaking outdoor terrace. Wish we could have stayed longer."
Richard 1-night trip
Posted 9 days ago
Grand Hotel Ortigia Siracusa
Grande Albergo Alfeo

Grande Albergo Alfeo

10/10 Excellent
"We enjoyed our stay"
Anna 3-night trip
Posted 3 weeks ago
Grande Albergo Alfeo
Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection

10/10 Excellent
"El mejor de Ortigia"
William 2-night trip
Posted 1 month ago
Palazzo Artemide - VRetreats, SLH Collection
Eureka Palace Hotel Spa

Eureka Palace Hotel Spa

8/10 Good
"The rooms were spacious and clean. The spa was also very good and well maintained"
IKECHUKWU 6-night trip
Posted 2 months ago
Eureka Palace Hotel Spa

Frequently asked questions

Are you searching for a great accommodation for your luxury holiday in Syracuse?
Travel to Fontanarossa Airport (CTA) Airport or Vincenzo Magliocco Airport (CIY) Airport, and then treat yourself to a stay at one of 9 Syracuse luxury hotels. While you're visiting, you might want to think about enjoying the ruins and sightseeing, which Syracuse is known for.
What's the best high-end place to stay in Syracuse?
Ortea Palace Hotel, Sicily, Autograph Collection is a luxury hotel with 2 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Grand Hotel Ortigia Siracusa and Grand Hotel Des Ètrangers - The Leading Hotels of the World are other upscale choices for your vacation.
How many luxury hotels will I be able to find in Syracuse?
Lie in the lap of luxury during your getaway to Syracuse in one of Expedia's 9 luxury hotels.
When can I expect good weather in Syracuse?
Planning for the weather is a good way to make your trip to Syracuse relaxing and enjoyable, especially when you're splurging. The hottest months are usually August and July with an average temp of 78°F, while the coldest months are February and January with an average of 56°F. Average annual precipitation for Syracuse is 26 inches.
What's there to see and do in Syracuse?
Experience all that Syracuse has to offer when you visit Temple of Apollo, Lungomare di Ortigia, and Piazza del Duomo. If you have a little extra time during your trip, you might want to check out Cathedral of Syracuse and Porto Piccolo.
How can I get around Syracuse?
It's easier to get around town in style when you know your options. To explore the surrounding area, ride one of the trains from Syracuse Station or Targia Station.

Explore a world of travel with Expedia