A coastal fortress with a stone wall and a tiled-roof building.

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Check availability on Syracuse Luxury Hotels

Tonight
Sep 30 - Oct 1
Tomorrow
Oct 1 - Oct 2
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Syracuse luxury hotels

A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A balcony with a glass table and two red chairs, overlooking a coastal view with buildings and boats.
A grand atrium with a central column, ornate railings, and a large mural on the wall.
A dining table with multiple plates and wine glasses, set against a backdrop of a scenic ocean view.

1. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
  • Mediterranean luxury awaits at this 5-star Syracuse hotel with spa, sauna, and two restaurants near Ortigia's beaches.
￥90,834
￥101,702 total
includes taxes & fees
Oct 14 - Oct 15
Ortea Palace Hotel, Sicily, Autograph Collection
A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A terrace with a view of the sea and a cruise ship, featuring outdoor seating and potted cacti.
A grand hallway with ornate columns, a tiled floor, and large potted plants.
A spacious dining area with round tables and blue chairs, large windows offering a city view, and a wooden ceiling structure.

2. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
  • Discover the epitome of Mediterranean luxury steps from Ortigia's coastline at this spa-focused retreat with poolside indulgence.
￥103,036
￥115,130 total
includes taxes & fees
Oct 3 - Oct 4
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A large swimming pool with a modern building in the background.
A sauna with wooden benches and a central stone pillar.
An outdoor dining area with tables and chairs, a pool, and palm trees in the background.
A beach with clear turquoise water, sandy shore, and sparse vegetation.

3. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
  • Sicilian spa escape boasts 2 outdoor pools and a serene full-service wellness center.
￥66,367
￥74,787 total
includes taxes & fees
Oct 23 - Oct 24
Wellness & Spa Hotel Principe di Fitalia
A historic building with a central entrance, multiple balconies, and a large potted plant in front.
A spacious living area with a large mirror, a chandelier, and a fireplace. There are multiple seating options including a sofa and chairs.
An interior view of a restaurant with stone arches, wooden beams, and tables set for dining.
An interior corridor with an arched stone doorway, a staircase, and a table with a vase of flowers.

4. Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel
Ortigia
  • Historic charm meets seaside luxury in Syracuse with private balconies, rainfall showers, and sea-view breakfast.
￥30,755
￥35,620 total
includes taxes & fees
Oct 31 - Nov 1
Algila' Ortigia Charme Hotel
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A modern bathroom with a freestanding bathtub, a round table with a magazine, and a view of a pool and greenery.
A modern bathroom with a freestanding bathtub, a small table with toiletries, and a view of the ocean.
A pathway lined with palm trees leading to a building with a red-tiled roof.

5. Minareto

Minareto
Syracuse
  • Syracuse seaside splendor offers indulgent relaxation with private beach access, beachfront dining, and Art Deco elegance.
￥58,746
￥66,404 total
includes taxes & fees
Oct 31 - Nov 1
Minareto
A balcony with a view of the sea, a cactus, and potted plants.
A large, multi-story building with a symmetrical facade, arched windows, and a central entrance with a colorful awning.
A dining area with a table set for two, overlooking a coastal view.
A poolside area with lounge chairs and umbrellas, a clear pool, and a building with multiple windows in the background.

6. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
  • Experience luxury at grand hotel with spa services, private beach, and seaside dining in Ortigia.
￥51,755
￥58,720 total
includes taxes & fees
Oct 7 - Oct 8
Grand Hotel Ortigia Siracusa
A riverside walkway with people walking and sitting, overlooking a body of water.
A buffet with various food items, including pastries, fruits, and beverages.
A bedroom with a stone wall, a bed with a headboard, a desk, a chair, a television, and a window with a view of the sea.
A stone staircase with a large urn on the landing, leading to a balcony with a metal railing overlooking the sea.

7. Charme Hotel Henry's House

Charme Hotel Henry's House
Ortigia
  • Luxurious Mediterranean retreat offers memory foam beds, designer toiletries, and sea-view rooftop terrace in Ortigia.
￥52,121
￥59,117 total
includes taxes & fees
Oct 31 - Nov 1
Charme Hotel Henry's House
A woman holding a wine glass on a balcony overlooking a street with historic buildings and a clock tower.
A grand lobby with arched ceilings, marble columns, a chandelier, and a reception desk.
A building with three balconies, a central entrance with an archway, and a sign indicating it is a small luxury hotel.
A bar with a stone ceiling, a marble countertop, and shelves stocked with liquor bottles.

8. Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection
Ortigia
  • Relax in a grand Beaux Arts hotel in Ortigia, where upscale comfort meets historic charm steps from Syracuse Cathedral.
￥50,728
￥57,585 total
includes taxes & fees
Oct 31 - Nov 1
Palazzo Artemide - VRetreats, SLH Collection
A spa room with a large window, a hot tub, and two candles.
A courtyard with a stone pathway, palm trees, and potted plants.
A spacious living room with a high ceiling, white sofas, a coffee table, and a large mirror.
A stone building with arched walkways and outdoor seating areas.

9. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Syracuse
  • Coastal luxury awaits at this five-star retreat offering a full-service spa, two outdoor pools, and Mediterranean dining near Fanusa Beach.
￥48,116
￥54,711 total
includes taxes & fees
Oct 21 - Oct 22
Dimora Caiammari Luxury Hotel & Spa
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A multi-story building with a rooftop terrace, balconies, and a street view.
A multi-story building with a rooftop terrace featuring outdoor seating and a hot tub.
A modern hotel room with a stone wall, a staircase, a seating area with two chairs, a small table, and a desk with a phone and a lamp.

10. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
  • Elegant Mediterranean luxury, impeccable service, and fine dining near Ortigia await at this boutique Syracuse hotel.
￥28,385
￥33,008 total
includes taxes & fees
Oct 28 - Oct 29
Caportigia Boutique Hotel
View all properties

Top Syracuse Hotel Reviews

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

10/10 Excellent
"Beautiful hotel with wonderful hospitality We absolutely loved our stay at Hotel Algilà Ortigia Charme. From the moment we arrived, the staff were warm, friendly and genuinely welcoming. The hotel is full of Sicilian character and charm, and its location in Ortigia was perfect for exploring on foot. Our room was comfortable and beautifully suited to the character of the hotel, and the staff were always happy to help with recommendations and anything we needed. After travelling throughout Sicily for two weeks, what stood out most was the genuine hospitality. We felt like valued guests, not just another reservation. Algilà was exactly what we hoped for from a Sicilian hotel — charming, personal and welcoming. We would happily stay here again and highly recommend it to anyone visiting Ortigia!"
Sarah 3-night trip
Posted 6 hours ago
Algila' Ortigia Charme Hotel
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

8/10 Good
"The hotel is conveniently located and balcony restaurant and bar had a great view."
SEAN 3-night trip
Posted 10 hours ago
Grand Hotel Ortigia Siracusa
Grand Hotel Villa Politi

Grand Hotel Villa Politi

10/10 Excellent
"Nice hotel, good breakfast, beautiful pool, decent rooms, helpful staff. Free parking is a plus. Easy to access Ortigia by car and easy to access local beaches by car."
Peter 3-night trip
Posted 22 hours ago
Grand Hotel Villa Politi
Grande Albergo Alfeo

Grande Albergo Alfeo

10/10 Excellent
"We enjoyed our stay"
Anna 3-night trip
Posted 22 hours ago
Grande Albergo Alfeo
Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection

10/10 Excellent
"El mejor de Ortigia"
William 2-night trip
Posted 2 weeks ago
Palazzo Artemide - VRetreats, SLH Collection
Eureka Palace Hotel Spa

Eureka Palace Hotel Spa

8/10 Good
"The rooms were spacious and clean. The spa was also very good and well maintained"
IKECHUKWU 6-night trip
Posted 1 month ago
Eureka Palace Hotel Spa

Frequently asked questions

Are you searching for a great accommodation for your luxury holiday in Syracuse?
Travel to Fontanarossa Airport (CTA) Airport or Vincenzo Magliocco Airport (CIY) Airport, and then treat yourself to a stay at one of 9 Syracuse luxury hotels. While you're visiting, you might want to think about enjoying the ruins and sightseeing, which Syracuse is known for.
What's the best high-end place to stay in Syracuse?
Ortea Palace Hotel, Sicily, Autograph Collection is a luxury hotel with 2 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Grand Hotel Ortigia Siracusa and Grand Hotel Des Ètrangers - The Leading Hotels of the World are other upscale choices for your vacation.
How many luxury hotels will I be able to find in Syracuse?
Lie in the lap of luxury during your getaway to Syracuse in one of Expedia's 9 luxury hotels.
When can I expect good weather in Syracuse?
Planning for the weather is a good way to make your trip to Syracuse relaxing and enjoyable, especially when you're splurging. The hottest months are usually August and July with an average temp of 78°F, while the coldest months are February and January with an average of 56°F. Average annual precipitation for Syracuse is 26 inches.
What's there to see and do in Syracuse?
Experience all that Syracuse has to offer when you visit Temple of Apollo, Lungomare di Ortigia, and Piazza del Duomo. If you have a little extra time during your trip, you might want to check out Cathedral of Syracuse and Porto Piccolo.
How can I get around Syracuse?
It's easier to get around town in style when you know your options. To explore the surrounding area, ride one of the trains from Syracuse Station or Targia Station.

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