A coastal fortress with a stone wall and a tiled-roof building.

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Check availability on Syracuse 5 Star Hotels

Tonight
Sep 3 - Sep 4
Tomorrow
Sep 4 - Sep 5
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Our top choices for Syracuse 5-star hotels

A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A dining table with multiple plates and wine glasses, set against a backdrop of a scenic ocean view.
A grand atrium with a central column, ornate railings, and a large mural on the wall.
A balcony with a view of the sea and a cityscape, furnished with two chairs and a small table with a vase of flowers.

1. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
United States
kira
￥80,285
￥90,153 total
includes taxes & fees
Sep 4 - Sep 5
Ortea Palace Hotel, Sicily, Autograph Collection
A balcony with a view of the sea, a cactus, and potted plants.
A large, multi-story building with a symmetrical facade, arched windows, and a central entrance with a colorful awning.
A poolside area with lounge chairs and umbrellas, a clear pool, and a building with multiple windows in the background.
A large, classical building with multiple windows and balconies, surrounded by a calm body of water with several yachts docked.

2. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
United States
NINA
￥55,438
￥62,822 total
includes taxes & fees
Sep 23 - Sep 24
Grand Hotel Ortigia Siracusa
A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A terrace with a view of the sea and a cruise ship, featuring outdoor seating and potted cacti.
A spacious dining area with round tables and blue chairs, large windows offering a city view, and a wooden ceiling structure.
A grand hallway with a marble floor, ornate columns, and a staircase leading to an upper level.

3. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
Australia
Leanne
￥104,769
￥117,086 total
includes taxes & fees
Sep 13 - Sep 14
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A multi-story building with a rooftop terrace featuring outdoor seating and a hot tub.
A multi-story building with a rooftop terrace, balconies, and a street view.
A modern hotel room with a stone wall, a staircase, a seating area with two chairs, a small table, and a desk with a phone and a lamp.

4. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
Canada
Alessia
￥33,452
￥38,637 total
includes taxes & fees
Sep 9 - Sep 10
Caportigia Boutique Hotel
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A table set with breakfast items overlooking a coastal view.
A pathway lined with palm trees leading to a building with a red-tiled roof.
A modern bathroom with a freestanding bathtub, a round table with a magazine, and a view of a pool and greenery.

5. Minareto

Minareto
Syracuse
United States
Nariman
￥66,427
￥74,910 total
includes taxes & fees
Sep 11 - Sep 12
Minareto
A large swimming pool with a modern building in the background.
An outdoor dining area with tables and chairs, a pool, and palm trees in the background.
A woman relaxing in a spa bath with a modern design, including a ceiling with blue lighting and a tiled floor.
A beach with clear turquoise water, sandy shore, and sparse vegetation.

6. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
United States
Jeffrey
￥74,887
￥84,216 total
includes taxes & fees
Sep 22 - Sep 23
Wellness & Spa Hotel Principe di Fitalia
A spa room with a large window, a hot tub, and two candles.
A stone building with arched walkways and outdoor seating areas.
A courtyard with a stone pathway, palm trees, and potted plants.
A spacious lobby with arched ceilings, a central round table with decorative items, and a modern chandelier.

7. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Syracuse
United States
Jing
￥52,988
￥60,127 total
includes taxes & fees
Oct 2 - Oct 3
Dimora Caiammari Luxury Hotel & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
￥54,250
￥61,531 total
Sep 15 - Sep 16
includes taxes & fees
9.6/10 Exceptional! (1,001 reviews)
Algila' Ortigia Charme Hotel
Grande Albergo Alfeo

Grande Albergo Alfeo

Via Nino Bixio 5 Syracuse SR
￥20,472
￥23,339 total
Sep 27 - Sep 28
includes taxes & fees
8.6/10 Excellent! (692 reviews)
Grande Albergo Alfeo
UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA

Via Diodoro Siculo 4 Syracuse SR
￥19,819
￥22,594 total
Oct 4 - Oct 5
includes taxes & fees
8.6/10 Excellent! (550 reviews)
UNA Hotels One Siracusa Wellness & SPA
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Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"Old world Italian charm and great service. Would have preferred something more centrally located with a pool and better breakfast."
Karen 3-night trip
Posted 5 days ago
Grand Hotel Ortigia Siracusa

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Grand Hotel Ortigia Siracusa, Ortea Palace Hotel, Sicily, Autograph Collection and Grand Hotel Des Ètrangers are some of the top 5-star hotels in Syracuse, according to our customer reviews. These plush hotels rate highly for things such as their amenities, location and guest services. Book your favorite and enjoy all the luxury perks.
How much does it cost to stay in a 5-star hotel in Syracuse?
There are a variety of pricing options for a 5-star hotel in Syracuse on Expedia. The amount you pay will depend on when you want to travel, length of your trip and other factors. Compare all of the available accommodations for your desired dates and make use of our pricing and other filters to find the ideal upscale stay.
  • Search for the lowest price per night from ￥22,594
What makes a hotel 5 stars in Syracuse?
Impeccable guest service characterizes every 5-star hotel in Syracuse. From the moment you enter the lobby, staff ensure your every need is met, whether arranging customized tours or providing in-room beauty treatments. On top of that, hotels must feature superior amenities to be entitled to a 5-star rating. These can include luxury bathrooms, on-site spa facilities, swimming pools, gourmet kitchens and knowledgeable concierge.

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