Find 5 Star Hotels in Syracuse from ￥18,377

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Check availability on Syracuse 5 Star Hotels

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Compare Syracuse 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

5.0 star property
Ortigia
9.4 out of 10, Exceptional, (250)
"Great location and very friendly staff"
United States
James
The price is ￥36,714
￥42,195 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Ortea Palace Hotel, Sicily, Autograph Collection
Aerial view
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

5.0 star property
Ortigia
9.0 out of 10, Wonderful, (570)
"Great stay!"
United States
Liza
The price is ￥31,666
￥36,642 total
includes taxes & fees
Dec 18 - Dec 19
Grand Hotel Ortigia Siracusa
Terrace/patio
Caportigia Boutique Hotel

Caportigia Boutique Hotel

5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (256)
"Fine quality hotel with exceptional service. "
United States
Peter
The price is ￥18,320
￥21,963 total
includes taxes & fees
Dec 6 - Dec 7
Caportigia Boutique Hotel
Building design
Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World

5.0 star property
Ortigia
9.6 out of 10, Exceptional, (73)
"Great hotel and saff"
United States
Galina
Grand Hotel Des Ètrangers - The Leading Hotels of the World
Lunch, dinner, brunch served; Italian cuisine, beach views
Minareto

Minareto

5.0 star property
Syracuse
8.8 out of 10, Excellent, (267)
"Winderfull views but the staff isn’t so supportive!"
United States
Jose
Minareto
Exterior
Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa

5.0 star property
Syracuse
9.2 out of 10, Wonderful, (209)
"We experienced outstanding service from all of the staff, the breakfast buffet was lovely, lots of options and all homemade. We had a fantastic dinner in the restaurant one evening, which we booked ahead of our trip. "
United Kingdom
David
Dimora Caiammari Luxury Hotel & Spa
Sports facility
Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia

5.0 star property
Syracuse
9.6 out of 10, Exceptional, (94)
"This was such a wonderful stay! Spotless beautiful property with friendly staff and delicious breakfast!!! Very impressed!"
United States
Jeffrey
The price is ￥61,555
￥69,519 total
includes taxes & fees
Dec 18 - Dec 19
Wellness & Spa Hotel Principe di Fitalia
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
Get rates
9.4/10 Exceptional! (896 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

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Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe

Top Syracuse Hotel Reviews

Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"breakfast was good"
John 3-night trip
Posted 1 month ago
Grand Hotel Ortigia Siracusa

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Grand Hotel Ortigia Siracusa, Ortea Palace Hotel, Sicily, Autograph Collection and Grand Hotel Des Ètrangers are some of the top 5-star hotels in Syracuse, according to our customer reviews. These plush hotels rate highly for things such as their amenities, location and guest services. Book your favorite and enjoy all the luxury perks.
How much does it cost to stay in a 5-star hotel in Syracuse?
There are a variety of pricing options for a 5-star hotel in Syracuse on Expedia. The amount you pay will depend on when you want to travel, length of your trip and other factors. Compare all of the available accommodations for your desired dates and make use of our pricing and other filters to find the ideal upscale stay.

  • Search for the lowest price per night from ￥18,377

What makes a hotel 5 stars in Syracuse?
Impeccable guest service characterizes every 5-star hotel in Syracuse. From the moment you enter the lobby, staff ensure your every need is met, whether arranging customized tours or providing in-room beauty treatments. On top of that, hotels must feature superior amenities to be entitled to a 5-star rating. These can include luxury bathrooms, on-site spa facilities, swimming pools, gourmet kitchens and knowledgeable concierge.

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