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Discover 3,668 Santa Clara hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Varanasi Hotel Boutique
Varanasi Hotel Boutique

OZ Hotel Collection
OZ Hotel Collection

Hotel Ayenda Casa Cano 1805
Hotel Ayenda Casa Cano 1805

Hotel 3 Banderas Manzanillo del Mar
Hotel 3 Banderas Manzanillo del Mar

Hotel Summer Frente Al Mar
Hotel Summer Frente Al Mar

Hotel Fenix Beach Cartagena
Hotel Fenix Beach Cartagena
Where to stay in Santa Clara

Cartagena Walled City
Cartagena Walled City is known for its ample dining options, and you can make a stop by Clock Tower and Bolivar Square while in the area.

Bocagrande
Boasting the city's most prominent hotels, this upscale area offers shopping at Plaza Bocagrande and Nao Mall, and is close to the popular Ciudad Amurallada. Enjoy various dining options and easy access to the Transcaribe station.

Cartagena Centro
Unique features of Cartagena Centro include the museums and historic sites. Make a stop by Plaza Santo Domingo or Bolivar Square while you're exploring the area.
Getsemani
Travelers come to Getsemani for its abundant dining options, and you can see top attractions like Plaza de la Trinidad and Los Pegasos Dock while you're in town.
La Boquilla
The beaches and abundant dining options are top of the list for many visitors to La Boquilla. A stop by La Boquilla Beach or Las Americas International Convention Center might round out your trip.
Explore a world of travel with Expedia
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Hotels in top Cartagena neighborhoods
- Hotels in Cartagena Walled City
- Hotels in Bocagrande
- Hotels in Cartagena Centro
- Hotels in Getsemani
- Hotels in La Boquilla
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