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Check prices for these dates

Tonight
Mar 16 - Mar 17
Tomorrow
Mar 17 - Mar 18
This weekend
Mar 20 - Mar 22
Next weekend
Mar 27 - Mar 29

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,005 reviews)
"Very nice for overnight stay"
United States
Scott
The price is ￥15,013
￥17,261 total
includes taxes & fees
Mar 22 - Mar 23
Drury Inn & Suites Sikeston, MO
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (751 reviews)
"The staff was great very helpful and friendly "
United States
Javier
The price is ￥7,881
￥8,509 total
includes taxes & fees
Mar 22 - Mar 23
New Orleans Inn Portageville
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (367 reviews)
"Great stay. "
United States
Paul
The price is ￥12,012
￥14,264 total
includes taxes & fees
Apr 6 - Apr 7
Sleep Inn at Discovery Park of America
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.2 out of 10, Very Good, (51 reviews)
"Room was clean and fairly priced. "
United States
Mickey
The price is ￥10,696
￥12,218 total
includes taxes & fees
Apr 3 - Apr 4
Super 8 By Wyndham Marston
Individually decorated, individually furnished, desk, blackout drapes

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (750 reviews)
"The room was clean and comfortable. Check in staff was friendly. "
United States
Jennifer
The price is ￥9,662
￥11,013 total
includes taxes & fees
Mar 18 - Mar 19
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (555 reviews)
"Very clean nice staff and well run "
United States
zach
The price is ￥11,499
￥13,655 total
includes taxes & fees
Mar 17 - Mar 18
Country Hearth Inn & Suites Union City
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (63 reviews)
"Nice quiet hotel "
United States
Steven
The price is ￥16,133
￥18,267 total
includes taxes & fees
Mar 22 - Mar 23
Fairfield Inn & Suites by Marriott Sikeston
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,003 reviews)
"nice and covenant have stay here a few times, staff always has a smile. "
United States
Roger
The price is ￥13,032
￥14,853 total
includes taxes & fees
Mar 22 - Mar 23
Best Western Plus Sikeston I-55
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (500 reviews)
"All was pretty good except for the breakfast."
United States
Jeffrey
The price is ￥10,726
￥12,738 total
includes taxes & fees
Mar 29 - Mar 30
Quality Inn Union City US 51
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (409 reviews)
"The staff was very friendly and accommodating "
United States
Arturo
The price is ￥11,181
￥12,407 total
includes taxes & fees
Mar 17 - Mar 18
The Riverstone Hotel Charleston-Sikeston
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (625 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is ￥9,919
￥11,008 total
includes taxes & fees
Mar 17 - Mar 18
Super 8 by Wyndham Charleston/Sikeston East MO
1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,005 reviews)
"Great clean and quiet room "
United States
Susan
The price is ￥10,862
￥12,380 total
includes taxes & fees
Mar 18 - Mar 19
Days Inn and Suites by Wyndham Sikeston
Free daily continental breakfast

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (449 reviews)
"Stay was excellent "
United States
Kourtney
The price is ￥14,855
￥16,819 total
includes taxes & fees
Mar 29 - Mar 30
Holiday Inn Express & Suites Sikeston Southwest by IHG
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (502 reviews)
"Great stay"
United States
grant
The price is ￥14,670
￥16,610 total
includes taxes & fees
Apr 12 - Apr 13
Hampton Inn Sikeston
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (282 reviews)
"The room was somewhat clean, but that’s the best I can say. The door from outside to the hallway didn’t lock or even close all the way. No staff and the office closed 11pm-5am. Sketchy part of town. No eateries close by. I would not recommend. Didn’t feel safe but we were exhausted so we stayed."
United States
Tammie
The price is ￥10,868
￥12,062 total
includes taxes & fees
Mar 27 - Mar 28
Quality Inn Cairo I-57
Standard Room, 2 Double Beds, Non Smoking | Blackout drapes, iron/ironing board, free WiFi, bed sheets

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (472 reviews)
"Everything great "
United States
Jayla
The price is ￥11,026
￥12,652 total
includes taxes & fees
Mar 20 - Mar 21
Reelfoot Lake Inn
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (14 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is ￥18,848
￥21,341 total
includes taxes & fees
Mar 22 - Mar 23
TownePlace Suites by Marriott Sikeston
Soundproofing, free WiFi, bed sheets

Travel Inn

Travel Inn
2.5 star property
Marston
6.0 out of 10, (118 reviews)
"Had a great time loved it "
United States
Shyianne
The price is ￥8,763
￥10,010 total
includes taxes & fees
Mar 29 - Mar 30
Travel Inn
Desk, free WiFi, bed sheets, alarm clocks

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (288 reviews)
"The hotel was very clean, beds were comfortable, and staff was friendly and helpful."
United States
aileen
The price is ￥14,799
￥16,867 total
includes taxes & fees
Mar 22 - Mar 23
Comfort Inn & Suites Sikeston I-55
Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105 reviews)
"Convenient "
United States
Marcelle
The price is ￥10,189
￥11,309 total
includes taxes & fees
Mar 17 - Mar 18
Eagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Great property "
David V 1-night trip
Posted 8 hours ago
Drury Inn & Suites Sikeston, MO

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is ￥9,662 per night from Mar 18 to Mar 19
￥9,662
per night
Mar 18 - Mar 19
8.4/10 Very Good! (750 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best vacation rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: Visitors like this East Prairie vacation home rental. It is located on a lake and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 32 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.