Top 10 Hotels in East Prairie, MO from ￥8,924 - Competitive Prices

A tree-lined landscape with a river and fields.

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Our top choices for East Prairie hotels

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

1. Drury Inn & Suites Sikeston, MO

Sikeston

Scott Andrew

￥14,498

￥16,669 total

includes taxes & fees

Sep 27 - Sep 28

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

2. Hampton Inn Sikeston

Sikeston

Jeffrey

￥15,774

￥17,860 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A buffet with various food items, including omelets and baked goods, served in metal containers.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

￥16,289

￥18,443 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a counter, a flat-screen TV, and a window with blinds.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

4. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

Crystal

￥9,178

￥10,185 total

includes taxes & fees

Sep 17 - Sep 18

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A Travel Inn and Suites building with a prominent illuminated sign, a brick facade, and a parking lot.

A reception area with a sign for 'Travel Inn and Suites'.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

5. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

￥9,702

￥11,058 total

includes taxes & fees

Oct 11 - Oct 12

A building with a fountain and flower beds in front.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

6. The Riverstone Hotel Charleston-Sikeston

Charleston

Jay

￥10,256

￥11,382 total

includes taxes & fees

Sep 18 - Sep 19

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

7. Best Western Plus Sikeston I-55

Sikeston

Bernice

￥13,526

￥15,416 total

includes taxes & fees

Sep 20 - Sep 21

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

8. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

￥15,668

￥17,742 total

includes taxes & fees

Sep 27 - Sep 28

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

9. Days Inn and Suites by Wyndham Sikeston

Sikeston

Val

￥10,287

￥11,724 total

includes taxes & fees

Sep 20 - Sep 21

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

10. Super 8 By Wyndham Marston

Marston

Rachel

￥8,894

￥10,159 total

includes taxes & fees

Sep 25 - Sep 26

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

11. Comfort Inn & Suites Sikeston I-55

Sikeston

Starlette

￥13,571

￥15,467 total

includes taxes & fees

Oct 11 - Oct 12

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.

A corridor with a vending machine displaying various beverages and a wall with hanging products.

12. Sleep Inn at Discovery Park of America

Union City

Ben

￥12,187

￥14,471 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A reception area with a counter, a coffee machine, and seating.

A bathroom with a bathtub, toilet, and shower curtain.

13. Country Yard Inn and Suite

Sikeston

William

￥8,936

￥10,631 total

includes taxes & fees

Oct 17 - Oct 18

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A motel with a covered entrance, multiple rooms, and a parking lot.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

14. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Kevin

￥8,861

￥10,099 total

includes taxes & fees

Sep 23 - Sep 24

A hotel dining area with a long counter, multiple tables, and chairs. There are curtains on the windows, a lamp, and a view of the outdoors.

A gym with treadmills, elliptical machines, and stationary bikes.

A reception area with a wooden counter, a television, and a sign for 'Quality Inn by Marriott'.

A hotel room with a large bed, a desk, a chair, and a bedside table.

15. Quality Inn Union City US 51

Union City

Chadwick

￥10,417

￥12,370 total

includes taxes & fees

Oct 11 - Oct 12

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

16. TownePlace Suites by Marriott Sikeston

Sikeston

Lauren

￥16,909

￥19,144 total

includes taxes & fees

Oct 11 - Oct 12

A living room with a sofa, chairs, a glass coffee table, and a TV.

A kitchen area with a coffee machine, microwave, and various appliances.

A swimming pool with a clear blue sky and clouds above.

17. Hospitality House Union City I 69 / US 51

Union City

Joan

￥8,068

￥9,581 total

includes taxes & fees

Sep 30 - Oct 1

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

18. Eagle Inn Charleston

Charleston

Jackson

￥11,876

￥13,179 total

includes taxes & fees

Sep 17 - Sep 18

A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

An indoor swimming pool with clear water, safety signs, and chairs around the pool.

A modern office space with a long desk, two chairs, and a computer. There are multiple tables and chairs in the background, and a colorful striped artwork on the wall.

A modern meeting room with red and grey chairs, a large flat-screen TV, and a wooden cabinet with decorative items.

19. Holiday Inn Express & Suites Union City by IHG

Union City

Terri

￥18,305

￥21,737 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with two beds, a television, a desk, and a mirror.

A hotel room with a dining area, a sofa, and a kitchen counter with appliances.

A reception area with a counter, a 'Manager on Duty' sign, a 'Pets Allowed' sign, a travel pin, and a window with a view.

A hotel room with a bed, a desk, a television, and a seating area with a small table.

20. Travel Inn Marston I-55 by Hotel O

Marston

Frank

￥7,423

￥8,924 total

includes taxes & fees

Sep 17 - Sep 18

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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Quality Inn Union City US 51

10/10 Excellent

"The staff was friendly. The room was clean and quiet. It is a good value."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Great stay and friendly, nice staff! Loved it!"

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"The room did not have an extra roll of toilet paper and also the hairdryer did not work. That was the only two things that was not. I was not happy with."

The Riverstone Hotel Charleston-Sikeston

8/10 Good

"Overall it was excellant, other then the toilet running constantly... Pool could have been cleaner, considering the heat-wave they were having............."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Clean room. The front desk was very kind and helpful."

Hampton Inn Sikeston

10/10 Excellent

"Really quiet place close to good restaurants and stores."

Holiday Inn Express & Suites Union City by IHG

10/10 Excellent

"This was a great location. The staff were friendly, the facility clean, and all the amenities were up to date and working properly. The gym is open 24 hours!"

For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

8/10 Good

"The property was good for our family get together offering lots of space for everyone. The host was very friendly and nice."

Reelfoot Lake Inn

10/10 Excellent

"clean room, nice lake view, very quiet area. Just a good decent place to stay. Not a fancy 5 star hotel, but well worth it to me. Great place....Thanks!"

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

￥8,861

￥10,099 total

Sep 23 - Sep 24

includes taxes & fees

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO

￥9,702

￥11,058 total

Oct 11 - Oct 12

includes taxes & fees

8.4/10 Very Good! (821 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

￥10,287

￥11,724 total

Sep 20 - Sep 21

includes taxes & fees

7.2/10 Good! (1,000 reviews)

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

￥12,187

￥14,471 total

Oct 11 - Oct 12

includes taxes & fees

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

￥13,526

￥15,416 total

Sep 20 - Sep 21

includes taxes & fees

8.4/10 Very Good! (1,004 reviews)

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

￥15,774

￥17,860 total

Oct 11 - Oct 12

includes taxes & fees

9/10 Wonderful! (621 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?

Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.

What are some of the best vacation rentals that East Prairie has to offer?

Duck Hunting, Fishing or Relaxing Family Vacation: Visitors like this East Prairie vacation home rental. It is located on a lake and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

Where can I learn more about changing or cancelling my trip to East Prairie?

To access more information about rescheduling or cancelling your trip to East Prairie, click here.

What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?

Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.

What's it like to stay in East Prairie?

Visitors are sure to enjoy all that East Prairie has to offer. There are 36 hotels and other accommodations in the surrounding area. Find out more about East Prairie.

What should I do while I'm visiting East Prairie?

The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Columbus-Belmont State Park in the area. Check out what more to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.

Find hotels in East Prairie, MO from ￥8,924

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in East Prairie

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for East Prairie hotels

1. Drury Inn & Suites Sikeston, MO

2. Hampton Inn Sikeston

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

4. Super 8 by Wyndham Charleston/Sikeston East MO

5. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

6. The Riverstone Hotel Charleston-Sikeston

7. Best Western Plus Sikeston I-55

8. Fairfield Inn & Suites by Marriott Sikeston

9. Days Inn and Suites by Wyndham Sikeston

10. Super 8 By Wyndham Marston

11. Comfort Inn & Suites Sikeston I-55

12. Sleep Inn at Discovery Park of America

13. Country Yard Inn and Suite

14. Super 8 by Wyndham Sikeston/Miner Area

15. Quality Inn Union City US 51

16. TownePlace Suites by Marriott Sikeston

17. Hospitality House Union City I 69 / US 51

18. Eagle Inn Charleston

19. Holiday Inn Express & Suites Union City by IHG

20. Travel Inn Marston I-55 by Hotel O

Stay near popular East Prairie attractions

Big Oak Tree State Park

Learn more about East Prairie

Top East Prairie Hotel Reviews

Quality Inn Union City US 51

Drury Inn & Suites Sikeston, MO

Days Inn and Suites by Wyndham Sikeston

The Riverstone Hotel Charleston-Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hampton Inn Sikeston

Holiday Inn Express & Suites Union City by IHG

For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

Reelfoot Lake Inn

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Days Inn and Suites by Wyndham Sikeston

Sleep Inn at Discovery Park of America

Best Western Plus Sikeston I-55

Hampton Inn Sikeston

Frequently asked questions

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