The Mississippi River near Hannibal, Missouri, USA

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Check prices for these dates

This weekend
Jun 19 - Jun 21
Next weekend
Jun 26 - Jun 28

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,021 reviews)
"Great place!"
United States
Jennifer
The price is ￥15,068
￥17,325 total
includes taxes & fees
Jun 21 - Jun 22
Drury Inn & Suites Sikeston, MO
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (770 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is ￥8,181
￥8,833 total
includes taxes & fees
Jun 21 - Jun 22
New Orleans Inn Portageville
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (648 reviews)
"Staff is great rooms clean no bugs and bed was comfortable "
United States
James
The price is ￥10,389
￥11,840 total
includes taxes & fees
Jun 21 - Jun 22
Super 8 by Wyndham Sikeston/Miner Area
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (578 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
United States
Brandi
The price is ￥16,829
￥19,055 total
includes taxes & fees
Jul 12 - Jul 13
Hampton Inn Sikeston
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (416 reviews)
"It was not at all what I expected. The website showed a very good hotel. It was awful. I would not paid even $40/ night if I knew how awful it is. I felt bad for the ladies working on front desk."
United States
Soheila
The price is ￥12,024
￥13,344 total
includes taxes & fees
Jun 19 - Jun 20
The Riverstone Hotel Charleston-Sikeston
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (571 reviews)
"Ok place to say the night if you are looking for a place to sleep. "
United States
Paul
The price is ￥10,099
￥11,992 total
includes taxes & fees
Jun 18 - Jun 19
Country Hearth Inn & Suites Union City
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (469 reviews)
"Only stayed one night, no complaints"
United States
Zachary
The price is ￥17,154
￥19,422 total
includes taxes & fees
Jun 28 - Jun 29
Holiday Inn Express & Suites Sikeston Southwest by IHG
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (91 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is ￥17,635
￥19,969 total
includes taxes & fees
Jun 25 - Jun 26
Fairfield Inn & Suites by Marriott Sikeston
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (399 reviews)
"The room was clean, the breakfast was good. We enjoyed our stay."
United States
David
The price is ￥13,980
￥16,601 total
includes taxes & fees
Jul 8 - Jul 9
Sleep Inn at Discovery Park of America
Individually decorated, individually furnished, desk, blackout drapes

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (789 reviews)
"I love it there."
United States
Sharika West
The price is ￥10,808
￥12,318 total
includes taxes & fees
Jun 25 - Jun 26
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very Good, (64 reviews)
"Great hotel for the price!!! Remodel very nice and modern. "
United States
Amy
The price is ￥14,862
￥16,976 total
includes taxes & fees
Jun 18 - Jun 19
Super 8 By Wyndham Marston
Standard Room, 2 Double Beds, Non Smoking | Blackout drapes, iron/ironing board, free WiFi, bed sheets

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (497 reviews)
"The lake view was beautiful and staff was amazing"
United States
Richard
The price is ￥11,066
￥12,699 total
includes taxes & fees
Jun 18 - Jun 19
Reelfoot Lake Inn
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (641 reviews)
"Clean rooms,"
United States
Karl
The price is ￥9,544
￥10,591 total
includes taxes & fees
Jul 12 - Jul 13
Super 8 by Wyndham Charleston/Sikeston East MO
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very Good, (525 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is ￥9,948
￥11,813 total
includes taxes & fees
Jul 1 - Jul 2
Quality Inn Union City US 51
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,012 reviews)
"Very convenient and staff was great."
United States
jeanne
The price is ￥13,978
￥15,932 total
includes taxes & fees
Jul 14 - Jul 15
Best Western Plus Sikeston I-55
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (186 reviews)
"Friendly staff, comfortable bed."
United States
James
The price is ￥19,062
￥22,635 total
includes taxes & fees
Jun 25 - Jun 26
Hampton Inn Union City
Iron/ironing board, free WiFi, bed sheets

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (139 reviews)
"Enjoyed our stay. All the appliances worked and our air conditioner kept us cool! Will definitely stay here again!"
United States
Sheryl
The price is ￥9,099
￥10,825 total
includes taxes & fees
Jun 21 - Jun 22
Country Yard Inn and Suite
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (393 reviews)
"Traveling through the area. It met our needs."
United States
Pamela
The price is ￥9,138
￥10,852 total
includes taxes & fees
Jun 28 - Jun 29
Hospitality House Union City I 69 / US 51
1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,009 reviews)
"When I stay at hotels I like to find hotels like this one for the $$$ value . This hotel was clean and the bed was very comfortable. Room 237 . I didn’t hear any interstate noise . I didn’t eat the breakfast but the coffee was very good . I would stay here again ."
United States
Kurt
The price is ￥11,176
￥12,739 total
includes taxes & fees
Jul 14 - Jul 15
Days Inn and Suites by Wyndham Sikeston
Exterior

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (330 reviews)
"I enjoy myself and I will recommend anybody to stay.."
United States
Faye
The price is ￥17,635
￥20,941 total
includes taxes & fees
Jun 28 - Jun 29
Holiday Inn Express & Suites Union City by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

4.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent
"Everything was good. Rooms were cleaned, breakfast was good and fresh, and staff was helpful and nice.."
Tonya 2-night trip
Posted 8 hours ago
Fairfield Inn & Suites by Marriott Sikeston

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
The price is ￥10,389 per night from Jun 21 to Jun 22
￥10,389
￥11,840 total
Jun 21 - Jun 22
includes taxes & fees
7/10 Good! (648 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best vacation rentals that East Prairie has to offer?
The Tackle Box at Reelfoot: Visitors like this East Prairie vacation home rental. It has air-conditioning and WiFi to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 33 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.