A beach with a wooden pavilion, clear blue sky, and dense green foliage.

Find 5 Star Hotels in Lower Matecumbe Key, FL from ￥36,008

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Lower Matecumbe Key 5 Star Hotels

Tonight
Sep 9 - Sep 10
Tomorrow
Sep 10 - Sep 11
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Our top choices for Lower Matecumbe Key 5-star hotels

A bathroom with a large bathtub, a window with curtains, and a view of palm trees and the sea.
A tropical resort with a swimming pool, palm trees, and a waterfall.
A bar area with a thatched roof, wooden chairs, and a view of the ocean.
A hotel room with a large bed, a television, a dining area with chairs, a table, and a view of the ocean.

1. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
United States
Mian
￥22,904
￥37,010 total
includes taxes & fees
Sep 15 - Sep 16
Cheeca Lodge & Spa
A resort pool with a view of the sea, surrounded by palm trees and lounge chairs.
A clean, empty garage with fluorescent lighting, a metal garage door, and visible plumbing on the ceiling.
A modern white building with a garage, surrounded by palm trees and a clear blue sky.
A wooden deck with a spiral staircase leading to an upper level.

2. Sea Glass Cove

Sea Glass Cove
Marathon
Sea Glass Cove
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Lower Matecumbe Key.
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

97000 Overseas Hwy Key Largo FL
￥36,334
￥49,328 total
Sep 28 - Sep 29
includes taxes & fees
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Amara Cay Resort

Amara Cay Resort

80001 Overseas Hwy Islamorada FL
￥22,041
￥36,008 total
Sep 28 - Sep 29
includes taxes & fees
8.8/10 Excellent! (1,315 reviews)
Amara Cay Resort
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

84001 Overseas Hwy Islamorada FL
￥28,088
￥42,811 total
Sep 16 - Sep 17
includes taxes & fees
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Still don't see what you're looking for?
See all properties in Lower Matecumbe Key.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Lower Matecumbe Key

Check out the local area in Lower Matecumbe Key—home to attractions like Robbie’s of Islamorada and Anne's Beach.

See all hotels in Lower Matecumbe Key
A beach with a wooden pavilion, clear blue sky, and dense green foliage.

Top Lower Matecumbe Key Hotel Reviews

Explore a world of travel with Expedia