A white colonial church with ornate architecture and a large wooden door.

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Check prices for these dates

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Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22

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Our top choices for Santa Ana hotels

A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

1. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ￥17,841
￥21,766 total
includes taxes & fees
Nov 9 - Nov 10
Villas Santa Ana-Ricardo
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

2. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,196 reviews)
"Great stay. Spa is amazing"
United States
Julio
The price is ￥51,031
￥65,167 total
includes taxes & fees
Dec 9 - Dec 10
Hotel Museo Spa Casa Santo Domingo
A garden pathway leading to a building with a green lawn and a clear blue sky.

3. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,000 reviews)
"Good place to stay"
United States
Michael
The price is ￥18,678
￥23,049 total
includes taxes & fees
Dec 9 - Dec 10
Hotel Soleil La Antigua
A courtyard with a tiled roof, a building with a dome, and a mountain in the background.

4. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,002 reviews)
"Everything was close to.. very nice staff and the property was amazing."
United States
Stephanie
The price is ￥32,488
￥43,598 total
includes taxes & fees
Nov 9 - Nov 10
Hotel Camino Real Antigua
A restaurant with a brick wall, wine racks, and tables set for dining.

5. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"Nice hotel friendly staff and helpful"
United States
Hilda
The price is ￥23,965
￥30,585 total
includes taxes & fees
Dec 9 - Dec 10
Los Pasos Boutique Hotel & Spa
A covered outdoor seating area with wicker furniture and hanging lights.

6. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (477 reviews)
"I had a great stay at Ciel Luxe Hotel! The room was clean and comfortable, the staff was friendly, and the location was convenient. I’d definitely stay here again!"
United States
Corey
The price is ￥13,164
￥16,119 total
includes taxes & fees
Dec 9 - Dec 10
Ciel-Luxe Hotels
A stone pathway leading to a central fountain, flanked by walls adorned with framed artwork.

7. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,002 reviews)
"Very nice property, location was great and amenities were excellent."
United States
Oscar
The price is ￥30,792
￥37,566 total
includes taxes & fees
Nov 9 - Nov 10
Porta Hotel Antigua
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

8. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (962 reviews)
"The breakfast and staff are incredible! Great location!"
United States
Jennifer
The price is ￥17,416
￥21,248 total
includes taxes & fees
Nov 16 - Nov 17
El Carmen Hotel
A courtyard with a fountain, stone pathway, and seating area surrounded by greenery.

9. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (955 reviews)
"What a beautiful hotel!"
United States
Kristen
The price is ￥38,487
￥49,331 total
includes taxes & fees
Dec 9 - Dec 10
El Convento Boutique Hotel
An indoor courtyard with stone flooring, multiple seating areas, and string lights.

10. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (390 reviews)
"The staff was wonderful! The location was perfect! The hotel was beautiful! I would definitely recommend! There’s hot water, and WiFi!"
United States
Carlos
The price is ￥10,056
￥12,410 total
includes taxes & fees
Dec 9 - Dec 10
Hotel Casa Carmina by AHS
An outdoor dining area with stone seating and tables, surrounded by lush greenery and a yellow building with a tiled roof.

11. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (814 reviews)
"Very nice hotel!"
United States
Katie
The price is ￥20,111
￥24,817 total
includes taxes & fees
Nov 12 - Nov 13
Hotel Las Farolas
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

12. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (264 reviews)
"Fantastic hotel"
Canada
Alysha
The price is ￥14,709
￥17,945 total
includes taxes & fees
Nov 29 - Nov 30
Casa Noble Hotel
A covered outdoor seating area with a sofa, coffee table, and chairs, surrounded by potted plants and a stone wall.

13. Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (418 reviews)
"Delicious breakfast, nive place, close to everything, I really enjoyed staying there"
United States
Ligia
The price is ￥24,896
￥30,374 total
includes taxes & fees
Nov 9 - Nov 10
Casa Santa Rosa Hotel Boutique
A courtyard with a fountain, potted plants, and outdoor seating.

14. Hotel Convento Santa Catalina

Hotel Convento Santa Catalina
3.5 star property
Historic Center, 1.6 km from Santa Ana
8.2 out of 10, Very good, (684 reviews)
"Very clean and staff is friendly. Location is amazing!"
United States
Rita
The price is ￥10,525
￥12,840 total
includes taxes & fees
Dec 8 - Dec 9
Hotel Convento Santa Catalina
A stone building with arched entrances and a balcony with wrought iron railings.

15. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (518 reviews)
"Great place to stay"
United States
Mauricio
The price is ￥18,319
￥22,561 total
includes taxes & fees
Nov 18 - Nov 19
Meson Panza Verde
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

16. San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (502 reviews)
"We loved it!! The location is great. The room was amazing, the breakfast, the staff… everything was perfect."
Mexico
Francisco Benjamin Macias
The price is ￥32,812
￥40,505 total
includes taxes & fees
Nov 30 - Dec 1
San Rafael Hotel
A covered walkway with wooden pillars and tropical plants.

17. Good Hotel Antigua Guatemala, a Member of Design Hotels

Good Hotel Antigua Guatemala, a Member of Design Hotels
4.0 star property
0.8 km from Santa Ana
9.4 out of 10, Exceptional, (571 reviews)
"The hotel was very wonderful!! Saul Bistro connects to the hotel which was amazing and convenient. The staff was the best!! I can’t say enough great things about this place"
United States
Brandon Jordani
The price is ￥41,460
￥50,581 total
includes taxes & fees
Dec 9 - Dec 10
Good Hotel Antigua Guatemala, a Member of Design Hotels
A courtyard with cobblestone flooring, a building with a tiled roof, and a mountain in the background.

18. All Suite El Marques de Antigua

All Suite El Marques de Antigua
3.5 star property
1 km from Santa Ana
9.4 out of 10, Exceptional, (413 reviews)
"Clean beautiful place to stay"
United States
Leny
The price is ￥11,518
￥14,185 total
includes taxes & fees
Dec 8 - Dec 9
All Suite El Marques de Antigua
An outdoor patio with tables and chairs, stone walls, and string lights.

19. Mestizo Antigua

Mestizo Antigua
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (221 reviews)
"Staff was very friendly and accommodating. Highly recommend!"
United States
Lucy
The price is ￥24,215
￥29,543 total
includes taxes & fees
Nov 24 - Nov 25
Mestizo Antigua
A lush garden with a rock waterfall, potted plants, and a well-maintained lawn.

20. Hotel Camelias Inn by AHS

Hotel Camelias Inn by AHS
3.0 star property
Historic Center, 1.2 km from Santa Ana
8.8 out of 10, Excellent, (709 reviews)
"Amazing front desk team, very helpful and give us great tips."
United States
Carlos
The price is ￥10,480
￥12,786 total
includes taxes & fees
Nov 11 - Nov 12
Hotel Camelias Inn by AHS
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.
Villas Santa Ana-Ricardo
3.5 star property
9.0
Wonderful
17 reviews
View
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.
Casa Noble Hotel
3.0 star property
9.6
Exceptional
264 reviews
View
A corridor with a bench, potted plants, and a hanging light fixture.
Nico Hotel
3.0 star property
9.0
Wonderful
474 reviews
View
A courtyard with potted plants, a dining area with tables and chairs, and a staircase leading to an upper level.
Hotel La Galeria
3.0 star property
9.4
Exceptional
306 reviews
View
An indoor courtyard with stone flooring, multiple seating areas, and string lights.
Hotel Casa Carmina by AHS
4.0 star property
8.8
Excellent
390 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Adriatika Hotel & Residence

Adriatika Hotel & Residence

8/10 Good
"Quiet central location. Kitchen is nice but doesn’t have any plates, glasses etc. Pool and jacuzzi area is nice. Restaurant is adequate and breakfast was good."
Nicholas 3-night trip
Posted 1 hour ago
Adriatika Hotel & Residence

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.