Find hotels in Santa Ana, Antigua Guatemala

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Our top choices for Santa Ana hotels

Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
8.8 out of 10, Excellent, (13 reviews)
"Space was clean and had a cozy vibe."
United States
Evelin
Villas Santa Ana-Ricardo

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (49 reviews)
"Great place !!"
United States
Abner Israel Polanco
The price is ¥10,145
¥12,377 total
includes taxes & fees
Feb 16 - Feb 17
Casa Buho B&B

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (22 reviews)
"A little too far from everything but as long as you have a car is ok plenty of parking there"
United States
Gustavo
The price is ¥7,356
¥8,975 total
includes taxes & fees
Feb 25 - Feb 26
Hostal Casa Buho

Hotel Posada del Angel

Hotel Posada del Angel
4.0 star property
1 km from Santa Ana
9.6 out of 10, Exceptional, (285 reviews)
"We had a great stay! The hotel is a very charming boutique hotel nestled in Antigua. The room was very comfortable and we were able to rest very well. The staff was always very helpful and friendly. "
United States
Janelle
Hotel Posada del Angel

Pensativo House Hotel

Pensativo House Hotel
4.5 star property
1 km from Santa Ana
9.4 out of 10, Exceptional, (396 reviews)
"Rooms were clean and bed and pillows were comfortable with good A/C. Staff was very helpful and were always ready to assist. Food was excellent. "
United States
Carlos Alvarez
Pensativo House Hotel

Hotel Las Marías

Hotel Las Marías
3.0 star property
1.9 km from Santa Ana
9.2 out of 10, Wonderful, (435 reviews)
"clean room in a good area"
United States
roghayeh
The price is ¥13,739
¥16,762 total
includes taxes & fees
Feb 15 - Feb 16
Hotel Las Marías

Don Valentino

Don Valentino
3.5 star property
Historic Center, 1.6 km from Santa Ana
7.4 out of 10, Good, (77 reviews)
"Great service! Clean rooms and the young guy in front desk was very attentive and helpful. "
United States
Azucena
The price is ¥7,844
¥9,569 total
includes taxes & fees
Mar 10 - Mar 11
Don Valentino

Hotel Posada San Vicente

Hotel Posada San Vicente
2.5 star property
Historic Center, 1.4 km from Santa Ana
8.0 out of 10, Very Good, (217 reviews)
"Clean with helpful staff. Beautiful rooftop viewing and lots of plants and flowers. Location close to everything "
Canada
DONALD EDWIN
The price is ¥8,143
¥9,934 total
includes taxes & fees
Feb 26 - Feb 27
Hotel Posada San Vicente

Hotel Cacique Real

Hotel Cacique Real
3.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (167 reviews)
"A beautiful hotel that’s in a nice location that isn’t far from all the main tourist attractions but is also slightly calmer than the main high streets. The staff were all really helpful and friendly and the breakfast was great."
United Kingdom
Magdalene
Hotel Cacique Real

Hotel La Posadita Antigua

Hotel La Posadita Antigua
3.0 star property
1.9 km from Santa Ana
8.6 out of 10, Excellent, (48 reviews)
"Nice place to stay and good location "
United States
Alfredo
Hotel La Posadita Antigua

Yes Please Hostel

Yes Please Hostel
2.5 star property
0.7 km from Santa Ana
8.0 out of 10, Very Good, (22 reviews)
"Excellent place for solo travelers"
United States
Greisy
The price is ¥7,375
¥8,997 total
includes taxes & fees
Feb 16 - Feb 17
Yes Please Hostel

Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.6 out of 10, Excellent, (375 reviews)
"Friendly and accomadating staff"
United States
Kaushal
Ciel-Luxe Hotels

Luna Maya Boutique Hotel

Luna Maya Boutique Hotel
3.0 star property
1.5 km from Santa Ana
9.6 out of 10, Exceptional, (32 reviews)
"Nice staff , nice breakfast "
United States
Lesly
The price is ¥10,190
¥12,432 total
includes taxes & fees
Feb 22 - Feb 23
Luna Maya Boutique Hotel

Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (231 reviews)
"Lovely place with exceptional service "
United States
Juan Carlos
The price is ¥38,628
¥47,126 total
includes taxes & fees
Feb 16 - Feb 17
Las Cruces Boutique Hotel

Indian Palace

Indian Palace
3.0 star property
2.8 km from Santa Ana
8.8 out of 10, Excellent, (33 reviews)
"Beautiful view to the volcanics clean area Beautiful pool, good game room i will recommend."
United States
Estuardo
The price is ¥12,249
¥14,944 total
includes taxes & fees
Feb 12 - Feb 13
Indian Palace

EL TEJAR HOSTAL

EL TEJAR HOSTAL
3.0 star property
21 km from Santa Ana
8.0 out of 10, Very Good, (17 reviews)
"Staff very friendly and helpful. Room clean and quiet. "
United States
ILEANA
The price is ¥6,170
¥7,527 total
includes taxes & fees
Feb 20 - Feb 21
EL TEJAR HOSTAL

Meson Panza Verde

Meson Panza Verde
3.5 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (447 reviews)
"This was the most amazing hotel we stayed in Antigua! Absolutely beautiful and comfortable! Staff was always very friendly and helpful. Restaurant had amazing atmosphere and food. Will definitely be returning! "
United States
Janelle
The price is ¥28,021
¥34,185 total
includes taxes & fees
Feb 23 - Feb 24
Meson Panza Verde

Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (188 reviews)
"Very nice place!"
Canada
Zaul
Casa Noble Hotel

Hotel Meson de Maria

Hotel Meson de Maria
3.5 star property
Historic Center, 1.6 km from Santa Ana
9.0 out of 10, Wonderful, (197 reviews)
"Clean room, friendly staff, great hotel overall. However the wifi wasn't great."
United States
Michael
Hotel Meson de Maria

Hotel Casa Bansley

Hotel Casa Bansley
2.5 star property
2.3 km from Santa Ana
9.8 out of 10, Exceptional, (49 reviews)
"Property is beautiful and staff are great"
United States
Michael
Hotel Casa Bansley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on Expedia customer reviews, Casa Buho B&B is the highest ranked property in Santa Ana. This hotel offers a restaurant and free parking. Another top choice in the area is Hostal Casa Buho.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 16 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.