Find hotels in Santa Ana, Antigua Guatemala

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Dec 27 - Dec 28
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Our top choices for Santa Ana hotels

Interior
Casa Buho B&B

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (48)
"Great place !!"
United States
Abner Israel Polanco
The price is ￥8,417
￥10,269 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Casa Buho B&B
Garden view
Hostal Casa Buho

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (21)
"Nice clean affordable accomodations and very accomodating and amicable hosts."
United States
Feng
The price is ￥7,156
￥8,796 total
includes taxes & fees
Jan 23 - Jan 24, 2026
Hostal Casa Buho
Front of property
Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
8.6 out of 10, Excellent, (12)
"Space was clean and had a cozy vibe."
United States
Evelin
Villas Santa Ana-Ricardo
In-room safe, desk, soundproofing, iron/ironing board
Adriatika Hotel & Residence

Adriatika Hotel & Residence

Adriatika Hotel & Residence
4.5 star property
21.9 km from Santa Ana
9.4 out of 10, Exceptional, (956)
"Great hotel close to the airport. "
United States
Itzhak
The price is ￥14,797
￥18,053 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Adriatika Hotel & Residence
Terrace/patio
Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1003)
"Great stay "
United States
BETTE
The price is ￥24,524
￥31,142 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Los Pasos Boutique Hotel & Spa
Exterior
Good Hotel Guatemala City

Good Hotel Guatemala City

Good Hotel Guatemala City
3.0 star property
23.9 km from Santa Ana
9.4 out of 10, Exceptional, (251)
"Really liked this location is great "
United States
Malika
The price is ￥15,038
￥18,347 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Good Hotel Guatemala City
View from room
Mestizo Antigua

Mestizo Antigua

Mestizo Antigua
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (156)
"The breakfast was fresh and delicious "
United States
Patricia
The price is ￥26,068
￥31,803 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Mestizo Antigua
Exterior
Naif Boutique Hotel

Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (375)
"Beautiful rooms and helpful staff in a very nicely centrally located hotel"
United States
Joe
The price is ￥19,377
￥23,640 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Naif Boutique Hotel
Garden
Hilton Guatemala City

Hilton Guatemala City

Hilton Guatemala City
4.5 star property
25.9 km from Santa Ana
8.6 out of 10, Excellent, (682)
"Great stay and amazing property "
United States
Hugo
The price is ￥15,970
￥19,483 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hilton Guatemala City
Interior entrance
Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center
4.5 star property
20.2 km from Santa Ana
9.0 out of 10, Wonderful, (1005)
"Great place to stay and relax. Beautiful rooms and great staff"
United States
Tracy
The price is ￥16,784
￥20,476 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Tikal Futura Hotel & Convention Center
Interior
Las Camelias Inn

Las Camelias Inn

Las Camelias Inn
3.0 star property
Historic Center, 1.2 km from Santa Ana
8.8 out of 10, Excellent, (583)
"Clean hotel with friendly staff. I appreciated the terrace views of Antigua it provided!"
United States
John
The price is ￥11,513
￥14,458 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Las Camelias Inn
Outdoor pool
Holiday Inn Guatemala City by IHG

Holiday Inn Guatemala City by IHG

Holiday Inn Guatemala City by IHG
3.5 star property
23.1 km from Santa Ana
9.2 out of 10, Wonderful, (1005)
"Best Holiday Inn I've ever stayed in! Really nice. Good restaurant, nice staff. Be patient with the hot water. It'll arrive in a minute or two, and be good thereafter."
United States
Alan
The price is ￥15,031
￥18,338 total
includes taxes & fees
Dec 29 - Dec 30
Holiday Inn Guatemala City by IHG
3 outdoor pools, pool umbrellas
Hotel Soleil La Antigua

Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.6 out of 10, Excellent, (1001)
"Overall good place to stay. Not a fan of the no outside food or drink policy, but aside from that this is a very nice place. Staff is especially kind and helpful."
United States
Cesar
Hotel Soleil La Antigua
Free daily continental breakfast
Ciel-Luxe Hotels

Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (352)
"Excellent customer service from the staff, great food, room was very clean and a block away from the park."
United States
Rodrigo
Ciel-Luxe Hotels
Exterior
Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (659)
"Friendly staff, clean rooms the location was excellent. "
United States
Elias
The price is ￥25,223
￥34,592 total
includes taxes & fees
Dec 29 - Dec 30
Hotel Posada de Don Rodrigo Antigua
Fitness studio
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.2 out of 10, Wonderful, (1022)
"Great room, the food was awesome and the amenities are just amazing."
United States
Cesar Luis Sinclair
The price is ￥37,264
￥47,372 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hotel Museo Spa Casa Santo Domingo
Egyptian cotton sheets, premium bedding, in-room safe, desk
El Convento Boutique Hotel

El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (810)
"Hotel was in a good location. "
United States
Paige
The price is ￥31,001
￥40,170 total
includes taxes & fees
Jan 12 - Jan 13, 2026
El Convento Boutique Hotel
Terrace/patio
El Carmen Hotel

El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (700)
"Delicious breakfast on the rooftop with stunning views of the volcanoes. Great friendly staff!! Would come back here again. "
Canada
Ryan
The price is ￥17,966
￥21,919 total
includes taxes & fees
Jan 26 - Jan 27, 2026
El Carmen Hotel
Property amenity
Porta Hotel Antigua

Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1002)
"Everything about this hotel was fantastic. The bed was so comfortable. "
United States
Raymond
The price is ￥27,672
￥35,326 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Porta Hotel Antigua
Front of property
La Inmaculada Hotel

La Inmaculada Hotel

La Inmaculada Hotel
3.5 star property
23.7 km from Santa Ana
9.2 out of 10, Wonderful, (611)
"Everything was perfect, the room was perfectly cleaned every day, the restaurant is amazing, the people that wirks there amazing!!"
United States
Claudia
La Inmaculada Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Adriatika Hotel & Residence

Adriatika Hotel & Residence

10/10 Excellent
"Great hotel close to the airport. "
Itzhak 1-night trip
Posted 2 days ago
Adriatika Hotel & Residence

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on Expedia customer reviews, Casa Buho B&B is the highest ranked property in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 17 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.