A white colonial church with ornate architecture and a large wooden door.

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Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

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Our top choices for Santa Ana hotels

A lush garden with neatly trimmed hedges forming a pathway, surrounded by dense greenery and a mountainous backdrop.

1. Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (26 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is ￥6,189
￥7,551 total
includes taxes & fees
Oct 22 - Oct 23
Hostal Casa Buho
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

2. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ￥16,036
￥19,564 total
includes taxes & fees
Oct 22 - Oct 23
Villas Santa Ana-Ricardo
A kitchen with white cabinets, a window with a view, and a potted plant on the windowsill.

3. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ￥2,102
￥4,495 total
includes taxes & fees
Oct 22 - Oct 23
Castillo De Los Gigantes
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

4. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,175 reviews)
"Great stay. Spa is amazing"
United States
Julio
The price is ￥39,016
￥49,531 total
includes taxes & fees
Oct 22 - Oct 23
Hotel Museo Spa Casa Santo Domingo
A restaurant with a brick wall, wine racks, and tables set for dining.

5. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,005 reviews)
"Nice hotel friendly staff and helpful"
United States
Hilda
The price is ￥25,010
￥31,462 total
includes taxes & fees
Nov 10 - Nov 11
Los Pasos Boutique Hotel & Spa
A cozy room with a round table, striped armchairs, and a potted plant.

6. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,000 reviews)
"What a beautiful place! We were blown away the moment we arrived. Everyone was beyond helpful and hospitable. The room was immaculate. We throughly enjoyed our stay there."
United States
Deborah Gonzales
The price is ￥29,958
￥40,512 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Camino Real Antigua
A garden pathway leading to a building with a green lawn and a clear blue sky.

7. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,000 reviews)
"Good place to stay"
United States
Michael
The price is ￥26,600
￥32,452 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Soleil La Antigua
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

8. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (952 reviews)
"The breakfast and staff are incredible! Great location!"
United States
Jennifer
The price is ￥13,704
￥16,718 total
includes taxes & fees
Oct 26 - Oct 27
El Carmen Hotel
A covered corridor with tiled flooring, potted plants, and a wooden bench.

9. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (810 reviews)
"Very nice hotel!"
United States
Katie
The price is ￥15,727
￥19,487 total
includes taxes & fees
Oct 29 - Oct 30
Hotel Las Farolas
A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

10. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (945 reviews)
"Beautiful Hotel."
United States
KEVIN
The price is ￥35,175
￥45,742 total
includes taxes & fees
Oct 29 - Oct 30
El Convento Boutique Hotel
A stone pathway leading to a central fountain, flanked by walls adorned with framed artwork.

11. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"Very nice hotel. Great view of the volcano from the restaurant."
United States
Ludim
The price is ￥28,732
￥35,755 total
includes taxes & fees
Oct 25 - Oct 26
Porta Hotel Antigua
An indoor courtyard with stone flooring, multiple seating areas, and string lights.

12. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (377 reviews)
"The staff was wonderful! The location was perfect! The hotel was beautiful! I would definitely recommend! There’s hot water, and WiFi!"
United States
Carlos
The price is ￥7,123
￥8,690 total
includes taxes & fees
Oct 27 - Oct 28
Hotel Casa Carmina by AHS
A stone building with arched entrances and a balcony with wrought iron railings.

13. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (513 reviews)
"Great place to stay"
United States
Mauricio
The price is ￥21,644
￥26,405 total
includes taxes & fees
Nov 18 - Nov 19
Meson Panza Verde
A corner with two upholstered chairs, a small round table, and a potted plant.

14. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (471 reviews)
"Great service and staff"
United States
Jose
The price is ￥13,438
￥16,395 total
includes taxes & fees
Nov 12 - Nov 13
Ciel-Luxe Hotels
A garden with a pergola, potted plants, and a chair.

15. Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (414 reviews)
"Very cozy and comfortable botique hotel. I thoroughly enjoyed my stay"
United States
Richard
The price is ￥22,116
￥26,982 total
includes taxes & fees
Oct 23 - Oct 24
Casa Santa Rosa Hotel Boutique
Courtyard

16. Hotel Genessis

Hotel Genessis
3.5 star property
0.9 km from Santa Ana
9.2 out of 10, Wonderful, (152 reviews)
"Nice hotel with friendly staff and parking (rare in Antigua)"
United States
Jonathan
The price is ￥15,440
￥18,837 total
includes taxes & fees
Oct 22 - Oct 23
Hotel Genessis
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

17. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (258 reviews)
"Clean room, good location and staff was very friendly"
United States
Kimberly
The price is ￥12,699
￥15,493 total
includes taxes & fees
Oct 25 - Oct 26
Casa Noble Hotel
A neatly made bed with colorful pillows, a wooden headboard, and a red chair.

18. Hotel Convento Santa Catalina

Hotel Convento Santa Catalina
3.5 star property
Historic Center, 1.6 km from Santa Ana
8.2 out of 10, Very good, (670 reviews)
"Great hotel, great location !"
United States
christina
The price is ￥7,569
￥9,234 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Convento Santa Catalina
A building with a covered patio area, a garden with various plants, and a hanging vine with purple flowers.

19. Hotel Aurora

Hotel Aurora
3.5 star property
Historic Center, 1.1 km from Santa Ana
9.6 out of 10, Exceptional, (430 reviews)
"Very close to everything, clean and beautiful"
United States
Mariceliz
The price is ￥14,458
￥17,639 total
includes taxes & fees
Oct 22 - Oct 23
Hotel Aurora
An outdoor patio with tables and chairs, stone walls, and string lights.

20. Mestizo Antigua

Mestizo Antigua
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (218 reviews)
"The hotel is an exceptionally beautiful boutique hotel with a quaint and tasteful blend of modern and local tradition, and the food is fresh and incredibly tasty blending delicate flavors and local cuisine. The staff really make it feel like home and like you’re part of the family. A remarkable stay that we highly recommend."
United States
thomas
The price is ￥19,922
￥24,305 total
includes taxes & fees
Oct 26 - Oct 27
Mestizo Antigua
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.
Villas Santa Ana-Ricardo
3.5 star property
9.0
Wonderful
17 reviews
View
A lush garden with neatly trimmed hedges forming a pathway, surrounded by dense greenery and a mountainous backdrop.
Hostal Casa Buho
3.0 star property
8.6
Excellent
26 reviews
View
A kitchen with white cabinets, a window with a view, and a potted plant on the windowsill.
Castillo De Los Gigantes
2.0 star property
6.0
1 review
View
A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.
Las Cruces Boutique Hotel
4.0 star property
9.8
Exceptional
287 reviews
View
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.
San Rafael Hotel
4.0 star property
9.8
Exceptional
497 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Clarion Suites Guatemala City

Clarion Suites Guatemala City

10/10 Excellent
"Me encantó, fue un viaje de descanso y asi lo pasamos"
Vanessa 2-night trip
Posted 4 hours ago
Clarion Suites Guatemala City

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.