A white colonial church with ornate architecture and a large wooden door.

Find hotels in Santa Ana, Antigua Guatemala

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

1. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ￥14,758
￥18,265 total
includes taxes & fees
Oct 4 - Oct 5
Villas Santa Ana-Ricardo
A lush garden with neatly trimmed hedges forming a pathway, surrounded by dense greenery and a mountainous backdrop.

2. Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (26 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is ￥5,974
￥7,288 total
includes taxes & fees
Oct 14 - Oct 15
Hostal Casa Buho
A rooftop with a red roof, a white railing, and a view of a mountainous landscape.

3. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ￥2,089
￥4,469 total
includes taxes & fees
Oct 10 - Oct 11
Castillo De Los Gigantes
A garden pathway leading to a building with a green lawn and a clear blue sky.

4. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,000 reviews)
"It is a beautiful and quiet hotel. Perfect place for families."
United States
Johanna Elizabeth
The price is ￥18,311
￥22,339 total
includes taxes & fees
Oct 1 - Oct 2
Hotel Soleil La Antigua
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

5. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,162 reviews)
"Outstanding staff and the hotel was beautiful"
United States
Mario
The price is ￥37,464
￥47,626 total
includes taxes & fees
Oct 1 - Oct 2
Hotel Museo Spa Casa Santo Domingo
A covered corridor with tiled flooring, potted plants, and a wooden bench.

6. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (807 reviews)
"Hotel was conveniently located. But the walls were really thin. We were in front of the restaurant and the main hall so you can hear EVERYTHING and Everyone. Overall ok hotel and convenient location."
United States
Erika
The price is ￥14,801
￥18,229 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Las Farolas
A stone pathway leading to a central fountain, flanked by walls adorned with framed artwork.

7. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"I loved my stay will be back my next time around"
United States
LESLIE A
The price is ￥22,848
￥28,434 total
includes taxes & fees
Oct 6 - Oct 7
Porta Hotel Antigua
A cozy room with a round table, striped armchairs, and a potted plant.

8. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,005 reviews)
"Very clean room staff was very helpful with accommodations and I would come back again"
United States
Simon
The price is ￥29,743
￥40,220 total
includes taxes & fees
Oct 7 - Oct 8
Hotel Camino Real Antigua
A corner with two upholstered chairs, a small round table, and a potted plant.

9. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (461 reviews)
"Great hospitality"
United States
abdessamad
The price is ￥13,358
￥16,297 total
includes taxes & fees
Oct 1 - Oct 2
Ciel-Luxe Hotels
A stone building with arched entrances and a balcony with wrought iron railings.

10. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (504 reviews)
"Great place to stay"
United States
Mauricio
The price is ￥15,191
￥18,746 total
includes taxes & fees
Oct 2 - Oct 3
Meson Panza Verde
A restaurant with a brick wall, wine racks, and tables set for dining.

11. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"Great breakfast."
Canada
Harvey
The price is ￥24,159
￥30,418 total
includes taxes & fees
Oct 27 - Oct 28
Los Pasos Boutique Hotel & Spa
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

12. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (928 reviews)
"Great breakfast and room service, affordable spa"
United States
Keishawn
The price is ￥14,103
￥17,205 total
includes taxes & fees
Oct 2 - Oct 3
El Carmen Hotel
A building with a covered patio area, a garden with various plants, and a hanging vine with purple flowers.

13. Hotel Aurora

Hotel Aurora
3.5 star property
Historic Center, 1.1 km from Santa Ana
9.6 out of 10, Exceptional, (426 reviews)
"Very close to everything, clean and beautiful"
United States
Mariceliz
The price is ￥11,212
￥13,679 total
includes taxes & fees
Oct 28 - Oct 29
Hotel Aurora
A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

14. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (936 reviews)
"Beautiful hotel and great stay."
United States
Judy
The price is ￥44,064
￥56,119 total
includes taxes & fees
Oct 6 - Oct 7
El Convento Boutique Hotel
An outdoor patio with stone flooring, wicker furniture, and umbrellas providing shade.

15. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (369 reviews)
"Great location, very friendly staff and very clean."
United States
Martha
The price is ￥5,525
￥6,741 total
includes taxes & fees
Oct 1 - Oct 2
Hotel Casa Carmina by AHS
A yellow building with a clock tower and an archway.

16. Hotel Convento Santa Catalina

Hotel Convento Santa Catalina
3.5 star property
Historic Center, 1.6 km from Santa Ana
8.2 out of 10, Very good, (653 reviews)
"Great hotel, great location !"
United States
christina
The price is ￥8,963
￥10,935 total
includes taxes & fees
Oct 1 - Oct 2
Hotel Convento Santa Catalina
A garden with a pergola, potted plants, and a chair.

17. Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (410 reviews)
"Delicious breakfast, nive place, close to everything, I really enjoyed staying there"
United States
Ligia
The price is ￥18,388
￥22,434 total
includes taxes & fees
Oct 1 - Oct 2
Casa Santa Rosa Hotel Boutique
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

18. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (250 reviews)
"The staff was very friendly and the room and surrounding property were very pretty and clean"
United States
Logan
The price is ￥13,438
￥16,394 total
includes taxes & fees
Oct 1 - Oct 2
Casa Noble Hotel
A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.

19. Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (279 reviews)
"Beautiful rooms, very attentive staff, and delicious breakfast!"
United States
Miria
The price is ￥30,097
￥36,719 total
includes taxes & fees
Oct 6 - Oct 7
Las Cruces Boutique Hotel
A courtyard with stone walls, a fountain, and various plants and flowers.

20. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (785 reviews)
"Excellent location helps to have short walking distance to all nearby highlights."
United States
jose
The price is ￥39,343
￥47,998 total
includes taxes & fees
Oct 6 - Oct 7
Hotel Posada de Don Rodrigo Antigua
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Barceló Guatemala City

Barceló Guatemala City

8/10 Good
"If you have a car while your stay at Guatemala City Barceló make sure you get the right information on how to access the parking as you have to exit the arrival area and then drive one block away."
Ricardo 2-night trip
Posted 5 hours ago
Barceló Guatemala City

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.