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Check prices for these dates

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Apr 3 - Apr 4
Tomorrow
Apr 4 - Apr 5
This weekend
Apr 3 - Apr 5
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Apr 10 - Apr 12

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Our top choices for Santa Ana hotels

Garden view

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (23 reviews)
"A little too far from everything but as long as you have a car is ok plenty of parking there"
United States
Gustavo
The price is ￥7,400
￥9,061 total
includes taxes & fees
Apr 19 - Apr 20
Hostal Casa Buho
Front of property

Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
8.8 out of 10, Excellent, (15 reviews)
"Space was clean and had a cozy vibe."
United States
Evelin
The price is ￥17,800
￥22,301 total
includes taxes & fees
Apr 26 - Apr 27
Villas Santa Ana-Ricardo
Front of property

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (51 reviews)
"Beautiful hotel with clean rooms and friendly staff. The only downsides are the distance to the center (a 30-minute walk) and the chickens and peacocks screaming early in the morning"
United States
Patrick
The price is ￥10,474
￥12,778 total
includes taxes & fees
Apr 5 - Apr 6
Casa Buho B&B
Garden

Hilton Guatemala City

Hilton Guatemala City
4.5 star property
25.9 km from Santa Ana
8.6 out of 10, Excellent, (704 reviews)
"The hotel property in excellent condition and very quiet and safe."
United States
Roger
The price is ￥16,875
￥20,588 total
includes taxes & fees
Apr 19 - Apr 20
Hilton Guatemala City
View from property

AC Hotel by Marriott Guatemala City

AC Hotel by Marriott Guatemala City
4.0 star property
26.4 km from Santa Ana
8.6 out of 10, Excellent, (1,002 reviews)
"Convenient Great location Great for business travel "
United States
Patricia
The price is ￥18,848
￥22,994 total
includes taxes & fees
Apr 26 - Apr 27
AC Hotel by Marriott Guatemala City
Interior

Hotel Vista Quince

Hotel Vista Quince
5.0 star property
25.5 km from Santa Ana
8.6 out of 10, Excellent, (247 reviews)
"We really enjoyed our stay, everything was great- we will be returning "
United States
Lucy
The price is ￥20,101
￥24,523 total
includes taxes & fees
Apr 4 - Apr 5
Hotel Vista Quince
Restaurant

Villas Santander - Deluxe Stay

Villas Santander - Deluxe Stay
3.0 star property
24.7 km from Santa Ana
7.4 out of 10, Good, (244 reviews)
"Spotless room, courteous staff "
United States
Walter
The price is ￥5,601
￥6,833 total
includes taxes & fees
Apr 20 - Apr 21
Villas Santander - Deluxe Stay
Restaurant

Villa Sicilia

Villa Sicilia
2.0 star property
24 km from Santa Ana
8.0 out of 10, Very Good, (124 reviews)
"It was nice to have a restaurant on site with a cooler of drink options for purchase as well! "
United States
Lynn
The price is ￥4,081
￥4,979 total
includes taxes & fees
Apr 16 - Apr 17
Villa Sicilia
Bar (on property)

Ever Green Hotel

Ever Green Hotel
3.5 star property
23.8 km from Santa Ana
9.0 out of 10, Wonderful, (74 reviews)
"Excelente"
Mexico
Guillermo
The price is ￥13,144
￥16,035 total
includes taxes & fees
Apr 4 - Apr 5
Ever Green Hotel
Restaurant

Hotel Antigua Inn

Hotel Antigua Inn
3.5 star property
23.8 km from Santa Ana
8.2 out of 10, Very Good, (70 reviews)
"Exelente hotel and location and friendly people. "
United States
Rudy A
The price is ￥12,424
￥15,157 total
includes taxes & fees
Apr 26 - Apr 27
Hotel Antigua Inn
Front of property

La Inmaculada Hotel

La Inmaculada Hotel
3.5 star property
23.7 km from Santa Ana
9.2 out of 10, Wonderful, (632 reviews)
"Great staff, convenient location, hotel has everything it offers."
United States
Colin
The price is ￥14,590
￥17,800 total
includes taxes & fees
Apr 5 - Apr 6
La Inmaculada Hotel
Hallway

Hotel Ciudad Vieja

Hotel Ciudad Vieja
3.0 star property
23.7 km from Santa Ana
9.2 out of 10, Wonderful, (230 reviews)
"Excellent spot! Garden oasis!"
United States
kathleen
The price is ￥12,750
￥15,555 total
includes taxes & fees
Apr 5 - Apr 6
Hotel Ciudad Vieja
Terrace/patio

Meraki Boutique Hotel

Meraki Boutique Hotel
3.5 star property
23.4 km from Santa Ana
9.0 out of 10, Wonderful, (428 reviews)
"It is a boutique hotel with comfortable beds, good AC and a great breakfast. The rooms are small but comfortable and the hotel is well run and in a good location. The staff are very helpful and the 24 hour front desk ensured that I got to the airport at 3:30AM. I'll stay there again. "
United States
Gary
The price is ￥12,277
￥14,978 total
includes taxes & fees
Apr 5 - Apr 6
Meraki Boutique Hotel
Free daily full breakfast

Hotel Santander Plaza

Hotel Santander Plaza
3.5 star property
23.3 km from Santa Ana
8.2 out of 10, Very Good, (596 reviews)
"The location is very good, with many options nearby, including restaurants, bakeries, and convenience stores. Breakfast was good and added a nice level of convenience to the stay."
United States
Servio
The price is ￥15,687
￥19,138 total
includes taxes & fees
Apr 16 - Apr 17
Hotel Santander Plaza
Breakfast, lunch, dinner served; international cuisine, garden views

Clarion Suites Guatemala City

Clarion Suites Guatemala City
4.0 star property
23.3 km from Santa Ana
9.2 out of 10, Wonderful, (1,002 reviews)
"Rooms were very clean and spacious. The breakfast was excellent. Definitely worth the price."
United States
Ryan
The price is ￥13,424
￥16,378 total
includes taxes & fees
Apr 5 - Apr 6
Clarion Suites Guatemala City
Garden

Good Hotel Guatemala City

Good Hotel Guatemala City
3.0 star property
23.9 km from Santa Ana
9.4 out of 10, Exceptional, (309 reviews)
"Nice place to stay in Guatemala City."
United States
Shane
The price is ￥18,528
￥22,604 total
includes taxes & fees
Apr 30 - May 1
Good Hotel Guatemala City
Exterior

Hyatt Centric Guatemala City

Hyatt Centric Guatemala City
4.5 star property
23.3 km from Santa Ana
9.4 out of 10, Exceptional, (867 reviews)
"Very nice hotel clean and friendly staff"
United States
jose
The price is ￥24,727
￥30,167 total
includes taxes & fees
Apr 11 - Apr 12
Hyatt Centric Guatemala City
View from property

Best Western Plus Hotel Stofella

Best Western Plus Hotel Stofella
4.0 star property
23.3 km from Santa Ana
8.8 out of 10, Excellent, (1,001 reviews)
"Great location Clean rooms. Good breakfast Friendly staff. "
United States
Andrew
The price is ￥14,632
￥17,851 total
includes taxes & fees
Apr 17 - Apr 18
Best Western Plus Hotel Stofella
4 restaurants, breakfast, lunch, dinner served; international cuisine

InterContinental Real Guatemala by IHG

InterContinental Real Guatemala by IHG
5.0 star property
23.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Huge room and amazing breakfast! "
United States
Yulia
The price is ￥22,334
￥29,194 total
includes taxes & fees
Apr 10 - Apr 11
InterContinental Real Guatemala by IHG
Superior Double Room | Premium bedding, desk, iron/ironing board, free WiFi

Hotel Royal Palace

Hotel Royal Palace
3.0 star property
24.5 km from Santa Ana
8.2 out of 10, Very Good, (152 reviews)
"Clean and quiet room. Helpful courteous stafff"
United States
valden
The price is ￥14,609
￥17,822 total
includes taxes & fees
Apr 20 - Apr 21
Hotel Royal Palace
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
Photo by Jacques Cramatte
Open Photo by Jacques Cramatte

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

Cross and Volcan de Agua View From Cerro de la Cruz, Antigua, Sacatepequez Department, Guatemala

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Barceló Guatemala City

Barceló Guatemala City

10/10 Excellent
"Friendly staff. Enjoyed eating dinner in the Kyoto restaurant."
Jeff 1-night trip
Posted 2 hours ago
Barceló Guatemala City

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on Expedia customer reviews, Casa Buho B&B is the highest ranked property in Santa Ana. This hotel offers a restaurant and free parking. Another top choice in the area is Hostal Casa Buho.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 14 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.