A white colonial church with ornate architecture and a large wooden door.

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Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

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Our top choices for Santa Ana hotels

A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

1. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ￥16,007
￥19,529 total
includes taxes & fees
Nov 2 - Nov 3
Villas Santa Ana-Ricardo
A cozy indoor space with a staircase, seating area, and various plants.

2. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
8.0 out of 10, Very good, (2 reviews)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ￥2,091
￥4,473 total
includes taxes & fees
Nov 5 - Nov 6
Castillo De Los Gigantes
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

3. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,186 reviews)
"Great stay. Spa is amazing"
United States
Julio
The price is ￥38,944
￥49,439 total
includes taxes & fees
Oct 29 - Oct 30
Hotel Museo Spa Casa Santo Domingo
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

4. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (957 reviews)
"The breakfast and staff are incredible! Great location!"
United States
Jennifer
The price is ￥17,363
￥21,182 total
includes taxes & fees
Nov 2 - Nov 3
El Carmen Hotel
A cobblestone courtyard with outdoor seating and umbrellas, surrounded by greenery and a building with a tiled roof.

5. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,001 reviews)
"What a beautiful place! We were blown away the moment we arrived. Everyone was beyond helpful and hospitable. The room was immaculate. We throughly enjoyed our stay there."
United States
Deborah Gonzales
The price is ￥29,860
￥40,379 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Camino Real Antigua
A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

6. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (949 reviews)
"Beautiful Hotel."
United States
KEVIN
The price is ￥36,886
￥47,371 total
includes taxes & fees
Oct 29 - Oct 30
El Convento Boutique Hotel
A corridor with arches, tiled flooring, and potted plants.

7. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (811 reviews)
"Very nice hotel!"
United States
Katie
The price is ￥15,818
￥19,560 total
includes taxes & fees
Oct 29 - Oct 30
Hotel Las Farolas
An outdoor pool area with wooden decking, surrounded by lush greenery and potted plants.

8. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,004 reviews)
"Very nice property, location was great and amenities were excellent."
United States
Oscar
The price is ￥29,542
￥36,530 total
includes taxes & fees
Oct 29 - Oct 30
Porta Hotel Antigua
An indoor courtyard with stone flooring, multiple seating areas, and string lights.

9. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (380 reviews)
"The staff was wonderful! The location was perfect! The hotel was beautiful! I would definitely recommend! There’s hot water, and WiFi!"
United States
Carlos
The price is ￥9,921
￥12,104 total
includes taxes & fees
Oct 29 - Oct 30
Hotel Casa Carmina by AHS
A garden pathway leading to a building with a green lawn and a clear blue sky.

10. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,001 reviews)
"Good place to stay"
United States
Michael
The price is ￥24,319
￥29,669 total
includes taxes & fees
Oct 30 - Oct 31
Hotel Soleil La Antigua
A hot tub with a waterfall feature, surrounded by brick walls and stone, with a view through a window.

11. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"Nice hotel friendly staff and helpful"
United States
Hilda
The price is ￥25,577
￥32,149 total
includes taxes & fees
Nov 10 - Nov 11
Los Pasos Boutique Hotel & Spa
A conservatory with a large window, a stone bench, and two chairs with cushions.

12. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (514 reviews)
"Great place to stay"
United States
Mauricio
The price is ￥18,965
￥23,137 total
includes taxes & fees
Nov 18 - Nov 19
Meson Panza Verde
A covered outdoor seating area with wicker furniture and hanging lights.

13. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (473 reviews)
"I had a great stay at Ciel Luxe Hotel! The room was clean and comfortable, the staff was friendly, and the location was convenient. I’d definitely stay here again!"
United States
Corey
The price is ￥13,355
￥16,293 total
includes taxes & fees
Nov 12 - Nov 13
Ciel-Luxe Hotels
A hallway with a wooden reception desk, potted plants, and a tiled floor.

14. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (259 reviews)
"Fantastic hotel"
Canada
Alysha
The price is ￥12,619
￥15,395 total
includes taxes & fees
Oct 29 - Oct 30
Casa Noble Hotel
A lobby with a central reception desk, potted cacti, a chandelier, and a view of the interior through an archway.

15. Mestizo Antigua

Mestizo Antigua
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (219 reviews)
"Staff was very friendly and accommodating. Highly recommend!"
United States
Lucy
The price is ￥19,884
￥24,258 total
includes taxes & fees
Oct 29 - Oct 30
Mestizo Antigua
A courtyard with cobblestone flooring, a building with a tiled roof, and a mountain in the background.

16. All Suite El Marques de Antigua

All Suite El Marques de Antigua
3.5 star property
1 km from Santa Ana
9.4 out of 10, Exceptional, (409 reviews)
"Very nice place. Clean, good amenities and excellent communication for travelers"
United States
Tullio Augusto
The price is ￥9,953
￥12,142 total
includes taxes & fees
Oct 29 - Oct 30
All Suite El Marques de Antigua
A yellow building with a clock tower and an archway.

17. Hotel Convento Santa Catalina

Hotel Convento Santa Catalina
3.5 star property
Historic Center, 1.6 km from Santa Ana
8.2 out of 10, Very good, (674 reviews)
"Great hotel, great location !"
United States
christina
The price is ￥10,504
￥12,814 total
includes taxes & fees
Nov 3 - Nov 4
Hotel Convento Santa Catalina
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

18. San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (499 reviews)
"We loved it!! The location is great. The room was amazing, the breakfast, the staff… everything was perfect."
Mexico
Francisco Benjamin Macias
The price is ￥32,607
￥40,253 total
includes taxes & fees
Oct 29 - Oct 30
San Rafael Hotel
A courtyard with stone walls, a fountain, and various plants and flowers.

19. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (788 reviews)
"Excellent location helps to have short walking distance to all nearby highlights."
United States
jose
The price is ￥39,373
￥48,035 total
includes taxes & fees
Oct 29 - Oct 30
Hotel Posada de Don Rodrigo Antigua
A multi-level outdoor garden with potted plants and a wooden pergola structure.

20. Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (507 reviews)
"Great Service and breakfasts …"
United States
GIOVANNI
The price is ￥14,241
￥17,374 total
includes taxes & fees
Nov 18 - Nov 19
Naif Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.
Villas Santa Ana-Ricardo
3.5 star property
9.0
Wonderful
17 reviews
View
A cozy indoor space with a staircase, seating area, and various plants.
Castillo De Los Gigantes
2.0 star property
8.0
Very good
2 reviews
View
A hallway with a wooden reception desk, potted plants, and a tiled floor.
Casa Noble Hotel
3.0 star property
9.6
Exceptional
259 reviews
View
An indoor courtyard with stone flooring, multiple seating areas, and string lights.
Hotel Casa Carmina by AHS
4.0 star property
8.8
Excellent
380 reviews
View
A multi-level outdoor garden with potted plants and a wooden pergola structure.
Naif Boutique Hotel
3.0 star property
9.0
Wonderful
507 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Adriatika Hotel & Residence

Adriatika Hotel & Residence

10/10 Excellent
"The room was spotless and the linens were super clean. Staff was helpful and always had a smile on their faces"
Marithe 1-night trip
Posted 2 hours ago
Adriatika Hotel & Residence

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.