Panama City Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥45,448 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in Panama City
Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City
Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.
Find the Best Panama City Vacation Packages
Panama City Hotel Deals
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ￥18,285 per night from Nov 10 to Nov 11
￥18,285
￥20,114 total
Nov 10 - Nov 11
includes taxes & fees
9/10 Wonderful! (4,482 reviews)
Wonderfull
Reviewed on Nov 5, 2025
Megapolis Hotel Panamá
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is ￥18,841 per night from Nov 30 to Dec 1
￥18,841
￥20,725 total
Nov 30 - Dec 1
includes taxes & fees
8.4/10 Very Good! (1,174 reviews)
Room was excellent
Reviewed on Nov 2, 2025
Waldorf Astoria Panama
47th St. & Uruguay Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ￥26,410 per night from Dec 6 to Dec 7
￥26,410
￥29,051 total
Dec 6 - Dec 7
includes taxes & fees
8.8/10 Excellent! (1,000 reviews)
Upon arrival to the Waldorf, Edgar was right there to assist us with our luggage to the room. It was at that moment I knew the W.A. hospitality was about to be extraordinary.
Reviewed on Oct 22, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Panama City
Avenida Balboa
4/5(554 reviews)
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Panama Canal Railway
4/5(10 reviews)
Enjoy an outing to Panama Canal Railway during your stay in Ancon. Stroll along the seaside or visit the shops in this vibrant area.
Albrook Shopping Mall
4/5(605 reviews)
You can enjoy some retail therapy with a trip to Albrook Shopping Mall, a favorite shopping spot in Ancon. Amble around this vibrant area's seaside and enjoy its top-notch restaurants.
What to do in Panama City
City Sightseeing Panama City Hop-On Hop-Off Bus Tour
￥4,508
per adult
80% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
￥14,878
per adult
94% of travellers recommend
Half day of Panama city and canal tour: shared and private
￥10,019
per adult
98% of travellers recommend
Other vacations you might like
Expedia's Latest Trends
Hotels
Flights
- Flights from Sepang (KUL) to Tioman Island (TOD)
- Flights from Naha (OKA) to Indianapolis (IND)
- Flights from Narita (NRT) to Ulaanbaatar (ULN)
- Flights from Mashiki (KMJ) to Osaka (KIX)
- Flights from Osaka (KIX) to Incheon (ICN)
- Flights from Narita (NRT) to Cali (CLO)
- Flights to Japan
- Flights from Fukuoka to CHI-All Airports
- Flights from Osaka (KIX) to Laguindingan (CGY)
- Flights from Chiang Mai (CNX) to Tokyo (HND)
- Flights from Naha (OKA) to Rome (FCO)
- Flights from Ho Chi Minh City (SGN) to Manila (MNL)
Activities
Packages
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
