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Our top choices for East Side Pioneers hotels

Exterior
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
East Side Pioneers
8.8 out of 10, Excellent, (893)
"Room was clean and comfortable Staff courteous Comfortable beds Great restaurant"
United States
Matney
The price is ￥12,526
￥14,420 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Lobby
Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
East Side Pioneers
9.6 out of 10, Exceptional, (547)
"Very courteous staff, loved the valet guy!"
United States
Jean
The price is ￥26,833
￥30,891 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Hilton Rochester Mayo Clinic Area
Fridge, microwave, oven, stovetop
Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
East Side Pioneers
9.2 out of 10, Wonderful, (168)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
The price is ￥24,663
￥28,393 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Broadway Plaza, Trademark Collection by Wyndham
Terrace/patio
Hampton Inn Rochester-South

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
3.3 km from East Side Pioneers
9.0 out of 10, Wonderful, (1005)
"We had a wonderful stay!"
United States
Sarah
The price is ￥12,658
￥14,572 total
includes taxes & fees
Jan 24 - Jan 25, 2026
Hampton Inn Rochester-South
Exterior
Spark by Hilton Rochester South

Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
7 km from East Side Pioneers
9.4 out of 10, Exceptional, (330)
"Great place"
United States
Abidemi
The price is ￥11,041
￥12,711 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Spark by Hilton Rochester South
Exterior
Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
6.9 km from East Side Pioneers
8.8 out of 10, Excellent, (1005)
"Clean room, clean hotel, friendly staff Would stay here again."
United States
Chee
The price is ￥11,430
￥13,160 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express Rochester South - Mayo Area by IHG
Front of property
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
7.3 km from East Side Pioneers
7.2 out of 10, Good, (1025)
"Staff was courteous and breakfast was well stocked."
United States
Doug
The price is ￥11,273
￥12,979 total
includes taxes & fees
Jan 1 - Jan 2, 2026
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Courtyard
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park, 2.3 km from East Side Pioneers
9.4 out of 10, Exceptional, (968)
"Room was amazing and the staff was very courteous. "
United States
Jennifer
The price is ￥17,849
￥20,861 total
includes taxes & fees
Jan 2 - Jan 3, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Indoor pool, open 7:00 AM to 11:00 PM, sun loungers
AmericInn by Wyndham Rochester

AmericInn by Wyndham Rochester

AmericInn by Wyndham Rochester
2.0 star property
12.2 km from East Side Pioneers
8.8 out of 10, Excellent, (1002)
"Enjoyed our stay, rated breakfast as a erage as we did not try it."
United States
jeanne
The price is ￥12,541
￥14,439 total
includes taxes & fees
Dec 30 - Dec 31
AmericInn by Wyndham Rochester
Terrace/patio
Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
3.4 km from East Side Pioneers
9.6 out of 10, Exceptional, (887)
"Great stay,clean and friendly"
United States
Janet
The price is ￥19,130
￥22,024 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Home2 Suites by Hilton Rochester Mayo Clinic Area
Serves lunch, dinner, and happy hour
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
3 km from East Side Pioneers
8.2 out of 10, Very Good, (1153)
"Good price, room clean, descent breakfast. I have stayed here several time"
United States
Amy M
The price is ￥11,426
￥13,155 total
includes taxes & fees
Jan 2 - Jan 3, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
Terrace/patio
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester, 1.3 km from East Side Pioneers
9.2 out of 10, Wonderful, (1006)
"Quick and easy check-in, walkable area and nice breakfast and accomodations. Would stay again!"
United States
Elizabeth
The price is ￥20,198
￥23,254 total
includes taxes & fees
Dec 30 - Dec 31
Hyatt House Rochester/Mayo Clinic Area
Executive Room, 2 Queen Beds, Refrigerator & Microwave, Pool View (Living Room) | Blackout drapes, soundproofing, iron/ironing board, rollaway beds
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
3.8 km from East Side Pioneers
8.2 out of 10, Very Good, (798)
"This hotel was"
United States
Sheila
The price is ￥13,983
￥16,097 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Exterior
Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
2.5 star property
8.2 km from East Side Pioneers
9.2 out of 10, Wonderful, (1002)
"Pool was nice "
Canada
Jesse
The price is ￥13,994
￥16,112 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn & Suites Rochester-North
Exterior
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park, 2.7 km from East Side Pioneers
9.2 out of 10, Wonderful, (773)
"Clean room and housekeeping service was excellent"
United States
Dawn
The price is ￥13,152
￥15,142 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Exterior
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park, 2.9 km from East Side Pioneers
8.8 out of 10, Excellent, (765)
"Clean room, friendly staff. The only minus is the lighting in the bathroom, way too dim. "
United States
Stacy
The price is ￥14,874
￥17,125 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Breakfast served
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester, 1.1 km from East Side Pioneers
8.8 out of 10, Excellent, (854)
"Everything was wonderful! Helpful, friendly staff, great location, nice amenities."
United States
kristi
The price is ￥16,758
￥19,292 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton Garden Inn Rochester Downtown, MN
Property amenity
TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester, 1.7 km from East Side Pioneers
9.6 out of 10, Exceptional, (483)
"Room was large, clean, beds were comfortable. Downstairs cafe and seating areas were very comfortable."
United States
Ann
The price is ￥19,884
￥22,891 total
includes taxes & fees
Jan 3 - Jan 4, 2026
TownePlace Suites by Marriott Rochester Mayo Clinic Area
Efficiency King Suite with Sofa Bed - Non-Smoking | Premium bedding, desk, blackout drapes, iron/ironing board
Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center
2.5 star property
6 km from East Side Pioneers
9.0 out of 10, Wonderful, (585)
"Nice place to stay "
United States
Melissa
The price is ￥12,682
￥14,600 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Sleep Inn & Suites West-Near Medical Center
Reception
America's Stay Inn Stewartville

America's Stay Inn Stewartville

America's Stay Inn Stewartville
2.5 star property
17.5 km from East Side Pioneers
8.0 out of 10, Very Good, (419)
"Room was nicer and furnished better than most high end places I’ve stayed at. It’s a small hotel on a busy road, but comfortable bed and clean."
Canada
Robert
America's Stay Inn Stewartville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in East Side Pioneers

Find the best East Side Pioneers areas and neighborhoods for the activities you enjoy most.
Rochester showing skyline and a city
Photo by Howard Lower Photography
Open Photo by Howard Lower Photography

Downtown Rochester

If you're spending some time in Downtown Rochester, Mayo Civic Center and Rochester Civic Theater are top sights worth seeing.

Kutzky Park

While there might not be top attractions in Kutzky Park, you can explore the larger area and discover places like Soldiers Field Veterans Memorial and Mayo Civic Center.

Rochester featuring forest scenes and a river or creek
Photo by Chad Johnson
Open Photo by Chad Johnson

Historic Southwest

While visiting Historic Southwest, you might make a stop by sights like Soldiers Field Veterans Memorial and Plummer House.

Slatterly Park

Slatterly Park might not have many top sights, but Rochester Art Center and Soldiers Field Veterans Memorial are two attractions nearby that you can check out.

Folwell

While there might not be top attractions in Folwell, you can explore the larger area and discover places like Soldiers Field Veterans Memorial and Apache Mall.

Top East Side Pioneers Hotel Reviews

Hampton Inn Rochester-South

Hampton Inn Rochester-South

10/10 Excellent
"Very nice selection and it's served until 10:00 am. The pool area is open 24 hrs and very nice. Easy parking with restaurants in walking distance."
Gregory J 1-night trip
Posted 3 days ago
Hampton Inn Rochester-South

Frequently asked questions

What's it like in East Side Pioneers?
Travelers are sure to enjoy a stay in Rochester's East Side Pioneers neighborhood. Are you looking for East Side Pioneers travel tips? Be sure to check out Rochester Art Center and Rochester Civic Theater while you're in the neighborhood.
What's a favorite place to stay in East Side Pioneers?
Based on Expedia customer reviews, Hilton Rochester Mayo Clinic Area is the highest ranked property in East Side Pioneers. This hotel is a short 6-minute walk from Mayo Clinic, and it offers a full-service spa and 2 restaurants. Another favorite option in the neighborhood is Hotel Indigo Rochester – Mayo Clinic Area by IHG.
How many hotels will I be able to find in East Side Pioneers?
If you're searching for places to stay in Rochester, choose from one of Expedia's 17 hotels and other accommodations in East Side Pioneers.
If I need to cancel my hotel reservation in East Side Pioneers, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to review top deals in East Side Pioneers.
Where can I learn more about changing or cancelling my trip to East Side Pioneers?
To access more information about changing or cancelling your trip to East Side Pioneers, click here.
What can I see and do in this Rochester neighborhood?
Spend some time exploring the natural setting of East Side Pioneers with a visit to Silver Lake Park and Mayo Park. You could also plan a visit to Rochester Art Center or Rochester Civic Theater while you're in the neighborhood. A few places to visit in the area around East Side Pioneers include Mayo Civic Center, Rochester Public Library, and Shops University Square. While you're out sightseeing, Plummer Building and Soldiers Field Veterans Memorial are a couple of additional sights to visit in Rochester.

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