Find Luxury Hotels in Downtown San Mateo, CA

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels

    Be picky

    Search almost a million properties worldwide

Check availability on Downtown San Mateo Luxury Hotels

Next weekend
In two weeks

Top Downtown San Mateo Luxury Hotels

Top Downtown San Mateo Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

Are you looking for a luxury hotel for your Downtown San Mateo vacation?
Use Expedia to arrange your flight to San Francisco Intl. Airport (SFO) airport or San Carlos, CA (SQL) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a trip, so we make it easy to get what you want to make your stay relaxing and comfortable. If you want a posh hotel with fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Downtown San Mateo has to offer. Downtown San Mateo has some interesting things to see and do including Cinemark Century San Mateo 12 and The San Mateo Japanese Garden, so you might want to take in the local sights during your visit.
What's there to see and do in Downtown San Mateo?
Enjoy all that Downtown San Mateo has to offer and visit San Francisco Bay, Chase Center, and Oracle Park. If you have extra time while you're in the area, you might want to see Cinemark Century San Mateo 12 and The San Mateo Japanese Garden.