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Find Luxury Hotels in South San Francisco, CA

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Our top choices for South San Francisco luxury hotels

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
4.0 star property
Oyster Point
9.2 out of 10, Wonderful, (1007)
"Very convenient stay for San Francisco. Clean hotel and very comfortable bed. Excellent gym. Will stay again. "
United States
Andy
The price is ¥18,178
¥21,738 total
includes taxes & fees
Jan 2 - Jan 3, 2026
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
4.0 star property
South San Francisco
8.4 out of 10, Very Good, (2055)
"Room was clean, staff were helpful. Overall stay was good"
Australia
Jenny Faatoatuiga
The price is ¥17,966
¥21,176 total
includes taxes & fees
Jan 4 - Jan 5, 2026
DoubleTree by Hilton San Francisco South Airport Blvd

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
Fisherman's Wharf
9.0 out of 10, Wonderful, (7250)
"Great place to stay!"
United States
Isaiah
The price is ¥15,606
¥24,819 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hotel Riu Plaza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
Fisherman's Wharf
9.0 out of 10, Wonderful, (3836)
"Excellent stay and great location! "
United States
CHRISTINE
The price is ¥18,314
¥28,742 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hotel Caza Fisherman's Wharf

Grand Hyatt San Francisco

Grand Hyatt San Francisco
4.0 star property
Union Square
8.8 out of 10, Excellent, (1005)
"Nice hotel, great location "
United States
Jay
The price is ¥20,980
¥32,064 total
includes taxes & fees
Jan 24 - Jan 25, 2026
Grand Hyatt San Francisco

Residence Inn by Marriott Berkeley

Residence Inn by Marriott Berkeley
4.0 star property
Downtown Berkeley
9.2 out of 10, Wonderful, (538)
"Staff were excellent. Room was spacious. Good breakfast and really nice bar upstairs. "
United States
Rona
The price is ¥25,677
¥29,579 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Residence Inn by Marriott Berkeley

Claremont Resort & Club

Claremont Resort & Club
5.0 star property
Claremont Hills
8.8 out of 10, Excellent, (1007)
"Great hotel"
United States
Peter
The price is ¥34,273
¥48,749 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Claremont Resort & Club

DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina
4.0 star property
Berkeley Marina
8.2 out of 10, Very Good, (4040)
"Clean rooms, great breakfast options & friendly staff"
United States
Beth
The price is ¥18,600
¥21,426 total
includes taxes & fees
Jan 18 - Jan 19, 2026
DoubleTree by Hilton Hotel Berkeley Marina

citizenM Menlo Park

citizenM Menlo Park
4.0 star property
Menlo Park
9.4 out of 10, Exceptional, (177)
"nice place to stay in the area"
United States
Pankaj
The price is ¥19,571
¥22,649 total
includes taxes & fees
Jan 2 - Jan 3, 2026
citizenM Menlo Park

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (2201)
"Great hotel "
United States
Tanya
The price is ¥17,204
¥20,248 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton San Francisco Financial District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top South San Francisco Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to South San Francisco?
Let Expedia help you arrange your flight to San Francisco Intl. Airport (SFO) airport or Oakland Intl. Airport (OAK) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that South San Francisco offers. Known for its sightseeing and tours, South San Francisco also has some interesting things to see and do including San Francisco Bay, so you may want to take in the local sights during your visit.
When can I expect good weather in South San Francisco?
Planning for the weather is an important factor for making your trip to South San Francisco a success, especially when you're splurging. The hottest months are usually September and August with an average temp of 62°F, while the coldest months are February and January with an average of 53°F. Average annual precipitation for South San Francisco is 23 inches.
What's there to see and do in South San Francisco?
Take in some sights and attractions while you're in South San Francisco by visiting San Francisco Bay, Santa Cruz Mountains, and See's Candies. If you have spare time during your trip, you might want to make a stop at San Bruno Point Park and K1 Speed.
How can I get around South San Francisco?
It's easier to get around town in style when you know your options. Make your way to South San Francisco Metro Station to catch metro. To see more of the larger area, hop on a train at South San Francisco Station.

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