Find & Book the Best Hotels in Mississippi County for 2026

Top Cities in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.

A tree-lined landscape with a river and fields.

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Our top choices for Mississippi County hotels

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

1. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

￥10,521 total

includes taxes & fees

Oct 11 - Oct 12

A building with a fountain and flower beds in front.

2. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

￥11,754 total

includes taxes & fees

Oct 12 - Oct 13

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Charleston

Jackson

￥11,667 total

includes taxes & fees

Oct 21 - Oct 22

A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Cairo

Santiago

￥12,027 total

includes taxes & fees

Oct 19 - Oct 20

A kitchen with wooden cabinets, a stainless steel stove, and a wall-mounted sign.

5. The Roost | Hot Tub, Ponds & Farm Views

Carlisle County

￥32,842 total

includes taxes & fees

Oct 18 - Oct 19

A hot tub in an outdoor setting with a wooden deck and lounge chairs.

6. Perfect Couples Retreat - firepit

Carlisle County

￥29,443 total

includes taxes & fees

Oct 12 - Oct 13

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Top Mississippi County Hotel Reviews

Hampton Inn Sikeston

10/10 Excellent

"Loved the modern, CLEAN, room and staff was extremely friendly and helpful. We were greeted and served by "Brittany" at check-in who was so nice and friendly and even gave us dinner suggestions. We would definitely stay here again!"

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"Everything was good about the room except the bathroom. The stopper on the sink did not work and there was a dent in the wall. The face/wash towels need to be changed out. They are no longer white. They are dull in color. The couch needs to be cleaned and freshen. The staff was excellent and everything else is good. I just wish that breakfast offered hot eggs and meat vs. only waffles. Otherwise the room was good."

Peaceful secluded cabin located near Horseshoe Lake

8/10 Good

"I booked this cabin for a getaway for two adults and two dogs who don't like other dogs, and it was the perfect location for that. There are no other cabins within sight or within earshot, the road that runs by the cabin is quiet, and there's a park that's similarly very quiet about a 5-minute drive away. Check in was smooth and the cabin is very cute. The facilities, especially the shower, are pretty basic, but everything worked. The cabin is small, but comfortable for two people. There's AC and heating, so the temperature was comfortable.My notes are less a critique of the cabin, and more things to know: The water smells like rotten eggs, to the point where the entire bathroom stank after a shower. My dogs happily drank the tap water, so it seems safe - the area is marshy, so I suspect that explains the smell. If you're sensitive to smells, this might be a challenge. This is woods in the southern Midwest, so mosquitoes were out in force, and my dogs were covered in sticky pricklies the second they left the (nicely!) mowed area of the cabin - again, nothing to do with the cabin, just the reality of the area, and it meant we didn't spend a ton of time outside near the cabin. I might be interested in revisiting during a colder time of year when bugs and plants are dormant. I recommend bringing your own dry firewood because it's humid so any wood at the site might not burn very easily."

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Top Cities in Mississippi County

Charleston

East Prairie

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Our top choices for Mississippi County hotels

1. Super 8 by Wyndham Charleston/Sikeston East MO