A tree-lined landscape with a river and fields.

Find hotels in East Prairie, MO from ￥8,425

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Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

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Our top choices for East Prairie hotels

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

1. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (651 reviews)
"Great hotel, clean spacious room, good breakfast choice"
United Kingdom
Deborah
The price is ￥15,000
￥17,057 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Sikeston
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

2. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,001 reviews)
"Awesome place will be staying in more of them"
United States
Tim
The price is ￥14,809
￥17,027 total
includes taxes & fees
Nov 15 - Nov 16
Drury Inn & Suites Sikeston, MO
A buffet with various food items, including omelets and baked goods, served in metal containers.

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.8 out of 10, Excellent, (519 reviews)
"I have always have a great stay each time I’ve been here. Beds comfortable and rooms very clean."
United States
Melissa
The price is ￥15,914
￥18,099 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express & Suites Sikeston Southwest by IHG
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

4. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,000 reviews)
"Clean rooms, great parking, very nice staff"
United States
Shelley
The price is ￥12,570
￥14,325 total
includes taxes & fees
Nov 8 - Nov 9
Best Western Plus Sikeston I-55
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

5. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is ￥15,914
￥18,098 total
includes taxes & fees
Nov 8 - Nov 9
Fairfield Inn & Suites by Marriott Sikeston
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

6. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (829 reviews)
"Very clean property and the staff were very accommodating."
United States
Craig
The price is ￥10,183
￥11,606 total
includes taxes & fees
Dec 3 - Dec 4
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Property amenity

7. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (29 reviews)
"I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great."
United States
Mark
The price is ￥17,174
￥19,532 total
includes taxes & fees
Nov 8 - Nov 9
TownePlace Suites by Marriott Sikeston
A building with a fountain and flower beds in front.

8. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is ￥10,476
￥11,729 total
includes taxes & fees
Nov 4 - Nov 5
The Riverstone Hotel Charleston-Sikeston
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

9. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.4 out of 10, Good, (1,001 reviews)
"It was clean, the room was nice and roomy, bed was very comfortable. Some things were in need of minor repairs, but nothing major."
United States
Earl
The price is ￥10,446
￥11,906 total
includes taxes & fees
Nov 4 - Nov 5
Days Inn and Suites by Wyndham Sikeston
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

10. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (695 reviews)
"It is a clean place, and we enjoyed our stay"
United States
Laura
The price is ￥9,132
￥10,407 total
includes taxes & fees
Nov 8 - Nov 9
Super 8 by Wyndham Sikeston/Miner Area
A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

11. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (322 reviews)
"The room was nice"
United States
Fred
The price is ￥13,739
￥15,659 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Inn & Suites Sikeston I-55
A hotel room with two beds, a desk, a chair, a TV, and a mirror.

12. Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (163 reviews)
"It was an ok room for the price paid."
United States
Marianne
The price is ￥8,373
￥9,963 total
includes taxes & fees
Nov 3 - Nov 4
Country Yard Inn and Suite
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

13. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is ￥10,397
￥11,642 total
includes taxes & fees
Nov 3 - Nov 4
Eagle Inn Charleston
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

14. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (82 reviews)
"Got there late and staff was very helpful. Room was clean and comfortable"
United States
Wendy
The price is ￥9,083
￥10,420 total
includes taxes & fees
Nov 4 - Nov 5
Super 8 By Wyndham Marston
A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

15. Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (356 reviews)
"It was the perfect stay."
United States
Kevin
The price is ￥17,962
￥21,331 total
includes taxes & fees
Nov 26 - Nov 27
Holiday Inn Express & Suites Union City by IHG
A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

16. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (446 reviews)
"Clean room, excellent staff, wonderful breakfast"
United States
Ben
The price is ￥11,867
￥14,092 total
includes taxes & fees
Nov 22 - Nov 23
Sleep Inn at Discovery Park of America
A hotel lobby with a reception desk, seating area, and a large window.

17. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (296 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is ￥11,344
￥12,590 total
includes taxes & fees
Nov 8 - Nov 9
Quality Inn Cairo I-57
A hotel lobby with a glass table and checkered chairs, an exit door, and a vending machine.

18. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
2.5 star property
Marston
6.0 out of 10, (130 reviews)
"Quiet safe area."
United States
Frank
The price is ￥6,755
￥8,425 total
includes taxes & fees
Nov 3 - Nov 4
Travel Inn Marston I-55 by Hotel O
An outdoor seating area with a fire pit, cushioned chairs, and a metal fence.

19. Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (204 reviews)
"Very clean Comfy beds Good variety of breakfast items"
United States
Melody
The price is ￥15,134
￥17,972 total
includes taxes & fees
Nov 8 - Nov 9
Hampton Inn Union City
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

20. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (682 reviews)
"Breakfast was light but good"
United States
zandra
The price is ￥9,241
￥10,349 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Charleston/Sikeston East MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in East Prairie

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

Hampton Inn Sikeston

2.5 star property
Sikeston
View
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
View
A buffet with various food items, including omelets and baked goods, served in metal containers.

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
Sikeston
View
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

Best Western Plus Sikeston I-55

2.5 star property
Sikeston
View
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

Fairfield Inn & Suites by Marriott Sikeston

3.0 star property
Sikeston
View
9.0
Wonderful
651 reviews
9.6
Exceptional
1,001 reviews
8.8
Excellent
519 reviews
8.4
Very good
1,000 reviews
9.4
Exceptional
118 reviews
The price is ￥15,000
￥17,057 total
includes taxes & fees
Nov 22 - Nov 23
The price is ￥14,809
￥17,027 total
includes taxes & fees
Nov 8 - Nov 9
The price is ￥15,914
￥18,099 total
includes taxes & fees
Nov 8 - Nov 9
The price is ￥12,570
￥14,325 total
includes taxes & fees
Nov 8 - Nov 9
The price is ￥15,914
￥18,098 total
includes taxes & fees
Nov 8 - Nov 9
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • No WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet friendly
  • Yes, WiFi included
  • Yes, Parking
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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"It was affordable and coean"
William 3-night trip
Posted 8 hours ago
Super 8 by Wyndham Sikeston/Miner Area

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
The price is ￥9,132 per night from Nov 8 to Nov 9
￥9,132
￥10,407 total
Nov 8 - Nov 9
includes taxes & fees
7/10 Good! (695 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best vacation rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: Visitors like this East Prairie vacation home rental. It is located on a lake and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 36 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Columbus-Belmont State Park and Fort Defiance State Park in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.