A tree-lined landscape with a river and fields.

Find hotels in East Prairie, MO from ￥10,393

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Aug 7 - Aug 9
In two weeks
Aug 14 - Aug 16

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for East Prairie hotels

Indoor pool, outdoor pool

1. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,004 reviews)
"Nice hotel with evening dinner and buffet breakfast."
United States
Sally
The price is ￥17,470
￥20,085 total
includes taxes & fees
Aug 16 - Aug 17
Drury Inn & Suites Sikeston, MO
Exterior

2. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (599 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
United States
Brandi
The price is ￥17,478
￥19,789 total
includes taxes & fees
Aug 23 - Aug 24
Hampton Inn Sikeston
Exterior

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (488 reviews)
"Very clean room breakfast was good"
United States
michael
The price is ￥14,638
￥16,574 total
includes taxes & fees
Aug 30 - Aug 31
Holiday Inn Express & Suites Sikeston Southwest by IHG
Laptop workspace, blackout drapes, cribs (free), WiFi (free)

4. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (651 reviews)
"The room was spacious and could have used a small loveseat for TV watching. The breakfast didn't include pastries or a waffle machine. There's instant oatmeal and apples, OJ, coffee and apple juice. I'm hoping as they continue to renovate it will be like other hotels I've stayed at for the same price."
United States
France
The price is ￥9,365
￥10,393 total
includes taxes & fees
Aug 2 - Aug 3
Super 8 by Wyndham Charleston/Sikeston East MO
Desk, blackout drapes, iron/ironing board (on request), WiFi (free)

5. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (805 reviews)
"I love it there."
United States
Sharika West
The price is ￥10,497
￥11,963 total
includes taxes & fees
Aug 2 - Aug 3
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Exterior

6. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (423 reviews)
"Definitely be back and will recommend to my family and friends"
United States
Bobby
The price is ￥11,213
￥12,444 total
includes taxes & fees
Aug 4 - Aug 5
The Riverstone Hotel Charleston-Sikeston
Free daily full breakfast

7. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,000 reviews)
"Good location. Other nearby hotels were questionable, but felt safe in Best Western."
United States
Kevin
The price is ￥14,983
￥17,077 total
includes taxes & fees
Aug 20 - Aug 21
Best Western Plus Sikeston I-55
Property amenity

8. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (101 reviews)
"Perfect last minute stop on our road trip Very clean, well maintained and pleasant staff"
United States
Dwain
The price is ￥17,314
￥19,604 total
includes taxes & fees
Aug 13 - Aug 14
Fairfield Inn & Suites by Marriott Sikeston
Lobby

9. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (420 reviews)
"Clean room, excellent staff, wonderful breakfast"
United States
Ben
The price is ￥13,222
￥15,700 total
includes taxes & fees
Aug 24 - Aug 25
Sleep Inn at Discovery Park of America
1 bedroom, desk, laptop workspace, blackout drapes

10. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,004 reviews)
"The hotel looked very good from the outside. And when you first went into the lobby was very nice. But the rooms were very basic. They was absolutely no pictures hung from the walls. The kitchen area just had a small refrigerator and a microwave setting on top of it. I had to ask for a coffee maker, and it was a single cup coffee maker. The free breakfast was very minimal. But at least everything was clean."
United States
Robert S
The price is ￥10,624
￥12,107 total
includes taxes & fees
Sep 1 - Sep 2
Days Inn and Suites by Wyndham Sikeston
Exterior

11. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (302 reviews)
"Hotel was nice an clean. Friendly staff. Clean hotel rooms and free breakfast every morning."
United States
Starlette
The price is ￥14,984
￥17,077 total
includes taxes & fees
Aug 23 - Aug 24
Comfort Inn & Suites Sikeston I-55
Free buffet breakfast

12. Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very Good, (533 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is ￥11,065
￥13,140 total
includes taxes & fees
Aug 29 - Aug 30
Quality Inn Union City US 51
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout drapes, WiFi (free)

13. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very Good, (69 reviews)
"Clean room, The receptionist very friendly, good parking."
United States
Temera
The price is ￥13,033
￥14,886 total
includes taxes & fees
Aug 3 - Aug 4
Super 8 By Wyndham Marston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, WiFi (free)

14. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (658 reviews)
"Staff is great rooms clean no bugs and bed was comfortable "
United States
James
The price is ￥10,057
￥11,463 total
includes taxes & fees
Aug 9 - Aug 10
Super 8 by Wyndham Sikeston/Miner Area
Iron/ironing board (on request), WiFi (free), bed sheets

15. Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (149 reviews)
"Great clean place to stay at"
United States
William
The price is ￥8,872
￥10,557 total
includes taxes & fees
Aug 3 - Aug 4
Country Yard Inn and Suite
Room, 1 King Bed, Non Smoking | View from room

16. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is ￥10,906
￥12,104 total
includes taxes & fees
Aug 4 - Aug 5
Eagle Inn Charleston
Property amenity

17. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (19 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is ￥18,573
￥21,030 total
includes taxes & fees
Aug 27 - Aug 28
TownePlace Suites by Marriott Sikeston
Lobby

18. Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (398 reviews)
"Over all a good stay however often times no one at front desk sauna not working no eggs or sausage with breakfast could atleast to boiled eggs"
United States
Richard
The price is ￥8,638
￥10,258 total
includes taxes & fees
Aug 12 - Aug 13
Hospitality House Union City I 69 / US 51
Lobby

19. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (293 reviews)
"Breakfast was sparse. This motel needs a complete overhaul. "
United States
Susan
The price is ￥10,370
￥11,509 total
includes taxes & fees
Aug 14 - Aug 15
Quality Inn Cairo I-57
Lobby

20. Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (575 reviews)
"Very clean and nice place and people."
United States
Jade
The price is ￥9,419
￥11,185 total
includes taxes & fees
Aug 16 - Aug 17
Country Hearth Inn & Suites Union City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Country Yard Inn and Suite

Country Yard Inn and Suite

10/10 Excellent
"A Good room for the cost!"
Micheal 1-night trip
Posted 1 hour ago
Country Yard Inn and Suite

More cheap stays in East Prairie

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
The price is ￥10,624 per night from Sep 1 to Sep 2
￥10,624
￥12,107 total
Sep 1 - Sep 2
includes taxes & fees

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Best Western Plus Sikeston I-55 and Days Inn and Suites by Wyndham Sikeston. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best vacation rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: Visitors like this East Prairie vacation home rental. It is located on a lake and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 37 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.