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Our top choices for East Prairie hotels

Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.
"Clean room, great location and friendly staff"
United States
Mark
The price is ￥14,021
￥16,120 total
includes taxes & fees
Dec 19 - Dec 20
Drury Inn & Suites Sikeston, MO
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is ￥11,123
￥12,676 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Plus Sikeston
Individually decorated, individually furnished, desk, blackout drapes
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (718)
Enjoy tranquil accommodations at this welcoming Sikeston hotel where helpful staff receive consistent praise. Located near Central Park and Sikeston Depot Museum, guests appreciate the quiet atmosphere, clean rooms, and daily continental breakfast.
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is ￥8,646
￥9,853 total
includes taxes & fees
Dec 15 - Dec 16
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (443)
Take a refreshing dip in the indoor pool or maintain your routine at the fitness center. Free breakfast, WiFi, and parking enhance your stay. Central Park and Sikeston Depot Museum are just moments away from this welcoming retreat.
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is ￥14,833
￥16,795 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn Sikeston
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (318)
Located in Union City, this hotel offers convenient access to Discovery Park of America. Enjoy free breakfast, WiFi, and parking. Jump into the indoor pool or get active in the 24-hour fitness center, making your Tennessee adventure complete.
"Wonderful breakfast, awesome room"
United States
Kimberly
The price is ￥12,582
￥14,941 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Sleep Inn at Discovery Park of America
Exterior
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
Experience comfort in the entertainment district of Union City at this welcoming hotel. Start your day with free breakfast before exploring nearby Discovery Park of America. After sightseeing, unwind in the indoor pool or maintain your routine at the 24-hour fitness center.
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is ￥16,827
￥19,981 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Express & Suites Union City by IHG
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi
Super 8 By Wyndham Marston

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
This hotel in Marston offers complimentary perks including daily full breakfast served between 6:00 AM and 9:00 AM, WiFi, and self parking. Conveniently located for travelers exploring the area.
"Great hotel, great staff"
United States
Dmitry
The price is ￥8,982
￥10,259 total
includes taxes & fees
Dec 16 - Dec 17
Super 8 By Wyndham Marston
Free buffet breakfast
Quality Inn Union City US 51

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (485)
Unwind at this Union City hotel offering a seasonal outdoor pool and hot tub for relaxation. Just a short distance from County Market Place and Reelfoot Shopping Center, guests enjoy free breakfast, WiFi, and parking.
"The staff I interacted with were pleasant and helpful. Initially they had me in a 2nd floor room, but accommodated my asking for a first floor due to problems I was having with my knee and back. The bed was comfortable and overall the room was nice except for the bathroom shower, it had mold growing in it. Breakfast the next morning was ok."
United States
Rose
The price is ￥10,463
￥12,425 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Quality Inn Union City US 51
Indoor pool, outdoor pool
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
Escape to this serene retreat with both indoor and outdoor pools for year-round enjoyment. The fitness center keeps your routine intact while complimentary breakfast energizes your day exploring nearby Central Park and Sikeston Depot Museum.
"Everything was clean, staff was friendly "
United States
Matthew
The price is ￥11,684
￥13,432 total
includes taxes & fees
Dec 18 - Dec 19
Pear Tree Inn Sikeston
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
New Orleans Inn Portageville

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (726)
This welcoming motel offers clean rooms praised by guests, plus convenient amenities including free WiFi and parking. The 24-hour front desk ensures assistance anytime during your stay in charming Portageville.
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Lobby
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (547)
Discover convenience at this friendly Union City motel, where free breakfast and parking enhance every stay. Explore County Market Place and Reelfoot Shopping Center nearby. Guests consistently praise the clean rooms and helpful staff.
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is ￥11,217
￥13,320 total
includes taxes & fees
Dec 15 - Dec 16
Country Hearth Inn & Suites Union City
Property amenity
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
This business-friendly hotel offers an indoor pool, restaurant, and complimentary breakfast. Located near Sikeston Depot Museum, guests enjoy free WiFi and parking while exploring local attractions.
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is ￥15,737
￥17,818 total
includes taxes & fees
Dec 21 - Dec 22
Fairfield Inn & Suites by Marriott Sikeston
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
"Staff was great! Room was nice. "
United States
Lana
The price is ￥9,676
￥10,737 total
includes taxes & fees
Dec 15 - Dec 16
Super 8 by Wyndham Charleston/Sikeston East MO
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (164)
Located near County Market Place and Reelfoot Shopping Center, this welcoming hotel offers a free breakfast and convenient parking. Take a morning swim in the indoor pool after enjoying the complimentary meal. The helpful staff earns consistent praise from guests.
"Clean room, nice breakfast"
United States
STUART
The price is ￥13,586
￥16,133 total
includes taxes & fees
Dec 26 - Dec 27
Hampton Inn Union City
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (273)
Start your day with complimentary full breakfast before exploring nearby attractions. This hotel provides free WiFi and parking, making it an ideal base for visiting Fort Defiance State Park and Ballard Wildlife Management Area.
"Break fast was excellent "
United States
Uma
The price is ￥11,394
￥12,645 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Quality Inn Cairo I-57
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
Discover comfort at this Sikeston hotel with an indoor pool and fitness center. Enjoy complimentary breakfast, WiFi, and parking while exploring nearby Central Park and Sikeston Depot Museum. Guests consistently praise the helpful staff and immaculate rooms.
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is ￥14,490
￥16,407 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Express & Suites Sikeston Southwest by IHG
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (282)
Experience refreshing comfort at this Sikeston hotel with an indoor swimming pool and fitness center. Near Central Park and Sikeston Depot Museum, travelers appreciate the helpful staff, complimentary WiFi, and free parking for a convenient, stress-free stay.
"Room was clean, breakfast was very good. "
United States
Connie
The price is ￥13,111
￥14,943 total
includes taxes & fees
Dec 21 - Dec 22
Comfort Inn & Suites Sikeston I-55
Property amenity
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.0 out of 10, Wonderful, (8)
Set near Central Park and Sikeston Depot Museum, this business-friendly hotel offers a refreshing indoor pool and convenient daily breakfast. Enjoy well-appointed accommodations with complimentary WiFi and self parking just 32 minutes from Cairo Regional Airport.
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is ￥18,386
￥20,818 total
includes taxes & fees
Dec 21 - Dec 22
TownePlace Suites by Marriott Sikeston
1 bedroom, desk, laptop workspace, blackout drapes
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1004)
This tranquil Sikeston hotel offers complimentary on-the-go breakfast and WiFi, plus convenient access to Central Park and Sikeston Depot Museum. Guests appreciate the helpful staff, clean rooms, and free parking, with a fitness center for morning workouts.
"A great stay in every aspect. "
United States
Gertrude
The price is ￥9,800
￥11,170 total
includes taxes & fees
Dec 21 - Dec 22
Days Inn and Suites by Wyndham Sikeston
Winery
MainStay Suites Union City, TN

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42)
Hiking trails surround this welcoming hotel with free breakfast and parking. The 24-hour fitness center and health club keep exercise routines on track, while in-room refrigerators and microwaves add convenience for extended stays.
"Perfect, staff was very helpful."
United States
Marcos
The price is ￥14,646
￥17,393 total
includes taxes & fees
Dec 15 - Dec 16
MainStay Suites Union City, TN
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

New Orleans Inn Portageville

New Orleans Inn Portageville

10/10 Excellent
"Rooms were clean and staff was friendly!"
Melissa 1-night trip
Posted 6 days ago
New Orleans Inn Portageville

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is ￥8,646 per night from Dec 15 to Dec 16
￥8,646
￥9,853 total
Dec 15 - Dec 16
includes taxes & fees
8.4/10 Very Good! (716 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Hampton Inn Sikeston, located 12.1 mi (19.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Drury Inn & Suites Sikeston, MO and Sleep Inn at Discovery Park of America. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best vacation rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: Visitors like this East Prairie vacation home rental. It is located on a lake and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 33 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and New Madrid Historical Museum in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.

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