A cityscape with modern skyscrapers, a Ferris wheel, and a clock tower.

Search Vacation Homes in Southwest Houston

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Southwest Houston vacation homes

1. Htown Home Near NRG, Med Center | BBQ Yard Games

Htown Home Near NRG, Med Center | BBQ Yard Games
Willow Meadows/Willowbend Area
10.0 out of 10, Exceptional, (20 reviews)
"Great house and very convenient proximity to NGC Center"
United States
Jeff D.
Htown Home Near NRG, Med Center | BBQ Yard Games

2. Updated Westbury Getaway Gem - 3 bedroom oasis

Updated Westbury Getaway Gem - 3 bedroom oasis
Westbury
9.8 out of 10, Exceptional, (17 reviews)
"Really nice property, I loved everything about my stay!"
United States
ccherrishh _.
Updated Westbury Getaway Gem - 3 bedroom oasis

3. Spacious 4-bedroom house with AC, WiFi, Houston Hideaway 10 min to NRG

Spacious 4-bedroom house with AC, WiFi, Houston Hideaway 10 min to NRG
Westbury
10.0 out of 10, Exceptional, (4 reviews)
"Host were responsive and its a very cool and clean place. Beds and linens were very comfortable."
United States
Michael R.
Spacious 4-bedroom house with AC, WiFi, Houston Hideaway 10 min to NRG

4. 5522 David & Jennie’s place 5 minutes to a community park

5522 David & Jennie’s place 5 minutes to a community park
Houston
10.0 out of 10, Exceptional, (23 reviews)
"Great property. We enjoyed our stay."
United States
Shelly C.
The price is ¥18,542
¥47,472 total
includes taxes & fees
Nov 16 - Nov 17
5522 David & Jennie’s place 5 minutes to a community park

5. Nr Med Center + NRG | BBQ Hot Tub Swing Set Games

Nr Med Center + NRG | BBQ Hot Tub Swing Set Games
Central Southwest
9.4 out of 10, Exceptional, (6 reviews)
"This property has everything you need to stay entertained while visiting the city. Almost makes you feel at home! Great stay"
United States
Ivan
Nr Med Center + NRG | BBQ Hot Tub Swing Set Games

6. Htown Hot Tub Getaway | Swing Set BBQ Yard Games

Htown Hot Tub Getaway | Swing Set BBQ Yard Games
Central Southwest
7.0 out of 10, Good, (4 reviews)
"wonderful House great communication from Hosts"
United States
Sandy K.
The price is ¥24,105
¥69,597 total
includes taxes & fees
Nov 16 - Nov 17
Htown Hot Tub Getaway | Swing Set BBQ Yard Games

7. 3BR Near Reliant Stadium Minutes Away

3BR Near Reliant Stadium Minutes Away
Braeswood Place
The price is ¥20,762
¥61,145 total
includes taxes & fees
Nov 16 - Nov 17
3BR Near Reliant Stadium Minutes Away

8. 🚨Nice 2 bed 2 bath apt near NRG & Med Center 🚨

🚨Nice 2 bed 2 bath apt near NRG & Med Center 🚨
Texas Medical Center
9.6 out of 10, Exceptional, (54 reviews)
"Great stay! Awesome location, and the host was amazing!"
United States
Anonymous traveler
🚨Nice 2 bed 2 bath apt near NRG & Med Center 🚨

9. Cozy 1-bedroom complete townhome in lovely Houston

Cozy 1-bedroom complete townhome in lovely Houston
Sharpstown
10.0 out of 10, Exceptional, (1 review)
"Fabulous apartment, perfectly appointed. Ideal place for me to work and relax whilst visiting my son at HCU. Will hopefully be back soon!"
United States
Lydia I.
The price is ¥23,286
¥29,323 total
includes taxes & fees
Nov 16 - Nov 17
Cozy 1-bedroom complete townhome in lovely Houston

10. SW Houston 1BR | King Bed, Sleeps 4

SW Houston 1BR | King Bed, Sleeps 4
Alief
10.0 out of 10, Exceptional, (4 reviews)
"We felt this was an excellent place to stay. Very secure parking and clean. It was a very quiet environment and close enough to area attractions."
United States
Shannon T.
SW Houston 1BR | King Bed, Sleeps 4

11. NRG• MD Anderson• G R Brown• TV Every Room• Extended Stay

NRG• MD Anderson• G R Brown• TV Every Room• Extended Stay
Central Southwest
9.8 out of 10, Exceptional, (10 reviews)
"Very welcoming, spacious, and clean."
United States
Nathanael L.
NRG• MD Anderson• G R Brown• TV Every Room• Extended Stay

12. MidCentury Modern Longterm Med Center Pool WD

MidCentury Modern Longterm Med Center Pool WD
Astrodome
10.0 out of 10, Exceptional, (2 reviews)
"Everything he offered was great, being in a gated community was definitely a bonus "
United States
Axel A.
The price is ¥24,148
¥44,423 total
includes taxes & fees
Nov 16 - Nov 17
MidCentury Modern Longterm Med Center Pool WD

13. 3BR Houston 1 Mi to NRG, Med Center, Downtown

3BR Houston 1 Mi to NRG, Med Center, Downtown
Willow Meadows/Willowbend Area
3BR Houston 1 Mi to NRG, Med Center, Downtown

14. Beautiful 4Bd 3Ba Home with Pool, Hot Tub & Cinema

Beautiful 4Bd 3Ba Home with Pool, Hot Tub & Cinema
Westbury
Beautiful 4Bd 3Ba Home with Pool, Hot Tub & Cinema

15. Luxury Home - near NRG, Medical Center, Downtown & Galleria (5 - 15 minutes)

Luxury Home - near NRG, Medical Center, Downtown & Galleria (5 - 15 minutes)
Willow Meadows/Willowbend Area
9.8 out of 10, Exceptional, (9 reviews)
"Overall stay was very good"
United States
NITIN M.
The price is ¥27,406
¥44,255 total
includes taxes & fees
Nov 16 - Nov 17
Luxury Home - near NRG, Medical Center, Downtown & Galleria (5 - 15 minutes)

16. Fun-Filled Backyard:Firepit-Grill-Games-Good Vibes

Fun-Filled Backyard:Firepit-Grill-Games-Good Vibes
Braeswood Place
Fun-Filled Backyard:Firepit-Grill-Games-Good Vibes

17. SW Houston 2BR | Two Kings, Fenced Yard, Pet OK

SW Houston 2BR | Two Kings, Fenced Yard, Pet OK
Alief
SW Houston 2BR | Two Kings, Fenced Yard, Pet OK

18. 4BR Home Near Med Center with Hot Tub & Cinema

4BR Home Near Med Center with Hot Tub & Cinema
Westbury
The price is ¥44,240
¥99,738 total
includes taxes & fees
Nov 16 - Nov 17
4BR Home Near Med Center with Hot Tub & Cinema

19. Sunny Retreat with 2BR Galleria Stay w/ Garage

Sunny Retreat with 2BR Galleria Stay w/ Garage
Greater Uptown
6.4 out of 10, (5 reviews)
"Overall got what we were expecting and stay went very well. For what the cost was we got an excellent deal and would recommend to anyone who doesn't mind navigating townhouse complex driveways (to no fault of the owner of course)."
United States
William R.
The price is ¥18,367
¥60,668 total
includes taxes & fees
Nov 22 - Nov 23
Sunny Retreat with 2BR Galleria Stay w/ Garage

20. The Houston Reston: Serene Retreat near TMC & NRG

The Houston Reston: Serene Retreat near TMC & NRG
South Main
The price is ¥42,483
¥101,579 total
includes taxes & fees
Dec 1 - Dec 2
The Houston Reston: Serene Retreat near TMC & NRG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Southwest Houston Hotel Reviews

Find out more about Southwest Houston

Southwest Houston Vacation Homes information

Number of reviews
142
Accommodation
285 Vacation Homes
Lowest Price
¥29,323
Highest Price
¥101,579

Explore a world of travel with Expedia