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Find Winery Hotels in Southeast Missouri, MO
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Our top choices for Southeast Missouri hotels with winery

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (677)
The price is ¥13,175
¥14,259 total
includes taxes & fees
Jan 7 - Jan 8, 2026

6.8 out of 10, (924)
The price is ¥12,647
¥14,462 total
includes taxes & fees
Jan 27 - Jan 28, 2026

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4Ste. Genevieve
10.0 out of 10, Exceptional, (18)
The price is ¥17,614
¥32,332 total
includes taxes & fees
Dec 28 - Dec 29

Beautiful Modern Loft In Wine Country!
Beautiful Modern Loft In Wine Country!Ste. Genevieve
10.0 out of 10, Exceptional, (271)
The price is ¥23,172
¥28,290 total
includes taxes & fees
Dec 30 - Dec 31

"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous FarmingtonFarmington
10.0 out of 10, Exceptional, (13)
The price is ¥18,945
¥36,592 total
includes taxes & fees
Dec 28 - Dec 29

The Weber Farm - Enjoy a beautiful 100 acre farm!
The Weber Farm - Enjoy a beautiful 100 acre farm!Frohna
10.0 out of 10, Exceptional, (32)
The price is ¥14,937
¥26,025 total
includes taxes & fees
Jan 1 - Jan 2, 2026

Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.
Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.Bloomsdale
10.0 out of 10, Exceptional, (8)
The price is ¥28,183
¥43,414 total
includes taxes & fees
Dec 28 - Dec 29

"Little Brick House on Main (1865)”
"Little Brick House on Main (1865)”Ste. Genevieve
10.0 out of 10, Exceptional, (63)
The price is ¥18,601
¥24,864 total
includes taxes & fees
Dec 28 - Dec 29
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Jackson MO
10/10 Excellent

Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
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