Find hotels in South Main, Houston

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 26 - Dec 27
Tomorrow
Dec 27 - Dec 28
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Main hotels

Lobby
Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1003)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is ￥13,647
￥15,966 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Suites Houston near Medical Center- NRG Stadium
Lobby
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1198)
"Love this place. Been staying here for many years. "
United States
Reynaldo
The price is ￥13,879
￥16,237 total
includes taxes & fees
Dec 28 - Dec 29
Wyndham Houston near NRG Park/Medical Center
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1001)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is ￥8,269
￥9,674 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Quality Inn & Suites NRG Park - Medical Center
Gazebo
Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (991)
"Easy access to stadium "
United States
Richard
The price is ￥10,760
￥12,590 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Wingate Houston near NRG Park/Medical Center
Exterior
Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (824)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is ￥10,916
￥12,772 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Candlewood Suites Houston Medical Center by IHG
Lobby
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very Good, (3967)
"Rooms were great and the staff was absolutely amazing. "
United States
Elmer
The price is ￥12,126
￥14,186 total
includes taxes & fees
Dec 27 - Dec 28
Club Quarters Hotel Downtown, Houston
Exterior
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 8.8 km from South Main
8.4 out of 10, Very Good, (1492)
"Staff members very nice, hotel as a whole very clean "
United States
Lester
The price is ￥17,363
￥20,315 total
includes taxes & fees
Dec 30 - Dec 31
The Royal Sonesta Houston Galleria
Outdoor pool
Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1003)
"The staff was super nice and the location worked great for us! "
Mexico
Valeria
The price is ￥12,020
￥14,063 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Tru by Hilton Houston Webster NASA
Terrace/patio
Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1090)
"Courteous staff, clean rooms, excellent location."
United States
Rebecca
The price is ￥15,773
￥18,455 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Courtyard by Marriott Houston Intercontinental Airport
Exterior
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1722)
"Nice hotel, the staff was very friendly "
United States
Debra
The price is ￥11,476
￥13,498 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
View from property
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Downtown Houston, 11.1 km from South Main
9.2 out of 10, Wonderful, (1358)
"Bed was very nice and comfortable! "
United States
Luis
The price is ￥19,493
￥23,290 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Terrace/patio
SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1608)
"It was a great stay. Efficient, nice staff and clean room. "
Canada
roham
The price is ￥14,466
￥16,924 total
includes taxes & fees
Jan 2 - Jan 3, 2026
SpringHill Suites by Marriott Houston Intercontinental Arprt
Exclusive Room, Multiple Beds, Non Smoking | Premium bedding, desk, iron/ironing board, free WiFi
Platinum Inn & Suites Webster

Platinum Inn & Suites Webster

Platinum Inn & Suites Webster
3.0 star property
30.8 km from South Main
7.8 out of 10, Good, (1006)
"It was a great stay just perfect"
United States
elvin
The price is ￥8,250
￥9,652 total
includes taxes & fees
Dec 29 - Dec 30
Platinum Inn & Suites Webster
Sundeck
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
4.4 km from South Main
8.4 out of 10, Very Good, (1788)
"The hotel was great and convenient. Easy check in an check out. Will definitely stay again. "
United States
Allison
The price is ￥13,629
￥16,127 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hilton Houston Plaza/Medical Center
Lobby sitting area
Hyatt Place Houston Downtown

Hyatt Place Houston Downtown

Hyatt Place Houston Downtown
3.0 star property
Houston Central Business District, 11 km from South Main
9.0 out of 10, Wonderful, (1569)
"Great service, room was relaxing. "
United States
Alice
The price is ￥14,865
￥17,793 total
includes taxes & fees
Dec 27 - Dec 28
Hyatt Place Houston Downtown
Lobby
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3614)
"Cute hotel, very clean and friendly staff. We enjoyed our stay!"
United States
Alison
The price is ￥20,358
￥23,818 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Blossom Hotel Houston, Curio Collection by Hilton
Exterior
Hilton Garden Inn Houston Hobby Airport, TX

Hilton Garden Inn Houston Hobby Airport, TX

Hilton Garden Inn Houston Hobby Airport, TX
3.0 star property
15 km from South Main
8.8 out of 10, Excellent, (1000)
"Staff was great and ver helpful. Food was amazing and I would stay there again."
United States
Arlyne
The price is ￥14,307
￥16,739 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hilton Garden Inn Houston Hobby Airport, TX
Exterior detail
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.9 km from South Main
8.2 out of 10, Very Good, (3156)
"Friendly staff and great location. "
United States
Tim
The price is ￥19,066
￥22,464 total
includes taxes & fees
Jan 26 - Jan 27, 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1184)
"Great property! "
United States
Lynn
The price is ￥16,551
￥24,113 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hyatt Regency Houston/Galleria
Lobby
Cambria Hotel Houston Downtown Convention Center

Cambria Hotel Houston Downtown Convention Center

Cambria Hotel Houston Downtown Convention Center
3.0 star property
Houston Central Business District, 11 km from South Main
8.8 out of 10, Excellent, (1705)
"Beautiful stay! "
United States
Lillian
The price is ￥16,114
￥18,853 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Cambria Hotel Houston Downtown Convention Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Menil Collection which includes art and interior views

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Main Hotel Reviews

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

10/10 Excellent
"nice "
Ayleen 1-night trip
Posted 1 day ago
The Royal Sonesta Houston Galleria

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness center. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

Explore a world of travel with Expedia