Top South Main Hotels

A city skyline with modern buildings and a park with a lake.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Compare popular hotels in South Main

Property	Star rating	Guest rating
Comfort Suites Houston near Medical Center- NRG Stadium	2.5 star property	8.8 Excellent 1,001 reviews	View
Wyndham Houston near NRG Park/Medical Center	3.5 star property	7.0 Good 1,359 reviews	View
Candlewood Suites Houston Medical Center by IHG	2.5 star property	7.4 Good 887 reviews	View
Quality Inn & Suites NRG Park - Medical Center	2.5 star property	6.6 1,006 reviews	View
Wingate Houston near NRG Park/Medical Center	3.0 star property	6.6 1,001 reviews	View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

See properties

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

See properties

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

See properties

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

See properties

A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

See properties

Top South Main Hotel Reviews

Blossom Hotel Houston, Curio Collection by Hilton

10/10 Excellent

"The staff were so welcoming and the customer service was top tier!"

Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Looking for sights you might find in a travel guide about South Main? Consider a visit to NRG Park while you're in the neighborhood.

Where is the best hotel for a stay in South Main?

Based on our traveler data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from NRG Park, and it offers a restaurant and an outdoor pool.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 60 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

Popular attractions in South Main include NRG Park. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

Explore a world of travel with Expedia

Houston Vacations

Book Hotels in South Main on Expedia.com

Find hotels in South Main, Houston

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for South Main hotels

1. Wyndham Houston near NRG Park/Medical Center

2. Wingate Houston near NRG Park/Medical Center

3. Candlewood Suites Houston Medical Center by IHG

4. Comfort Suites Houston near Medical Center- NRG Stadium

5. Quality Inn & Suites NRG Park - Medical Center

6. Hyatt Place Houston Medical Center

7. Blossom Hotel Houston, Curio Collection by Hilton

8. Hyatt House Houston Medical Center

9. Best Western Plus Pearland/Houston Medical Center Hotel

10. Home2 Suites by Hilton Houston Medical Center, TX

11. Hilton Garden Inn Houston Medical Center, TX

12. The Westin Houston Medical Center/Museum District

13. Hotel Ylem

14. DoubleTree by Hilton Hotel Houston - Greenway Plaza

15. Hilton Houston Plaza/Medical Center

16. Hyatt Place Houston/Galleria

17. Homewood Suites by Hilton Houston Memorial

18. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

19. Studio 6 Houston, TX – Pearland/Medical Center

20. Home2 Suites by Hilton at the Galleria

Compare popular hotels in South Main

Where to stay in South Main

Downtown Houston

The Galleria

Texas Medical Center

Montrose

Houston Central Business District

Top South Main Hotel Reviews

Blossom Hotel Houston, Curio Collection by Hilton

Frequently asked questions

Explore a world of travel with Expedia