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Our top choices for South Main hotels

1. Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
2. Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
3. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG
4. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG Stadium
5. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center
6. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical Center
7. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by Hilton
8. Hyatt House Houston Medical Center
Hyatt House Houston Medical Center
9. Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center Hotel
10. Home2 Suites by Hilton Houston Medical Center, TX
Home2 Suites by Hilton Houston Medical Center, TX
11. Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TX
12. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum District
13. Hotel Ylem
Hotel Ylem
14. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway Plaza
15. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
16. Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria
17. Homewood Suites by Hilton Houston Memorial
Homewood Suites by Hilton Houston Memorial
18. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
19. Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical Center
20. Home2 Suites by Hilton at the Galleria
Home2 Suites by Hilton at the GalleriaCompare popular hotels in South Main
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,001 reviews | View | ||||||
![]() Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,359 reviews | View | ||||||
![]() Candlewood Suites Houston Medical Center by IHG | 7.4 Good 887 reviews | View | ||||||
![]() Quality Inn & Suites NRG Park - Medical Center | 6.6 1,006 reviews | View | ||||||
![]() Wingate Houston near NRG Park/Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews

Blossom Hotel Houston, Curio Collection by Hilton
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