Find hotels in South Main, Houston from ￥10,922
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Discover 6,646 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.
Comfort Suites Houston near Medical Center- NRG Stadium
South Main
8.6 out of 10, Excellent, (1008)
"Loved staying at the Comfort Suites ."
Linda
The price is ￥14,244
￥16,666 total
includes taxes & fees
Nov 30 - Dec 1
Wyndham Houston near NRG Park/Medical Center
South Main
7.2 out of 10, Good, (1191)
"Perfect "
Maria
The price is ￥15,189
￥17,771 total
includes taxes & fees
Nov 15 - Nov 16
Wingate Houston near NRG Park/Medical Center
South Main
6.6 out of 10, (969)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
Roy
The price is ￥12,120
￥14,182 total
includes taxes & fees
Nov 12 - Nov 13
Quality Inn & Suites NRG Park - Medical Center
South Main
6.4 out of 10, (1006)
"Everything was great"
Yeimi
The price is ￥9,335
￥10,922 total
includes taxes & fees
Dec 11 - Dec 12
Candlewood Suites Houston Medical Center by IHG
South Main
7.4 out of 10, Good, (811)
"Yes the where"
Robert
The price is ￥11,353
￥13,283 total
includes taxes & fees
Nov 16 - Nov 17
Hyatt Place Houston Medical Center
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2115)
"Great stay"
Vallie
The price is ￥16,822
￥19,785 total
includes taxes & fees
Nov 26 - Nov 27
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.
Northside
While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.
Top South Main Hotel Reviews
Magnolia Hotel Houston, A Tribute Portfolio Hotel
10/10 Excellent
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