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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,291 reviews)
"Would stay again!"
Austin
The price is ￥14,297
￥16,728 total
includes taxes & fees
May 24 - May 25
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,019 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is ￥15,069
￥17,631 total
includes taxes & fees
May 31 - Jun 1
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Great location"
Jeremy
The price is ￥11,922
￥13,948 total
includes taxes & fees
May 28 - May 29
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (865 reviews)
"My stay was perfect "
Fredrick
The price is ￥13,185
￥15,427 total
includes taxes & fees
May 24 - May 25
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is ￥11,922
￥13,947 total
includes taxes & fees
May 24 - May 25
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (75 reviews)
"The property was very clean and the staff was great. I would stay here again when back in town."
Cruz
The price is ￥9,493
￥11,109 total
includes taxes & fees
May 31 - Jun 1
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (247 reviews)
"Simply amazing stay "
Jesus
The price is ￥13,153
￥15,390 total
includes taxes & fees
May 25 - May 26
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,896 reviews)
"Nice overnight stay. Great for close to airport!!!"
Jaime
The price is ￥14,459
￥17,008 total
includes taxes & fees
Jun 1 - Jun 2
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,771 reviews)
"Gorgeous, perfect location, super comfy beds"
Caitlin
The price is ￥16,068
￥18,799 total
includes taxes & fees
May 29 - May 30
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.2 out of 10, Wonderful, (63 reviews)
"We loved it, very nice employees and very clean."
Jorge
The price is ￥15,256
￥17,849 total
includes taxes & fees
May 24 - May 25
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,213 reviews)
"Wonderful place to stay!"
Lisa
The price is ￥18,768
￥21,959 total
includes taxes & fees
Jun 7 - Jun 8
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (172 reviews)
"It was very clean"
Jesus
The price is ￥12,448
￥14,999 total
includes taxes & fees
May 24 - May 25
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Great location and the staff was great. Very comfortable beds and rooms were very clean. I always come back to this hotel."
Matthew
The price is ￥15,250
￥17,842 total
includes taxes & fees
May 25 - May 26
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
"Parking was easy."
Chris
The price is ￥15,929
￥18,637 total
includes taxes & fees
Jun 1 - Jun 2
La Quinta Inn & Suites by Wyndham Richmond-Sugarland
La Quinta Inn & Suites by Wyndham Richmond-Sugarland30.3 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Close proximity to plenty of restaurants and to Brazos Bend State Park!"
Katie
The price is ￥13,367
￥15,372 total
includes taxes & fees
May 25 - May 26
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (36 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is ￥11,437
￥13,382 total
includes taxes & fees
Jun 6 - Jun 7
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,000 reviews)
"I had an amazing stay! The staff were among the friendliest staff I’ve ever experienced."
Wesley
The price is ￥15,352
￥18,137 total
includes taxes & fees
May 28 - May 29
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,172 reviews)
"Room very clean and spacious
Good choice for breakfast and staffs very polite"
Kofoworola
The price is ￥13,367
￥15,372 total
includes taxes & fees
May 24 - May 25
Spark by Hilton Houston Bush Intercontinental Airport
Spark by Hilton Houston Bush Intercontinental Airport31.2 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Great option close to the airport! "
Lisa
The price is ￥14,109
￥16,509 total
includes taxes & fees
Jun 6 - Jun 7
Hyatt Place Houston/Sugar Land
Hyatt Place Houston/Sugar Land21.4 km from South Main
8.8 out of 10, Excellent, (1,886 reviews)
"Great location and nice walking trail behind the property!"
michael
The price is ￥15,500
￥17,825 total
includes taxes & fees
May 24 - May 25
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,019 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 865 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,000 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,002 reviews | View | ||||||
 Comfort Suites Houston Near Medical Center- NRG Stadium | 8.8 Excellent 11 reviews | View |
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Hotel Zaza Houston Museum District
10/10 Excellent
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