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Sep 26 - Sep 27
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Discover 6,578 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Wyndham Houston near NRG Park/Medical Center
Lobby

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1165)
"I use the app and its been really helpful for our trips we have planned so far."
The price is ￥14,800
￥17,317 total
includes taxes & fees
Oct 4 - Oct 5
Wyndham Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Gazebo

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (940)
"Walking distance to NRG Stadium "
The price is ￥11,810
￥13,818 total
includes taxes & fees
Oct 1 - Oct 2
Wingate Houston near NRG Park/Medical Center
Quality Inn & Suites NRG Park - Medical Center
1 bedroom, hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1009)
"Wonderful experience absolutely love my stay"
The price is ￥8,768
￥10,259 total
includes taxes & fees
Oct 27 - Oct 28
Quality Inn & Suites NRG Park - Medical Center
Candlewood Suites Houston Medical Center by IHG
Exterior

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (798)
"The staff is great. The area is questionable due to homeless population."
The price is ￥11,660
￥13,642 total
includes taxes & fees
Oct 19 - Oct 20
Candlewood Suites Houston Medical Center by IHG
Hyatt Regency Houston/Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers

Hyatt Regency Houston/Galleria

4.0 star property
9.0 out of 10, Wonderful, (1070)
" Good hotel"
The price is ￥24,815
￥29,205 total
includes taxes & fees
Oct 23 - Oct 24
Hyatt Regency Houston/Galleria
Hyatt Place Houston Medical Center
Lobby

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1999)
"Great place to stay!"
The price is ￥20,779
￥24,439 total
includes taxes & fees
Oct 5 - Oct 6
Hyatt Place Houston Medical Center
Blossom Hotel Houston
Front of property

Blossom Hotel Houston

4.0 star property
9.0 out of 10, Wonderful, (3547)
"Great stay "
The price is ￥23,451
￥27,437 total
includes taxes & fees
Oct 19 - Oct 20
Blossom Hotel Houston
The Lancaster Hotel
Exterior

The Lancaster Hotel

4.0 star property
9.6 out of 10, Exceptional, (1028)
"Great place... lots of nice people and nice rooms."
The Lancaster Hotel
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Exterior detail

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.2 out of 10, Very Good, (2597)
"Great stay!!!"
The price is ￥17,820
￥20,994 total
includes taxes & fees
Sep 28 - Sep 29
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Whitehall Houston
City view from property

The Whitehall Houston

4.0 star property
8.6 out of 10, Excellent, (1759)
"Great staff nice rooms"
The price is ￥21,414
￥25,054 total
includes taxes & fees
Oct 5 - Oct 6
The Whitehall Houston
Omni Houston Hotel
Interior

Omni Houston Hotel

4.0 star property
9.0 out of 10, Wonderful, (1016)
"Really enjoyed my stay. "
The price is ￥25,126
￥29,840 total
includes taxes & fees
Oct 18 - Oct 19
Omni Houston Hotel
Hyatt Regency Houston West
Breakfast, lunch, brunch served; American cuisine, garden views

Hyatt Regency Houston West

3.5 star property
8.6 out of 10, Excellent, (1174)
"Great stay for work trips."
The price is ￥16,444
￥19,239 total
includes taxes & fees
Oct 10 - Oct 11
Hyatt Regency Houston West
Hyatt House Houston Medical Center
Lobby

Hyatt House Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1117)
"Have stayed there many times"
The price is ￥20,779
￥24,439 total
includes taxes & fees
Oct 4 - Oct 5
Hyatt House Houston Medical Center
Holiday Inn Express & Suites Houston – Downtown North by IHG
Exterior

Holiday Inn Express & Suites Houston – Downtown North by IHG

2.5 star property
9.2 out of 10, Wonderful, (582)
"Staff was friendly, room was clean, and quiet area!"
The price is ￥17,789
￥20,812 total
includes taxes & fees
Oct 19 - Oct 20
Holiday Inn Express & Suites Houston – Downtown North by IHG
Haven Inn & Suites Downtown Houston
Premium bedding, desk, iron/ironing board, free WiFi

Haven Inn & Suites Downtown Houston

2.5 star property
9.4 out of 10, Exceptional, (1013)
"Was great stay."
Haven Inn & Suites Downtown Houston
La Quinta Inn & Suites by Wyndham Houston Southwest
Exterior

La Quinta Inn & Suites by Wyndham Houston Southwest

3.0 star property
7.0 out of 10, Good, (1027)
"Great stay. "
The price is ￥9,421
￥11,021 total
includes taxes & fees
Sep 29 - Sep 30
La Quinta Inn & Suites by Wyndham Houston Southwest
Club Quarters Hotel Downtown, Houston
Lobby

Club Quarters Hotel Downtown, Houston

4.0 star property
8.4 out of 10, Very Good, (3722)
"Overall great property to stay at. "
The price is ￥14,665
￥17,160 total
includes taxes & fees
Sep 29 - Sep 30
Club Quarters Hotel Downtown, Houston
The Royal Sonesta Houston Galleria
Exterior

The Royal Sonesta Houston Galleria

4.0 star property
8.4 out of 10, Very Good, (1274)
"Great hotel "
The price is ￥21,512
￥25,168 total
includes taxes & fees
Oct 23 - Oct 24
The Royal Sonesta Houston Galleria
Heights House Hotel - Houston Heights Downtown, an Ascend Collection Hotel
View from room

Heights House Hotel - Houston Heights Downtown, an Ascend Collection Hotel

3.0 star property
7.8 out of 10, Good, (1020)
"Loved the commons/patio area "
The price is ￥14,509
￥16,976 total
includes taxes & fees
Oct 19 - Oct 20
Heights House Hotel - Houston Heights Downtown, an Ascend Collection Hotel
Sonesta ES Suites Houston Galleria
Lobby

Sonesta ES Suites Houston Galleria

3.0 star property
8.2 out of 10, Very Good, (1113)
"This hotel was great, lovely & convenience is a double plus! My family and I enjoyed our stay."
The price is ￥16,391
￥19,178 total
includes taxes & fees
Oct 4 - Oct 5
Sonesta ES Suites Houston Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Menil Collection which includes art and interior views

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Houston featuring a city and a high rise building

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.

Top South Main Hotel Reviews

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

10/10 Excellent
"Very clean, wonderful staff"
Shawntorria 1-night trip
Posted 2 days ago
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.