What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on our traveler data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from NRG Park, and it offers a restaurant and an outdoor pool.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 61 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page .

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

Top South Main Hotels

A city skyline with modern buildings and a park with a lake.

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Our top choices for South Main hotels

1. Wyndham Houston at Reliant Park & Medical Center

South Main

Miguel

￥17,178 total

includes taxes & fees

Sep 17 - Sep 18

2. Candlewood Suites Houston Medical Center by IHG

South Main

Michelle

￥13,747 total

includes taxes & fees

Sep 8 - Sep 9

3. Comfort Suites Houston near Medical Center- NRG Stadium

South Main

chris

￥18,788 total

includes taxes & fees

Sep 8 - Sep 9

4. Quality Inn & Suites NRG Park - Medical Center

South Main

Oscar

￥12,920 total

includes taxes & fees

Sep 17 - Sep 18

5. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

1.4 km from South Main

Kevin

￥21,677 total

includes taxes & fees

Sep 17 - Sep 18

6. Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Lamarr

￥23,318 total

includes taxes & fees

Sep 17 - Sep 18

7. Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

ALFRED

￥23,318 total

includes taxes & fees

Sep 17 - Sep 18

8. Blossom Hotel Houston, Curio Collection by Hilton

Texas Medical Center, 3.5 km from South Main

Kamauri

￥26,090 total

includes taxes & fees

Sep 6 - Sep 7

9. Hotel Ylem

2.3 km from South Main

GUSTAVO

￥12,518 total

includes taxes & fees

Sep 10 - Sep 11

10. Courtyard By Marriott Houston Medical Center Reliant Park

2.7 km from South Main

Jorge

￥20,595 total

includes taxes & fees

Sep 17 - Sep 18

11. The Westin Houston Medical Center/Museum District

Texas Medical Center, 4.4 km from South Main

Kevin

￥25,550 total

includes taxes & fees

Sep 6 - Sep 7

12. Hilton Houston Plaza/Medical Center

Texas Medical Center, 4.4 km from South Main

Cindy

￥14,428 total

includes taxes & fees

Sep 7 - Sep 8

13. Home2 Suites by Hilton Houston Medical Center, TX

Texas Medical Center, 4.7 km from South Main

Charles

￥23,813 total

includes taxes & fees

Sep 17 - Sep 18

14. Hilton Garden Inn Houston Medical Center, TX

Texas Medical Center, 4.7 km from South Main

Tameka

￥20,816 total

includes taxes & fees

Sep 17 - Sep 18

15. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Greenway Plaza-Upper Kirby, 6.5 km from South Main

Lanita

￥11,684 total

includes taxes & fees

Sep 7 - Sep 8

16. Hyatt Place Houston/Galleria

8.7 km from South Main

Adaobi

￥19,646 total

includes taxes & fees

Sep 17 - Sep 18

17. DoubleTree by Hilton Hotel Houston - Greenway Plaza

Greenway Plaza-Upper Kirby, 6.6 km from South Main

Raphael

￥14,320 total

includes taxes & fees

Sep 10 - Sep 11

18. Hyatt Regency Houston/Galleria

8.7 km from South Main

Darin

￥27,394 total

includes taxes & fees

Sep 7 - Sep 8

19. Quality Suites Houston Hobby Airport

Southeast Houston, 13.3 km from South Main

Carlos

￥12,414 total

includes taxes & fees

Sep 10 - Sep 11

20. Hotel Zaza Houston Museum District

6.3 km from South Main

Tina

￥46,776 total

includes taxes & fees

Sep 7 - Sep 8

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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

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A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

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A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

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An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.

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A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

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Top South Main Hotel Reviews

Hilton Houston Plaza/Medical Center

8/10 Good

"Food could be better."

DoubleTree by Hilton Hotel Houston - Greenway Plaza

8/10 Good

"The downstairs escalator from the garage is broken so you have to walk up the escalator like stairs. The parking in the garage is expensive and a little complicated. Overall, very nice location and staff. The room was clean enough besides the occasional random hairs."

The Whitehall Houston

10/10 Excellent

"We had a wonderful stay at The Whitehall hotel for my sister’s birthday! Special thanks to Ana Maria, the house supervisor, for welcoming us warmly. The check-in process was smooth and efficient because of her! For breakfast, we were expecting a breakfast buffet but were surprised at the a la carte style and how good it was. Would recommend anyone to stay here!"

Find hotels in South Main, Houston

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Our top choices for South Main hotels

1. Wyndham Houston at Reliant Park & Medical Center

2. Candlewood Suites Houston Medical Center by IHG

3. Comfort Suites Houston near Medical Center- NRG Stadium

4. Quality Inn & Suites NRG Park - Medical Center

5. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

6. Hyatt Place Houston Medical Center

7. Hyatt House Houston Medical Center

8. Blossom Hotel Houston, Curio Collection by Hilton

9. Hotel Ylem

10. Courtyard By Marriott Houston Medical Center Reliant Park

11. The Westin Houston Medical Center/Museum District

12. Hilton Houston Plaza/Medical Center

13. Home2 Suites by Hilton Houston Medical Center, TX

14. Hilton Garden Inn Houston Medical Center, TX

15. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

16. Hyatt Place Houston/Galleria

17. DoubleTree by Hilton Hotel Houston - Greenway Plaza

18. Hyatt Regency Houston/Galleria

19. Quality Suites Houston Hobby Airport

20. Hotel Zaza Houston Museum District

Where to stay in South Main

Downtown Houston

The Galleria

Texas Medical Center

Montrose

Houston Central Business District

Top South Main Hotel Reviews

Hilton Houston Plaza/Medical Center

Frequently asked questions

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