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Oct 23 - Oct 25
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Oct 30 - Nov 1

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Our top choices for South Main hotels

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

1. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,003 reviews)
"Clean rooms and staff is great."
United States
Tamy
The price is ￥14,266
￥16,692 total
includes taxes & fees
Oct 27 - Oct 28
Comfort Suites Houston near Medical Center- NRG Stadium
A modern lobby with a blue carpet, seating area, and large windows.

2. Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,469 reviews)
"Great stay!!"
United States
Matthew
The price is ￥14,123
￥16,524 total
includes taxes & fees
Oct 26 - Oct 27
Wyndham Houston at Reliant Park & Medical Center
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.

3. Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,003 reviews)
"We had a excellent stay"
United States
Jasmine
The price is ￥10,785
￥12,619 total
includes taxes & fees
Nov 17 - Nov 18
Quality Inn & Suites NRG Park - Medical Center
A spacious lobby with a central seating area, a bar, and a reception desk.

4. Wingate Houston near Reliant Park/Medical Center

Wingate Houston near Reliant Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,003 reviews)
"Great place"
United States
Crystal
The price is ￥17,278
￥20,215 total
includes taxes & fees
Nov 1 - Nov 2
Wingate Houston near Reliant Park/Medical Center
A modern kitchen with a microwave, a sink, and a window. There are two black bar stools and a dining table with chairs in the adjacent dining area.

5. 3 BR Condo near Reliant/NRG Stadium

3 BR Condo near Reliant/NRG Stadium
2.0 star property
South Main
8.0 out of 10, Very good, (1 review)
"Checkin was unpleasant because I was given the wrong lockbox information and had trouble reaching the management company. Finally I did and after an hour I got the key. They the WiFi didn’t work and I couldn’t reach anyone - another frustrating hour wasted. The hidden router just needed to be plugged in. The place itself was very comfortable and very convenient for the Reliant Stadium."
United States
Jeffrey
The price is ￥18,050
￥59,019 total
includes taxes & fees
Oct 21 - Oct 22
3 BR Condo near Reliant/NRG Stadium
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.

6. Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (900 reviews)
"Amazing friendly staff."
United States
Olga
The price is ￥12,364
￥14,466 total
includes taxes & fees
Nov 8 - Nov 9
Candlewood Suites Houston Medical Center by IHG
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
1.4 km from South Main
9.4 out of 10, Exceptional, (1,009 reviews)
"Very clean, friendly staff and great breakfast."
United States
Elisa
The price is ￥17,436
￥20,527 total
includes taxes & fees
Oct 26 - Oct 27
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.

8. Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
3.0 star property
2.7 km from South Main
8.6 out of 10, Excellent, (1,000 reviews)
"Great Hotel!"
United States
Jorge
The price is ￥16,213
￥19,165 total
includes taxes & fees
Oct 22 - Oct 23
Courtyard By Marriott Houston Medical Center Reliant Park
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

9. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,702 reviews)
"Will stay again, convenient location"
United States
Dominie
The price is ￥20,025
￥23,552 total
includes taxes & fees
Oct 29 - Oct 30
Hyatt Place Houston Medical Center
A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.

10. Hotel Ylem

Hotel Ylem
3.5 star property
2.3 km from South Main
8.4 out of 10, Very good, (1,578 reviews)
"clean hotel, very nice I enjoyed my stay!"
United States
aundrea
The price is ￥11,154
￥13,843 total
includes taxes & fees
Nov 10 - Nov 11
Hotel Ylem
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

11. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,282 reviews)
"Great location and the bed was amazingly comfortable!!"
United States
Debra
The price is ￥19,964
￥23,481 total
includes taxes & fees
Nov 7 - Nov 8
Hyatt House Houston Medical Center
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

12. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.6 out of 10, Excellent, (2,208 reviews)
"Room was great, staff was helpful"
United States
Marvin
The price is ￥14,686
￥17,367 total
includes taxes & fees
Nov 8 - Nov 9
Hilton Houston Plaza/Medical Center
A rooftop pool area with lounge chairs and a view of a tall building at night.

13. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,263 reviews)
"Great place"
United States
Matthew
The price is ￥25,464
￥31,694 total
includes taxes & fees
Oct 25 - Oct 26
The Westin Houston Medical Center/Museum District
A reception area with a wooden reception desk, two refrigerators, and clocks displaying different city names.

14. Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (470 reviews)
"Happy to stayed there!"
United States
AYTUNC
The price is ￥12,839
￥15,021 total
includes taxes & fees
Oct 25 - Oct 26
Best Western Plus Pearland/Houston Medical Center Hotel
A high-rise hotel with a modern design, featuring a central courtyard with palm trees and a swimming pool.

15. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.9 km from South Main
8.4 out of 10, Very good, (4,614 reviews)
"Hotel was just amazing !"
United States
Nelly
The price is ￥19,834
￥23,370 total
includes taxes & fees
Oct 30 - Oct 31
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
A modern hotel interior with a central spiral staircase, large glass windows, and a buffet area with various food items.

16. The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 8.8 km from South Main
8.8 out of 10, Excellent, (2,346 reviews)
"Very nice place, great breakfast"
United States
artur
The price is ￥22,755
￥26,623 total
includes taxes & fees
Oct 23 - Oct 24
The Royal Sonesta Houston Galleria
A spacious living area with a dining table, chairs, and a chandelier.

17. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
6.3 km from South Main
9.2 out of 10, Wonderful, (1,012 reviews)
"Great place!"
United States
Madiha
The price is ￥38,596
￥52,520 total
includes taxes & fees
Oct 30 - Oct 31
Hotel Zaza Houston Museum District
An outdoor patio area with round wooden tables and wicker chairs, featuring a lantern and modern lighting fixtures.

18. Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX
3.0 star property
Texas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,002 reviews)
"Will stay again , highly recommend!"
United States
Shatara
The price is ￥16,767
￥19,617 total
includes taxes & fees
Oct 29 - Oct 30
Hilton Garden Inn Houston Medical Center, TX
A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.

19. Home2 Suites by Hilton at the Galleria

Home2 Suites by Hilton at the Galleria
3.0 star property
Greater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,064 reviews)
"Access to the gym and pool facilities 24/7 and breakfast each morning is was great. It’s definitely on my list to stay again when I’m back in town."
United States
Dwan
The price is ￥16,715
￥19,557 total
includes taxes & fees
Nov 5 - Nov 6
Home2 Suites by Hilton at the Galleria
A hotel room with a sofa, ottoman, desk, and a bed.

20. Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1,671 reviews)
"Great place to stay"
Australia
Katrina
The price is ￥18,070
￥21,246 total
includes taxes & fees
Nov 1 - Nov 2
Hyatt Place Houston/Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Main

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,003 reviews
View
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
900 reviews
View
A modern lobby with a blue carpet, seating area, and large windows.
Wyndham Houston at Reliant Park & Medical Center
3.5 star property
7.2
Good
1,469 reviews
View
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,003 reviews
View
A spacious lobby with a central seating area, a bar, and a reception desk.
Wingate Houston near Reliant Park/Medical Center
3.0 star property
6.6
1,003 reviews
View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to Reliant Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveler data, Wyndham Houston at Reliant Park & Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from Reliant Park, and it offers a restaurant and an outdoor pool.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
Reliant Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like Reliant Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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