Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Rice University
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's lively festivals and fascinating museums.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the entertainment choices and great live music in this vibrant area.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art scene and entertainment choices in this vibrant area.
Things to do
Houston Museum of Natural Sciences: Planetarium Ticket
Space Center Houston Admission Ticket
Houston: Houston Botanic Garden Entry Ticket
Houston Museum of Natural Science General Admission Ticket
Houston: Space Center Houston Admission Ticket
Houston Museum of Natural Science and Cockrell Butterfly Center
South Main Hotel Deals
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Great location and friendly staff. The room looked slightly dated, it was very clean, spacious and comfortable
Reviewed on Nov 15, 2025
Heritage Place Houston Brookhollow
位置很便利，以前应该是万豪旗下，现在自营了
Reviewed on Nov 9, 2025
Blossom Hotel Houston, Curio Collection by Hilton
The best hotel in this area.
Reviewed on Nov 13, 2025
Club Quarters Hotel Downtown, Houston
Good handicapped room, with space but needs bars to hold onto in shower, toilet has a bar but shower does not. Like the Nespresso machine in the room.
Reviewed on Nov 8, 2025
DoubleTree by Hilton Hotel Houston - Greenway Plaza
Loved the stay
Reviewed on Nov 10, 2025
Holiday Inn Houston Downtown by IHG
The coffee machine was broke
Reviewed on Nov 11, 2025
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Arena and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Houston Zoo and Children's Museum of Houston, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Midtown Arts and Theater Center Houston or Children's Museum of Houston and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
South Main, TX
- George R. Brown Convention Center
- MD Anderson Cancer Center
- Rice University
- Toyota Center
- Daikin Park
- University of Houston
- Houston Zoo
- CityCentre
- Memorial City Mall
- Downtown Aquarium
- Smart Financial Centre at Sugar Land
- Discovery Green
- Baybrook Mall
- Sam Houston Race Park
- Houston Museum of Fine Arts
- Pearland Town Center
- Memorial Park
- Memorial Hermann Memorial City Medical Center
