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Our top choices for South Main hotels
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"convenient to medical center"
Mike
The price is ￥9,508
￥11,124 total
includes taxes & fees
Aug 16 - Aug 17
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,008 reviews)
"Good parking"
joseph
The price is ￥12,264
￥14,349 total
includes taxes & fees
Jul 19 - Jul 20
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,343 reviews)
"Location"
Gurgen
The price is ￥14,882
￥17,413 total
includes taxes & fees
Aug 3 - Aug 4
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,014 reviews)
"Very good all around. Very close to the stadium."
marty
The price is ￥13,715
￥16,048 total
includes taxes & fees
Aug 8 - Aug 9
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (886 reviews)
"This place had"
Marvin
The price is ￥9,834
￥11,505 total
includes taxes & fees
Aug 8 - Aug 9
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.2 out of 10, Wonderful, (156 reviews)
"Clean room & nice location"
Andres
The price is ￥9,995
￥11,694 total
includes taxes & fees
Jul 27 - Jul 28
GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport31.4 km from South Main
6.8 out of 10, (1,258 reviews)
"It was a great stay for the price"
Damian
The price is ￥7,618
￥8,913 total
includes taxes & fees
Jul 21 - Jul 22
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown28.8 km from South Main
8.6 out of 10, Excellent, (756 reviews)
"The staff was really attentive, rooms were clean and it was a good price for our stay"
MARIA
The price is ￥8,754
￥10,068 total
includes taxes & fees
Jul 19 - Jul 20
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.0 out of 10, Very Good, (2,333 reviews)
"Great hotel, staff was really helpful."
Samuel Josué
The price is ￥13,715
￥16,047 total
includes taxes & fees
Jul 22 - Jul 23
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (349 reviews)
"Clean quiet rooms nice breakfast great staff"
Keitha
The price is ￥13,863
￥16,221 total
includes taxes & fees
Jul 21 - Jul 22
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHG6.5 km from South Main
7.8 out of 10, Good, (1,531 reviews)
"The kitchen staff was wonderful and one of the nicest breakfast I've had at any hotel!"
Christy
The price is ￥10,137
￥11,861 total
includes taxes & fees
Jul 30 - Jul 31
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (49 reviews)
"Great space"
Domingos
The price is ￥11,556
￥13,520 total
includes taxes & fees
Jul 25 - Jul 26
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,286 reviews)
"The hotel is adequate for a short stay , the front desk personnel was excellent , free parking , average breakfast ."
Ronald
The price is ￥13,642
￥15,688 total
includes taxes & fees
Jul 20 - Jul 21
Heritage Place Houston Brookhollow
Heritage Place Houston Brookhollow15.4 km from South Main
8.6 out of 10, Excellent, (1,099 reviews)
"Good place to stay"
Jorge
The price is ￥8,864
￥10,425 total
includes taxes & fees
Jul 21 - Jul 22
Platinum Inn & Suites Webster
Platinum Inn & Suites Webster30.8 km from South Main
8.0 out of 10, Very Good, (1,004 reviews)
"The room was very clean and the staff was wonderful, definitely would stay here again."
Katrina
The price is ￥9,799
￥11,465 total
includes taxes & fees
Aug 13 - Aug 14
Haven Inn & Suites Downtown Houston
Haven Inn & Suites Downtown Houston18.7 km from South Main
9.4 out of 10, Exceptional, (1,061 reviews)
"Great stay!"
Dalisia
The price is ￥10,213
￥11,948 total
includes taxes & fees
Jul 19 - Jul 20
Quality Suites Houston Hobby Airport
Quality Suites Houston Hobby AirportSoutheast Houston, 13.3 km from South Main
8.4 out of 10, Very Good, (1,245 reviews)
"Room was clean and early check in was very helpful and inexpensive"
Mary Eloise
The price is ￥10,792
￥12,627 total
includes taxes & fees
Aug 11 - Aug 12
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Nice stay
Overall nice and quiet stay."
Jesus
The price is ￥14,756
￥17,263 total
includes taxes & fees
Aug 11 - Aug 12
La Quinta Inn & Suites by Wyndham Richmond-Sugarland
La Quinta Inn & Suites by Wyndham Richmond-Sugarland30.3 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Great place to stay!"
Michelle
The price is ￥14,605
￥16,796 total
includes taxes & fees
Jul 30 - Jul 31
Holiday Inn Express & Suites Houston IAH - Beltway 8 by IHG
Holiday Inn Express & Suites Houston IAH - Beltway 8 by IHG29.9 km from South Main
8.4 out of 10, Very Good, (1,098 reviews)
"Clean and nice breakfast included."
Jian
The price is ￥12,861
￥15,048 total
includes taxes & fees
Aug 14 - Aug 15
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,014 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,343 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 886 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,008 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View |
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
8/10 Good
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