Find hotels in South Main, Houston from ¥10,888

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Discover 6,512 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1163)
"I use the app and its been really helpful for our trips we have planned so far."
The price is ¥13,737
¥16,073 total
includes taxes & fees
Sep 26 - Sep 27
Wyndham Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (798)
"The staff is great. The area is questionable due to homeless population."
The price is ¥11,514
¥13,471 total
includes taxes & fees
Sep 28 - Sep 29
Candlewood Suites Houston Medical Center by IHG

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (940)
"Walking distance to NRG Stadium "
The price is ¥11,661
¥13,643 total
includes taxes & fees
Sep 25 - Sep 26
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1008)
"Wonderful experience absolutely love my stay"
The price is ¥9,167
¥10,726 total
includes taxes & fees
Oct 7 - Oct 8
Quality Inn & Suites NRG Park - Medical Center

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

3.5 star property
9.2 out of 10, Wonderful, (1010)
"Clean and comfortable hotel"
The price is ¥11,218
¥12,900 total
includes taxes & fees
Oct 16 - Oct 17
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

Champions Club and Hotel, Houston Westchase

4.0 star property
9.0 out of 10, Wonderful, (447)
"Great place to stay"
Champions Club and Hotel, Houston Westchase

Blossom Hotel Houston

4.0 star property
9.0 out of 10, Wonderful, (3535)
"Great stay "
The price is ¥18,524
¥21,673 total
includes taxes & fees
Oct 23 - Oct 24
Blossom Hotel Houston

Drury Inn & Suites Houston Near the Galleria

3.0 star property
9.4 out of 10, Exceptional, (1232)
"Love this place ide so stay again and recommend "
The price is ¥13,874
¥16,233 total
includes taxes & fees
Oct 14 - Oct 15
Drury Inn & Suites Houston Near the Galleria

Houston Marriott South at Hobby Airport

3.5 star property
8.8 out of 10, Excellent, (1239)
"Great clean stay , very quiet and close to the airport "
The price is ¥12,281
¥14,773 total
includes taxes & fees
Oct 4 - Oct 5
Houston Marriott South at Hobby Airport

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

3.0 star property
9.0 out of 10, Wonderful, (935)
"The staff was AMAZING."
The price is ¥11,983
¥14,021 total
includes taxes & fees
Oct 7 - Oct 8
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

The Chifley Houston, Tapestry Collection by Hilton

4.0 star property
9.2 out of 10, Wonderful, (1110)
"excellent hotel, spacious rooms"
The price is ¥23,714
¥27,744 total
includes taxes & fees
Oct 4 - Oct 5
The Chifley Houston, Tapestry Collection by Hilton

The Laura Hotel, Houston Downtown, Autograph Collection

4.5 star property
9.0 out of 10, Wonderful, (1012)
"Great place to stay!"
The price is ¥27,898
¥37,341 total
includes taxes & fees
Oct 4 - Oct 5
The Laura Hotel, Houston Downtown, Autograph Collection

Palace Inn 290 & Jones Rd

2.5 star property
8.8 out of 10, Excellent, (468)
"Staff was friendly, rooms were neat and clean. The area was quiet."
The price is ¥7,967
¥9,323 total
includes taxes & fees
Sep 25 - Sep 26
Palace Inn 290 & Jones Rd

La Quinta Inn & Suites by Wyndham Houston Channelview

3.5 star property
8.6 out of 10, Excellent, (812)
"Excellent and friendly staff "
The price is ¥12,297
¥14,388 total
includes taxes & fees
Sep 28 - Sep 29
La Quinta Inn & Suites by Wyndham Houston Channelview

Haven Inn & Suites Downtown Houston

2.5 star property
9.4 out of 10, Exceptional, (1012)
"Was great stay."
Haven Inn & Suites Downtown Houston

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

3.0 star property
8.8 out of 10, Excellent, (1546)
"Clean spacious wheelchair accessible room, friendly helpful staff, good breakfast"
The price is ¥12,369
¥14,548 total
includes taxes & fees
Oct 5 - Oct 6
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

3.0 star property
8.8 out of 10, Excellent, (1021)
"Clean and good place to stay "
The price is ¥12,421
¥14,284 total
includes taxes & fees
Oct 7 - Oct 8
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Hyatt Regency Houston/Galleria

4.0 star property
9.0 out of 10, Wonderful, (1066)
" Good hotel"
The price is ¥24,798
¥29,185 total
includes taxes & fees
Oct 23 - Oct 24
Hyatt Regency Houston/Galleria

Omni Houston Hotel

4.0 star property
9.0 out of 10, Wonderful, (1015)
"Enjoyed the stay "
The price is ¥24,977
¥29,662 total
includes taxes & fees
Oct 18 - Oct 19
Omni Houston Hotel

Prestige Inn

2.5 star property
8.6 out of 10, Excellent, (249)
"Good experience "
Prestige Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.

Top South Main Hotel Reviews

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Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.