Find hotels in South Main, Houston

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,273 reviews)
"Hotel clean and convenient "
United States
Mitzi
The price is ¥15,246
¥17,838 total
includes taxes & fees
Apr 12 - Apr 13
Wyndham Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,004 reviews)
"Close and convenient to NRG."
United States
Cynthia
The price is ¥18,067
¥21,138 total
includes taxes & fees
Apr 2 - Apr 3
Comfort Suites Houston near Medical Center- NRG Stadium

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (845 reviews)
"Room was clean. It had a musty smell though. "
United States
Ryan
The price is ¥12,465
¥14,584 total
includes taxes & fees
Apr 5 - Apr 6
Candlewood Suites Houston Medical Center by IHG

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,007 reviews)
"Great location"
United States
Jeremy
The price is ¥12,625
¥14,772 total
includes taxes & fees
Apr 6 - Apr 7
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,006 reviews)
"Courteous staff, clean room, quite property"
United States
Javier
The price is ¥10,384
¥12,149 total
includes taxes & fees
Apr 14 - Apr 15
Quality Inn & Suites NRG Park - Medical Center

Palace Inn Blue 290 W 43rd & Bingle Rd

Palace Inn Blue 290 W 43rd & Bingle Rd
2.5 star property
19.4 km from South Main
9.6 out of 10, Exceptional, (25 reviews)
"loveeeee. so cute came here for spring break. comfy little spot definitely recommend!"
United States
Danielle
The price is ¥14,223
¥16,642 total
includes taxes & fees
Apr 3 - Apr 4
Palace Inn Blue 290 W 43rd & Bingle Rd

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.2 out of 10, Wonderful, (22 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is ¥11,363
¥13,294 total
includes taxes & fees
Apr 2 - Apr 3
Hotel Royale

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (197 reviews)
"Yes very great place"
United States
Lloyd
The price is ¥14,958
¥17,500 total
includes taxes & fees
Apr 13 - Apr 14
Best Western Plus Pearland/Houston Medical Center Hotel

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (161 reviews)
"Nice place to stay"
United States
Bella
The price is ¥14,854
¥17,902 total
includes taxes & fees
Apr 13 - Apr 14
Palace Inn Blue Edgebrook

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,193 reviews)
"Enjoyed my stay!"
United States
Chelsea Renee
The price is ¥20,240
¥23,682 total
includes taxes & fees
Apr 17 - Apr 18
Courtyard by Marriott Houston Intercontinental Airport

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,007 reviews)
"Clean and courteous staff."
United States
chris
The price is ¥14,369
¥16,813 total
includes taxes & fees
Apr 14 - Apr 15
Tru by Hilton Houston Webster NASA

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Houston Central Business District, 11 km from South Main
9.2 out of 10, Wonderful, (1,468 reviews)
"Great location, great hotel and staff. Will stay here again. "
United States
larry
The price is ¥21,095
¥25,176 total
includes taxes & fees
Apr 11 - Apr 12
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,817 reviews)
"Clean room and courteous staff. "
United States
Sarah
The price is ¥14,627
¥17,205 total
includes taxes & fees
Apr 24 - Apr 25
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,133 reviews)
"Great breakfast and staff was wonderful."
United States
Jeffery
The price is ¥13,448
¥15,465 total
includes taxes & fees
Apr 5 - Apr 6
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Crystal Inn - NorthWest - 290

Crystal Inn - NorthWest - 290
2.0 star property
24.8 km from South Main
9.8 out of 10, Exceptional, (47 reviews)
"The staff were very nice everything was clean inside and out. "
United States
Tyisha
The price is ¥17,127
¥19,696 total
includes taxes & fees
Apr 1 - Apr 2
Crystal Inn - NorthWest - 290

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Great short stay!!!"
United States
BriAnna
The price is ¥14,703
¥17,202 total
includes taxes & fees
Apr 12 - Apr 13
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very Good, (1,738 reviews)
"The staff was very helpful and made our stay enjoyable."
United States
cynthia
The price is ¥14,814
¥17,333 total
includes taxes & fees
Apr 2 - Apr 3
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Hilton Houston North

Hilton Houston North
3.5 star property
30.5 km from South Main
8.4 out of 10, Very Good, (1,010 reviews)
"Very convenient location, clean, and staff was exceptional "
United States
Shatoria
The price is ¥18,793
¥21,988 total
includes taxes & fees
Apr 11 - Apr 12
Hilton Houston North

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.6 out of 10, Excellent, (4,044 reviews)
"Good location and value "
United States
Marc
The price is ¥15,677
¥18,342 total
includes taxes & fees
Apr 1 - Apr 2
Club Quarters Hotel Downtown, Houston

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,706 reviews)
"wonderful stay "
United States
Stepfan
The price is ¥20,615
¥24,120 total
includes taxes & fees
Apr 3 - Apr 4
SpringHill Suites by Marriott Houston Intercontinental Arprt
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,004 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
845 reviews
View
Premium bedding, pillowtop beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,273 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,007 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,006 reviews
View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness center. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 65 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
Where can I learn more about changing or cancelling my trip to South Main?
For more details about changing or cancelling your trip to South Main, head over to our customer service page.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

Explore a world of travel with Expedia