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Our top choices for South Main hotels
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Room was clean, bed was comfortable, breakfast was good. Perfect place to stay for going to NRG Stadium as it’s an easy walk"
Daniel
The price is ￥11,565
￥13,530 total
includes taxes & fees
Feb 15 - Feb 16
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,000 reviews)
"Clean room, helpful staff and good location to hospital."
George
The price is ￥15,521
￥18,159 total
includes taxes & fees
Feb 15 - Feb 16
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (835 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
Myra
The price is ￥14,055
￥16,444 total
includes taxes & fees
Feb 19 - Feb 20
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Easy access to stadium "
Richard
The price is ￥10,694
￥12,512 total
includes taxes & fees
Feb 16 - Feb 17
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,212 reviews)
"Front desk staff was very professional and kind."
MARINA
The price is ￥15,277
￥17,875 total
includes taxes & fees
Feb 15 - Feb 16
Holiday Inn Express Hotel & Suites Pearland by IHG
Holiday Inn Express Hotel & Suites Pearland by IHG16.6 km from South Main
8.8 out of 10, Excellent, (1,003 reviews)
"Excellent staff from front desk to housekeeping!"
Alexis
The price is ￥14,208
￥16,710 total
includes taxes & fees
Feb 16 - Feb 17
Fairfield Inn & Suites Houston Intercontinental Airport
Fairfield Inn & Suites Houston Intercontinental Airport30.6 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Great place, nice room"
Lester
The price is ￥13,135
￥15,635 total
includes taxes & fees
Feb 22 - Feb 23
Four Points by Sheraton Houston Intercontinental Airport
Four Points by Sheraton Houston Intercontinental Airport29.9 km from South Main
8.4 out of 10, Very Good, (1,003 reviews)
"The staff was friendly and the hotel was clean"
Lisa
The price is ￥12,855
￥15,040 total
includes taxes & fees
Feb 20 - Feb 21
Quality Suites Houston Hobby Airport
Quality Suites Houston Hobby AirportSoutheast Houston, 13.3 km from South Main
8.4 out of 10, Very Good, (1,309 reviews)
"Clean, quiet, amazing stay with great price."
Amy
The price is ￥10,129
￥11,852 total
includes taxes & fees
Feb 19 - Feb 20
Hilton Garden Inn Houston/Bush Intercontinental Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport31.1 km from South Main
8.4 out of 10, Very Good, (1,002 reviews)
"Place was amazing and the staff were great!!!"
Marlene
The price is ￥11,338
￥13,335 total
includes taxes & fees
Feb 21 - Feb 22
Comfort Suites Houston West at Clay Road
Comfort Suites Houston West at Clay Road22.8 km from South Main
8.4 out of 10, Very Good, (1,001 reviews)
"Friendly staff, breakfast excellent perfect location! Will definitely stay here again"
wanda
The price is ￥11,817
￥13,824 total
includes taxes & fees
Feb 22 - Feb 23
Hampton Inn Houston-Brookhollow
Hampton Inn Houston-Brookhollow20.4 km from South Main
8.2 out of 10, Very Good, (1,001 reviews)
"The staff is awesome! What a great place to stay! "
Cynthia
The price is ￥11,763
￥13,763 total
includes taxes & fees
Feb 22 - Feb 23
GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport31.4 km from South Main
6.6 out of 10, (1,001 reviews)
"Staff was very friendly , room was very clean "
Charlette
The price is ￥8,246
￥9,648 total
includes taxes & fees
Feb 27 - Feb 28
Hilton Houston North
Hilton Houston North30.5 km from South Main
8.4 out of 10, Very Good, (1,001 reviews)
"I had a great stay at this hotel. The room was clean and comfortable."
Victor
The price is ￥19,918
￥23,304 total
includes taxes & fees
Feb 22 - Feb 23
Home2 Suites by Hilton Houston IAH Airport Beltway 8
Home2 Suites by Hilton Houston IAH Airport Beltway 829.9 km from South Main
8.4 out of 10, Very Good, (811 reviews)
"Great room close to airport "
Kelli
The price is ￥12,330
￥14,427 total
includes taxes & fees
Feb 22 - Feb 23
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG9.6 km from South Main
8.0 out of 10, Very Good, (1,000 reviews)
"Clean room, friendly and responsive staff"
Clara
The price is ￥15,735
￥18,409 total
includes taxes & fees
Feb 17 - Feb 18
Hampton Inn & Suites Houston I-10 West Park Row
Hampton Inn & Suites Houston I-10 West Park Row29.4 km from South Main
8.8 out of 10, Excellent, (684 reviews)
"Room was very clean and front desk staff were great!"
Bobby
The price is ￥12,234
￥14,420 total
includes taxes & fees
Feb 20 - Feb 21
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD28.7 km from South Main
9.0 out of 10, Wonderful, (990 reviews)
"The hotel was very clean the staff was amazing. We enjoyed our stay"
Teanna
The price is ￥12,222
￥14,300 total
includes taxes & fees
Feb 22 - Feb 23
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (154 reviews)
"Such a great place to stay! Absolutely amazing!"
Charlette
The price is ￥13,700
￥16,512 total
includes taxes & fees
Feb 23 - Feb 24
Hilton Garden Inn Houston NW America Plaza
Hilton Garden Inn Houston NW America Plaza25 km from South Main
8.6 out of 10, Excellent, (1,000 reviews)
"It was very relaxing and the staff are very friendly and helpful. "
Chantel
The price is ￥14,281
￥16,526 total
includes taxes & fees
Feb 20 - Feb 21
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,000 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 835 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,212 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,000 reviews | View | ||||||
 Comfort Suites Near Texas Medical Center - NRG Stadium | 9.0 Wonderful 6 reviews | View |
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Main Hotel Reviews
Hyatt Place Houston Medical Center
10/10 Excellent
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