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Discover 6,512 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

Champions Club and Hotel, Houston Westchase
Champions Club and Hotel, Houston Westchase
Where to stay in South Main

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.
Top South Main Hotel Reviews

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
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Hotels in top Houston neighborhoods
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Hotels near popular Houston Attractions
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Hotels Close to Nearby Airports
Explore more hotels
- Cambria Hotel Houston Downtown Convention Center
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- Hilton Houston Plaza/Medical Center
- Hyatt Place Houston Medical Center
- The Chifley Houston, Tapestry Collection by Hilton
- Marriott Marquis Houston
- Heritage Place Houston Brookhollow
- Hyatt Regency Houston Downtown
- Omni Houston Hotel
- Holiday Inn Houston Downtown by IHG
- SpringHill Suites by Marriott Houston Intercontinental Arprt
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