What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on our traveler data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from NRG Park, and it offers a restaurant and an outdoor pool.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 61 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page .

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

Top South Main Hotels

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Our top choices for South Main hotels

1. Wyndham Houston at Reliant Park & Medical Center

South Main

Timothy

￥17,616 total

includes taxes & fees

Sep 7 - Sep 8

Hypo-allergenic bedding available, in-room safe, desk, blackout drapes

2. Quality Inn & Suites NRG Park - Medical Center

South Main

Oscar

￥13,031 total

includes taxes & fees

Sep 14 - Sep 15

3. Candlewood Suites Houston Medical Center by IHG

South Main

Michelle

￥15,546 total

includes taxes & fees

Sep 14 - Sep 15

Desk, laptop workspace, iron/ironing board (on request)

4. Comfort Suites Houston near Medical Center- NRG Stadium

South Main

Linda

￥18,425 total

includes taxes & fees

Sep 8 - Sep 9

5. Wingate Houston at Reliant Park & Medical Center

South Main

Terry

￥15,506 total

includes taxes & fees

Sep 10 - Sep 11

6. Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

JEAN MICHEL

￥23,555 total

includes taxes & fees

Sep 6 - Sep 7

7. Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Leland

￥23,788 total

includes taxes & fees

Sep 7 - Sep 8

8. Hotel Ylem

2.3 km from South Main

Meryem

￥15,422 total

includes taxes & fees

Sep 14 - Sep 15

9. Courtyard By Marriott Houston Medical Center Reliant Park

2.7 km from South Main

Jorge

￥19,946 total

includes taxes & fees

Sep 4 - Sep 5

Outdoor pool, free cabanas, pool umbrellas

10. The Westin Houston Medical Center/Museum District

Texas Medical Center, 4.4 km from South Main

Stanley

￥27,279 total

includes taxes & fees

Sep 6 - Sep 7

11. Hilton Houston Plaza/Medical Center

Texas Medical Center, 4.4 km from South Main

Cindy

￥15,394 total

includes taxes & fees

Sep 7 - Sep 8

Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers

12. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Greenway Plaza-Upper Kirby, 6.5 km from South Main

Lanita

￥12,549 total

includes taxes & fees

Sep 8 - Sep 9

13. The Royal Sonesta Houston Galleria

The Galleria, 8.8 km from South Main

Tristan

￥22,289 total

includes taxes & fees

Sep 4 - Sep 5

Presidential Suite, 1 King Bed | Premium bedding, in-room safe, desk, iron/ironing board

14. DoubleTree by Hilton Hotel Houston - Greenway Plaza

Greenway Plaza-Upper Kirby, 6.6 km from South Main

Raphael

￥16,743 total

includes taxes & fees

Sep 14 - Sep 15

15. Homewood Suites by Hilton Houston Memorial

16.4 km from South Main

Roland

￥18,161 total

includes taxes & fees

Sep 13 - Sep 14

Suite, 1 Bedroom | Desk, blackout drapes, iron/ironing board, WiFi (free)

16. Hyatt Place Houston/Galleria

8.7 km from South Main

Natasha

￥20,335 total

includes taxes & fees

Sep 3 - Sep 4

17. Quality Suites Houston Hobby Airport

Southeast Houston, 13.3 km from South Main

Carlos

￥12,552 total

includes taxes & fees

Sep 7 - Sep 8

18. Holiday Inn Express Houston - Galleria Area by IHG

The Galleria, 8.6 km from South Main

Michelle

￥22,851 total

includes taxes & fees

Sep 4 - Sep 5

19. Drury Inn & Suites Houston Near the Galleria

The Galleria, 9.4 km from South Main

Andrei

￥17,605 total

includes taxes & fees

Sep 6 - Sep 7

20. Home2 Suites by Hilton at the Galleria

Greater Uptown, 8 km from South Main

Tyson

￥19,813 total

includes taxes & fees

Sep 7 - Sep 8

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Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

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A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

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A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

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An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.

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A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

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