South Main, TX
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the great live music and acclaimed art scene in this vibrant area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and acclaimed theater scene in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.
Space Center Houston
This iconic “mission control ” was immortalized for its role in the first moon landing.
Things to do
Space Center Houston Admission Ticket
NASA's Space Center Admission Plus Houston City Tour
Houston: Space Center Houston Admission Ticket
Houston: Houston Botanic Garden Entry Ticket
Houston Museum of Natural Science and Cockrell Butterfly Center
South Main Hotel Deals
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Great Staff at front desk! Very personal able and helpful! I was also very surprised how nice the property was.
Reviewed on Feb 20, 2026
Hotel Zaza Houston Museum District
Thoughtfully designed property with perks like complimentary shuttle to/from the hotel in 3 mile radius, proximity to great museums, and little amenities like chocolates or prosecco in the room for Valentine’s Day. :)
Reviewed on Feb 16, 2026
Blossom Hotel Houston, Curio Collection by Hilton
Everything was very clean
Reviewed on Feb 18, 2026
The Whitehall Houston
Staff was incredibly nice! Just stayed one night but I felt comfortable and safe.
Reviewed on Feb 19, 2026
The Royal Sonesta Houston Galleria
Very clean room! Spacious and comfy
Reviewed on Feb 19, 2026
Club Quarters Hotel Downtown, Houston
It was a pleasant experience 😁
Reviewed on Feb 17, 2026
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
