Find hotels in Santee, SC from ¥8,757

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Compare 290 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Santee hotels

Tru By Hilton Santee

2.5 star property
9.2 out of 10, Wonderful, (519)
"The property is clean guess friendly convenient for hotel stayers 😊"
The price is ¥14,865
¥16,501 total
includes taxes & fees
Sep 14 - Sep 15
Tru By Hilton Santee

Baymont by Wyndham Santee

2.5 star property
8.0 out of 10, Very Good, (1334)
"Competitive pricing for the area, clean beds & friendly staff."
The price is ¥11,773
¥13,069 total
includes taxes & fees
Sep 3 - Sep 4
Baymont by Wyndham Santee

SureStay Hotel by Best Western Manning

2.5 star property
8.6 out of 10, Excellent, (1004)
"People were fantasticly friendly. "
The price is ¥15,454
¥17,154 total
includes taxes & fees
Sep 7 - Sep 8
SureStay Hotel by Best Western Manning

Fairfield Inn by Marriott Orangeburg

2.5 star property
8.4 out of 10, Very Good, (635)
"Staff very pleasant."
The price is ¥12,363
¥13,724 total
includes taxes & fees
Sep 21 - Sep 22
Fairfield Inn by Marriott Orangeburg

Hampton Inn Santee-I-95

2.5 star property
9.6 out of 10, Exceptional, (1000)
"The rooms, the gym, pool- all very clean. The staff was so friendly. It was a great stay."
The price is ¥19,428
¥21,565 total
includes taxes & fees
Sep 22 - Sep 23
Hampton Inn Santee-I-95

Fairfield Inn & Suites by Marriott Santee

2.5 star property
9.8 out of 10, Exceptional, (1006)
"Wonderful place to stay!"
The price is ¥19,133
¥21,238 total
includes taxes & fees
Sep 9 - Sep 10
Fairfield Inn & Suites by Marriott Santee

Best Western Plus Santee Inn

2.5 star property
8.8 out of 10, Excellent, (1000)
"We really enjoyed our stay and will be back!"
The price is ¥14,764
¥16,386 total
includes taxes & fees
Sep 14 - Sep 15
Best Western Plus Santee Inn

Days Inn by Wyndham St George

2.5 star property
7.6 out of 10, Good, (1000)
"Check on was quick and easy Room was very clean and area was quiet.we had a really good night sleep "
The price is ¥8,757
¥9,721 total
includes taxes & fees
Sep 21 - Sep 22
Days Inn by Wyndham St George

Comfort Inn & Suites Santee

2.5 star property
8.0 out of 10, Very Good, (1004)
"Good place to stay"
The price is ¥14,887
¥16,525 total
includes taxes & fees
Sep 14 - Sep 15
Comfort Inn & Suites Santee

Holiday Inn Santee by IHG

3.0 star property
8.2 out of 10, Very Good, (937)
"Nice clean, great location "
The price is ¥18,986
¥21,073 total
includes taxes & fees
Sep 16 - Sep 17
Holiday Inn Santee by IHG

Travelodge by Wyndham Santee

2.0 star property
7.0 out of 10, Good, (651)
"Did not stay there look at at the rooms and property and book elsewhere "
The price is ¥9,125
¥10,129 total
includes taxes & fees
Sep 3 - Sep 4
Travelodge by Wyndham Santee

Quality Inn & Suites

2.5 star property
6.0 out of 10, (432)
"Don’t expect much for a cheap motel there might be a cockroach or two in your room but to be right off the highway it’s convenient. "
The price is ¥9,258
¥11,090 total
includes taxes & fees
Sep 9 - Sep 10
Quality Inn & Suites

Red Roof Inn Santee

2.0 star property
6.6 out of 10, (623)
"Despite offering breakfast, it was lackluster "
The price is ¥10,743
¥11,925 total
includes taxes & fees
Sep 3 - Sep 4
Red Roof Inn Santee

Super 8 by Wyndham Santee

2.0 star property
6.8 out of 10, (433)
"The nicest bathroom on our 12 day trip"
The price is ¥11,039
¥12,254 total
includes taxes & fees
Sep 3 - Sep 4
Super 8 by Wyndham Santee

Ramada by Wyndham Santee I-95

2.0 star property
6.2 out of 10, (534)
"Pool was nice and clean."
The price is ¥11,384
¥12,637 total
includes taxes & fees
Sep 15 - Sep 16
Ramada by Wyndham Santee I-95

Econo Lodge

2.0 star property
6.4 out of 10, (309)
"No towels and dirty sink."
The price is ¥9,208
¥10,221 total
includes taxes & fees
Sep 28 - Sep 29
Econo Lodge

Hampton Inn Manning

2.5 star property
8.4 out of 10, Very Good, (966)
"Good for the weekend. "
The price is ¥16,249
¥18,038 total
includes taxes & fees
Sep 15 - Sep 16
Hampton Inn Manning

Bells Marina & Resort

2.5 star property
8.6 out of 10, Excellent, (75)
"Had a great stay"
Bells Marina & Resort

Red Roof Inn St George, SC

2.5 star property
7.6 out of 10, Good, (604)
"Check in was fantastic and easy… killed 2 roaches on the wall and found a dead one on the underside of the spare bed’s pillow…"
The price is ¥9,740
¥10,813 total
includes taxes & fees
Sep 7 - Sep 8
Red Roof Inn St George, SC

Motel 6 Saint George, SC – I-95

2.0 star property
6.6 out of 10, (170)
"great team"
The price is ¥9,414
¥10,450 total
includes taxes & fees
Sep 5 - Sep 6
Motel 6 Saint George, SC – I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Santee

Love dining out, golf, and lake views? Get away to Santee!

Top Santee Hotel Reviews

More cheap stays in Santee

More cheap stays in Santee

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Where is the best place for a stay in Santee?

Fairfield Inn & Suites by Marriott Santee is a favorite property for Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on traveler reviews include Hampton Inn Santee-I-95 and Tru By Hilton Santee. See all available top hotels, or vacation rentals in Santee.

What are some of the best vacation rentals in Santee?

Wyndham Vacation Resorts Lake Marion: Visitors give good reviews to this Santee vacation home rental, which is equipped with an outdoor pool, free WiFi, and cable TV to help you feel comfortable during your stay. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a dishwasher, and a stovetop, so you can cook with friends or family. Some other homes for rent in Santee include Private Dock + Pool Table: Lake Marion Getaway and Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!. See all vacation rentals in Santee.

If I need to cancel my hotel reservation in Santee, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of check in. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santee.

Where can I learn more about changing or cancelling my trip to Santee?

For more information about updating your trip to Santee or cancelling it, click here.

What's the best budget-friendly hotel in Santee?

Based on reviews, Baymont by Wyndham Santee is a popular hotel for our travelers who want a more economical choice, and features free breakfast and free WiFi. View all budget hotels in Santee.

What's the best hotel for a family vacation in Santee?

Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another choice for your family trip. Find more child-friendly accommodations in Santee.

What is the top LGBTQ-friendly accommodation in Santee?

Fairfield Inn & Suites by Marriott Santee is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn Santee-I-95 and Holiday Inn Santee by IHG are other good options for your stay. See all available hotels listed as LGBTQ-friendly in Santee.

What's the best pet-friendly accommodation in Santee?

Baymont by Wyndham Santee is a top hotel for people traveling with their pets, and offers concierge services and free WiFi for its human guests. Other good choices for you and your pet's trip include Tru By Hilton Santee and Fairfield Inn & Suites by Marriott Santee. See more pet-friendly hotel accommodations in Santee.

Where is the best place to stay near Santee State Park?

Baymont by Wyndham Santee is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 3 mi (4.8 km) from Santee State Park. Other good choices within 5 miles include Best Western Plus Santee Inn and Holiday Inn Santee, an IHG Hotel.

What about the best place to stay close to Santee Outlets?

One of the top choices for your stay is Baymont by Wyndham Santee, located a short 0.4 mi (0.6 km) from Santee Outlets, and this hotel offers free breakfast and free parking. Best Western Plus Santee Inn and Fairfield Inn & Suites by Marriott Santee are two other good choices in the immediate area.

What's the best golf hotel in Santee?

Holiday Inn Santee by IHG is a top hotel that has an adjacent golf course and features free WiFi. Other good options to stay near a golf course include Ramada by Wyndham Santee I-95 and Super 8 by Wyndham Santee. Visit Santee Cooper Country Club or Santee National Golf Club to perfect your golf swing. See more golf hotels in Santee.

What are some accommodations with pools in Santee?

Fairfield Inn & Suites by Marriott Santee is a top hotel with a pool, free buffet breakfast, and free WiFi. Quality Inn & Suites is another choice with an onsite pool. View all hotels with pools in Santee.

What's the best place to stay near Columbia Metropolitan Airport (CAE)?

Country Inn & Suites by Radisson, Columbia Airport, SC is a popular hotel, featuring free breakfast and an indoor pool. It's located a short 1.7 mi (2.8 km) from Columbia Metropolitan Airport. Other places to stay close to the airport are Sleep Inn Airport and Red Roof Inn Columbia, SC Airport.

What is staying in Santee like?

Families will find kid-friendly activities in Santee, and visitors give high marks for the top-notch restaurants. This welcoming city also attracts tourists with its golf courses and coffeehouses. In Santee, there are 129 hotels and other accommodations to choose from. Find out more about Santee.

What is there to see in Santee?

Favorite places to visit include Santee Cooper Country Club, Santee National Golf Club, and Santee State Park. A couple of additional sights to add to your agenda are Lake Marion and Santee Town Hall. Check out what more to see and do in Expedia's Santee guide.

What's the seasonal weather like in Santee?

The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.