Medical Center District, TX

San Antonio

Tower of the Americas San Antonio: 180 Degree Aerial Panorama
River walk in San Antonio
Tourists River Walk San Antonio Texas
Riverboat on the San Antonio River Walk, San Antonio, Texas, United States of America.
River walk in San Antonio

Popular places to visit

Things to do


Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is ¥14,222 per night from Jun 11 to Jun 12
¥14,222
¥16,810 total
Jun 11 - Jun 12
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (3,415 reviews)
"Great customer service 🙂"

Reviewed on Jun 8, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is ¥17,167 per night from Jun 14 to Jun 15
¥17,167
¥20,399 total
Jun 14 - Jun 15
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
8.6/10 Excellent! (1,076 reviews)
"The Marriot from check in to check out was top notch. Ricky checked me in and was by far the most pleasant, helpful, and accommodating of any concierge I’ve ever encountered. Great stay!"

Reviewed on Jun 8, 2026

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
The price is ¥14,413 per night from Jun 17 to Jun 18
¥14,413
¥17,038 total
Jun 17 - Jun 18
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,347 reviews)
"Everything was perfect! Breakfast & dinner was a plus"

Reviewed on Jun 8, 2026

Drury Inn & Suites San Antonio Northwest Medical Center
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is ¥20,499 per night from Jul 9 to Jul 10
¥20,499
¥24,232 total
Jul 9 - Jul 10
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (4,737 reviews)
"FABULOUS hotel"

Reviewed on Jun 8, 2026

Drury Plaza Hotel San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is ¥19,729 per night from Jul 7 to Jul 8
¥19,729
¥27,897 total
Jul 7 - Jul 8
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (2,811 reviews)
"Decor was beautiful. Hotel was very quiet. Need more places to hang bathroom towels."

Reviewed on Jun 7, 2026

Hotel Valencia Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
The price is ¥14,270 per night from Jun 23 to Jun 24
¥14,270
¥16,868 total
Jun 23 - Jun 24
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (6,495 reviews)
"I am extremely disappointed with my stay at this hotel and would not recommend it to anyone. Upon arrival, my room was not ready, despite checking in at the scheduled time. After waiting, I was finally given a room that had an overwhelming bleach smell, making it very uncomfortable to stay in. The ..."

Reviewed on Jun 8, 2026

Riverwalk Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District

Downtown San Antonio

The stunning river views and popular shops are just a few highlights of Downtown San Antonio. Make a stop by Alamodome or Aztec Theater while you're exploring the area.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Uptown

While visiting Uptown, you might make a stop by sights like San Antonio Zoo and Aquarium and Alamo Quarry Market.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Stone Ridge Market and Shops at Hardy Oak while you're in town.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.



Medical Center District, TX

Explore a world of travel with Expedia