Medical Center District, TX
San Antonio
Visit Medical Center District
Popular places to visit
Lackland Air Force Base
Lackland Air Force Base is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Discover the entertainment venues and shops in this family-friendly area.
River Walk
River Walk is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Discover the fascinating museums and shops in this walkable area.
Six Flags Fiesta Texas
Enjoy the rides and games at Six Flags Fiesta Texas and see why this is a favorite theme park in San Antonio. Experience the lively festivals and acclaimed theater scene in this family-friendly area.
San Antonio SeaWorld
Make time to visit the sea animals who live at San Antonio SeaWorld and find out why this is a popular attraction in San Antonio. Amble around this family-friendly area's seaside or experience its lively festivals.
Henry B. González Convention Center
During your trip, find out what's happening at Henry B. González Convention Center, a top convention center in San Antonio. Experience the great live music and fascinating museums in this walkable area.
Alamodome
Catch an event at Alamodome during your trip to San Antonio. Experience the acclaimed theater scene and fascinating museums in this walkable area.
Things to do
San Antonio Zoo Any Day Ticket
￥4,643
per adult
96% of travellers recommend
San Antonio Old Town Trolley Hop-on Hop-Off Tour
￥8,484
per adult
92% of travellers recommend
The Haunted Ghost Bus Tour in San Antonio
￥8,630
per adult
96% of travellers recommend
San Antonio: Discovery Tour at Natural Bridge Caverns
￥5,954
per adult
98% of travellers recommend
San Antonio: Twisted Trails Zip Rails, Ropes & Climbing Wall
￥6,562
per adult
Medical Center District Hotel Deals
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
The price is ￥14,234 per night from Jun 7 to Jun 8
￥14,234
￥16,824 total
Jun 7 - Jun 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (3,400 reviews)
"Breakfast was good. Housekeeping staff were good. That's about it. Ice machines out of order. Television in both rooms malfunctioned and one replaced with smaller unit. Second television lost connection three times and required reset of Internet connection. Everything about the hotel seemed old and ..."
Reviewed on Jun 6, 2026
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
The price is ￥16,213 per night from Jun 12 to Jun 13
￥16,213
￥19,266 total
Jun 12 - Jun 13
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
8.6/10 Excellent! (1,072 reviews)
"Very good"
Reviewed on Jun 1, 2026
Drury Inn & Suites San Antonio Northwest Medical Center
9806 Interstate Hwy 10 W San Antonio TX
The price is ￥14,424 per night from Jun 21 to Jun 22
￥14,424
￥17,051 total
Jun 21 - Jun 22
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,340 reviews)
"The breakfast was exceptional. It was a full buffet style hot breakfast with 3 different meats, eggs, waffles, potatoes, oatmeal, yogurt, juices, coffee & tea. The room was spacious and clean. The shower was a dream! I would revisit this hotel again in a heartbeat!"
Reviewed on Jun 6, 2026
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
The price is ￥24,042 per night from Jun 7 to Jun 8
￥24,042
￥28,420 total
Jun 7 - Jun 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (4,725 reviews)
"The front desk staff, food and beverage staff, and housekeeping were all amazing! The bar/restaurant downstairs was absolutely amazing, food, drinks and desserts were great! The complimentary breakfast was great as well. Location was perfect, we didn’t have to get our vehicle out of valet until the ..."
Reviewed on Jun 5, 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
The price is ￥13,537 per night from Jun 8 to Jun 9
￥13,537
￥16,003 total
Jun 8 - Jun 9
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (6,474 reviews)
"Online photos were deceiving. Hotel was outdated, very nasty, room smelled like mildew. Was given another room only to find the FRIDGE SITTING IN THE SHOWER! My son’s room also had a smell, last night of stay water starting dripping down in the bathroom and eventually the ceiling fell down. General ..."
Reviewed on Jun 6, 2026
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
The price is ￥19,745 per night from Jul 7 to Jul 8
￥19,745
￥27,918 total
Jul 7 - Jul 8
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (2,800 reviews)
"The hotel rooms were very clean and nice. The hotel restaurant was okay. Parking would have been nice. And a pool would have given it an excellent rating"
Reviewed on Jun 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Medical Center District
Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District
Downtown San Antonio
The stunning river views and popular shops are just a few highlights of Downtown San Antonio. Make a stop by San Antonio River or Alamo while you're exploring the area.
Far West Side
While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.
Photo by Sarah C.
Open Photo by Sarah C.
Uptown
While visiting Uptown, you might make a stop by sights like San Antonio Zoo and Aquarium and Alamo Quarry Market.
Stone Oak
Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Stone Ridge Market and Shops at Hardy Oak while you're in town.
La Cantera District
If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.
Medical Center District, TX
Explore a world of travel with Expedia
- Motels in Alamo Plaza
- Hotels near Natural Bridge Caverns
- Scuba Diving Hotels in Hill Country
- Rv Parks in Bigfoot
- Resorts in Canyon Lake
- Medical Center District Hotels
- Hotels with an Indoor Pool in San Antonio
- San Antonio Hotels
- Family Hotels in Northeast Side
- Rv Parks in Canyon Lake
- Hotels near South Texas Medical Center
- Treehouses in Cibolo
- Ranches in Bandera County
- Helotes Hotels
- Hotels near Lackland Air Force Base Visitor Center
- Ranches in San Antonio
- South San Antonio Hotels
- Fort Sam Houston Hotels
- The Dominion Hotels
- Aparthotels in Universal City
- Hotels near Cathedral of San Fernando
- Hotels near La Villita
- Holiday Park Resorts in Rio Medina
- B&B in Elmendorf
- B&B in San Antonio
- Cibolo Hotels
- Hotels near San Antonio Intl.
- Luxury Hotels in Hollywood Park
- Cabin Rentals in New Braunfels
- Casino Hotels in Brooks City Base
- Schertz Hotels
- Hotels near San Antonio Convention & Visitors Bureau
- Lodges in San Antonio
- Inns in Comfort
- Beach Hotels in Ventura
- All-Inclusive Hotel Hotels in Stone Oak
- Cheap Hotels in Boerne
- Hotels near North Star Mall
- Hotels near Six Flags Fiesta Texas
- Cheap Hotels in Gruene
- Hotels near San Antonio Station
- Hotels near San Pedro Springs Park
- New Braunfels Hotels
- Hotels near Schlitterbahn New Braunfels Waterpark
- Treehouses in San Antonio
- Hotels near River Walk
- Hotels near Randolph Air Force Base
- Castles in San Antonio Station
- Pet-Friendly Hotels in Medical Center District
- Resorts in Universal City
- Downtown San Antonio Hotels
- Hotels near Aquatica San Antonio Waterpark
- Hotels near Brooke Army Medical Center
- Green Hotels in Selma
- Scuba Diving Hotels in Midtown
- Ranches in Bandera
- Stone Oak Hotels
- Cheap Hotels in Adkins
- Cheap Hotels in San Antonio
- Timberwood Park Hotels
- Brooks City Base Hotels
- Hotels with Early Check-in in Downtown San Antonio
- Hotels near La Cantera Golf Club
- Hotels near Lackland Air Force Base
- Historic Hotels in Universal City
- Cheap Hotels in Fort Sam Houston
- Hotels near Wilford Hall Medical Center
- La Vernia Hotels
- Scenic Oaks Hotels
- Luxury Hotels in Boerne
- Hotels near Henry B. González Convention Center
- Hotels near Travis Park
- Hotels near San Antonio River
- Resorts in Comfort
- Hotels near St. Mary's University
- Hotels near University of Texas at San Antonio
- Shopping Hotels in Schertz
- Hotels with Early Check-in in New Braunfels
- Cheap Hotels in Brooks City Base
- Inns in Pleasanton
- Hotels near The Shops of La Cantera
- Hotels near San Antonio Zoo and Aquarium
- Cheap Hotels in Stone Oak
- Comanche Hotels
- Cheap Hotels in Converse
- Hotels near Texas Ski Ranch
- Resorts & Hotels with Spas in West San Antonio
- Universal City Hotels
- Hotels near Freeman Coliseum
- Adkins Hotels
- Farmstay in Bandera
- B&B in Bandera
- Resorts in Natalia
