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Find hotels in Puxico, MO from ￥8,973

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Check prices for these dates

This weekend
Jul 17 - Jul 19
Next weekend
Jul 24 - Jul 26

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Our top choices for Puxico hotels

Mingo Wilderness
Coffee service

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,006 reviews)
"Clean room and convenient location."
United States
Morgan
The price is ￥11,407
￥12,773 total
includes taxes & fees
Jul 18 - Jul 19
Motel 6 Poplar Bluff, MO
Lobby

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,005 reviews)
"Great place to stay. Clean, great staff and the food is good. Would stay again."
United States
Stephanie
The price is ￥15,918
￥17,982 total
includes taxes & fees
Aug 9 - Aug 10
Drury Inn & Suites Poplar Bluff
Lobby

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (935 reviews)
"I absolutely love staying at Fairfield, that's my go to place. The staff is extremely nice, and amazing, the rooms are clean the bed us comfortable."
United States
Tequilla
The price is ￥16,432
￥18,564 total
includes taxes & fees
Aug 9 - Aug 10
Fairfield Inn & Suites by Marriott Poplar Bluff
Desk, iron/ironing board, free WiFi, bed sheets

Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (270 reviews)
"Air was not cold, bathroom door did not close, not a good selection for breakfast"
United States
Amanda
The price is ￥8,283
￥9,301 total
includes taxes & fees
Aug 13 - Aug 14
Econo Lodge Dexter
Breakfast area

Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (355 reviews)
"Nice rooms, friendly staff, "
United States
Sarah
The price is ￥10,089
￥11,329 total
includes taxes & fees
Jul 22 - Jul 23
Dexter Inn
Breakfast, lunch and dinner served

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (749 reviews)
"Great staff especially Ms Wilma at the front desk!"
United States
Denise
The price is ￥14,034
￥15,854 total
includes taxes & fees
Aug 9 - Aug 10
Holiday Inn Poplar Bluff by IHG
In-room safe, desk, WiFi (free), bed sheets

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (656 reviews)
"The person at check in was brash. There isn't much for breakfast options."
United States
Larinda
The price is ￥10,994
￥12,420 total
includes taxes & fees
Jul 25 - Jul 26
Super 8 by Wyndham Poplar Bluff Missouri
Lobby

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (425 reviews)
"Hot tub, pool and entire staff!!!!"
United States
Christy
The price is ￥14,063
￥15,888 total
includes taxes & fees
Jul 26 - Jul 27
Comfort Inn Poplar Bluff North
Lobby sitting area

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (102 reviews)
"Nice place to stay"
United States
JANEEN
The price is ￥14,972
￥16,297 total
includes taxes & fees
Jul 21 - Jul 22
EC Reed's Mercantile and Hotel
Breakfast, lunch and dinner served

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (415 reviews)
"Clean room, staff was super helpful"
United States
Katherine
The price is ￥14,766
￥16,581 total
includes taxes & fees
Jul 19 - Jul 20
Travelodge by Wyndham Dexter
Desk, iron/ironing board, free WiFi, bed sheets

OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (139 reviews)
"Loved the room "
United States
Jessica
The price is ￥7,335
￥8,973 total
includes taxes & fees
Jul 28 - Jul 29
OYO Hickory House Inn
Lobby

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.8 out of 10, Exceptional, (49 reviews)
"Great place to stay"
United States
Lauren
The price is ￥17,103
￥19,204 total
includes taxes & fees
Jul 22 - Jul 23
Hampton Inn By Hilton Dexter
Front of property

Lake Wappapello

Lake Wappapello
2.0 star property
Williamsville
8.8 out of 10, Excellent, (3 reviews)
"Pet friendly. Family-friendly "
United States
Tonya
The price is ￥12,369
￥13,047 total
includes taxes & fees
Aug 1 - Aug 2
Lake Wappapello
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

See all hotels in Puxico
A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Room was clean. Shower was handicap accessible which we didn't need but it was the last room available. Still, shower was nice. We arrived as kick back dinner was ending but desk host made sure we could still have food available, which was very good. Seemed like a good price for the money. Would stay again."
Arthur 1-night trip
Posted 16 hours ago
Drury Inn & Suites Poplar Bluff

More cheap stays in Puxico

Econo Lodge Dexter

Econo Lodge Dexter

913 Outer Rd Dexter MO
The price is ￥8,283 per night from Aug 13 to Aug 14
￥8,283
￥9,301 total
Aug 13 - Aug 14
includes taxes & fees
6.8/10 (270 reviews)

Frequently asked questions

What's the best place for a stay in Puxico?
Motel 6 Poplar Bluff, MO, located 19.4 mi (31.3 km) from the heart of Puxico, is a top choice for your stay based on our traveler data. Two other choices for your trip to the area are Fairfield Inn & Suites by Marriott Poplar Bluff and Hampton Inn Poplar Bluff. See all available top hotels, or vacation rentals in Puxico.
What are some of the best vacation home rentals in Puxico?
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy: This vacation home rental near Puxico offers a fireplace, a balcony, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. See all vacation rentals in Puxico.
If I need to cancel my hotel reservation in Puxico, will I receive a refund?
Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.
Where can I learn more about changing or cancelling my trip to Puxico?
To find more details about picking new dates or cancelling your trip to Puxico, click here.
What is staying in Puxico like?
Travelers to Puxico will find plenty to explore and enjoy. There are 54 hotels and other accommodations in the surrounding area. Find out more about Puxico.
What is there to see in Puxico?
A couple of favorite places to visit are Mark Twain National Forest and Mingo Wilderness. You'll also find Lake Wappapello and Lake Wappapello State Park in the area. Check out what more to see and do in Expedia's Puxico guide.
What's the seasonal weather like in Puxico?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Puxico is 59 inches.